ATE515498T1 - Verfahren zur aufreinigung von montelukast und dessen aminsalzen - Google Patents
Verfahren zur aufreinigung von montelukast und dessen aminsalzenInfo
- Publication number
- ATE515498T1 ATE515498T1 AT07788281T AT07788281T ATE515498T1 AT E515498 T1 ATE515498 T1 AT E515498T1 AT 07788281 T AT07788281 T AT 07788281T AT 07788281 T AT07788281 T AT 07788281T AT E515498 T1 ATE515498 T1 AT E515498T1
- Authority
- AT
- Austria
- Prior art keywords
- montelukast
- purification
- salts
- amine salts
- treo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83685606P | 2006-08-09 | 2006-08-09 | |
EP06118690A EP1886998A1 (de) | 2006-08-09 | 2006-08-09 | Verfahren zur Reinigung von Montelukast und dessen Aminesalzen |
PCT/EP2007/058180 WO2008017669A1 (en) | 2006-08-09 | 2007-08-07 | Purification process of montelukast and its amine salts |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE515498T1 true ATE515498T1 (de) | 2011-07-15 |
Family
ID=37625598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07788281T ATE515498T1 (de) | 2006-08-09 | 2007-08-07 | Verfahren zur aufreinigung von montelukast und dessen aminsalzen |
Country Status (19)
Country | Link |
---|---|
US (1) | US8188285B2 (de) |
EP (2) | EP1886998A1 (de) |
JP (1) | JP5188501B2 (de) |
KR (1) | KR20090035696A (de) |
CN (1) | CN101501000B (de) |
AT (1) | ATE515498T1 (de) |
AU (1) | AU2007283615A1 (de) |
CA (1) | CA2657775A1 (de) |
ES (1) | ES2372414T3 (de) |
HR (1) | HRP20110575T1 (de) |
IL (1) | IL196303A (de) |
MX (1) | MX2009000524A (de) |
NO (1) | NO20091051L (de) |
PL (1) | PL2077996T3 (de) |
PT (1) | PT2077996E (de) |
RU (1) | RU2009108272A (de) |
SI (1) | SI2077996T1 (de) |
WO (1) | WO2008017669A1 (de) |
ZA (1) | ZA200900890B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008510840A (ja) | 2005-07-05 | 2008-04-10 | テバ ファーマシューティカル インダストリーズ リミティド | モンテルカストの精製 |
KR101469015B1 (ko) * | 2008-02-25 | 2014-12-05 | 주식회사 종근당 | 몬테루카스트의 제조방법 및 이에 사용되는 중간체 |
EP2265586A4 (de) * | 2008-03-17 | 2012-10-03 | Reddys Lab Ltd Dr | Herstellung von montelukast und seinen salzen |
KR101123292B1 (ko) | 2008-09-26 | 2012-03-19 | 주식회사 엘지생명과학 | 몬테루카스트 나트륨염의 제조방법 |
WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
KR100990046B1 (ko) * | 2010-07-30 | 2010-10-26 | 동국제약 주식회사 | 신규한 몬테루카스트 4-할로 벤질아민염 및 이를 이용한 몬테루카스트 나트륨염의 제조방법 |
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
WO2012077133A1 (en) * | 2010-12-07 | 2012-06-14 | Ind-Swift Laboratories Limited | Processes for preparation of montelukast sodium and purification of diol intermediate |
CN102060762B (zh) * | 2011-01-28 | 2013-05-29 | 海南美大制药有限公司 | 孟鲁司特化合物及其新制法 |
CN103570618A (zh) * | 2013-09-30 | 2014-02-12 | 浙江车头制药股份有限公司 | 一种孟鲁司特钠盐的制备方法 |
CN105924392B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种孟鲁司特钠制备方法 |
CN105646344B (zh) * | 2016-02-29 | 2018-08-14 | 山东新时代药业有限公司 | 一种孟鲁司特的纯化方法 |
CN105585524B (zh) * | 2016-02-29 | 2018-03-02 | 山东新时代药业有限公司 | 一种由孟鲁司特酸制备孟鲁司特钠的方法 |
US10723721B2 (en) * | 2017-07-24 | 2020-07-28 | Interquim, S.A. | Process for preparing and purifying the LFA-1 antagonist lifitegrast |
JP2021536467A (ja) | 2018-09-06 | 2021-12-27 | インノファーマスクリーン インコーポレイテッド | 喘息またはパーキンソン病の処置のための方法および組成物 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8403224A (nl) * | 1984-10-24 | 1986-05-16 | Oce Andeno Bv | Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen. |
DK0480717T3 (da) * | 1990-10-12 | 1999-02-08 | Merck Frosst Canada Inc | Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister |
TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
CN1420113A (zh) | 2001-11-16 | 2003-05-28 | 北京上地新世纪生物医药研究所 | 孟鲁司特钠的制备方法及其制备中间体 |
CN1171873C (zh) | 2001-12-26 | 2004-10-20 | 北京上地新世纪生物医药研究所 | 一种孟鲁司特钠的制备方法及其制备中间体 |
US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
CA2528228C (en) * | 2003-06-06 | 2011-09-20 | Morepen Laboratories Limited | A method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
ATE522507T1 (de) * | 2003-10-10 | 2011-09-15 | Synhton B V | Montelukast in fester phase |
EP1708708A1 (de) * | 2004-01-30 | 2006-10-11 | Teva Pharmaceutical Industries Ltd. | Montelukast-freie säure-polymorphen |
US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
JP2007532686A (ja) | 2004-04-21 | 2007-11-15 | テバ ファーマシューティカル インダストリーズ リミティド | モンテルカストナトリウムを調製する方法 |
US7501517B2 (en) | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
US7829716B2 (en) | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
EP1812394B1 (de) * | 2004-07-19 | 2011-03-02 | Matrix Laboratories Ltd | Verfahren zur herstellung von montelukast und salzen davon |
PL205637B1 (pl) * | 2004-10-22 | 2010-05-31 | Inst Farmaceutyczny | Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli |
JP2008510840A (ja) | 2005-07-05 | 2008-04-10 | テバ ファーマシューティカル インダストリーズ リミティド | モンテルカストの精製 |
EP1940793A4 (de) | 2005-07-05 | 2011-03-23 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast |
WO2007012075A2 (en) | 2005-07-20 | 2007-01-25 | Dr. Reddy's Laboratories Ltd. | Preparation of montelukast |
ES2403067T3 (es) | 2005-12-13 | 2013-05-13 | Msn Laboratories Limited | Un procedimiento mejorado para la preparación de montelukast y sus sales farmaceúticamente aceptables |
CA2632954A1 (en) | 2005-12-23 | 2007-06-28 | Glade Organics Private Limited | An improved process for the manufacture of montelukast sodium |
KR20080105070A (ko) | 2006-02-21 | 2008-12-03 | 케마지스 리미티드 | 몬테루카스트 암모늄염의 신규한 다형체 및 그 제조 방법 |
US7528254B2 (en) | 2006-02-27 | 2009-05-05 | Chemagis Ltd. | Process for preparing montelukast and salts thereof |
WO2007107297A1 (en) | 2006-03-17 | 2007-09-27 | Synthon B.V. | Montelukast amantadine salt |
US20090281323A1 (en) | 2006-04-12 | 2009-11-12 | Glade Organics Private Limited | Process for the manufacture of montelukast sodium |
WO2008001213A1 (en) | 2006-06-26 | 2008-01-03 | Aurobindo Pharma Limited | An improved process for the preparation of leukotriene receptor antagonist (montelukast sodium) |
GB0614485D0 (en) | 2006-07-21 | 2006-09-27 | Pliva Istrazivanje I Razvoj D | Process |
WO2008015703A2 (en) | 2006-08-04 | 2008-02-07 | Matrix Laboratories Ltd | Process for the preparation of montelukast and its salts thereof |
-
2006
- 2006-08-09 EP EP06118690A patent/EP1886998A1/de not_active Withdrawn
-
2007
- 2007-08-07 JP JP2009523276A patent/JP5188501B2/ja not_active Expired - Fee Related
- 2007-08-07 MX MX2009000524A patent/MX2009000524A/es active IP Right Grant
- 2007-08-07 PL PL07788281T patent/PL2077996T3/pl unknown
- 2007-08-07 CA CA002657775A patent/CA2657775A1/en not_active Abandoned
- 2007-08-07 WO PCT/EP2007/058180 patent/WO2008017669A1/en active Application Filing
- 2007-08-07 SI SI200730709T patent/SI2077996T1/sl unknown
- 2007-08-07 ES ES07788281T patent/ES2372414T3/es active Active
- 2007-08-07 PT PT07788281T patent/PT2077996E/pt unknown
- 2007-08-07 US US12/376,779 patent/US8188285B2/en not_active Expired - Fee Related
- 2007-08-07 ZA ZA200900890A patent/ZA200900890B/xx unknown
- 2007-08-07 KR KR1020097002477A patent/KR20090035696A/ko not_active Application Discontinuation
- 2007-08-07 AU AU2007283615A patent/AU2007283615A1/en not_active Abandoned
- 2007-08-07 CN CN2007800295684A patent/CN101501000B/zh not_active Expired - Fee Related
- 2007-08-07 RU RU2009108272/04A patent/RU2009108272A/ru not_active Application Discontinuation
- 2007-08-07 EP EP07788281A patent/EP2077996B1/de active Active
- 2007-08-07 AT AT07788281T patent/ATE515498T1/de not_active IP Right Cessation
-
2008
- 2008-12-31 IL IL196303A patent/IL196303A/en not_active IP Right Cessation
-
2009
- 2009-03-09 NO NO20091051A patent/NO20091051L/no not_active Application Discontinuation
-
2011
- 2011-08-02 HR HR20110575T patent/HRP20110575T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
JP2010500325A (ja) | 2010-01-07 |
WO2008017669A1 (en) | 2008-02-14 |
PT2077996E (pt) | 2011-09-13 |
IL196303A0 (en) | 2009-09-22 |
EP1886998A1 (de) | 2008-02-13 |
US8188285B2 (en) | 2012-05-29 |
ZA200900890B (en) | 2010-04-28 |
MX2009000524A (es) | 2009-01-27 |
CN101501000A (zh) | 2009-08-05 |
HRP20110575T1 (hr) | 2011-09-30 |
SI2077996T1 (sl) | 2011-10-28 |
ES2372414T3 (es) | 2012-01-19 |
AU2007283615A1 (en) | 2008-02-14 |
JP5188501B2 (ja) | 2013-04-24 |
IL196303A (en) | 2014-03-31 |
EP2077996B1 (de) | 2011-07-06 |
PL2077996T3 (pl) | 2011-11-30 |
KR20090035696A (ko) | 2009-04-10 |
NO20091051L (no) | 2009-05-05 |
US20090247759A1 (en) | 2009-10-01 |
CN101501000B (zh) | 2012-04-04 |
CA2657775A1 (en) | 2008-02-14 |
EP2077996A1 (de) | 2009-07-15 |
RU2009108272A (ru) | 2010-09-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |