ATE553192T1 - Eine dna-zielsequenz von einem xeroderma pigmentosum-gen abspaltende meganukleasevarianten und ihre verwendung - Google Patents

Eine dna-zielsequenz von einem xeroderma pigmentosum-gen abspaltende meganukleasevarianten und ihre verwendung

Info

Publication number
ATE553192T1
ATE553192T1 AT07734243T AT07734243T ATE553192T1 AT E553192 T1 ATE553192 T1 AT E553192T1 AT 07734243 T AT07734243 T AT 07734243T AT 07734243 T AT07734243 T AT 07734243T AT E553192 T1 ATE553192 T1 AT E553192T1
Authority
AT
Austria
Prior art keywords
xeroderma pigmentosum
target sequence
dna target
meganuclease variants
sequence separating
Prior art date
Application number
AT07734243T
Other languages
English (en)
Inventor
Sylvain Arnould
Christophe Perez-Michaut
Julianne Smith
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Application granted granted Critical
Publication of ATE553192T1 publication Critical patent/ATE553192T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT07734243T 2006-02-13 2007-02-13 Eine dna-zielsequenz von einem xeroderma pigmentosum-gen abspaltende meganukleasevarianten und ihre verwendung ATE553192T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2006/000589 WO2007093836A1 (en) 2006-02-13 2006-02-13 Meganuclease variants cleaving a dna target sequence from a xp gene and uses thereof
PCT/IB2007/000924 WO2007093918A2 (en) 2006-02-13 2007-02-13 Meganuclease variants cleaving a dna target sequence from a xeroderma pigmentosum gene and uses thereof

Publications (1)

Publication Number Publication Date
ATE553192T1 true ATE553192T1 (de) 2012-04-15

Family

ID=36579794

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07734243T ATE553192T1 (de) 2006-02-13 2007-02-13 Eine dna-zielsequenz von einem xeroderma pigmentosum-gen abspaltende meganukleasevarianten und ihre verwendung

Country Status (8)

Country Link
US (2) US20090222937A1 (de)
EP (1) EP1989299B1 (de)
JP (1) JP2009526521A (de)
CN (1) CN101384712A (de)
AT (1) ATE553192T1 (de)
AU (1) AU2007216264A1 (de)
CA (1) CA2639149A1 (de)
WO (2) WO2007093836A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009095742A1 (en) * 2008-01-31 2009-08-06 Cellectis New i-crei derived single-chain meganuclease and uses thereof
WO2004067753A2 (en) 2003-01-28 2004-08-12 Cellectis Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof.
WO2006097854A1 (en) 2005-03-15 2006-09-21 Cellectis Heterodimeric meganucleases and use thereof
ES2602184T3 (es) 2005-10-18 2017-02-20 Precision Biosciences Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
WO2007093836A1 (en) * 2006-02-13 2007-08-23 Cellectis Meganuclease variants cleaving a dna target sequence from a xp gene and uses thereof
EP2160467B1 (de) 2007-06-05 2015-10-28 Bayer CropScience NV Verfahren und mittel zum exakten austausch von ziel-dna in eukaryontischen organismen
AU2008263502A1 (en) 2007-06-06 2008-12-18 Cellectis Method for enhancing the cleavage activity of I-Crei derived meganucleases
WO2009019528A1 (en) * 2007-08-03 2009-02-12 Cellectis Meganuclease variants cleaving a dna target sequence from the human interleukin-2 receptor gamma chain gene and uses thereof
EP2215223B1 (de) 2007-10-31 2013-05-01 Precision Biosciences, Inc. Rational konstruierte einzelketten-meganukleasen mit nicht-palindrom-erkennungssequenzen
WO2009074842A1 (en) * 2007-12-13 2009-06-18 Cellectis Improved chimeric meganuclease enzymes and uses thereof
WO2009114321A2 (en) 2008-03-11 2009-09-17 Precision Biosciencs, Inc. Rationally-designed meganucleases for maize genome engineering
AU2009271011B2 (en) * 2008-07-14 2015-10-22 Precision Biosciences, Inc. Recognition sequences for I-Crei-derived meganucleases and uses thereof
CA2736336A1 (en) * 2008-09-08 2010-03-11 Cellectis Meganuclease variants cleaving a dna target sequence from a glutamine synthetase gene and uses thereof
EP2180058A1 (de) * 2008-10-23 2010-04-28 Cellectis Meganuklease-Rekombinationssystem
WO2010136981A2 (en) 2009-05-26 2010-12-02 Cellectis Meganuclease variants cleaving the genome of a pathogenic non-integrating virus and uses thereof
WO2011036510A1 (en) * 2009-09-24 2011-03-31 Cellectis Meganuclease variants cleaving the genome of the herpes simplex virus and uses thereof
WO2011007193A1 (en) 2009-07-17 2011-01-20 Cellectis Viral vectors encoding a dna repair matrix and containing a virion-associated site specific meganuclease for gene targeting
WO2011021062A1 (en) * 2009-08-21 2011-02-24 Cellectis Meganuclease variants cleaving a dna target sequence from the human lysosomal acid alpha-glucosidase gene and uses thereof
WO2011036640A2 (en) 2009-09-24 2011-03-31 Cellectis Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations
CN102762726A (zh) 2009-11-27 2012-10-31 巴斯夫植物科学有限公司 嵌合内切核酸酶及其用途
BR112012012588B1 (pt) 2009-11-27 2019-03-26 Basf Plant Science Company Gmbh Endonuclease, método para recombinação homóloga de polinucleotídeos e método para mutação direcionada de polinucleotídeos
EP2504429B1 (de) 2009-11-27 2016-04-20 BASF Plant Science Company GmbH Chimäre endonukleasen und ihre verwendung
US20130227715A1 (en) * 2010-02-26 2013-08-29 Cellectis Use of endonucleases for inserting transgenes into safe harbor loci
EP2563915A1 (de) * 2010-04-30 2013-03-06 Cellectis I-crei-varianten mit neuer spezifität und verfahren zu ihrer erzeugung
CA2799095A1 (en) 2010-05-12 2011-11-17 Cellectis Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof
EP2569435A1 (de) 2010-05-12 2013-03-20 Cellectis Eine dna-zielsequenz von einem rhodopsin-gen abspaltende meganukleasevarianten und ihre verwendung
WO2011154158A1 (en) 2010-06-09 2011-12-15 Bayer Bioscience N.V. Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
WO2011154159A1 (en) 2010-06-09 2011-12-15 Bayer Bioscience N.V. Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
US20130196320A1 (en) 2010-06-15 2013-08-01 Cellectis Method for improving cleavage of dna by endonuclease sensitive to methylation
JP2013534423A (ja) 2010-07-07 2013-09-05 セレクティス Nanog遺伝子中のdna標的配列を切断するメガヌクレアーゼバリアント及びその使用
WO2012010976A2 (en) 2010-07-15 2012-01-26 Cellectis Meganuclease variants cleaving a dna target sequence in the tert gene and uses thereof
WO2012007848A2 (en) 2010-07-16 2012-01-19 Cellectis Meganuclease variants cleaving a dna target sequence in the was gene and uses thereof
SG189482A1 (en) 2010-10-27 2013-05-31 Cellectis Method for increasing the efficiency of double-strand break-induced mutagenesis
US9044492B2 (en) 2011-02-04 2015-06-02 Cellectis Sa Method for modulating the efficiency of double-strand break-induced mutagenesis
WO2012138901A1 (en) 2011-04-05 2012-10-11 Cellectis Sa Method for enhancing rare-cutting endonuclease efficiency and uses thereof
KR101982360B1 (ko) 2011-04-05 2019-05-24 셀렉티스 콤팩트 tale-뉴클레아제의 발생 방법 및 이의 용도
WO2012158778A1 (en) 2011-05-16 2012-11-22 Cellectis S.A. Doubly secure transgenic algae or cyanobacteria strains to prevent their establishment and spread in natural ecosystems
US9540623B2 (en) 2011-07-08 2017-01-10 Cellectis Method for increasing the efficiency of double-strand-break induced mutagenesis
BR122014004140B8 (pt) 2011-08-22 2023-03-28 Bayer Cropscience Ag Vetor recombinante ou construção recombinante, bem como métodos para obter e produzir uma planta de algodão ou célula vegetal tolerante a um inibidor de hppd, e para cultivar um campo de plantas de algodão
EP2612918A1 (de) 2012-01-06 2013-07-10 BASF Plant Science Company GmbH In planta-Rekombination
BR112015013784A2 (pt) 2012-12-12 2017-07-11 Massachusetts Inst Technology aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas
KR20250012194A (ko) 2013-06-17 2025-01-23 더 브로드 인스티튜트, 인코퍼레이티드 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
CN105683379A (zh) 2013-06-17 2016-06-15 布罗德研究所有限公司 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化
DK3011031T3 (da) 2013-06-17 2020-12-21 Broad Inst Inc Fremføring og anvendelse af crispr-cas-systemerne, vektorer og sammensætninger til levermålretning og -terapi
IL289736B2 (en) 2013-12-12 2025-09-01 Massachusetts Inst Technology Administration, use and therapeutic applications of CRISPR–Cas gene editing systems and gene editing preparations
JP2017501149A (ja) 2013-12-12 2017-01-12 ザ・ブロード・インスティテュート・インコーポレイテッド 粒子送達構成成分を用いた障害及び疾患の標的化のためのcrispr−cas系及び組成物の送達、使用及び治療適用
RU2708459C2 (ru) 2014-10-29 2019-12-09 БайсиклРД Лимитед Бициклические пептидные лиганды, специфичные для мт1-ммр
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
EP3230452B1 (de) 2014-12-12 2025-06-11 The Broad Institute, Inc. Deaktivierte guides für crispr-transkriptionsfaktoren
EP3985115A1 (de) 2014-12-12 2022-04-20 The Broad Institute, Inc. Geschützte guide-rnas (pgrnas)
WO2016094880A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
EP3702456A1 (de) 2014-12-24 2020-09-02 The Broad Institute, Inc. Crispr mit destabilisierungsdomänen oder mit destabilisierungsdomänenassoziierung
WO2016205749A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
CN110603261A (zh) 2016-12-23 2019-12-20 拜斯科阿迪有限公司 具有新型键结构的肽衍生物
US10857196B2 (en) * 2017-04-27 2020-12-08 Bicycletx Limited Bicyclic peptide ligands and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Cd137に対して特異的な二環式ペプチドリガンド
JP2021514953A (ja) 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
WO2020041380A1 (en) 2018-08-20 2020-02-27 The Broad Institute, Inc. Methods and compositions for optochemical control of crispr-cas9
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
US11384344B2 (en) 2018-12-17 2022-07-12 The Broad Institute, Inc. CRISPR-associated transposase systems and methods of use thereof
EP3897849A1 (de) 2018-12-21 2021-10-27 BicycleTx Limited Für pd-l1 spezifische bicyclische peptidliganden
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
AU2020358863A1 (en) 2019-10-03 2022-05-12 Celyntra Therapeutics Sa CRISPR systems with engineered dual guide nucleic acids
AU2020368539A1 (en) 2019-10-16 2022-04-28 Massachusetts Institute Of Technology Engineered muscle targeting compositions
CA3209863A1 (en) 2021-02-25 2022-09-01 Andrea BARGHETTI Compositions and methods for targeting, editing, or modifying genes
EP4419672A2 (de) 2021-06-01 2024-08-28 Artisan Development Labs, Inc. Zusammensetzungen und verfahren zum targeting, editieren oder modifizieren von genen
CA3237482A1 (en) 2021-11-03 2023-05-11 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Precise genome editing using retrons
WO2023141602A2 (en) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
WO2023167882A1 (en) 2022-03-01 2023-09-07 Artisan Development Labs, Inc. Composition and methods for transgene insertion
WO2024044723A1 (en) 2022-08-25 2024-02-29 Renagade Therapeutics Management Inc. Engineered retrons and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010908A (en) * 1992-08-21 2000-01-04 The Regents Of The University Of California Gene therapy by small fragment homologous replacement
WO2004067753A2 (en) * 2003-01-28 2004-08-12 Cellectis Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof.
WO2007049095A1 (en) * 2005-10-25 2007-05-03 Cellectis Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
WO2007093836A1 (en) * 2006-02-13 2007-08-23 Cellectis Meganuclease variants cleaving a dna target sequence from a xp gene and uses thereof

Also Published As

Publication number Publication date
WO2007093836A1 (en) 2007-08-23
CN101384712A (zh) 2009-03-11
JP2009526521A (ja) 2009-07-23
WO2007093918A2 (en) 2007-08-23
US20090222937A1 (en) 2009-09-03
WO2007093918A3 (en) 2008-01-24
US20130061341A1 (en) 2013-03-07
CA2639149A1 (en) 2007-08-23
AU2007216264A1 (en) 2007-08-23
EP1989299B1 (de) 2012-04-11
EP1989299A2 (de) 2008-11-12

Similar Documents

Publication Publication Date Title
ATE553192T1 (de) Eine dna-zielsequenz von einem xeroderma pigmentosum-gen abspaltende meganukleasevarianten und ihre verwendung
ATE532857T1 (de) Eine dna-zielsequenz von mäuse-rosa26-lokus abspaltende meganukleasevarianten und ihre verwendung
WO2008010093A3 (en) Meganuclease variants cleaving a dna target sequence from a rag gene and uses thereof
WO2008102274A3 (en) Meganuclease variants cleaving a dna target sequence from the beta-2-microglobulin gene and uses thereof
WO2009019614A3 (en) Meganuclease variants cleaving a dna target sequence from the human interleukin-2 receptor gamma chain gene and uses thereof
WO2007057781A8 (en) Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof.
WO2009013622A3 (en) Meganuclease variants cleaving a dna target sequence from the human hemoglobin beta gene and uses thereof
BRPI0508656A (pt) enzimas lipolìticas fúngicas
SG142154A1 (en) Methods for genomic analysis
WO2010136981A3 (en) Meganuclease variants cleaving the genome of a pathogenic non-integrating virus and uses thereof
WO2004023092A3 (en) Genetic analysis and authentication
DK1791933T3 (da) Fremgangsmåde til enzymatisk afkogning af olie
WO2010138796A3 (en) Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis
ATE494370T1 (de) Vektoren auf transposonbasis und verfahren zur integration von nukleinsäuren
GB2489187A (en) Compositions,methods and related uses for cleaving modified DNA
WO2007049156A3 (en) I-CreI HOMING ENDONUCLEASE VARIANTS HAVING NOVEL CLEAVAGE SPECIFICITY AND USE THEREOF
WO2008059382A3 (en) Meganuclease variants cleaving a dna target sequence from the hprt gene and uses thereof
DE60041072D1 (de) Em nachweis
WO2009086215A3 (en) Pathway analysis of cell culture phenotypes and uses thereof
WO2006138606A3 (en) Cell signaling genes and related methods
WO2008054514A3 (en) Differential expression profiling analysis of cell culture phenotypes and the uses thereof
EP2071022A4 (de) S-adenosylmethionin-synthetase-mutanten, diese codierende dnas und verwendungen der mutanten
WO2008157299A3 (en) Differential expression profiling analysis of cell culture phenotypes and uses thereof
EP2135951A4 (de) Transgene nager mit ngf-beta-gen-mutanten und herstellungsverfahren dafür, herstellungsverfahren für die entsprechenden mutanten proteine und erhaltene mutante proteine
WO2009069132A3 (en) Novel reverse transcriptase inhibitors