ATE540054T1 - Antimikrobielle theta defensine und verfahren zu deren verwendung - Google Patents

Antimikrobielle theta defensine und verfahren zu deren verwendung

Info

Publication number
ATE540054T1
ATE540054T1 AT00930577T AT00930577T ATE540054T1 AT E540054 T1 ATE540054 T1 AT E540054T1 AT 00930577 T AT00930577 T AT 00930577T AT 00930577 T AT00930577 T AT 00930577T AT E540054 T1 ATE540054 T1 AT E540054T1
Authority
AT
Austria
Prior art keywords
cys
xaa1
arg
xaa5
xaa4
Prior art date
Application number
AT00930577T
Other languages
English (en)
Inventor
Michael Selsted
Yi-Quan Tang
Jun Yuan
Andre Ouellette
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE540054T1 publication Critical patent/ATE540054T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
AT00930577T 1999-05-10 2000-05-10 Antimikrobielle theta defensine und verfahren zu deren verwendung ATE540054T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/309,487 US6335318B1 (en) 1999-05-10 1999-05-10 Antimicrobial theta defensins and methods of using same
PCT/US2000/012842 WO2000068265A1 (en) 1999-05-10 2000-05-10 Antimicrobial theta defensins and methods of using same

Publications (1)

Publication Number Publication Date
ATE540054T1 true ATE540054T1 (de) 2012-01-15

Family

ID=23198440

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00930577T ATE540054T1 (de) 1999-05-10 2000-05-10 Antimikrobielle theta defensine und verfahren zu deren verwendung

Country Status (6)

Country Link
US (5) US6335318B1 (de)
EP (1) EP1187850B1 (de)
AT (1) ATE540054T1 (de)
AU (1) AU4837300A (de)
CA (1) CA2372821C (de)
WO (1) WO2000068265A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653442B1 (en) * 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US6790829B1 (en) 1997-07-25 2004-09-14 Seatek Marine Biotechnology, Inc. Cyclic decapeptide antibiotics
US6335318B1 (en) * 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
EP1206534A1 (de) * 1999-08-19 2002-05-22 Genset Prostatakrebs-assoziiertes gen 3 (pg3) und dessen biallelische marker
AUPQ339899A0 (en) 1999-10-13 1999-11-04 University Of Queensland, The Novel molecules
DE60045045D1 (de) 1999-11-05 2010-11-11 Hexima Ltd Nukleinsäuremoleküle zur kodierung cyclisierbare aminosäuresequenzen
WO2002013857A2 (en) * 2000-08-17 2002-02-21 Intercell Biomedizinische Forschungs- Und Entwicklungs Ag A vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide or a derivative thereof
US7338936B2 (en) * 2000-11-28 2008-03-04 House Ear Institute Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
US6716813B2 (en) * 2000-11-28 2004-04-06 House Ear Institute Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
AU2002240137A1 (en) * 2001-01-30 2002-08-12 University Of Iowa Research Foundation Antiviral activities of primate theta defensins and mammalian cathelicidins
WO2002085401A1 (en) * 2001-04-18 2002-10-31 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
US6713078B2 (en) * 2001-04-18 2004-03-30 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
US7314858B2 (en) * 2001-04-18 2008-01-01 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
DE10201862A1 (de) 2002-01-18 2003-08-07 Deutsches Krebsforsch Konjugat zur Behandlung prokaryontischer Infektionen
AU2003215257A1 (en) 2002-02-19 2003-09-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Modified defensins and their use
US7119070B2 (en) * 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
FR2839514A1 (fr) * 2002-05-07 2003-11-14 Centre Nat Rech Scient Nouveaux peptides cycliques, leur utilisation comme agents anti-microbiens
WO2003101394A2 (en) * 2002-05-31 2003-12-11 Ciphergen Biosystems, Inc. Defensins: use as antiviral agents
US20040096820A1 (en) * 2002-05-31 2004-05-20 Ciphergen Biosystems, Inc. Comparative proteomics of progressor and nonprogressor populations
DE10226216A1 (de) * 2002-06-13 2003-12-24 Bayer Ag Behandlung von schweren Infektionen und septischem Schock
JP4026491B2 (ja) * 2002-12-13 2007-12-26 ソニー株式会社 画像信号処理装置、画像信号処理方法、並びにプログラムおよび媒体
SE0203700D0 (sv) * 2002-12-16 2002-12-16 Bohlin Lars On-Growth Inhibiting Compounds
WO2004056307A2 (en) * 2002-12-19 2004-07-08 Yitzchak Hillman Disease treatment via antimicrobial peptide inhibitors
US20040219612A1 (en) * 2003-05-02 2004-11-04 Beckman Coulter, Inc. Methods for detecting intracellular defensins in various leukocyte subpopulations
US20050244916A1 (en) * 2004-03-22 2005-11-03 Michael Yeaman Methods for predicting protein activity based on identification of multidimensional signatures
US7232939B2 (en) 2004-05-28 2007-06-19 E.I. Du Pont De Nemours And Company Nucleic acid molecules encoding cyclotide polypeptides and methods of use
US20080255052A1 (en) * 2004-12-23 2008-10-16 The Regents Of The University Of California Immunologic regulation by theta defensins
EP1850861A1 (de) * 2005-02-08 2007-11-07 Novozymes A/S Systemische behandlung von infektionen mit defensinen
CA2601525A1 (en) * 2005-03-18 2006-09-21 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
US7534762B2 (en) * 2005-03-18 2009-05-19 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
US8202835B2 (en) * 2005-06-17 2012-06-19 Yitzchak Hillman Disease treatment via antimicrobial peptides or their inhibitors
US9044438B2 (en) 2005-06-17 2015-06-02 Yitzchak Hillman Disease treatment via antimicrobial peptides or their inhibitors
WO2007009978A1 (en) * 2005-07-15 2007-01-25 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
EP2687347B1 (de) * 2006-02-21 2018-01-03 System Spa Verzierung mit Pulvermaterial
JP2009535027A (ja) * 2006-04-27 2009-10-01 シンガポール ヘルス サービシーズ ピーティーイー リミテッド 抗菌ペプチド
CN102409003B (zh) * 2010-09-26 2013-05-15 中国农业科学院饲料研究所 多拷贝高效表达重组菌丝霉素的毕赤酵母
BR112013016535A2 (pt) 2010-12-28 2016-09-20 Bio Fd&C Co Ltd extratos vegetais para o tratamento e prevenção de infecções
US10967031B2 (en) 2010-12-28 2021-04-06 Kamedis Ltd. Synergistic herbal compositions with prebiotic properties for treatment of skin infections, allergies and inflammation
CN109248310B (zh) 2011-06-02 2022-07-01 加利福尼亚大学董事会 利用θ-防御素的炎性蛋白酶的阻断
AU2020302913B2 (en) 2019-06-26 2023-02-23 The University Of Southern California Novel theta defensin analogs
US12012440B2 (en) 2020-06-26 2024-06-18 The University Of Southern California Compositions and methods for treatment of fungal infections
CN115433263A (zh) * 2021-06-02 2022-12-06 中国科学院动物研究所 人类口腔放线菌来源的防御素、及其编码基因和用途

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5844072A (en) 1992-05-26 1998-12-01 University Of California Antibiotic cryptdin peptides and methods of their use
US4543252A (en) 1982-01-21 1985-09-24 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US4659692A (en) 1982-11-19 1987-04-21 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US4705777A (en) 1985-02-25 1987-11-10 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US5242902A (en) 1989-09-06 1993-09-07 The Regents Of The University Of California Defensin peptide compositions and methods for their use
US5721210A (en) * 1990-07-09 1998-02-24 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
US5547939A (en) 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5422424A (en) 1992-05-26 1995-06-06 The Regents Of The University Of California Antibiotic cryptdin peptides and methods of their use
US5459235A (en) 1993-03-19 1995-10-17 The Regents Of The University Of California Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US5708145A (en) 1993-07-20 1998-01-13 University Of California Immunglobulins reactive with protegrins
US6159936A (en) 1993-07-20 2000-12-12 The Regents Of The University Of California Compositions and methods for treating and preventing microbial and viral infections
US5464823A (en) 1993-07-20 1995-11-07 The Regents Of The University Of California Mammalian antibiotic peptides
US5804558A (en) 1993-07-20 1998-09-08 University Of California Protegrins
US5693486A (en) 1993-07-20 1997-12-02 Intrabiotics DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
US5804553A (en) 1994-04-05 1998-09-08 University Of California Prophenins - antibiotic peptides
US6307016B1 (en) 1995-07-06 2001-10-23 Intrabiotics Pharmaceuticals, Inc. Parevins and tachytegrins
CA2230160A1 (en) 1995-08-23 1997-03-06 The University Of British Columbia Antimicrobial cationic peptides and methods of screening for the same
US5994306A (en) 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
US5916872A (en) 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
FR2767832B1 (fr) 1997-08-29 2001-08-10 Genset Sa Polypeptide defensine humaine def-x, adn genomique et adnc, composition les contenant et applications au diagnostic et au traitement therapeutique
EP1012285B1 (de) 1997-09-10 2005-08-03 ZymoGenetics, Inc. Beta-defensine
US6043220A (en) 1997-12-03 2000-03-28 Intrabiotics Pharmaceuticals, Inc. Threonine-containing protegrins
US6335318B1 (en) * 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
US7119070B2 (en) * 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use

Also Published As

Publication number Publication date
US6335318B1 (en) 2002-01-01
US7399823B1 (en) 2008-07-15
AU4837300A (en) 2000-11-21
EP1187850A1 (de) 2002-03-20
WO2000068265A1 (en) 2000-11-16
US20030162718A1 (en) 2003-08-28
US6514727B1 (en) 2003-02-04
US6890537B2 (en) 2005-05-10
CA2372821C (en) 2014-07-08
EP1187850B1 (de) 2012-01-04
CA2372821A1 (en) 2000-11-16
US20050261193A1 (en) 2005-11-24

Similar Documents

Publication Publication Date Title
ATE540054T1 (de) Antimikrobielle theta defensine und verfahren zu deren verwendung
Balhorn Mammalian protamines: structure and molecular interactions
DE602005020165D1 (de) Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin
JPH0665680B2 (ja) 動物組織の修復
KR960704934A (ko) 항혈전활성을 갖는 펩티드 및 이의 제조방법(Peptide having antithrombotic activity and process for producing the same)
DE69700561T2 (de) Verfahren zur Entfernung von N-Terminalem Methionin
KITAGAWA et al. Amino Acid Sequence of Copper, Zinc-Superoxide Dimutase from Spinach Leaves
MX2022000251A (es) Compuestos que comprenden un ligando de proteina de activacion de fibroblasto y uso del mismo.
JPH02131594A (ja) デ‐ｂ３０‐インシュリンおよびデ‐ｂ３０‐インシュリン誘導体の製造方法
ATE439856T1 (de) Verwendung von peptiden, die aus der b beta kette des humanen fibrinogens abgeleitet wurden, zur behandlung von schock
WO2001047956A3 (en) Method for obtaining proteins having improved functional characteristics
Bruschi et al. Non-heme iron proteins of Desulfovibrio: the primary structure of ferredoxin I from Desulfovibrio africanus
CN1254379A (zh) 通过使用融合蛋白生产酰胺化肽的方法
DE60126802D1 (de) Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung zur hemmung oder stimulierung von angiogenese
WO2008067651B1 (en) Gender selection with the use of antibodies
Glansbeek et al. Expression of Recombinant Human Soluble Type II Transforming Growth Factor-β Receptor inPichia pastorisandEscherichia coli: Two Powerful Systems to Express a Potent Inhibitor of Transforming Growth Factor-β
DE60219361D1 (de) Verfahren zur rekombinanten herstellung von plazenta wachstumsfaktor
ATE331735T1 (de) Verfahren zur monomerisierung von humanen serumalbumin-polymeren
Castillo et al. Comparison of natural extraction and recombinant mussel adhesive proteins approaches
MX2023007869A (es) Compuestos que comprenden un ligando de proteina de activacion de fibroblasto y uso del mismo.
EP0821003A4 (de) Peptide und diese enthaltende heilmittel für autoimmunkrankheiten
MY150639A (en) T cell adhesion molecule and antibody thereto
MXPA01012836A (es) Metodo para estabilizar proteinas en mezclas complejas durante su almacenamiento en solventes acuosos.
DE60125386D1 (de) Verfahren zur Prävention einer durch Gefrieren induzierten Abnahme der Aktivität eines Proteins
DE68904578D1 (de) Enzym zur alpha-amidierung von c-termini und verfahren zu dessen herstellung.