SG11201608296PA - Small molecular probes, processes and use thereof - Google Patents

Small molecular probes, processes and use thereof

Info

Publication number
SG11201608296PA
SG11201608296PA SG11201608296PA SG11201608296PA SG11201608296PA SG 11201608296P A SG11201608296P A SG 11201608296PA SG 11201608296P A SG11201608296P A SG 11201608296PA SG 11201608296P A SG11201608296P A SG 11201608296PA SG 11201608296P A SG11201608296P A SG 11201608296PA
Authority
SG
Singapore
Prior art keywords
processes
molecular probes
small molecular
small
probes
Prior art date
Application number
SG11201608296PA
Inventor
Govindaraju Thimmaiah
Nagarjun Narayanaswamy
Kolla Rajasekhar
Original Assignee
Jncasr Bangalore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jncasr Bangalore filed Critical Jncasr Bangalore
Publication of SG11201608296PA publication Critical patent/SG11201608296PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
    • C07D421/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
SG11201608296PA 2014-04-04 2015-04-03 Small molecular probes, processes and use thereof SG11201608296PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1819CH2014 2014-04-04
PCT/IB2015/052463 WO2015151071A2 (en) 2014-04-04 2015-04-03 Small molecular probes, processes and use thereof

Publications (1)

Publication Number Publication Date
SG11201608296PA true SG11201608296PA (en) 2016-11-29

Family

ID=54241394

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201608296PA SG11201608296PA (en) 2014-04-04 2015-04-03 Small molecular probes, processes and use thereof

Country Status (5)

Country Link
US (1) US10745393B2 (en)
EP (1) EP3126357A2 (en)
CA (1) CA2944763A1 (en)
SG (1) SG11201608296PA (en)
WO (1) WO2015151071A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016168467A2 (en) * 2015-04-14 2016-10-20 Case Western Reserve University Fluorescent probes for abasic site detection
CN106810544A (en) * 2015-11-27 2017-06-09 南京理工大学 Iodate-N- ethyls -2-（2-H- aphthopyrans -3- vinyl）Benzothiazole and its preparation method and application
CN107417671B (en) * 2017-05-19 2020-04-24 三峡大学 Coumarin derivative containing quinoline substitution, preparation method thereof and application of coumarin derivative on ratio type pH fluorescent probe
CN109608427B (en) * 2018-12-29 2020-06-30 山东师范大学 Two-photon fluorescent probe for qualitatively detecting nitric oxide concentration and synthesis method and application thereof
CN110483394A (en) * 2019-09-02 2019-11-22 广东工业大学 A kind of application of compound
CN112442020B (en) * 2019-09-03 2022-06-14 南京大学 Fluorescent probe capable of tracing mitochondria-lysosome interaction in super-resolution mode
CN111217806B (en) * 2020-03-03 2021-06-01 中国科学院化学研究所 Hemicyanine compound based on benzothiazole-linked heterocycle and preparation method and application thereof
CN112409292B (en) * 2020-11-27 2022-05-17 太原理工大学 Multifunctional fluorescent probe, preparation method and application
CN113527347B (en) * 2021-07-15 2023-12-08 淮阴工学院 Near infrared fluorescence labeling fatty acid and preparation method thereof
CN115960110B (en) * 2023-01-31 2024-04-12 山西大学 Efficient photodynamic photosensitizer and preparation method and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3033159A1 (en) 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen DIMETHINE COMPOUNDS OF THE CUMARINE SERIES, METHOD FOR THE PRODUCTION THEREOF AND THE USE THEREOF AS LUMINOUS DYES
JP2648992B2 (en) * 1991-12-02 1997-09-03 富士写真フイルム株式会社 Silver halide photographic material
US7563907B2 (en) * 2002-12-05 2009-07-21 Dyomics Gmbh Compounds based on polymethines
US7563891B2 (en) 2004-05-21 2009-07-21 Becton, Dickinson & Company Long wavelength thiol-reactive fluorophores
WO2006020156A2 (en) * 2004-07-15 2006-02-23 The General Hospital Corporation Heterocyclic dye compounds for in vivo imaging and diagnosis of alzheimer’s disease
US7625758B2 (en) * 2005-01-26 2009-12-01 Berkelman Thomas R Coumarin-based cyanine dyes for non-specific protein binding
US8962342B2 (en) 2007-06-06 2015-02-24 Beckton, Dickinson And Company Near-infrared dyes as surface enhanced raman scattering reporters

Also Published As

Publication number Publication date
US10745393B2 (en) 2020-08-18
US20170137418A1 (en) 2017-05-18
CA2944763A1 (en) 2015-10-08
WO2015151071A3 (en) 2016-01-07
WO2015151071A2 (en) 2015-10-08
EP3126357A2 (en) 2017-02-08

Similar Documents

Publication Publication Date Title
IL254402B (en) Oligonucleotide probes and uses thereof
EP3221452A4 (en) Oligonucleotide probes and uses thereof
HK1231471A1 (en) 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof 6-- 6--2-
DK3139979T3 (en) DEVICE, ATOMIZER AND PROCEDURE
SG11201608296PA (en) Small molecular probes, processes and use thereof
HK1232169A1 (en) Substituted 4-phenylpiperidines, their preparation and use 4-
GB2588261B (en) Apparatus, use of the apparatus and arrangement
GB2545861B (en) Combined NMR-resistivity measurement apparatus, systems, and methods
GB2542079B (en) Ranging measurement apparatus, methods, and systems
GB2543202B (en) Well ranging apparatus, methods, and systems
SG11201607082PA (en) New tetracyano-anthraquino-dimethane polymers and use thereof
GB2549200B (en) Well ranging apparatus, methods and systems
GB201408673D0 (en) Medicaments,uses and methods
GB201405784D0 (en) Novel methods, polypeptides and uses thereof
HK1243077A1 (en) Piperidinylpyrazolopyrimidinones and their use
PL3040062T3 (en) Absorbent structure, and absorbent item comprising this absorbent structure
ZA201801948B (en) Compounds as stimuli-responsive probes, methods and applications thereof
EP3157680A4 (en) Molecular analysis system and use thereof
GB201420222D0 (en) Molecular probes and methods using the same
GB201405715D0 (en) Methods, apparatus and materials
IL249122A0 (en) Imidazol- or 1,2,4-triazol-derivatives and their use
GB201420223D0 (en) Molecular probes and methods using the same
GB201502394D0 (en) Ranging method, ranging device, location device and location method
PL3386988T3 (en) Novel dihydropyranopyrimidinone derivatives, and use thereof
PT3166945T (en) Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof