ATE532830T1 - Langwellige thiolgruppenreaktive fluorophore - Google Patents

Langwellige thiolgruppenreaktive fluorophore

Info

Publication number
ATE532830T1
ATE532830T1 AT10163379T AT10163379T ATE532830T1 AT E532830 T1 ATE532830 T1 AT E532830T1 AT 10163379 T AT10163379 T AT 10163379T AT 10163379 T AT10163379 T AT 10163379T AT E532830 T1 ATE532830 T1 AT E532830T1
Authority
AT
Austria
Prior art keywords
thiol group
long wave
group reactive
reactive fluorophores
fluorophores
Prior art date
Application number
AT10163379T
Other languages
English (en)
Inventor
Bruce Pitner
Douglas Sherman
Arounaguiry Ambroise
Joseph Thomas
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Application granted granted Critical
Publication of ATE532830T1 publication Critical patent/ATE532830T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT10163379T 2004-05-21 2005-05-20 Langwellige thiolgruppenreaktive fluorophore ATE532830T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57394404P 2004-05-21 2004-05-21
US59951404P 2004-08-06 2004-08-06

Publications (1)

Publication Number Publication Date
ATE532830T1 true ATE532830T1 (de) 2011-11-15

Family

ID=35788237

Family Applications (1)

Application Number Title Priority Date Filing Date
AT10163379T ATE532830T1 (de) 2004-05-21 2005-05-20 Langwellige thiolgruppenreaktive fluorophore

Country Status (7)

Country Link
US (4) US7563891B2 (de)
EP (3) EP2036953A3 (de)
JP (1) JP2008500446A (de)
AT (1) ATE532830T1 (de)
AU (1) AU2005280581B9 (de)
CA (1) CA2567387A1 (de)
WO (1) WO2006025887A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007240316A1 (en) 2006-04-20 2007-11-01 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
US7553869B2 (en) 2006-07-28 2009-06-30 Pierce Biotechnology, Inc. Protein probe compounds, compositions, and methods
WO2008013543A1 (en) * 2006-07-28 2008-01-31 Pierce Biotechnology, Inc. Protein probe compounds, compositions, and methods
US8772047B2 (en) * 2007-05-22 2014-07-08 Becton, Dickinson And Company Dyes having ratiometric fluorescence response for detecting metabolites
WO2008154332A1 (en) * 2007-06-06 2008-12-18 Becton, Dickinson And Company Near-infrared dyes as surface enhanced raman scattering reporters
WO2009021039A1 (en) * 2007-08-06 2009-02-12 University Of Kentucky Research Foundation Device for detection of molecules of interest
US9023661B2 (en) 2007-10-18 2015-05-05 Becton, Dickinson And Company Visual glucose sensor and methods of use thereof
CN101177539B (zh) * 2007-10-26 2010-10-27 淮海工学院 含香豆素的半菁染料
US8389290B2 (en) 2007-11-30 2013-03-05 Becton, Dickinson And Company Biosensor device for sensing amphipathic analytes
WO2009107448A1 (ja) * 2008-02-29 2009-09-03 独立行政法人理化学研究所 チオールの検出方法
JP2009242379A (ja) * 2008-03-11 2009-10-22 Osaka Prefecture Univ 共役化合物、該共役化合物を用いた光電変換素子及び光電気化学電池及び光電変換素子電解液
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
US8403332B2 (en) * 2009-12-28 2013-03-26 Nissan Kogyo Co., Ltd Seal member
CN102183471A (zh) * 2011-01-11 2011-09-14 山西大学 检测硫醇的方法和试剂盒
WO2013035513A1 (ja) * 2011-09-09 2013-03-14 株式会社島津製作所 親水性チオールプローブ
KR101508564B1 (ko) 2011-12-09 2015-04-07 고려대학교 산학협력단 스쿠아레인 유도체, 염료감응 태양전지용 염료 및 염료감응 태양전지
WO2013148957A1 (en) 2012-03-28 2013-10-03 Becton, Dickinson And Company Hydrogel adhesion to molded polymers
CN102659775A (zh) * 2012-04-28 2012-09-12 苏州大学 一种检测硫醇类化合物的荧光探针及其制备方法和用途
US9791451B2 (en) * 2013-08-30 2017-10-17 Council Of Scientific & Industrial Research Squaraine based fluorescent probe and a process for the preparation thereof
EP3126357A2 (de) * 2014-04-04 2017-02-08 Jawaharlal Nehru Centre For Advanced Scientific Research Kleinmolekulare sonden, verfahren und deren verwendung
WO2017087051A1 (en) * 2015-11-20 2017-05-26 Duke University Glucose biosensors and uses thereof
CN108727859B (zh) * 2017-05-23 2019-12-17 福州大学 方酸染料及其在比色荧光双响应铜离子探针制备的应用
KR102441852B1 (ko) * 2018-02-28 2022-09-13 후지필름 가부시키가이샤 수지 조성물, 막, 광학 필터, 화상 표시 장치, 고체 촬상 소자, 및 화합물
CN114524809B (zh) * 2022-02-14 2023-06-13 五邑大学 一种香豆素衍生物及其制备方法和应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5113035B2 (de) * 1973-04-02 1976-04-24
JPS57146771A (en) * 1981-03-09 1982-09-10 Mitsubishi Chem Ind Ltd Coumarin derivative
JPS5855861A (ja) * 1981-09-30 1983-04-02 Toshihiko Namihisa 新規な螢光標識抗体及びその製造方法
US4507480A (en) 1983-05-09 1985-03-26 Xerox Corporation Squaraines
JPS60169453A (ja) 1984-02-13 1985-09-02 Mitsubishi Chem Ind Ltd ２，４−ビス（２′−モノ置換アミノ−４′−ジ置換アミノフエニル）シクロブテンジイリウム−１，３−ジオレ−ト類
JPS60228448A (ja) 1984-04-27 1985-11-13 Mitsubishi Chem Ind Ltd スクアリリウム化合物
US5122602A (en) * 1989-02-13 1992-06-16 Miles Inc. Chromogenic merocyanine enzyme substrates
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
GB9602265D0 (en) * 1996-02-05 1996-04-03 Amersham Int Plc Benzophenoxazine dyes
CA2251985A1 (en) * 1996-04-19 1997-10-30 Alan Lewis Hamilton Squarate dyes and their use in fluorescent sequencing method
US5696157A (en) * 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US5830912A (en) * 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
WO1998038496A1 (en) 1997-02-28 1998-09-03 Lakowicz Joseph R Measuring analytes with metal-ligand complex probes
JPH10330337A (ja) * 1997-06-02 1998-12-15 Aisin Seiki Co Ltd 複環式アミド酸及び複環式マレイミド並びにこれらの製造方法
ES2314996T3 (es) 1997-12-31 2009-03-16 Duke University Biosensor de glucosa.
US6214628B1 (en) 1998-01-14 2001-04-10 Joseph R. Lakowicz Method of conducting an assay of a sample containing an analyte of interest
US6538129B1 (en) 1999-04-07 2003-03-25 Ewald A. Terpetschnig Luminescent compounds
AU759888B2 (en) 1998-07-17 2003-05-01 University Of Maryland At Baltimore Engineered proteins for analyte sensing
US6395556B1 (en) 1998-11-11 2002-05-28 Joseph R. Lakowicz Polarization based sensing
DE69909327T2 (de) 1998-12-21 2004-04-22 Sequella, Inc. Verwendungsmethoden und zusammenstellungen enthaltend überwachungsystem
WO2000058405A2 (en) 1999-03-31 2000-10-05 Amersham Pharmacia Biotech Uk Limited Squaraine dyes
DE19937024A1 (de) * 1999-08-05 2001-02-08 Bayer Ag Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker
US7566783B2 (en) 2000-07-21 2009-07-28 Joseph R Lakowicz Long wavelength long lifetime luminophores
US6605459B2 (en) * 2001-07-13 2003-08-12 Paradigm Genetics, Inc. Methods for measuring cysteine and determining cysteine synthase activity
US6977180B2 (en) 2001-08-28 2005-12-20 Duke University Biosensor
DE10160524A1 (de) * 2001-12-05 2003-06-26 Dyomics Gmbh Neue Fluoreszenzmarker mit großem Stokes-Shift
US7851593B2 (en) 2002-01-04 2010-12-14 Becton, Dickinson And Company Binding proteins as biosensors
US6855556B2 (en) * 2002-01-04 2005-02-15 Becton, Dickinson And Company Binding protein as biosensors
US20030153026A1 (en) 2002-01-04 2003-08-14 Javier Alarcon Entrapped binding protein as biosensors
AU2003221788A1 (en) 2002-04-30 2003-11-17 University Of Maryland, Baltimore Fluorescence sensing
US20040087842A1 (en) 2002-05-30 2004-05-06 Lakowicz Joseph R. Fluorescent probes for saccharrides
DE60326256D1 (de) 2002-10-16 2009-04-02 Univ Duke Biosensor zum nachweis von glukose
US20040234962A1 (en) 2003-05-02 2004-11-25 Javier Alarcon Multicoated or multilayer entrapment matrix for protein biosensor
AU2004239208A1 (en) 2003-05-09 2004-11-25 University Of Maryland Baltimore County Proteins, sensors, and methods of characterizing analytes using the same
US7304168B2 (en) * 2003-08-14 2007-12-04 Board Of Regents, University Of Texas System Photo-caged fluorescent molecules

Also Published As

Publication number Publication date
EP2036953A3 (de) 2010-07-14
AU2005280581B2 (en) 2011-09-08
US8071794B2 (en) 2011-12-06
JP2008500446A (ja) 2008-01-10
US20060280652A1 (en) 2006-12-14
WO2006025887A3 (en) 2006-08-10
US20110184168A1 (en) 2011-07-28
WO2006025887A2 (en) 2006-03-09
EP2223971B1 (de) 2011-11-09
EP1751236A2 (de) 2007-02-14
US20100167417A1 (en) 2010-07-01
CA2567387A1 (en) 2006-03-09
US7767821B2 (en) 2010-08-03
EP2223971A1 (de) 2010-09-01
AU2005280581B9 (en) 2012-02-02
AU2005280581A1 (en) 2006-03-09
US20100003763A1 (en) 2010-01-07
US7563891B2 (en) 2009-07-21
US8129525B2 (en) 2012-03-06
EP2036953A2 (de) 2009-03-18

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