ATE530912T1 - Signalverbesserungsystem mit mehrfachen markierten mitteln - Google Patents

Signalverbesserungsystem mit mehrfachen markierten mitteln

Info

Publication number
ATE530912T1
ATE530912T1 AT01998830T AT01998830T ATE530912T1 AT E530912 T1 ATE530912 T1 AT E530912T1 AT 01998830 T AT01998830 T AT 01998830T AT 01998830 T AT01998830 T AT 01998830T AT E530912 T1 ATE530912 T1 AT E530912T1
Authority
AT
Austria
Prior art keywords
analyte
dipstick
antibody
colloidal gold
wicked
Prior art date
Application number
AT01998830T
Other languages
English (en)
Inventor
Helen Lee
Ling Huang
Magda Dineva
Hsiang Hu
Original Assignee
Diagnostics For The Real World Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostics For The Real World Ltd filed Critical Diagnostics For The Real World Ltd
Application granted granted Critical
Publication of ATE530912T1 publication Critical patent/ATE530912T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/918—Immunological

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT01998830T 2000-11-30 2001-11-30 Signalverbesserungsystem mit mehrfachen markierten mitteln ATE530912T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0029154.2A GB0029154D0 (en) 2000-11-30 2000-11-30 Signal enhancement with multiple labelled-antibodies
GBGB0109313.7A GB0109313D0 (en) 2000-11-30 2001-04-17 Signal enhancement with multiple laballed-antibodies
PCT/GB2001/005325 WO2002044729A1 (en) 2000-11-30 2001-11-30 Signal enhancement system with multiple labelled-moieties

Publications (1)

Publication Number Publication Date
ATE530912T1 true ATE530912T1 (de) 2011-11-15

Family

ID=26245354

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01998830T ATE530912T1 (de) 2000-11-30 2001-11-30 Signalverbesserungsystem mit mehrfachen markierten mitteln

Country Status (7)

Country Link
US (3) US7776617B2 (de)
EP (1) EP1340083B1 (de)
CN (1) CN100472212C (de)
AT (1) ATE530912T1 (de)
AU (1) AU2002222117A1 (de)
GB (2) GB0029154D0 (de)
WO (1) WO2002044729A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016836D0 (en) 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
GB0016813D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (4)
GB0025245D0 (en) 2000-10-14 2000-11-29 Lee Helen Multiple target detection
GB0029154D0 (en) * 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies
EP1428018B1 (de) 2001-09-06 2010-06-09 Straus Holdings Inc. Schneller und empfindlicher nachweis von molekülen
US7700372B2 (en) * 2002-10-08 2010-04-20 Tara Nylese Portable diagnostic device and method for determining temporal variations in concentrations
US20100279279A1 (en) * 2003-09-17 2010-11-04 Robert Danielzadeh Compositions and methods for analysis of target analytes
US7090803B1 (en) * 2003-10-28 2006-08-15 American Bio Medica Corporation Lateral flow immunoassay device
ATE479096T1 (de) * 2004-07-29 2010-09-15 Relia Diagnostic Systems Llc Querstromsystem und assay
ATE511920T1 (de) 2004-12-13 2011-06-15 Bayer Healthcare Llc In sich geschlossener testsensor
EP1937829A4 (de) * 2005-09-26 2011-08-03 Rapid Micro Biosystems Inc Kassette mit wachstumsmedium
US20080138842A1 (en) * 2006-12-11 2008-06-12 Hans Boehringer Indirect lateral flow sandwich assay
US7919331B2 (en) 2006-12-21 2011-04-05 Silver Lake Research Corporation Chromatographic test strips for one or more analytes
CA2965208C (en) * 2007-05-10 2022-06-14 Acorda Therapeutics Inc. Methods for detecting cardiac damage
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
US20110229913A1 (en) * 2008-11-28 2011-09-22 Infopia Co., Ltd. Method for Amplification of Signal in Immunochromatographic Assay and Immunochromatographic Kit Using the Method
WO2010096394A2 (en) 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
CN102414561A (zh) * 2009-04-28 2012-04-11 创新实验室技术公司 侧流式免疫层析测定设备
RU2606016C2 (ru) 2011-01-14 2017-01-10 Редвуд Байосайнс, Инк. Меченые альдегидом полипептиды иммуноглобулина и способы их применения
MX368123B (es) 2011-11-07 2019-09-19 Rapid Micro Biosystems Inc Cassette para pruebas de esterilidad.
WO2013075031A1 (en) 2011-11-16 2013-05-23 Becton, Dickinson And Company Methods and systems for detecting an analyte in a sample
CN102539790A (zh) * 2011-12-31 2012-07-04 南开大学 一种生物素的酶联免疫检测试剂盒
CN104364388B (zh) 2012-04-16 2017-12-19 快速微型生物系统公司 细胞培养装置
BR112015010695B1 (pt) 2013-01-11 2023-03-07 Becton, Dickinson And Company Dispositivo microfluídico e método para realizar um ensaio de uma amostra líquida, método para formar um dispositivo microfluídico, sistema e kit
CN103344776A (zh) * 2013-06-08 2013-10-09 赵磊 多功能体外检测生物芯片及其制备方法
CN106029863A (zh) 2013-11-06 2016-10-12 贝克顿·迪金森公司 微流体性装置和制造和使用其的方法
AU2014348910B2 (en) 2013-11-13 2017-04-20 Becton, Dickinson And Company Optical imaging system and methods for using the same
WO2015183266A1 (en) * 2014-05-28 2015-12-03 Express Diagnostics Int'l., Inc. Ethyl glucuronide lateral flow test strips, immunoassays, devices and methods for detecting or measuring thereof
PL3403579T3 (pl) 2014-10-14 2020-10-19 Becton, Dickinson And Company Zarządzanie próbkami krwi z wykorzystaniem pianki o otwartych komórkach
PL3094252T3 (pl) 2014-10-14 2022-02-21 Becton, Dickinson And Company Zarządzanie próbką krwi z zastosowaniem pianki otwartokomórkowej
CA2976005A1 (en) * 2015-02-06 2016-08-11 Cell Idx, Inc. Antigen-coupled immunoreagents
JP6426832B2 (ja) 2015-03-10 2018-11-21 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物体液の極微標本管理装置
CN108136395B (zh) 2015-09-01 2022-05-13 贝克顿·迪金森公司 用于分离样本相的深度过滤装置
CN105403707B (zh) * 2015-09-29 2017-05-17 南方医科大学 一种检测靶物质的信号放大方法及使用该方法的免疫层析试纸和装置
CN109071634A (zh) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 抗体偶联物及其制备和使用方法
CN107643399A (zh) * 2017-03-06 2018-01-30 广州佰芮慷生物科技有限公司 一种提高免疫检测系统灵敏性的方法及使用该方法的装置
JP7250757B2 (ja) * 2017-07-27 2023-04-03 ベラックス バイオメディカル インコーポレイテッド 逐次的ラテラルフローデバイス
WO2019036399A2 (en) * 2017-08-14 2019-02-21 Fujirebio Diagnostics, Inc. METHOD OF CONTIGATION OF ANTIBODIES
EP3765851A1 (de) * 2018-03-13 2021-01-20 Roche Diagnostics GmbH Reduzierung von interferenzen in immunoassays
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN108872611B (zh) * 2018-05-23 2021-04-02 浙江安吉赛安芙生物科技有限公司 一种胶体金利用标记羊抗鼠二抗后间接连接鼠抗标记的金标免疫层析试纸条的制备方法
WO2020128908A2 (en) * 2018-12-20 2020-06-25 Medimmune, Llc Methods for selection and expansion of t cells expressing pd-1
CN109596832B (zh) * 2018-12-25 2020-06-19 海卫特(广州)医疗科技有限公司 孕酮免疫层析检测试纸条及其制作方法
GB201912866D0 (en) * 2019-09-06 2019-10-23 Cambridge Molecular Diagnostics Ltd Miltiply labelled polymetric molecule for detection assays
CN112129956B (zh) * 2020-09-02 2022-05-27 武汉生之源生物科技股份有限公司 一种胶体金免疫层析的胶体金标记液及其制备方法和应用
GB202103321D0 (en) * 2021-03-10 2021-04-21 Cambridge Molecular Diagnostics Ltd Multiply labelled polymeric constructs for detection assays

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228237A (en) 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
US4434150A (en) 1981-10-19 1984-02-28 Ortho Diagnostic Systems, Inc. Immunological reagents employing polymeric backbone possessing reactive functional groups
US5073484A (en) 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US4626501A (en) * 1983-09-02 1986-12-02 Integrated Genetics, Inc. Labeled DNA
IL75020A (en) * 1984-05-10 1988-10-31 Abbott Lab Biotin-antibiotin immunoassay for the detection of ligands
AU7385387A (en) 1986-06-09 1987-12-10 Ortho Diagnostic Systems Inc. Immunoassay using detection of colloidal gold
US5206136A (en) * 1986-11-19 1993-04-27 Genetic Systems Corporation Rapid membrane affinity concentration assays
EP0290269A3 (de) * 1987-05-06 1989-08-09 Cyberfluor Inc. Immunoassayverfahren und Reagenzien und Herstellungsverfahren der letzteren
US4943522A (en) 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
CA1308022C (en) 1988-08-11 1992-09-29 Eleftherios P. Diamandis Multiple fluorescence labelling with europium chelators
US5252459A (en) * 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
JPH03202769A (ja) * 1989-03-07 1991-09-04 Adeza Biomedical Corp 子宮内膜症診断の方法及び試薬
US5188937A (en) 1989-04-06 1993-02-23 Becton, Dickinson And Company Layered sandwich assay method for chlamydia and materials therefor
WO1992012428A1 (en) 1991-01-11 1992-07-23 Quidel Corporation A one-step lateral flow nonbibulous assay
DK137992D0 (da) * 1992-11-13 1992-11-13 Alk Lab As Fremgangsmaade til paavisning af et immunologisk aktivt stof i en proeve under anvendelse af et maerkningsstof
EP0799421B1 (de) * 1994-12-22 2003-02-19 Abbott Laboratories Differenziertes timingsverfahren zum nachweiss multiple analyte in eine testprobe
GB9502112D0 (en) 1995-02-03 1995-03-22 British Biocell Int Assay device and method
US5679519A (en) * 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US5773234A (en) 1995-08-07 1998-06-30 Quidel Corporation Method and device for chlamydia detection
US6096563A (en) * 1996-03-29 2000-08-01 Strategic Diagnostics Inc. Dual particle immunoassay method and kit
US5876944A (en) 1996-06-10 1999-03-02 Bayer Corporation Method for amplification of the response signal in a sandwich immunoassay
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
WO1998036278A1 (en) * 1997-02-15 1998-08-20 Beth Israel Deaconess Medical Center, Inc. Multiple-site antibody capture immunoassays and kits
NZ508062A (en) 1998-05-13 2002-04-26 Accelr8 Technology Corp Enumeration method of analyte detection
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
GB2342992A (en) 1998-10-22 2000-04-26 Horticulture Res Int Dipstick detection system
JP3680090B2 (ja) * 2000-05-25 2005-08-10 株式会社ニチレイ 分析装置
US6803196B1 (en) * 2000-10-13 2004-10-12 Affymetrix, Inc. Methods and compositions for detecting signals in binding assays using microparticles
GB0029154D0 (en) 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies

Also Published As

Publication number Publication date
CN1500212A (zh) 2004-05-26
GB0109313D0 (en) 2001-05-30
EP1340083B1 (de) 2011-10-26
US9494584B2 (en) 2016-11-15
EP1340083A1 (de) 2003-09-03
AU2002222117A1 (en) 2002-06-11
WO2002044729A1 (en) 2002-06-06
US20080206853A1 (en) 2008-08-28
US20040048395A1 (en) 2004-03-11
GB0029154D0 (en) 2001-01-17
US7972837B2 (en) 2011-07-05
US7776617B2 (en) 2010-08-17
US20120094272A1 (en) 2012-04-19
CN100472212C (zh) 2009-03-25

Similar Documents

Publication Publication Date Title
ATE530912T1 (de) Signalverbesserungsystem mit mehrfachen markierten mitteln
GB2345964B (en) Assay using porosity-reduction to inhibit migration
ATE307338T1 (de) Immunochromatographische assay-vorrichtungen mit trennungselementen
ATE423972T1 (de) Vorrichtung und verfahren um gleichzeitig verschiedene antikörper und antigene nachzuweisen in klinischen, nahrungsmittel- und umwelt-proben
US7300750B2 (en) Analyte assay device with preabsorbing zone
DK1111386T3 (da) Teststrimmel til bestemmelse af en analyt i en flydende pröve
RU2009101049A (ru) Повышенная специфичность детектирования анализируемого вещества путем измерения связанных и не связанных меток
AU2015241521B2 (en) Immunoassay utilizing trapping conjugate
RU2004122925A (ru) Система внутренней калибровки проточных тест-систем
CY1107621T1 (el) Μεθοδος ανιχνευσης αντισωματων σε ενα δειγμα
ATE258309T1 (de) Immunoassay-vorrichtung für diagnostische zwecke
ATE309538T1 (de) Harnbestimmung der ovarienreserve
CA2690718A1 (en) Device, kit and method for hookworm antigen capture and detection
WO2002004670A3 (en) Improved capture and detection of target nucleic acid in dipstick assays
WO2006071970A3 (en) Methods for the detection of analytes in a sample
SE0001670D0 (sv) Mass-spectrometry-based biosensor
ATE232981T1 (de) Differenziertes timingsverfahren zum nachweiss multiple analyte in eine testprobe
WO2002071069A1 (fr) Procede d'analyse d'eprouvettes par une liaison specifique
NO20016080D0 (no) Analyse
WO2001027621A3 (en) Competitive inhibition elisa for antibody detection
DK1200826T3 (da) Immunoassay og testanordning med integreret reference
ATE312203T1 (de) Dynamische bestimmung von analyten durch arrays auf inneren oberflächen
SE0003662D0 (sv) Assay method and kit therefor
ECSP003702A (es) Inhibicion de la enzima ligada al ensayo basado en el principio de sanduce (/ elisa) para la deteccion y cuantificacion de anticuerpos en muestras biologicas

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties