ATE52080T1 - Piperidinole und aryloxymethyl-pyrrolidinole mit blutdrucksenkenden, antidepressiven und antiarrhythmischen wirkungen. - Google Patents
Piperidinole und aryloxymethyl-pyrrolidinole mit blutdrucksenkenden, antidepressiven und antiarrhythmischen wirkungen.Info
- Publication number
- ATE52080T1 ATE52080T1 AT85300667T AT85300667T ATE52080T1 AT E52080 T1 ATE52080 T1 AT E52080T1 AT 85300667 T AT85300667 T AT 85300667T AT 85300667 T AT85300667 T AT 85300667T AT E52080 T1 ATE52080 T1 AT E52080T1
- Authority
- AT
- Austria
- Prior art keywords
- piperidinols
- hyperpressor
- arhythmic
- pyrrolidinols
- aryloxymethyl
- Prior art date
Links
- 230000001430 anti-depressive effect Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- -1 4-indanyl Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical class ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/576,904 US4508724A (en) | 1984-02-03 | 1984-02-03 | Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarrhythmic or hypotensive activity |
| EP85300667A EP0152236B1 (de) | 1984-02-03 | 1985-01-31 | Piperidinole und Aryloxymethyl-Pyrrolidinole mit blutdrucksenkenden, antidepressiven und antiarrhythmischen Wirkungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE52080T1 true ATE52080T1 (de) | 1990-05-15 |
Family
ID=24306486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85300667T ATE52080T1 (de) | 1984-02-03 | 1985-01-31 | Piperidinole und aryloxymethyl-pyrrolidinole mit blutdrucksenkenden, antidepressiven und antiarrhythmischen wirkungen. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4508724A (de) |
| EP (1) | EP0152236B1 (de) |
| JP (1) | JPS60163861A (de) |
| AT (1) | ATE52080T1 (de) |
| CA (1) | CA1257277A (de) |
| DE (1) | DE3577196D1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63192751A (ja) * | 1987-02-06 | 1988-08-10 | Ube Ind Ltd | ４−ヒドロキシピペリジンの製造方法 |
| US5231184A (en) * | 1987-11-23 | 1993-07-27 | Janssen Pharmaceutica N.V. | Pridazinamine derivatives |
| US4927634A (en) * | 1987-12-16 | 1990-05-22 | Richardson-Vicks Inc. | Pharmaceutical compositions containing dyclonine HC1 and phenol |
| DE3814517A1 (de) * | 1988-02-05 | 1989-08-17 | Bayer Ag | Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| US5173484A (en) * | 1988-02-05 | 1992-12-22 | Bayer Aktiengesellschaft | Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them |
| WO1990012004A1 (fr) * | 1989-04-07 | 1990-10-18 | Fujisawa Pharmaceutical Co., Ltd. | Nouveaux composes de naphthalene et leur procede de production |
| US5169855A (en) * | 1990-03-28 | 1992-12-08 | Du Pont Merck Pharmaceutical Company | Piperidine ether derivatives as psychotropic drugs or plant fungicides |
| US5693691A (en) * | 1995-08-21 | 1997-12-02 | Brewer Science, Inc. | Thermosetting anti-reflective coatings compositions |
| US6110937A (en) | 1997-04-03 | 2000-08-29 | Syntex Usa, Inc. | Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain |
| EP1182192A4 (de) * | 1999-04-09 | 2002-06-05 | Mochida Pharm Co Ltd | 4-hydroxypiperidin-derivate mit antiarrhythmischem effekt |
| JP2005097120A (ja) * | 2000-10-06 | 2005-04-14 | Mochida Pharmaceut Co Ltd | ４−ヒドロキシピペリジン誘導体の非潮解性塩 |
| WO2004048326A1 (ja) * | 2002-11-25 | 2004-06-10 | Mochida Pharmaceutical Co., Ltd. | ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤 |
| DE102012006884A1 (de) | 2012-04-04 | 2013-10-10 | Merck Patent Gmbh | Cyclische Amide als MetAP-2 Inhibitoren |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3446897A (en) * | 1966-09-30 | 1969-05-27 | Robins Co Inc A H | Compositions and methods for the control of cardiac arrhythmia with o-substituted pyrrolidinols and s-substituted thiopyrrolidinols |
| US3679666A (en) * | 1969-04-03 | 1972-07-25 | Hoffmann La Roche | 4-(4-hydroxypiperidino)-4'-fluorobutyrophenones |
-
1984
- 1984-02-03 US US06/576,904 patent/US4508724A/en not_active Expired - Fee Related
-
1985
- 1985-01-17 JP JP60006645A patent/JPS60163861A/ja active Pending
- 1985-01-31 AT AT85300667T patent/ATE52080T1/de active
- 1985-01-31 EP EP85300667A patent/EP0152236B1/de not_active Expired - Lifetime
- 1985-01-31 DE DE8585300667T patent/DE3577196D1/de not_active Expired - Fee Related
- 1985-02-01 CA CA000473358A patent/CA1257277A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60163861A (ja) | 1985-08-26 |
| DE3577196D1 (de) | 1990-05-23 |
| US4508724A (en) | 1985-04-02 |
| EP0152236B1 (de) | 1990-04-18 |
| CA1257277A (en) | 1989-07-11 |
| EP0152236A2 (de) | 1985-08-21 |
| EP0152236A3 (en) | 1987-05-13 |
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