ATE548112T1 - Mikrofluidikchip, der zur synthese von radioaktiv markierten molekülen in einem für die bilderzeugung am menschen mittels positronenemissionstopographie geeigneten massstab befähigt ist - Google Patents

Mikrofluidikchip, der zur synthese von radioaktiv markierten molekülen in einem für die bilderzeugung am menschen mittels positronenemissionstopographie geeigneten massstab befähigt ist

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Publication number
ATE548112T1
ATE548112T1 AT06825335T AT06825335T ATE548112T1 AT E548112 T1 ATE548112 T1 AT E548112T1 AT 06825335 T AT06825335 T AT 06825335T AT 06825335 T AT06825335 T AT 06825335T AT E548112 T1 ATE548112 T1 AT E548112T1
Authority
AT
Austria
Prior art keywords
microfluidiic
synthesis
positron emission
chip
labeled molecules
Prior art date
Application number
AT06825335T
Other languages
English (en)
Inventor
Arkadij M Elizarov
Hartmuth Kolb
James Heath
Dam R Michael Van
Original Assignee
Siemens Medical Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions filed Critical Siemens Medical Solutions
Application granted granted Critical
Publication of ATE548112T1 publication Critical patent/ATE548112T1/de

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/29—Mixing by periodically deforming flexible tubular members through which the material is flowing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
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AT06825335T 2005-09-29 2006-09-29 Mikrofluidikchip, der zur synthese von radioaktiv markierten molekülen in einem für die bilderzeugung am menschen mittels positronenemissionstopographie geeigneten massstab befähigt ist ATE548112T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72160705P 2005-09-29 2005-09-29
PCT/US2006/038418 WO2007041486A2 (en) 2005-09-29 2006-09-29 Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography

Publications (1)

Publication Number Publication Date
ATE548112T1 true ATE548112T1 (de) 2012-03-15

Family

ID=37775141

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AT06825335T ATE548112T1 (de) 2005-09-29 2006-09-29 Mikrofluidikchip, der zur synthese von radioaktiv markierten molekülen in einem für die bilderzeugung am menschen mittels positronenemissionstopographie geeigneten massstab befähigt ist

Country Status (8)

Country Link
US (2) US8075851B2 (de)
EP (1) EP1940543B1 (de)
JP (1) JP5344921B2 (de)
KR (1) KR100984963B1 (de)
AT (1) ATE548112T1 (de)
CA (1) CA2624243C (de)
ES (1) ES2379921T3 (de)
WO (1) WO2007041486A2 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100984963B1 (ko) 2005-09-29 2010-10-05 지멘스 메디컬 솔루션즈 유에스에이, 인크. 양전자 방출 단층촬영에 의한 인체 영상화에 적합한 규모의방사성 표지 분자를 합성할 수 있는 마이크로유체 칩
US7463353B2 (en) * 2006-05-31 2008-12-09 Uchicago Argonne, Llc Modular, micro-scale, optical array and biodetection system
US7556780B1 (en) * 2006-09-11 2009-07-07 Atomic Energy Council-Institute Of Nuclear Energy Research Device for 123I-ADAM and automatic manufacturing device thereof
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2653861B1 (de) 2006-12-14 2014-08-13 Life Technologies Corporation Verfahren zur Nukleinsäure-Sequenzierung mittels großer FET-Arrays
WO2008140616A2 (en) * 2006-12-21 2008-11-20 Hammersmith Imanet Limited Nucleophilic radiofluorination using microfabricated devices
WO2008091694A2 (en) * 2007-01-23 2008-07-31 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
US8071035B2 (en) 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
CA2684220A1 (en) * 2007-04-12 2008-10-23 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
WO2009015048A2 (en) * 2007-07-20 2009-01-29 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release
JP5309312B2 (ja) * 2007-11-01 2013-10-09 Ｊｆｅテクノス株式会社 マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法
JP5667049B2 (ja) 2008-06-25 2015-02-12 ライフ テクノロジーズ コーポレーション 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置
US20100093098A1 (en) * 2008-10-14 2010-04-15 Siemens Medical Solutions Nonflow-through appratus and mehod using enhanced flow mechanisms
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8546128B2 (en) * 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
KR20110106895A (ko) * 2008-12-22 2011-09-29 바이엘 파마 악티엔게젤샤프트 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8273300B2 (en) * 2009-07-09 2012-09-25 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
US8435454B2 (en) 2009-07-09 2013-05-07 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
US11135321B2 (en) * 2009-09-23 2021-10-05 Best Medical International, Inc. Automated radiopharmaceutical production and quality control system
US8376317B2 (en) * 2010-03-29 2013-02-19 Purdue Research Foundation Microfluidic purge valve
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
EP2598804B1 (de) 2010-06-30 2021-10-20 Life Technologies Corporation Verfahren zur erzeugung eines ausgangssignals in einem isfet-array
TWI569025B (zh) 2010-06-30 2017-02-01 生命技術公司 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
US8653567B2 (en) 2010-07-03 2014-02-18 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
US8980185B2 (en) 2010-08-26 2015-03-17 The Board Of Trustees Of The University Of Illinois Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate
US9618475B2 (en) 2010-09-15 2017-04-11 Life Technologies Corporation Methods and apparatus for measuring analytes
EP2619564B1 (de) 2010-09-24 2016-03-16 Life Technologies Corporation Transistorschaltungen mit zusammengehörigen paaren
US20130266487A1 (en) * 2010-12-17 2013-10-10 Ge Healthcare Limited Shielding collar
US9139316B2 (en) 2010-12-29 2015-09-22 Cardinal Health 414, Llc Closed vial fill system for aseptic dispensing
KR101293158B1 (ko) 2011-05-13 2013-08-12 성균관대학교산학협력단 방사성 화합물 합성모듈
WO2013012813A1 (en) 2011-07-15 2013-01-24 Cardinal Health 414, Llc Modular cassette synthesis unit
US9417332B2 (en) 2011-07-15 2016-08-16 Cardinal Health 414, Llc Radiopharmaceutical CZT sensor and apparatus
WO2013012822A1 (en) 2011-07-15 2013-01-24 Cardinal Health 414, Llc Systems, methods, and devices for producing, manufacturing, and control of radiopharmaceuticals
EP2761623A4 (de) * 2011-09-30 2016-01-20 Ge Healthcare Ltd Partitionierte reaktionsgefässe
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
KR101318218B1 (ko) * 2012-01-19 2013-10-15 서강대학교산학협력단 방사성 물질의 분리 검출 또는 정량분석을 위한 크로마토그래피용 미세컬럼관 및 이를 사용하는 방사성 물질의 검출 방법
BE1020600A3 (fr) * 2012-03-30 2014-01-07 Ion Beam Applic Module jetable pour dispositif de synthese de radioisotopes et procede de fabrication dudit module.
US9063121B2 (en) 2012-05-09 2015-06-23 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US10309947B2 (en) 2013-02-27 2019-06-04 Trace-Ability, Inc. System and method for radiosynthesis, quality control and dose dispensing
CN103191791B (zh) * 2013-03-01 2014-09-10 东南大学 生物微粒高通量分选和计数检测的集成芯片系统及应用
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
WO2014149779A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical device with thin conductive element
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
WO2015050998A2 (en) 2013-10-01 2015-04-09 The Broad Institute, Inc. Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte
US10076751B2 (en) * 2013-12-30 2018-09-18 General Electric Company Systems and methods for reagent storage
US10895563B2 (en) 2014-02-26 2021-01-19 Trace-Ability, Inc. Palette-based systems for analyte characterization
US11002717B2 (en) 2014-02-26 2021-05-11 Trace-Ability, Inc. Systems and methods for characterizing radioactive analytes
DK3594360T3 (da) 2014-04-24 2021-08-30 Lucira Health Inc Kolorimetrisk detektering af nukleinsyre amplifikation
WO2015188165A1 (en) * 2014-06-06 2015-12-10 The Regents Of The University Of California Self-shielded, benchtop chemistry system
WO2016044532A1 (en) * 2014-09-17 2016-03-24 The Regents Of The University Of California Vacuum battery system for portable microfluidic pumping
ES2913351T3 (es) * 2014-09-27 2022-06-01 Trace Ability Inc Sistemas basados en paleta para la caracterización de analitos
EP3234575B1 (de) 2014-12-18 2023-01-25 Life Technologies Corporation Vorrichtung zur messung von analyten unter verwendung von grossflächigen fet-arrays
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
KR102593647B1 (ko) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 트랜스미터 구성을 갖춘 높은 데이터율 집적 회로
CA3015378C (en) * 2016-03-14 2023-09-26 Diassess Inc. Selectively vented biological assay devices and associated methods
AU2017232340B2 (en) 2016-03-14 2022-04-28 Pfizer Inc. Systems and methods for performing biological assays
AU2017232342B2 (en) 2016-03-14 2022-04-21 Pfizer Inc. Devices and methods for biological assay sample preparation and delivery
US20190201560A1 (en) * 2016-09-06 2019-07-04 The Regents Of The University Of California Method and device for concentration and formulation of radiopharmaceuticals
WO2018067965A1 (en) * 2016-10-07 2018-04-12 The Regents Of The University Of California Device and method for microscale chemical reactions
US10377701B2 (en) 2016-11-08 2019-08-13 The Regents Of The University Of California Methods for multi-dose synthesis of [F-18]FDDNP for clinical settings
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
EP3658841B1 (de) 2017-11-22 2024-03-27 Hewlett-Packard Development Company, L.P. Temperaturregelnde mikrofluidische vorrichtungen
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
AU2021258264A1 (en) * 2020-04-24 2022-11-17 The Trustees Of The University Of Pennsylvania Digital fluid teleportation, advanced biological virtualization, and large scale integration of organ-on-chips and microphysiological models
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
WO2022231607A1 (en) * 2021-04-30 2022-11-03 Hewlett-Packard Development Company, L.P. Microfluidic device

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002166A (en) * 1932-03-30 1935-05-21 Bandes Julius Playing card cabinet
US2716017A (en) * 1952-08-28 1955-08-23 Grinnell Corp Diaphragm valves
US3613729A (en) * 1970-02-16 1971-10-19 Packard Instrument Co Inc Valve system
US4536121A (en) * 1983-04-22 1985-08-20 Foster Wheeler Energy Corporation Divided rotary valve feeder
FI840846A0 (fi) * 1984-03-02 1984-03-02 Labsystems Oy Ventilanordning
US4721133A (en) * 1985-09-26 1988-01-26 Alcon Laboratories, Inc. Multiple use valving device
US4977948A (en) * 1988-07-15 1990-12-18 General Motors Corporation Countergravity casting apparatus and method using elastomeric sealing gasket and cooled vacuum chamber
US4924241A (en) * 1989-08-01 1990-05-08 Diagraph Corporation Printhead for ink jet printing apparatus
US6099457A (en) * 1990-08-13 2000-08-08 Endotech, Inc. Endocurietherapy
EP0637997B1 (de) 1992-05-01 1998-07-01 Trustees Of The University Of Pennsylvania Analyse bei messung des durchflusswiderstandes
US5413227A (en) * 1992-10-05 1995-05-09 Midwest Research Institute Improved vortex reactor system
US5624555A (en) * 1993-10-04 1997-04-29 National Research Council Of Canada Fluid fractionating, stacked permeable membrane assembly
DE69406945T2 (de) 1993-10-18 1998-03-12 Ici Plc Katalytisches verfahren
US5679580A (en) * 1994-03-09 1997-10-21 Midwest Research Institute Rapid evaporation method for analysis
US6924128B2 (en) * 1994-12-06 2005-08-02 Targeted Genetics Corporation Packaging cell lines for generation of high titers of recombinant AAV vectors
US5765591A (en) * 1995-11-20 1998-06-16 Argonaut Technologies, Inc. Valve apparatus and method for distributing fluids
US6720710B1 (en) * 1996-01-05 2004-04-13 Berkeley Microinstruments, Inc. Micropump
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5988603A (en) * 1997-03-13 1999-11-23 Midwest Research Institute Level maintenance in cyclone contractors
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US5900201A (en) * 1997-09-16 1999-05-04 Eastman Kodak Company Binder coagulation casting
US6145810A (en) * 1998-04-14 2000-11-14 Asepco, Inc. Aseptic valve construction with diaphragm having straight neck
US6830729B1 (en) * 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US7150994B2 (en) * 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US6391541B1 (en) 1999-05-28 2002-05-21 Kurt E. Petersen Apparatus for analyzing a fluid sample
WO2001001025A2 (en) * 1999-06-28 2001-01-04 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
WO2001041931A2 (en) 1999-12-09 2001-06-14 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US6599484B1 (en) * 2000-05-12 2003-07-29 Cti, Inc. Apparatus for processing radionuclides
US6518477B2 (en) * 2000-06-09 2003-02-11 Hanford Nuclear Services, Inc. Simplified integrated immobilization process for the remediation of radioactive waste
AU2002211389A1 (en) 2000-10-03 2002-04-15 California Institute Of Technology Microfluidic devices and methods of use
WO2002055198A2 (en) 2000-11-06 2002-07-18 Nanostream Inc Microfluidic flow control devices
US7378280B2 (en) 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
FR2818922B1 (fr) * 2000-12-28 2003-10-03 Atofina Procede et dispositif pour la mise en oeuvre d'une reaction en milieu liquide avec degagement gazeux
US6431976B1 (en) * 2001-01-26 2002-08-13 Visteon Global Technologies, Inc. Rotary distribution chamber for selective distribution of a fluid
US6742544B2 (en) 2001-03-07 2004-06-01 Symyx Technologies, Inc. Injection valve array
CA2450676C (en) 2001-03-09 2010-03-30 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
EP1384022A4 (de) * 2001-04-06 2004-08-04 California Inst Of Techn Nukleinsäure-amplifikation verwendende mikrofluidvorrichtungen
US6631826B2 (en) 2001-07-20 2003-10-14 Parata Systems, Llc Device to count and dispense articles
SE0103110D0 (sv) 2001-09-18 2001-09-18 Aamic Ab Microscale fluid handling system
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
GB0129816D0 (en) * 2001-12-13 2002-01-30 The Technology Partnership Plc Testing device for chemical or biochemical analysis
GB0206117D0 (en) 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
US6814337B2 (en) * 2002-04-03 2004-11-09 Ronald Anthony Schmaltz Valve for controlling fluid flow through a tube, and related systems and methods
US6752371B2 (en) * 2002-06-19 2004-06-22 Arichell Technologies, Inc. Valve actuator having small isolated plunger
WO2003087410A1 (en) 2002-04-11 2003-10-23 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
US6830545B2 (en) * 2002-05-13 2004-12-14 Everest Vit Tube gripper integral with controller for endoscope of borescope
US7125510B2 (en) * 2002-05-15 2006-10-24 Zhili Huang Microstructure fabrication and microsystem integration
AU2003223937A1 (en) 2002-05-17 2003-12-02 University Of Copenhagen An elisa measuring de novo peptide-mhc interaction
US20040101444A1 (en) * 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
US7186383B2 (en) 2002-09-27 2007-03-06 Ast Management Inc. Miniaturized fluid delivery and analysis system
CA2523189A1 (en) * 2003-04-22 2004-11-04 Molecular Technologies, Inc. System and method for synthesis of molecular imaging probes including fdg
US7296592B2 (en) * 2003-09-16 2007-11-20 Eksigent Technologies, Llc Composite polymer microfluidic control device
US20050265906A1 (en) * 2004-06-01 2005-12-01 Palo Alto Scientific, Inc. Apparatus and Method for Preventing Radioactive Contamination of Radiopharmaceutical Manufacturing Components
US20060078475A1 (en) * 2004-07-29 2006-04-13 Yu-Chong Tai Modular microfluidic packaging system
US20080264863A1 (en) * 2004-12-03 2008-10-30 California Institute Of Technology Microfluidic Sieve Valves
US8206593B2 (en) * 2004-12-03 2012-06-26 Fluidigm Corporation Microfluidic chemical reaction circuits
US20060204699A1 (en) * 2004-12-08 2006-09-14 George Maltezos Parylene coated microfluidic components and methods for fabrication thereof
GB2421202B (en) * 2004-12-15 2009-12-09 Syrris Ltd Modular microfluidic system
US7582263B2 (en) * 2005-01-27 2009-09-01 Octrolix Bv Universal interface for a micro-fluidic chip
WO2006116629A2 (en) 2005-04-27 2006-11-02 Siemens Medical Solutions Usa, Inc. The preparation of molecular imaging probes using click chemistry
DE102005031920B4 (de) * 2005-07-07 2007-12-20 Isotopen Technologien München AG Vorrichtung und Verfahren zur Herstellung einer geringen Menge einer radioaktiven Substanzverbindung
EP1928603A1 (de) 2005-09-02 2008-06-11 California Institute Of Technology Verfahren und vorrichtung zur mechanischen auslösung von ventilen in fluidischen vorrichtungen
KR100984963B1 (ko) 2005-09-29 2010-10-05 지멘스 메디컬 솔루션즈 유에스에이, 인크. 양전자 방출 단층촬영에 의한 인체 영상화에 적합한 규모의방사성 표지 분자를 합성할 수 있는 마이크로유체 칩
KR20090006053A (ko) 2006-02-03 2009-01-14 아르카디츠 엘리자로프 엘라스토머 가스 투과성 가스켓을 가지는 미세유체 방법 및구조

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