ATE528649T1 - Verfahren zum nachweis falsch gefalteter proteine und prionen - Google Patents

Verfahren zum nachweis falsch gefalteter proteine und prionen

Info

Publication number
ATE528649T1
ATE528649T1 AT06720716T AT06720716T ATE528649T1 AT E528649 T1 ATE528649 T1 AT E528649T1 AT 06720716 T AT06720716 T AT 06720716T AT 06720716 T AT06720716 T AT 06720716T AT E528649 T1 ATE528649 T1 AT E528649T1
Authority
AT
Austria
Prior art keywords
prions
misfolded proteins
complexes
detecting
proteins
Prior art date
Application number
AT06720716T
Other languages
English (en)
Inventor
Cindy Orser
Tao Pan
Jasmeet Sethi
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Application granted granted Critical
Publication of ATE528649T1 publication Critical patent/ATE528649T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
AT06720716T 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen ATE528649T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65273305P 2005-02-15 2005-02-15
PCT/US2006/005095 WO2006088823A2 (en) 2005-02-15 2006-02-14 Method for detecting misfolded proteins and prions

Publications (1)

Publication Number Publication Date
ATE528649T1 true ATE528649T1 (de) 2011-10-15

Family

ID=36916969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06720716T ATE528649T1 (de) 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen

Country Status (10)

Country Link
US (1) US8372593B2 (de)
EP (1) EP1853915B1 (de)
JP (1) JP5048522B2 (de)
CN (1) CN101156068B (de)
AT (1) ATE528649T1 (de)
AU (1) AU2006214463B2 (de)
BR (1) BRPI0607350A2 (de)
CA (1) CA2597912C (de)
MX (1) MX2007009819A (de)
WO (1) WO2006088823A2 (de)

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AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
DK1931695T3 (da) 2005-09-09 2013-07-01 Novartis Ag Prionspecifikke peptoidreagenser
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
JP2010515879A (ja) * 2007-01-12 2010-05-13 オールプリオン・アーゲー プリオンタンパク質を取り出すための方法
CN102014967A (zh) * 2008-03-21 2011-04-13 阿德利夫股份有限公司 芘携带肽穿过血脑屏障的用途
WO2010062377A2 (en) * 2008-10-31 2010-06-03 Yale University Methods and compositions for the detection and treatment of preeclampsia
EP2391644B1 (de) 2009-01-30 2016-04-13 System of Systems Analytics, Inc. Konformationsdynamische peptide
WO2011149917A1 (en) 2010-05-25 2011-12-01 Adlyfe, Inc. STABILIZED AMYLOID- β OLIGOMERS AND USES THEREOF
JP2014514576A (ja) 2011-04-27 2014-06-19 エイディーライフ インコーポレイティッド アミロイドタンパク質の眼における検出法
CN102901825A (zh) * 2011-07-29 2013-01-30 中国科学院生物物理研究所 丙二醛修饰蛋白质作为错误折叠蛋白质荧光探剂的应用
DE102012104504B4 (de) * 2012-05-24 2021-10-07 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung Polypeptidmarker
JP6178586B2 (ja) 2013-02-20 2017-08-09 サヴィッド・セラピューティックス株式会社 ビオチン改変体、ストレプトアビジン変異体およびそれらの利用
CN105092854A (zh) * 2014-05-07 2015-11-25 湖州数问生物技术有限公司 体外诊断装置和试剂盒
JP6980953B2 (ja) * 2014-09-11 2021-12-15 ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ミスフォールディングタンパク質の検出
WO2022105923A1 (zh) * 2020-11-21 2022-05-27 浙江数问生物技术有限公司 用于检测生物样本中的错误折叠蛋白质的装置和方法

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US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5565186A (en) 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5854215A (en) 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
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EP0914614B1 (de) 1996-05-14 2003-09-03 Winnacker, Ernst-Ludwig, Prof. Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
US20060178302A1 (en) 1997-02-05 2006-08-10 Northwestern University & The University Of Southern California Amyloid beta protein (globular assembly and uses thereof)
US5891641A (en) 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
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DE59805338D1 (de) 1997-09-19 2002-10-02 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
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EP1200469A2 (de) 1999-07-27 2002-05-02 Imperial College Innovations Limited Fragmente des zellulären prionproteins und verfahren zur diagnose und behandlung von durch prionen ausgelöste erkrankungen
GB9917724D0 (en) 1999-07-28 1999-09-29 Medical Res Council Peptides
WO2001014412A1 (en) 1999-08-23 2001-03-01 The Regents Of The University Of California Compounds useful to mimic peptide beta-strands
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US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
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US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
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JP2004155688A (ja) 2002-04-30 2004-06-03 Biofrontier Kenkyusho:Kk シャペロン活性を有する合成ペプチド、脱炭酸活性の測定方法、伝達性海綿状脳症用薬剤及びその探索方法
FR2842303B1 (fr) * 2002-07-09 2004-09-24 Commissariat Energie Atomique Methode de detection automatisable de la prpres et ses applications
WO2004018511A2 (en) 2002-08-23 2004-03-04 Copenhagen Biotech Assets Aps Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
MXPA05005920A (es) 2002-12-03 2006-03-17 American Nat Red Cross Ligandos de proteina prion y metodos de uso.
US7510848B2 (en) 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
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US20070054322A1 (en) 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ545385A (en) 2003-08-13 2010-12-24 Novartis Vaccines & Diagnostic Prion-specific peptide reagents
JP3910569B2 (ja) 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US20060057671A1 (en) 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

Also Published As

Publication number Publication date
JP2008530565A (ja) 2008-08-07
HK1110936A1 (en) 2008-07-25
WO2006088823A2 (en) 2006-08-24
US8372593B2 (en) 2013-02-12
US20110081660A1 (en) 2011-04-07
WO2006088823A3 (en) 2007-03-29
EP1853915A2 (de) 2007-11-14
CN101156068A (zh) 2008-04-02
CA2597912A1 (en) 2006-08-24
CA2597912C (en) 2013-06-04
JP5048522B2 (ja) 2012-10-17
EP1853915B1 (de) 2011-10-12
AU2006214463B2 (en) 2012-08-30
MX2007009819A (es) 2007-11-07
CN101156068B (zh) 2015-03-18
EP1853915A4 (de) 2008-09-03
AU2006214463A1 (en) 2006-08-24
BRPI0607350A2 (pt) 2009-09-01

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