ATE528649T1 - Verfahren zum nachweis falsch gefalteter proteine und prionen - Google Patents

Verfahren zum nachweis falsch gefalteter proteine und prionen

Info

Publication number
ATE528649T1
ATE528649T1 AT06720716T AT06720716T ATE528649T1 AT E528649 T1 ATE528649 T1 AT E528649T1 AT 06720716 T AT06720716 T AT 06720716T AT 06720716 T AT06720716 T AT 06720716T AT E528649 T1 ATE528649 T1 AT E528649T1
Authority
AT
Austria
Prior art keywords
prions
misfolded proteins
complexes
detecting
proteins
Prior art date
Application number
AT06720716T
Other languages
English (en)
Inventor
Cindy Orser
Tao Pan
Jasmeet Sethi
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Application granted granted Critical
Publication of ATE528649T1 publication Critical patent/ATE528649T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
AT06720716T 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen ATE528649T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65273305P 2005-02-15 2005-02-15
PCT/US2006/005095 WO2006088823A2 (en) 2005-02-15 2006-02-14 Method for detecting misfolded proteins and prions

Publications (1)

Publication Number Publication Date
ATE528649T1 true ATE528649T1 (de) 2011-10-15

Family

ID=36916969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06720716T ATE528649T1 (de) 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen

Country Status (10)

Country Link
US (1) US8372593B2 (de)
EP (1) EP1853915B1 (de)
JP (1) JP5048522B2 (de)
CN (1) CN101156068B (de)
AT (1) ATE528649T1 (de)
AU (1) AU2006214463B2 (de)
BR (1) BRPI0607350A2 (de)
CA (1) CA2597912C (de)
MX (1) MX2007009819A (de)
WO (1) WO2006088823A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (de) 2001-05-31 2013-02-27 Adlyfe, Inc. Verfahren zum erkennen von inkorrekt gefalteten proteinen
EP1931695B1 (de) 2005-09-09 2013-04-10 Novartis AG Prionspezifische Peptoidreagentien
EP2156181B1 (de) * 2006-07-28 2015-11-04 Adlyfe, Inc. Peptidsonden für diagnostik und therapie
CA2675039A1 (en) * 2007-01-12 2008-07-17 Alicon Ag Method for removing prion protein
EP2268314A2 (de) * 2008-03-21 2011-01-05 Adlyfe, Inc. Verwendung von pyrol zum befördern von peptiden durch die blut-gehirn-schranke
CN105021821B (zh) * 2008-10-31 2018-05-11 耶鲁大学 先兆子痫检测和治疗的方法和组合物
MX2011007916A (es) 2009-01-30 2011-11-18 Adlyfe Inc Péptidos conformacionalmente dinámicos.
WO2011149917A1 (en) 2010-05-25 2011-12-01 Adlyfe, Inc. STABILIZED AMYLOID- β OLIGOMERS AND USES THEREOF
EP2712425A2 (de) 2011-04-27 2014-04-02 Adlyfe, Inc. Visueller nachweis von amyloidproteinen
CN102901825A (zh) * 2011-07-29 2013-01-30 中国科学院生物物理研究所 丙二醛修饰蛋白质作为错误折叠蛋白质荧光探剂的应用
DE102012104504B4 (de) * 2012-05-24 2021-10-07 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung Polypeptidmarker
JP6178586B2 (ja) * 2013-02-20 2017-08-09 サヴィッド・セラピューティックス株式会社 ビオチン改変体、ストレプトアビジン変異体およびそれらの利用
CN105092854A (zh) * 2014-05-07 2015-11-25 湖州数问生物技术有限公司 体外诊断装置和试剂盒
EP3191599B1 (de) * 2014-09-11 2023-08-02 Board Of Regents Of the University Of Texas System Detektion von fehlgefalteten proteinen
CA3199642A1 (en) * 2020-11-21 2022-05-27 Shuwen Biotech Co. Ltd. Apparatus and method for detecting misfolded protein in biological sample

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5434050A (en) 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
NZ246059A (en) 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5565186A (en) 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5854215A (en) 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
EP1416280A3 (de) 1995-09-14 2005-08-10 The Regents of the University of California Antikörper spezifisch für natives PrPsc
US5750361A (en) 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ATE249046T1 (de) 1996-05-14 2003-09-15 Winnacker Ernst Ludwig Prof Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
US20060178302A1 (en) 1997-02-05 2006-08-10 Northwestern University & The University Of Southern California Amyloid beta protein (globular assembly and uses thereof)
US5891641A (en) 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US20010001061A1 (en) 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
EP1003539A4 (de) 1997-08-14 2002-09-11 Univ California FLUORESZIERENDE AMYLOID A beta PEPTIDE UND DEREN VERWENDUNG
DE59805338D1 (de) 1997-09-19 2002-10-02 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
WO1999041279A2 (en) 1998-02-13 1999-08-19 Arch Development Corporation Methods and compositions comprising the use of blocked b-amyloid peptide
US5977324A (en) 1998-02-20 1999-11-02 The Regents Of The University Of California Process for concentrating protein with disease-related conformation
US6214565B1 (en) 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
US6211149B1 (en) 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
US6750025B1 (en) 1998-07-09 2004-06-15 V.I. Technologies, Inc. Method of detecting and isolating prion protein and variants thereof
GB2348203B (en) 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
US20050112607A1 (en) 1999-01-23 2005-05-26 Bamdad Cynthia C. Rapid and sensitive detection of protein aggregation
CA2361013A1 (en) * 1999-01-25 2000-07-27 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
US6166187A (en) 1999-03-05 2000-12-26 The Regents Of The University Of California Method of concentrating prion proteins in blood samples
EP1623994A3 (de) 1999-05-17 2008-07-16 ConjuChem Biotechnologies Inc. Schutz endogener therapeutisch aktiver Peptide vor Peptidaseaktivität durch Konjugation an Blutbestandteile
CA2379237A1 (en) 1999-07-27 2001-02-01 Imperial College Innovations Limited Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases
GB9917724D0 (en) 1999-07-28 1999-09-29 Medical Res Council Peptides
WO2001014412A1 (en) 1999-08-23 2001-03-01 The Regents Of The University Of California Compounds useful to mimic peptide beta-strands
US6399314B1 (en) 1999-12-29 2002-06-04 American Cyanamid Company Methods of detection of amyloidogenic proteins
AU2001251358A1 (en) 2000-04-05 2001-10-23 V.I. Technologies, Inc. Prion-binding ligands and methods of using same
MXPA03000226A (es) 2000-07-07 2004-05-21 Applied Research Systems Diagnosticos tempranos de enfermedades conformacionales.
US6780641B2 (en) 2000-07-10 2004-08-24 University Of British Columbia Immortalized human microglia cell line
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
WO2002053723A2 (en) * 2001-01-08 2002-07-11 Health Protection Agency Degradation and detection of tse infectivity
CA2443929C (en) * 2001-04-17 2007-12-04 Ista, S.P.A. Detection and quantification of prion isoforms in neurodegenerative diseases using mass spectrometry
WO2002094191A2 (en) 2001-05-23 2002-11-28 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (de) 2001-05-31 2013-02-27 Adlyfe, Inc. Verfahren zum erkennen von inkorrekt gefalteten proteinen
JP2004536600A (ja) 2001-06-26 2004-12-09 ニュー ヨーク ステイト オフィス オブ メンタル ヘルス 細胞に基づいた高スループットスクリーニング法
WO2003050139A2 (en) 2001-12-10 2003-06-19 Applied Research Systems Ars Holding N.V. Prion inhibiting peptides and derivatives thereof
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US7939641B2 (en) 2002-04-09 2011-05-10 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
JP2004155688A (ja) 2002-04-30 2004-06-03 Biofrontier Kenkyusho:Kk シャペロン活性を有する合成ペプチド、脱炭酸活性の測定方法、伝達性海綿状脳症用薬剤及びその探索方法
FR2842303B1 (fr) 2002-07-09 2004-09-24 Commissariat Energie Atomique Methode de detection automatisable de la prpres et ses applications
US20060057636A1 (en) 2002-08-21 2006-03-16 Peter Heegaard Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
CA2836951C (en) 2002-12-03 2017-01-10 North Carolina State University Prion protein ligands and methods of use
US7510848B2 (en) 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
JP2004361227A (ja) * 2003-06-04 2004-12-24 Tohoku Univ アミロイドβ結合蛋白質の同定方法
US20070054322A1 (en) 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
NZ580256A (en) 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
JP3910569B2 (ja) 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
EP2156181B1 (de) 2006-07-28 2015-11-04 Adlyfe, Inc. Peptidsonden für diagnostik und therapie

Also Published As

Publication number Publication date
MX2007009819A (es) 2007-11-07
CN101156068A (zh) 2008-04-02
JP5048522B2 (ja) 2012-10-17
EP1853915A4 (de) 2008-09-03
BRPI0607350A2 (pt) 2009-09-01
CA2597912C (en) 2013-06-04
WO2006088823A3 (en) 2007-03-29
CA2597912A1 (en) 2006-08-24
EP1853915A2 (de) 2007-11-14
AU2006214463B2 (en) 2012-08-30
CN101156068B (zh) 2015-03-18
EP1853915B1 (de) 2011-10-12
JP2008530565A (ja) 2008-08-07
WO2006088823A2 (en) 2006-08-24
US20110081660A1 (en) 2011-04-07
HK1110936A1 (en) 2008-07-25
US8372593B2 (en) 2013-02-12
AU2006214463A1 (en) 2006-08-24

Similar Documents

Publication Publication Date Title
EP1853915A4 (de) Verfahren zum nachweis falsch gefalteter proteine und prionen
CY1121291T1 (el) Ανοσοδοκιμασιες ενισχυσης σηματος
ATE525649T1 (de) Nachweis von proteinen mit veränderter konformation
ATE425266T1 (de) Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten
NO20072721L (no) Polypeptides that bind BR3 and uses thereof
EP4292654A3 (de) Detektion von fehlgefalteten proteinen
WO2005016127A3 (en) Prion-specific peptide reagents
WO2014207049A3 (de) Verfahren zur bestimmung von proteinaggregaten unter verwendung von oberflächen-fida
EP2019836A4 (de) Verfahren, zusammensetzungen und kits für den nachweis von proteinaggregaten
PH12019550236A1 (en) Detection of misfolded tau protein
WO2006086799A3 (en) Prion-specific peptide reagents
MX2007002908A (es) Sondas inmovilizadas y metodos para detectar proteinas prionicas alteradas conformacionalmente.
DE60325382D1 (de) Verfahren zur diagnose von gebärmutterhalskrebs
WO2008042190A3 (en) Detection of neurodegenerative disease
WO2011109112A3 (en) Method of detecting tau protein and tau fragments in serum
WO2008108873A3 (en) Molecular biosensors for detecting macromolecules and other analytes
UA94945C2 (ru) Способ выделения и определения вирусной нагрузки в образце панкреатина
ATE549416T1 (de) Verfahren und zusammensetzungen zum nachweis von autoimmunkrankheiten
NO20073454L (no) Påvisning og kvantifisering av cyklodekstriner
ATE537448T1 (de) Nachweis von rho-proteinen
ATE489623T1 (de) Peptide zum nachweis von ehrlichia ewingii antikörper
DE602004017317D1 (de) Verwendung der proteine proteinase 3 (prn3) und leukozyten elastatse inhibitor (ileu) als marker für kolorektale karzinome
DE602006013143D1 (de) Verfahren zum nachweis aggregatbildender zirkulierender proteinformen und mittel zum einfangen gebildeter aggregate
WO2006096697A3 (en) Methods for determining the bivalency of protein and antibody therapeutics
ATE504833T1 (de) Verfahren zur bestimmung des phänotyps von zellen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties