ATE551371T1 - Neue temperatur- und ph-empfindliche copolymere - Google Patents

Neue temperatur- und ph-empfindliche copolymere

Info

Publication number
ATE551371T1
ATE551371T1 AT05742424T AT05742424T ATE551371T1 AT E551371 T1 ATE551371 T1 AT E551371T1 AT 05742424 T AT05742424 T AT 05742424T AT 05742424 T AT05742424 T AT 05742424T AT E551371 T1 ATE551371 T1 AT E551371T1
Authority
AT
Austria
Prior art keywords
unit
new temperature
sensitive
sensitive copolymers
types
Prior art date
Application number
AT05742424T
Other languages
German (de)
English (en)
Inventor
Yi Yan Yang
Kumaresh Soppimath
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Application granted granted Critical
Publication of ATE551371T1 publication Critical patent/ATE551371T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/62—Monocarboxylic acids having ten or more carbon atoms; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/08—Homopolymers or copolymers of acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
AT05742424T 2004-06-10 2005-05-24 Neue temperatur- und ph-empfindliche copolymere ATE551371T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/865,681 US7316816B2 (en) 2004-06-10 2004-06-10 Temperature and pH sensitive copolymers
PCT/SG2005/000164 WO2005121196A1 (en) 2004-06-10 2005-05-24 Novel temperature and ph sensitive copolymers

Publications (1)

Publication Number Publication Date
ATE551371T1 true ATE551371T1 (de) 2012-04-15

Family

ID=35461359

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05742424T ATE551371T1 (de) 2004-06-10 2005-05-24 Neue temperatur- und ph-empfindliche copolymere

Country Status (6)

Country Link
US (2) US7316816B2 (OSRAM)
EP (1) EP1765894B9 (OSRAM)
JP (1) JP4874969B2 (OSRAM)
CN (1) CN100582130C (OSRAM)
AT (1) ATE551371T1 (OSRAM)
WO (1) WO2005121196A1 (OSRAM)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7316816B2 (en) * 2004-06-10 2008-01-08 Agency For Science Technology And Research Temperature and pH sensitive copolymers
KR100665672B1 (ko) 2005-04-13 2007-01-09 성균관대학교산학협력단 새로운 온도 및 ｐＨ 민감성 블록 공중합체 및 이를 이용한고분자 하이드로겔
US8021689B2 (en) * 2006-02-21 2011-09-20 Ecole Polytechnique Federale de Lausanne (“EPFL”) Nanoparticles for immunotherapy
WO2008004978A1 (en) * 2006-07-05 2008-01-10 Agency For Science, Technology And Research Micelles for drug delivery
ATE542841T1 (de) * 2006-12-12 2012-02-15 Unilever Nv Polymere
KR100868724B1 (ko) 2007-05-30 2008-11-13 한국생산기술연구원 가역적 온도감응성을 가지는 자기집합성 나노운반체의제조방법
GB0712482D0 (en) * 2007-06-27 2007-08-08 Eastman Kodak Co Thermally-responsive dispersants for media formulations
JP5296787B2 (ja) * 2007-07-19 2013-09-25 オールエクセル，インコーポレイティド 抗癌剤としての自己集合性の両親媒性ポリマー
US9987221B2 (en) * 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
US8003621B2 (en) * 2007-09-14 2011-08-23 Nitto Denko Corporation Drug carriers
US8703194B2 (en) * 2007-11-02 2014-04-22 Agency For Science, Technology And Research Stimulus-responsive biodegradable polymers and methods of preparation
US8597269B2 (en) * 2008-04-11 2013-12-03 Medtronic Minimed, Inc. Reservoir seal retainer systems and methods
FR2930444B1 (fr) * 2008-04-29 2010-06-04 Servier Lab Micelles polymerisees
JP5382567B2 (ja) * 2008-05-02 2014-01-08 公立大学法人大阪府立大学 温度感受性リポソーム
EP2128180A1 (en) 2008-05-29 2009-12-02 Unilever N.V. Amphiphilic branched polymers and their use as emulsifiers
US8318207B2 (en) * 2009-02-12 2012-11-27 University Of South Carolina Encapsulation and controlled release of small molecules for intracellular delivery using thermally responsive nanocapsules
CN101649034B (zh) * 2009-08-31 2011-05-25 苏州大学 pH/温度响应的双亲水性嵌段共聚物及其制备方法
JP5472072B2 (ja) * 2010-01-13 2014-04-16 信越化学工業株式会社 ネガ型レジスト組成物及びパターン形成方法
WO2011118587A1 (ja) * 2010-03-23 2011-09-29 国立大学法人九州大学 温度、ｐＨ及び塩濃度感応性分離材及びその用途
US10012653B2 (en) 2011-06-15 2018-07-03 Board Of Regents, The University Of Texas System Nanoparticles for targeting acid tumor microenvironments
TWI462753B (zh) * 2011-11-29 2014-12-01 Univ Nat Chiao Tung 雙乳化核殼奈米結構及其製備方法
EP2859088A4 (en) 2012-06-07 2016-04-13 Univ Queensland RELEASE MEDIA
CN102964547B (zh) * 2012-12-05 2014-07-09 南通大学 一种嵌段结构pH响应型糖基智能水凝胶及其制备方法
CN103694426B (zh) * 2013-11-25 2015-10-21 同济大学 一种含碱基对的多重响应型聚合物的制备方法
WO2015082656A1 (en) * 2013-12-04 2015-06-11 Nexdot Nanoparticles complexed with functionalizable enhanced affinity ligands and use thereof
US10953110B2 (en) 2014-04-25 2021-03-23 Board Of Regents, The University Of Texas System Dual emissive metal nanoparticles as ratiometric pH indicators
JP6254045B2 (ja) * 2014-05-20 2017-12-27 キリン株式会社 細胞内の温度を測定するためのレシオ型蛍光性プローブ
SG11201610433PA (en) * 2014-06-13 2017-01-27 Agency Science Tech & Res A copolymer and a micellar particle comprising the copolymer
CN104382851B (zh) * 2014-10-17 2018-12-28 南开大学 一种智能靶向载药复合胶束的制备方法
US10717799B2 (en) * 2015-03-04 2020-07-21 Dow Global Technologies Llc Copolymers as excipients for effective solubilization of poorly water-soluble substances from solid mixtures
CN105131199B (zh) * 2015-08-28 2018-01-23 吴奇 一种制剂及其制备方法与应用
JP6638706B2 (ja) * 2016-08-03 2020-01-29 東ソー株式会社 ブロック共重合体およびそれを用いた表面処理剤
DE102016119102A1 (de) 2016-10-07 2018-04-12 Forschungszentrum Jülich GmbH Translokation von synthetischen Polymeren durch Lipidmembrane
JP2020502226A (ja) * 2016-12-23 2020-01-23 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション 薬物の標的送達のための生体適合性の親水性ポリマーコンジュゲート
CN106977674B (zh) * 2017-03-09 2018-12-21 浙江理工大学 一种pH响应型抗菌聚合物纳米颗粒及其制备方法
JP2018154752A (ja) * 2017-03-17 2018-10-04 東ソー株式会社 共重合体およびその製造方法
US11911532B2 (en) 2017-03-29 2024-02-27 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
CN107432934A (zh) * 2017-04-24 2017-12-05 合肥工业大学 一种嵌段型支化聚合物药物载体及其制备方法和应用
CN107397959B (zh) * 2017-07-28 2020-10-16 国家纳米科学中心 一种表面具有超微结构的纳米拮抗剂的制备方法和应用
CN110538618B (zh) * 2018-05-28 2022-01-14 浙江工业大学 一种以核壳结构微凝胶作为开关的温度和pH双响应智能开关膜的制备方法
EP3953400A4 (en) * 2019-04-12 2023-01-04 The Regents of The University of Michigan T-BLOCK COPOLYMERS AND NANO-FIBROUS GEL-LIFTING MICROSPHERES COMPRISING THEM
CN111269365B (zh) * 2019-04-15 2021-04-27 中国农业科学院农业质量标准与检测技术研究所 一种温敏Wulff型硼亲和纳米颗粒及其制备方法与用途
CN111595954B (zh) * 2019-11-18 2022-07-15 远大医药（中国）有限公司 吲达帕胺原料药中dcc和dcu含量的检测方法
JP2023522187A (ja) 2020-04-17 2023-05-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー バイオ医薬製剤のためのポリマー賦形剤
CN114105703A (zh) * 2021-12-17 2022-03-01 宁波大学 一种缓释抑菌型氨基酸水溶肥及其制备方法
CN114917398A (zh) * 2022-05-06 2022-08-19 深圳市世格赛思医疗科技有限公司 一种可收缩伤口的组织粘合材料及其制备方法与应用
TW202410920A (zh) 2022-05-23 2024-03-16 小利蘭史丹佛大學董事會 包括聚合物賦形劑之抗體生物醫藥調配物
WO2024006539A1 (en) * 2022-07-01 2024-01-04 Vitakey Inc. Nutraceutical particles
CN116178699B (zh) * 2022-09-09 2024-12-03 浙江大学医学院附属第一医院 一种可促进药物入胞的药物递送载体材料及其制备方法和应用
WO2025145010A1 (en) * 2023-12-29 2025-07-03 The University Of Chicago Amphiphilic block copolymers, polymersomes, and methods of use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925542A (en) * 1965-03-03 1975-12-09 Oreal Hair lacquer and wave setting compositions containing vinyl acetate-crotonic acid-containing polymers
CA1260194A (en) * 1984-03-28 1989-09-26 Japan Synthetic Rubber Co Ltd MULTI-COMPONENT COPOLYMER RUBBER, ITS PRODUCTION, AND PRODUCT SO OBTAINED
US5108568A (en) * 1989-07-07 1992-04-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Controlled method of reducing electrophoretic mobility of macromolecules, particles or cells
US5141835A (en) * 1990-05-10 1992-08-25 Fuji Photo Film Co., Ltd. Liquid developer for electrostatic photography
US5226902A (en) * 1991-07-30 1993-07-13 University Of Utah Pulsatile drug delivery device using stimuli sensitive hydrogel
JP3069982B2 (ja) * 1991-12-18 2000-07-24 昭和電工株式会社 高分子ゲルおよびその製造方法
JPH08311290A (ja) * 1995-05-23 1996-11-26 Showa Denko Kk 吸液材料用組成物、吸液材料成形体およびその製造方法
ZA97248B (en) * 1996-01-18 1997-07-18 Rohm & Haas Method for identifying and quantifying polymers utilizing immunoassay techniques
FR2762394B1 (fr) * 1997-04-16 1999-05-28 Bio Merieux Compose ligand de coordination et utilisation pour fixer un materiel biologique
DE19811919A1 (de) * 1998-03-18 1999-09-23 Basf Ag Verwendung von Copolymerisaten monoethylenisch ungesättigter Carbonsäuren als Solubilisatoren
CN1283677A (zh) * 2000-04-29 2001-02-14 河南蓝牌集团商丘啤酒有限公司 绞股蓝营养保健啤酒及生产方法
WO2001087227A2 (en) 2000-05-17 2001-11-22 Labopharm, Inc. Drug containing polymeric micelles
US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
US6849681B2 (en) * 2002-07-10 2005-02-01 Meadwestvaco Corporation Carboxylic acid-modified vinylic polymeric compositions
US20040044124A1 (en) * 2002-08-27 2004-03-04 Westvaco Corporation Rosin-fatty acid vinylic polymer compositions
WO2004096140A2 (en) 2003-04-25 2004-11-11 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
US7316816B2 (en) * 2004-06-10 2008-01-08 Agency For Science Technology And Research Temperature and pH sensitive copolymers

Also Published As

Publication number Publication date
US7316816B2 (en) 2008-01-08
EP1765894B9 (en) 2012-08-01
WO2005121196A1 (en) 2005-12-22
EP1765894A4 (en) 2010-11-03
US20080182959A1 (en) 2008-07-31
JP4874969B2 (ja) 2012-02-15
JP2008502785A (ja) 2008-01-31
EP1765894B1 (en) 2012-03-28
EP1765894A1 (en) 2007-03-28
CN1984935A (zh) 2007-06-20
CN100582130C (zh) 2010-01-20
US20050277739A1 (en) 2005-12-15
US8541013B2 (en) 2013-09-24

Similar Documents

Publication Publication Date Title
ATE551371T1 (de) Neue temperatur- und ph-empfindliche copolymere
DE602005018489D1 (de) Temperaturempfindliche polymere
ATE354122T1 (de) Tragbares durchflusszytometer
TW200619241A (en) Redox polymers for use in electrochemical-based sensors
BRPI0701461B8 (pt) instrumento cirúrgico tendo um sistema de retroalimentação
ATE372792T1 (de) Superabsorptionsfähiges polymer
TR200802094T1 (tr) Led aydınlatıcılar için optik tertibat.
BRPI0416472A (pt) plantas de algodão resistentes a insetos e métodos de detecção das mesmas
DE602005016527D1 (de) Verfahren zur schnelldiagnose von zielen in menschlichen körperflüssigkeiten
ATE330038T1 (de) Nukleinsäure-biosensor
PT1737667E (pt) Dispositivo de ejeção de fluido
DK2332582T3 (da) ACE2-aktivering til behandling af hjerte-, lunge-og nyresygdomme samt forhøjet blodtryk
BRPI0914103A2 (pt) utilização de um copolímero hidrossolúvel ou álcali-solúvel
ATE413904T1 (de) Wasserfeste haarstylingzusammensetzung enthaltend zwei copolymere
FR2900734B1 (fr) Detection des maladies veineuses thromboemboliques par le dosage des d-dimeres et de la fibrine soluble
DE602006007887D1 (de) Haftkleber und Klebepflaster
CR8385A (es) Pirimidinas sustituidas con sulfoximina como inhibidores de cdk y/o vegf, su preparacion y sus usos como medicamento
EP1448582A4 (en) TELOMERASE INTERFERENCE
BR0108042A (pt) Membranas de limitação de difusão de analito fundido usando monÈmeros hidrófilos fotopolimerizáveis
BRPI0517236A (pt) composição de hidrogel
JP2007319942A5 (OSRAM)
DK1432286T3 (da) Høreapparat med brændstofcelle
EP1837349A4 (en) MODIFIED STYRENE MALEIC ACID COPOLYMER AND USE THEREOF
DE50213235D1 (de) Klimakammer
ATE457332T1 (de) Wasserhaltige polymermatrix aus hydrophoben polymeren