ATE528649T1 - Verfahren zum nachweis falsch gefalteter proteine und prionen - Google Patents

Verfahren zum nachweis falsch gefalteter proteine und prionen

Info

Publication number
ATE528649T1
ATE528649T1 AT06720716T AT06720716T ATE528649T1 AT E528649 T1 ATE528649 T1 AT E528649T1 AT 06720716 T AT06720716 T AT 06720716T AT 06720716 T AT06720716 T AT 06720716T AT E528649 T1 ATE528649 T1 AT E528649T1
Authority
AT
Austria
Prior art keywords
prions
misfolded proteins
complexes
detecting
proteins
Prior art date
Application number
AT06720716T
Other languages
English (en)
Inventor
Cindy Orser
Tao Pan
Jasmeet Sethi
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Application granted granted Critical
Publication of ATE528649T1 publication Critical patent/ATE528649T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
AT06720716T 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen ATE528649T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65273305P 2005-02-15 2005-02-15
PCT/US2006/005095 WO2006088823A2 (en) 2005-02-15 2006-02-14 Method for detecting misfolded proteins and prions

Publications (1)

Publication Number Publication Date
ATE528649T1 true ATE528649T1 (de) 2011-10-15

Family

ID=36916969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06720716T ATE528649T1 (de) 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen

Country Status (11)

Country Link
US (1) US8372593B2 (de)
EP (1) EP1853915B1 (de)
JP (1) JP5048522B2 (de)
CN (1) CN101156068B (de)
AT (1) ATE528649T1 (de)
AU (1) AU2006214463B2 (de)
BR (1) BRPI0607350A2 (de)
CA (1) CA2597912C (de)
HK (1) HK1110936A1 (de)
MX (1) MX2007009819A (de)
WO (1) WO2006088823A2 (de)

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CA2448981C (en) 2001-05-31 2014-03-18 Arete Associates Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
DK1931695T3 (da) 2005-09-09 2013-07-01 Novartis Ag Prionspecifikke peptoidreagenser
JP5097206B2 (ja) 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
WO2008083972A2 (en) * 2007-01-12 2008-07-17 Alicon Ag Method for removing prion protein
JP2011517666A (ja) * 2008-03-21 2011-06-16 エイディーライフ インコーポレイティッド 血液脳関門を横断してペプチドを運搬するためのピレンの使用
CN107677828A (zh) * 2008-10-31 2018-02-09 耶鲁大学 子痫前期检测和治疗的方法和组合物
US20100233095A1 (en) * 2009-01-30 2010-09-16 Adlyfe, Inc. Conformationally dynamic peptides
US9556247B2 (en) 2010-05-25 2017-01-31 System Of Systems Analytics, Inc. Stabilized amyloid-beta oligomers and uses thereof
WO2012149145A2 (en) 2011-04-27 2012-11-01 Adlyfe, Inc. Ocular detection of amyloid proteins
CN102901825A (zh) * 2011-07-29 2013-01-30 中国科学院生物物理研究所 丙二醛修饰蛋白质作为错误折叠蛋白质荧光探剂的应用
DE102012104504B4 (de) * 2012-05-24 2021-10-07 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung Polypeptidmarker
JP6178586B2 (ja) * 2013-02-20 2017-08-09 サヴィッド・セラピューティックス株式会社 ビオチン改変体、ストレプトアビジン変異体およびそれらの利用
CN105092854A (zh) * 2014-05-07 2015-11-25 湖州数问生物技术有限公司 体外诊断装置和试剂盒
AU2015314783B2 (en) * 2014-09-11 2021-10-21 Amprion, Inc. Detection of misfolded proteins
MX2023006026A (es) * 2020-11-21 2023-07-04 Shuwen Biotech Co Ltd Aparato y metodo para detectar una proteina mal plegada en una muestra biologica.

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US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP5097206B2 (ja) 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ

Also Published As

Publication number Publication date
EP1853915A2 (de) 2007-11-14
MX2007009819A (es) 2007-11-07
AU2006214463B2 (en) 2012-08-30
CA2597912A1 (en) 2006-08-24
AU2006214463A1 (en) 2006-08-24
JP5048522B2 (ja) 2012-10-17
JP2008530565A (ja) 2008-08-07
CA2597912C (en) 2013-06-04
EP1853915A4 (de) 2008-09-03
US20110081660A1 (en) 2011-04-07
WO2006088823A3 (en) 2007-03-29
HK1110936A1 (en) 2008-07-25
US8372593B2 (en) 2013-02-12
CN101156068B (zh) 2015-03-18
BRPI0607350A2 (pt) 2009-09-01
CN101156068A (zh) 2008-04-02
EP1853915B1 (de) 2011-10-12
WO2006088823A2 (en) 2006-08-24

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