ATE534631T1 - Verfahren zur optischen trennung von isochinolinderivaten - Google Patents

Verfahren zur optischen trennung von isochinolinderivaten

Info

Publication number
ATE534631T1
ATE534631T1 AT09714576T AT09714576T ATE534631T1 AT E534631 T1 ATE534631 T1 AT E534631T1 AT 09714576 T AT09714576 T AT 09714576T AT 09714576 T AT09714576 T AT 09714576T AT E534631 T1 ATE534631 T1 AT E534631T1
Authority
AT
Austria
Prior art keywords
optical separation
isoquinoline derivatives
isoquinoline
derivatives
separation
Prior art date
Application number
AT09714576T
Other languages
English (en)
Inventor
Franca Segnalini
Angela Tuozzi
Angelo Gentile
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Application granted granted Critical
Publication of ATE534631T1 publication Critical patent/ATE534631T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT09714576T 2008-02-28 2009-02-25 Verfahren zur optischen trennung von isochinolinderivaten ATE534631T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000319A ITMI20080319A1 (it) 2008-02-28 2008-02-28 Processo per la risoluzione di derivati isochinolinici
PCT/EP2009/052234 WO2009106547A1 (en) 2008-02-28 2009-02-25 Process for the resolution of isoquinoline derivatives

Publications (1)

Publication Number Publication Date
ATE534631T1 true ATE534631T1 (de) 2011-12-15

Family

ID=40291711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09714576T ATE534631T1 (de) 2008-02-28 2009-02-25 Verfahren zur optischen trennung von isochinolinderivaten

Country Status (14)

Country Link
US (1) US8703955B2 (de)
EP (1) EP2268617B1 (de)
CN (1) CN101896462B (de)
AT (1) ATE534631T1 (de)
CA (1) CA2708666C (de)
EA (1) EA017743B1 (de)
ES (1) ES2375920T3 (de)
HK (1) HK1150239A1 (de)
HR (1) HRP20110941T1 (de)
IL (1) IL206444A (de)
IT (1) ITMI20080319A1 (de)
PL (1) PL2268617T3 (de)
SI (1) SI2268617T1 (de)
WO (1) WO2009106547A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0808272A2 (pt) * 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
CA2685491A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2685488A1 (en) 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
BRPI0811687A2 (pt) * 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
BRPI0816519A2 (pt) * 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
WO2009133556A2 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8148527B1 (en) * 2011-01-18 2012-04-03 Divi's Laboratories, Ltd. Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline
CN103319406A (zh) * 2012-03-20 2013-09-25 迪维斯实验室有限公司 1-(4-甲氧苄基)-八氢-异喹啉的拆分
CN104610145B (zh) * 2015-01-27 2017-07-18 江苏嘉逸医药有限公司 苯磺顺阿曲库铵中间体r‑四氢罂粟碱‑n‑乙酰‑l‑亮氨酸盐的分离方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
DE19711739C1 (de) 1997-03-20 1998-08-20 Knorr Bremse Systeme Governor für Druckluftbeschaffungsanlagen von Fahrzeugen
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
EP1831132A2 (de) * 2004-08-02 2007-09-12 Matrix Laboratories Ltd Optische trennung von racemischen organischen säuren mit (1s, 4s)-4-[3,4-dichlorphenyl]-1,2,3,4-tetrahydro-n-methyl-1-naphthalonamin
KR20070080108A (ko) 2006-02-06 2007-08-09 주식회사종근당 질소의 알파 위치에 비대칭탄소가 있는 라세믹 유도체의광학 이성질체 분리 방법

Also Published As

Publication number Publication date
ES2375920T3 (es) 2012-03-07
PL2268617T3 (pl) 2012-05-31
EP2268617A1 (de) 2011-01-05
EA017743B1 (ru) 2013-02-28
HK1150239A1 (en) 2011-11-11
CA2708666C (en) 2016-06-14
EA201071000A1 (ru) 2011-02-28
ITMI20080319A1 (it) 2009-08-29
HRP20110941T1 (hr) 2012-03-31
CN101896462B (zh) 2012-09-26
CA2708666A1 (en) 2009-09-03
IL206444A0 (en) 2010-12-30
WO2009106547A1 (en) 2009-09-03
US20100298570A1 (en) 2010-11-25
SI2268617T1 (sl) 2012-05-31
IL206444A (en) 2013-10-31
US8703955B2 (en) 2014-04-22
EP2268617B1 (de) 2011-11-23
CN101896462A (zh) 2010-11-24

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