ATE554086T1 - Scopin-salze und deren verwendung in verfahren zur herstellung von n-demethyl-tiotropium und tiotropiumbromid - Google Patents

Scopin-salze und deren verwendung in verfahren zur herstellung von n-demethyl-tiotropium und tiotropiumbromid

Info

Publication number
ATE554086T1
ATE554086T1 AT07810332T AT07810332T ATE554086T1 AT E554086 T1 ATE554086 T1 AT E554086T1 AT 07810332 T AT07810332 T AT 07810332T AT 07810332 T AT07810332 T AT 07810332T AT E554086 T1 ATE554086 T1 AT E554086T1
Authority
AT
Austria
Prior art keywords
tiotropium
scopine
salts
producing
demethyl
Prior art date
Application number
AT07810332T
Other languages
German (de)
English (en)
Inventor
Jonathan Busolli
Nicola Diulgheroff
Roberta Volonto
Alessandro Pontiroli
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of ATE554086T1 publication Critical patent/ATE554086T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT07810332T 2006-07-10 2007-07-10 Scopin-salze und deren verwendung in verfahren zur herstellung von n-demethyl-tiotropium und tiotropiumbromid ATE554086T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83023106P 2006-07-10 2006-07-10
US83520106P 2006-08-03 2006-08-03
US83520006P 2006-08-03 2006-08-03
US83603706P 2006-08-07 2006-08-07
US11/643,013 US20070167480A1 (en) 2005-12-19 2006-12-19 Pure and stable tiotropium bromide
PCT/US2007/015787 WO2008008376A2 (en) 2006-07-10 2007-07-10 Scopine salts and their use in processes for the preparation of n-demethyl-tiotropium and tiotropium bromide

Publications (1)

Publication Number Publication Date
ATE554086T1 true ATE554086T1 (de) 2012-05-15

Family

ID=38814323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07810332T ATE554086T1 (de) 2006-07-10 2007-07-10 Scopin-salze und deren verwendung in verfahren zur herstellung von n-demethyl-tiotropium und tiotropiumbromid

Country Status (9)

Country Link
US (1) US20070167480A1 (cg-RX-API-DMAC7.html)
EP (1) EP2018379B1 (cg-RX-API-DMAC7.html)
JP (2) JP5048408B2 (cg-RX-API-DMAC7.html)
AT (1) ATE554086T1 (cg-RX-API-DMAC7.html)
CA (1) CA2658165A1 (cg-RX-API-DMAC7.html)
ES (1) ES2384652T3 (cg-RX-API-DMAC7.html)
PL (1) PL2018379T3 (cg-RX-API-DMAC7.html)
TW (1) TW200813046A (cg-RX-API-DMAC7.html)
WO (1) WO2008008376A2 (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080039974A (ko) * 2005-08-06 2008-05-07 베링거 인겔하임 인터내셔날 게엠베하 중증 지속성 천식의 치료에서 티오트로퓸 염의 용도
EP1971332B1 (en) * 2006-01-04 2011-03-09 Boehringer Ingelheim International GmbH Use of tiotropium salts in the treatment of moderate persistent asthma
PT2240477E (pt) * 2008-01-10 2014-11-19 Generics Uk Ltd Um novo processo para a preparação de ésteres de escopina
WO2010075090A2 (en) * 2008-12-15 2010-07-01 Auspex Pharmaceuticals, Inc. Scopine modulators of muscarinic acetylcholine receptor
WO2010084924A1 (ja) 2009-01-26 2010-07-29 旭硝子株式会社 電子デバイス用基板の製造方法、電子デバイスの製造方法、電子デバイス用基板、および電子デバイス
WO2011015883A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
US8697719B2 (en) * 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011095800A2 (en) * 2010-02-02 2011-08-11 Generics [Uk] Limited Analytical methods
TR201102068A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
CZ304368B6 (cs) * 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ304808B6 (cs) 2012-03-16 2014-11-05 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma
CZ305012B6 (cs) 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
CN106188012B (zh) * 2014-06-20 2018-11-30 深圳信立泰药业股份有限公司 一种阿利沙坦酯结晶及其制备方法及含有该结晶的药物组合物
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate
WO2021133280A1 (en) * 2019-12-27 2021-07-01 Deva Holding An improved process for preparation of scopine hydrobromide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1469781A (en) * 1974-06-10 1977-04-06 Boehringer Sohn Ingelheim Production of scopine
DE3211185A1 (de) * 1982-03-26 1983-09-29 Boehringer Ingelheim KG, 6507 Ingelheim Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
MXPA02005666A (es) * 2000-10-12 2002-11-29 Boehringer Ingelheim Pharma Nuevos polvos para anhalacion que contienen tiotropio.
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
DE10050995A1 (de) * 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE602004021921D1 (de) * 2003-05-28 2009-08-20 Theravance Inc Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
EP2322522A1 (de) * 2003-11-03 2011-05-18 Boehringer Ingelheim International Gmbh Neue Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
EP1879888A2 (en) * 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide

Also Published As

Publication number Publication date
CA2658165A1 (en) 2008-01-17
ES2384652T3 (es) 2012-07-10
WO2008008376A2 (en) 2008-01-17
PL2018379T3 (pl) 2012-09-28
US20070167480A1 (en) 2007-07-19
EP2018379B1 (en) 2012-04-18
TW200813046A (en) 2008-03-16
JP2008063319A (ja) 2008-03-21
JP2012197282A (ja) 2012-10-18
WO2008008376A8 (en) 2008-03-27
JP5048408B2 (ja) 2012-10-17
WO2008008376A3 (en) 2008-11-13
JP5155472B2 (ja) 2013-03-06
EP2018379A2 (en) 2009-01-28

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