ATE532857T1 - Eine dna-zielsequenz von mäuse-rosa26-lokus abspaltende meganukleasevarianten und ihre verwendung - Google Patents

Eine dna-zielsequenz von mäuse-rosa26-lokus abspaltende meganukleasevarianten und ihre verwendung

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Publication number
ATE532857T1
ATE532857T1 AT08807158T AT08807158T ATE532857T1 AT E532857 T1 ATE532857 T1 AT E532857T1 AT 08807158 T AT08807158 T AT 08807158T AT 08807158 T AT08807158 T AT 08807158T AT E532857 T1 ATE532857 T1 AT E532857T1
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Austria
Prior art keywords
target sequence
dna target
separating
rosa26 locus
variant
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AT08807158T
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English (en)
Inventor
Agnes Gouble
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Cellectis
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Publication of ATE532857T1 publication Critical patent/ATE532857T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT08807158T 2007-06-06 2008-06-06 Eine dna-zielsequenz von mäuse-rosa26-lokus abspaltende meganukleasevarianten und ihre verwendung ATE532857T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2007/002830 WO2008149176A1 (en) 2007-06-06 2007-06-06 Meganuclease variants cleaving a dna target sequence from the mouse rosa26 locus and uses thereof
PCT/IB2008/002500 WO2008152523A1 (en) 2007-06-06 2008-06-06 Meganuclease variants cleaving a dna target sequence from the mouse rosa26 locus and uses thereof

Publications (1)

Publication Number Publication Date
ATE532857T1 true ATE532857T1 (de) 2011-11-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT08807158T ATE532857T1 (de) 2007-06-06 2008-06-06 Eine dna-zielsequenz von mäuse-rosa26-lokus abspaltende meganukleasevarianten und ihre verwendung

Country Status (13)

Country Link
US (2) US8426177B2 (de)
EP (1) EP2167656B1 (de)
JP (1) JP2010528648A (de)
CN (1) CN101821386A (de)
AT (1) ATE532857T1 (de)
AU (1) AU2008263501A1 (de)
BR (1) BRPI0812779A2 (de)
CA (1) CA2690027A1 (de)
DK (1) DK2167656T3 (de)
ES (1) ES2380233T3 (de)
HK (1) HK1141049A1 (de)
IL (1) IL202555A (de)
WO (2) WO2008149176A1 (de)

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