ATE524458T1 - Als p2x7-rezeptor-antagonist wirkendes chinolinderivat - Google Patents

Als p2x7-rezeptor-antagonist wirkendes chinolinderivat

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Publication number
ATE524458T1
ATE524458T1 AT08855156T AT08855156T ATE524458T1 AT E524458 T1 ATE524458 T1 AT E524458T1 AT 08855156 T AT08855156 T AT 08855156T AT 08855156 T AT08855156 T AT 08855156T AT E524458 T1 ATE524458 T1 AT E524458T1
Authority
AT
Austria
Prior art keywords
receptor antagonist
quinoline derivative
derivative acting
acting
quinoline
Prior art date
Application number
AT08855156T
Other languages
German (de)
English (en)
Inventor
Simon Guile
Toby Thompson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE524458T1 publication Critical patent/ATE524458T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
AT08855156T 2007-11-30 2008-11-28 Als p2x7-rezeptor-antagonist wirkendes chinolinderivat ATE524458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99126507P 2007-11-30 2007-11-30
PCT/SE2008/051370 WO2009070116A1 (en) 2007-11-30 2008-11-28 A quinoline derivative acting as a p2x7-receptor antagonist

Publications (1)

Publication Number Publication Date
ATE524458T1 true ATE524458T1 (de) 2011-09-15

Family

ID=40676391

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08855156T ATE524458T1 (de) 2007-11-30 2008-11-28 Als p2x7-rezeptor-antagonist wirkendes chinolinderivat

Country Status (9)

Country Link
US (1) US8106073B2 (enExample)
EP (1) EP2225222B1 (enExample)
JP (1) JP2011505356A (enExample)
AR (1) AR069508A1 (enExample)
AT (1) ATE524458T1 (enExample)
ES (1) ES2370960T3 (enExample)
PE (1) PE20091036A1 (enExample)
TW (1) TW200932229A (enExample)
WO (1) WO2009070116A1 (enExample)

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ES2388454T3 (es) * 2007-03-22 2012-10-15 Astrazeneca Ab Derivados de quinolina para el tratamiento de enfermedades inflamatorias
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
EA022494B1 (ru) 2009-12-17 2016-01-29 Мерк Шарп Энд Домэ Корп. Соединения хинолинамида в качестве положительных аллостерических модуляторов мускаринового рецептора m1
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
BR112014001454A2 (pt) 2011-07-22 2017-06-27 Actelion Pharmaceuticals Ltd derivados de amidas heterocíclicas como antagonistas do receptor de p2x7
NZ628910A (en) 2012-01-20 2016-02-26 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
WO2014091415A1 (en) 2012-12-12 2014-06-19 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
CN104854087B (zh) 2012-12-18 2017-03-22 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物
ES2616883T3 (es) 2013-01-22 2017-06-14 Actelion Pharmaceuticals Ltd. Derivados amida heterocíclicos como antagonistas del receptor P2X7
WO2014115072A1 (en) 2013-01-22 2014-07-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
CA2948888A1 (en) * 2014-06-05 2015-12-10 Merck Patent Gmbh Novel quinoline derivatives and their use in neurodegenerative diseases
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity

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AR004735A1 (es) 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.
IL126557A (en) 1996-05-20 2002-09-12 Darwin Discovery Ltd Quinoline (thio) carboxamides inhibiting TNF or PDE-IV and pharmaceutical preparations containing them
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JP2011505356A (ja) 2011-02-24
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US8106073B2 (en) 2012-01-31
EP2225222A4 (en) 2010-12-01
EP2225222B1 (en) 2011-09-14
ES2370960T3 (es) 2011-12-26
US20090143428A1 (en) 2009-06-04
TW200932229A (en) 2009-08-01
PE20091036A1 (es) 2009-08-15
WO2009070116A1 (en) 2009-06-04
HK1148002A1 (en) 2011-08-26

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