ATE546494T1 - Energieübertragungsfarbstoff enthaltend einen aromatisch-substituierten xanthenfarbstoff als donor- und/oder akzeptor-farbstoff - Google Patents

Energieübertragungsfarbstoff enthaltend einen aromatisch-substituierten xanthenfarbstoff als donor- und/oder akzeptor-farbstoff

Info

Publication number
ATE546494T1
ATE546494T1 AT04075950T AT04075950T ATE546494T1 AT E546494 T1 ATE546494 T1 AT E546494T1 AT 04075950 T AT04075950 T AT 04075950T AT 04075950 T AT04075950 T AT 04075950T AT E546494 T1 ATE546494 T1 AT E546494T1
Authority
AT
Austria
Prior art keywords
group
phenyl
substituted
polycyclic aromatic
dye
Prior art date
Application number
AT04075950T
Other languages
English (en)
Inventor
Scott Benson
Steven Michael Menchen
Peter David Theisen
Krishna Upadhya
Joan Dale Hauser
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of ATE546494T1 publication Critical patent/ATE546494T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00Diaryl- or thriarylmethane dyes
    • C09B11/04Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08Phthaleins; Phenolphthaleins; Fluorescein

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Coloring (AREA)
  • Luminescent Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT04075950T 1997-10-01 1998-09-18 Energieübertragungsfarbstoff enthaltend einen aromatisch-substituierten xanthenfarbstoff als donor- und/oder akzeptor-farbstoff ATE546494T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/942,067 US6008379A (en) 1997-10-01 1997-10-01 Aromatic-substituted xanthene dyes

Publications (1)

Publication Number Publication Date
ATE546494T1 true ATE546494T1 (de) 2012-03-15

Family

ID=25477531

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98948346T ATE263213T1 (de) 1997-10-01 1998-09-18 Durch aromatische gruppen substituierte xanthenfarbstoffe
AT04075950T ATE546494T1 (de) 1997-10-01 1998-09-18 Energieübertragungsfarbstoff enthaltend einen aromatisch-substituierten xanthenfarbstoff als donor- und/oder akzeptor-farbstoff

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98948346T ATE263213T1 (de) 1997-10-01 1998-09-18 Durch aromatische gruppen substituierte xanthenfarbstoffe

Country Status (9)

Country Link
US (1) US6008379A (de)
EP (2) EP1019453B1 (de)
JP (8) JP2001518479A (de)
AT (2) ATE263213T1 (de)
AU (1) AU727178B2 (de)
CA (1) CA2304645C (de)
DE (1) DE69822855T2 (de)
DK (1) DK1019453T3 (de)
WO (1) WO1999016832A1 (de)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU762888B2 (en) 1997-02-12 2003-07-10 Us Genomics Methods and products for analyzing polymers
US6008379A (en) * 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US5936087A (en) * 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6583168B1 (en) * 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US6229024B1 (en) * 1998-01-23 2001-05-08 Laurence C. Schmued Method for detecting neuronal degeneration and anionic fluorescein homologue stains therefor
WO2000064988A1 (en) * 1999-04-23 2000-11-02 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
DE19923168A1 (de) * 1999-05-20 2000-11-23 Roche Diagnostics Gmbh Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker
US6232076B1 (en) 2000-02-04 2001-05-15 Genaissance Pharmaceuticals, Inc. Stabilizer of dye sequencing products
US6221604B1 (en) * 2000-02-07 2001-04-24 Pe Corporation Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US7169922B2 (en) 2000-08-04 2007-01-30 Invitrogen Corporation Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
ATE356222T1 (de) 2000-10-06 2007-03-15 Univ Columbia Massives parallelverfahren zur dekodierung von dna und rna
AU2002213125B2 (en) * 2000-10-11 2007-11-22 Applied Biosystems, Llc. Fluorescent nucleobase conjugates having anionic linkers
EP1354064A2 (de) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatische nukleinsäuresynthese: zusammensetzungen und verfahren, um die zuverlässigkeit des monomereinbaus zu erhöhen
US7129346B2 (en) * 2000-12-20 2006-10-31 Molecular Probes, Inc. Crown ether derivatives
US6962992B2 (en) 2000-12-20 2005-11-08 Molecullar Probes, Inc. Crown ether derivatives
US7579463B2 (en) 2000-12-20 2009-08-25 Life Technologies Corporation Crown ether derivatives
CA2445960A1 (en) * 2001-02-21 2002-12-19 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
DK1412517T3 (da) * 2001-03-09 2007-03-05 Boston Probes Inc Fremgangsmåder, kits og sammensætninger af kombinationsoligomerer
JP2005505749A (ja) 2001-05-21 2005-02-24 アクララ バイオサイエンシーズ, インコーポレイテッド タンパク質を分析するための方法および組成物
US6887690B2 (en) * 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
US7052512B2 (en) * 2001-07-18 2006-05-30 Boston Scientific Scimed, Inc. Fluorescent dyed lubricant for medical devices
US6764710B2 (en) 2001-07-18 2004-07-20 Scimed Life Systems, Inc. Light emitting markers for use with substrates
CA2453390A1 (en) * 2001-07-25 2003-02-06 Applera Corporation Time-delay integration in electrophoretic detection systems
US20030082547A1 (en) 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7256019B2 (en) 2001-08-29 2007-08-14 Ge Healthcare Bio-Sciences Corp. Terminal phosphate blocked nucleoside polyphosphates
US7223541B2 (en) 2001-08-29 2007-05-29 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides and methods of use
US7560254B2 (en) 2001-08-29 2009-07-14 Ge Healthcare Bio-Sciences Corp. Allele specific primer extension
DE60235376D1 (de) 2001-08-29 2010-04-01 Ge Healthcare Bio Sciences Markierte nukleosidpolyphosphate
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
AU2002362013B2 (en) 2001-11-21 2008-04-24 Applied Biosystems, Llc. Digital assay
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US7445894B2 (en) 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
CA2483868A1 (en) 2002-05-03 2004-05-21 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US7091348B2 (en) * 2002-07-01 2006-08-15 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
DK3363809T3 (da) * 2002-08-23 2020-05-04 Illumina Cambridge Ltd Modificerede nukleotider til polynukleotidsekvensering
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US7414116B2 (en) * 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
JP4588451B2 (ja) * 2002-09-08 2010-12-01 アプライド バイオシステムズ, エルエルシー Pnaダイマーおよびpnaオリゴマー合成に関する方法、組成物およびライブラリー
US8445702B2 (en) * 2003-05-05 2013-05-21 Life Technologies Corporation Zinc binding compounds and their method of use
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
US7432298B2 (en) * 2003-05-09 2008-10-07 Applied Biosystems Inc. Fluorescent polymeric materials containing lipid soluble rhodamine dyes
WO2004101709A1 (en) 2003-05-09 2004-11-25 Applera Corporation Phenyl xanthene dyes
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US7431915B2 (en) 2003-10-31 2008-10-07 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
DE602004018732D1 (de) * 2003-11-20 2009-02-12 Exiqon As Löscher-Zusammensetzung mit Anthraquinon
EP1720944B1 (de) 2003-12-05 2013-07-17 Life Technologies Corporation Cyanin farbstoffverbindungen
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
GB0329161D0 (en) * 2003-12-16 2004-01-21 Precisense As Reagant for detecting an analyte
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
EP1711504A2 (de) 2004-01-21 2006-10-18 Molecular Probes Inc. Derivate von cephalosporin und clavulansäure zum nachweis von beta-lactamase in einer probe
EP2471923B1 (de) 2004-05-28 2014-08-20 Asuragen, Inc. Verfahren und Zusammensetzungen mit microRNA
EP1766089A1 (de) * 2004-06-30 2007-03-28 Applera Corporation Analogsondenkomplexe
US20060024833A1 (en) 2004-07-27 2006-02-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
US7671218B2 (en) * 2004-08-13 2010-03-02 Elitech Holdings B.V. Phosphonate fluorescent dyes and conjugates
US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
ES2503765T3 (es) 2004-11-12 2014-10-07 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
EP1836319B1 (de) 2005-01-06 2012-09-19 Life Technologies Corporation Polypeptide mit nukleinsäurebindender aktivität sowie verfahren zur nukleinsäureamplifikation
EP1872135A2 (de) 2005-03-15 2008-01-02 Applera Corporation Verwendung von antikörper-surrogatantigen-systemen zum nachweis von analyten
JP2008541055A (ja) 2005-05-03 2008-11-20 アプレラ コーポレイション 蛍光検出システムおよびそれとともに使用するための色素セット
EP1885718B1 (de) 2005-05-11 2017-03-15 Life Technologies Corporation Chemische fluoreszente verbindungen mit hoher selektivität für doppelstrang-dna sowie verfahren zu ihrer verwendung
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
US7521577B2 (en) 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
EP1994182B1 (de) 2006-03-15 2019-05-29 Siemens Healthcare Diagnostics Inc. Abgleit-nucleobase-analoga
WO2007140015A2 (en) 2006-05-26 2007-12-06 Althea Technologies, Inc Biochemical analysis of partitioned cells
US8350064B2 (en) 2006-07-21 2013-01-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Fluorescent xanthenes and white light fluorophores
EP2589961A3 (de) 2006-09-06 2013-08-07 The Regents of the University of California Molekulare Diagnose und Klassifizierung bösartiger Melanome
EP2071927A2 (de) 2006-09-28 2009-06-24 Illumina, Inc. Zusammensetzungen und verfahren zur nukleotidsequenzierung
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US8586743B2 (en) 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
WO2008151089A2 (en) * 2007-05-30 2008-12-11 Invitrogen Corporation Fluorescent phospholipase a2 indicators
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US20110014611A1 (en) 2007-10-19 2011-01-20 Jingyue Ju Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequences by synthesis
EP3431615A3 (de) 2007-10-19 2019-02-20 The Trustees of Columbia University in the City of New York Dna-sequenzierung mit nichtfluoreszierenden, reversiblen nukleotidterminatoren und spaltbaren, etikettmodifizierten nukleotidterminatoren
WO2009067628A1 (en) 2007-11-20 2009-05-28 Applied Biosystems Inc. Reversible di-nucleotide terminator sequencing
US20090171078A1 (en) * 2007-11-20 2009-07-02 Applied Biosystems Inc. Method of sequencing nucleic acids using elaborated nucleotide phosphorotiolate compounds
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
ES2424329T3 (es) 2008-03-05 2013-10-01 The Regents Of The University Of California Diagnóstico molecular y clasificación de melanoma maligno
PL2757091T3 (pl) 2008-04-01 2017-10-31 Biosearch Tech Inc Stabilizowane ciemne wygaszające sondy fluoroforowe kwasu nukleinowego
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
DE102008047689A1 (de) * 2008-09-18 2010-03-25 Mark Helm Reaktive Fluoreszenzfarbstoffe und Leuko-Fluoresenzfarbstoffe auf Xanthenbasis und Verfahren zur Herstellung derselben
US20100159452A1 (en) * 2008-12-22 2010-06-24 Roche Molecular Systems, Inc. Method For Detecting a Target Nucleic Acid in a Sample
WO2010091126A1 (en) 2009-02-03 2010-08-12 Biotium, Inc. Xanthene dyes comprising a sulfonamide group
WO2010135384A2 (en) 2009-05-21 2010-11-25 Siemens Healthcare Diagnostics Inc. Universal tags with non-natural nucleobases
WO2010135692A2 (en) 2009-05-22 2010-11-25 Asuragen, Inc. Mirna biomarkers of prostate disease
EP2470897A4 (de) 2009-08-28 2013-05-29 Asuragen Inc Mirna-biomarker für lungenerkrankungen
CN102712614B (zh) * 2009-12-04 2015-12-02 拜奥蒂乌姆股份有限公司 杂环取代的呫吨染料
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
KR101911966B1 (ko) 2010-10-29 2018-10-25 아수라겐, 인크. 반복 서열을 분석하기 위한 mPCR 방법
EP2913408A1 (de) 2010-12-29 2015-09-02 Life Technologies Corporation Ddao-verbindungen als fluoreszenzreferenzsandards
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US10064960B2 (en) 2011-11-25 2018-09-04 Danmarks Tekniske Universitet Formulation of solid nano-sized particles in a gel-forming system
WO2014093291A1 (en) 2012-12-10 2014-06-19 Advandx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
CA3128911C (en) 2013-01-30 2023-10-17 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
JP5578455B2 (ja) * 2013-02-01 2014-08-27 株式会社リコー π共役系化合物とその用途、およびそれらを用いた素子、装置
EP2970356B1 (de) 2013-03-15 2018-05-30 Illumina Cambridge Limited Modifizierte nucleotide und nucleoside
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
ES2806751T3 (es) 2013-09-26 2021-02-18 Nat Univ Singapore Composiciones y métodos utilizando andamios de lisofosfatidilcolina
CN104672198B (zh) * 2013-11-26 2018-11-16 东友精细化工有限公司 化合物及着色固化性树脂组合物
JP6706208B2 (ja) 2014-01-05 2020-06-03 バイオマーナ ホールディングス リミテッド Mirna比率を使用する肺がん決定
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
ES2832748T3 (es) 2014-08-19 2021-06-11 Hoffmann La Roche Procedimientos y composiciones para la detección de ácidos nucleicos
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
CN107249570B (zh) 2014-11-21 2022-08-09 丹麦技术大学 用于局部药物释放的凝胶制剂
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
CN107636165A (zh) 2015-01-12 2018-01-26 生命科技公司 用于核酸文库质量控制和定量的方法、系统和其组合物
WO2016177774A1 (en) 2015-05-04 2016-11-10 Academisch Medisch Centrum Method of quantifying mirnas using normalization
CA2992616C (en) 2015-07-23 2023-01-03 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
SG11201809729XA (en) 2016-05-20 2018-12-28 Univ Denmark Tech Dtu Palpable marker composition
CN106188085B (zh) * 2016-07-15 2018-07-17 北京百灵威科技有限公司 一种制备荧光素的工艺方法
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
JP6858545B2 (ja) * 2016-12-19 2021-04-14 株式会社Dnpファインケミカル 色素
EP3661539B1 (de) 2017-08-02 2024-10-09 The Regents of The University of California Gegen menschliche nerven gerichtete optimierte peptide und ihre verwendung in der bildgeführten chirurgie, diagnostik und freisetzung von therapeutika
KR20210043584A (ko) 2018-08-10 2021-04-21 라이프 테크놀로지스 코포레이션 규소로 치환된 로다민 염료 및 염료 접합체
CN113614182A (zh) 2018-12-20 2021-11-05 生命技术公司 经修饰的罗丹明染料和其在生物测定中的用途
WO2020132607A1 (en) 2018-12-20 2020-06-25 Life Technologies Corporation Asymmetric rhodamine dye and use thereof in biological assays
EP3719144A1 (de) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung
EP3982922A1 (de) 2019-06-12 2022-04-20 Technical University of Denmark Dissacharid-formulierungen zur kontrollierten arzneimittelfreisetzung
EP3999664A1 (de) 2019-07-19 2022-05-25 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Verfahren zur bestimmung des ansprechens auf die behandlung eines patienten mit nicht-kleinzelligem lungenkarzinom (nsclc)
CN116323965A (zh) 2020-07-23 2023-06-23 生命技术公司 使用染料的用于生物分析的组合物、系统和方法
EP4185596A1 (de) 2020-07-23 2023-05-31 Life Technologies Corporation Energieübertragungsfarbstoffkonjugate zur verwendung in biologischen tests
US20240207421A1 (en) 2020-12-04 2024-06-27 Alume Biosciences, Inc. Nerve targeting peptides and methods of use
JP2024505421A (ja) 2021-01-14 2024-02-06 アルーム・バイオサイエンシーズ・インコーポレイテッド 外科手技において輸尿管を可視化するための方法および組成物
CN113563360A (zh) * 2021-08-16 2021-10-29 中国科学技术大学 一种两亲性荧光染料及其合成方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
JPS57116693A (en) * 1981-01-14 1982-07-20 Ricoh Co Ltd Thermal recording material
US4415732A (en) 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
JPS641949A (en) 1987-06-24 1989-01-06 Hitachi Ltd Regeneration of electrophoretic gel
US5231191A (en) 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US5188934A (en) * 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5750409A (en) * 1991-11-18 1998-05-12 Boehringer Mannheim Gmbh Pentacyclic compounds and their use as absorption or fluorescent dyes
EP0561738B1 (de) * 1992-03-17 1997-06-04 Ciba SC Holding AG Fluoran Farbbildner
DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
EP0658167B1 (de) * 1992-09-03 1999-04-14 The Perkin-Elmer Corporation 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden
US5374527A (en) 1993-01-21 1994-12-20 Applied Biosystems, Inc. High resolution DNA sequencing method using low viscosity medium
WO1995016910A1 (en) 1993-12-17 1995-06-22 Perkin-Elmer Corporation Uncharged polymers for separation of biomolecules by capillary electrophoresis
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5543026A (en) 1994-02-07 1996-08-06 The Perkin-Elmer Corporation Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments
EP0833936A4 (de) * 1995-06-23 2005-03-02 Baylor College Medicine Alternative farbstoff-markierte primer, ribonucleotide, deoxyribonucleotide und dideoxyribonucleotide zur automatischen dna analyse und homogenen amplifikations-/detektionsnachweisen
US6008379A (en) * 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes

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AU9493598A (en) 1999-04-23
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DK1019453T3 (da) 2004-08-02
EP1441011B1 (de) 2012-02-22
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US6008379A (en) 1999-12-28
EP1019453A1 (de) 2000-07-19
JP2011168787A (ja) 2011-09-01
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CA2304645C (en) 2008-08-26
JP2001518479A (ja) 2001-10-16
JP2011178999A (ja) 2011-09-15
WO1999016832A1 (en) 1999-04-08
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JP2005002336A (ja) 2005-01-06
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JP2015061911A (ja) 2015-04-02
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