ATE510569T1 - Verwendung von gelatine und einem vernetzungsmittel zur herstellung einer vernetzenden therapeutischen zusammensetzung - Google Patents

Verwendung von gelatine und einem vernetzungsmittel zur herstellung einer vernetzenden therapeutischen zusammensetzung

Info

Publication number
ATE510569T1
ATE510569T1 AT07785970T AT07785970T ATE510569T1 AT E510569 T1 ATE510569 T1 AT E510569T1 AT 07785970 T AT07785970 T AT 07785970T AT 07785970 T AT07785970 T AT 07785970T AT E510569 T1 ATE510569 T1 AT E510569T1
Authority
AT
Austria
Prior art keywords
cross
linking
gelatin
preparing
therapeutic composition
Prior art date
Application number
AT07785970T
Other languages
German (de)
English (en)
Inventor
Christoph Gaissmaier
Michael Ahlers
Original Assignee
Tetec Tissue Engineering Technologies Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetec Tissue Engineering Technologies Ag filed Critical Tetec Tissue Engineering Technologies Ag
Application granted granted Critical
Publication of ATE510569T1 publication Critical patent/ATE510569T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT07785970T 2006-07-10 2007-07-10 Verwendung von gelatine und einem vernetzungsmittel zur herstellung einer vernetzenden therapeutischen zusammensetzung ATE510569T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006033168A DE102006033168A1 (de) 2006-07-10 2006-07-10 Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung
PCT/EP2007/006104 WO2008006544A2 (de) 2006-07-10 2007-07-10 Verwendung von gelatine und einem vernetzungsmittel zur herstellung einer vernetzenden therapeutischen zusammensetzung

Publications (1)

Publication Number Publication Date
ATE510569T1 true ATE510569T1 (de) 2011-06-15

Family

ID=38669114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07785970T ATE510569T1 (de) 2006-07-10 2007-07-10 Verwendung von gelatine und einem vernetzungsmittel zur herstellung einer vernetzenden therapeutischen zusammensetzung

Country Status (7)

Country Link
US (2) US8637081B2 (enExample)
EP (1) EP2037974B1 (enExample)
JP (1) JP5319524B2 (enExample)
AT (1) ATE510569T1 (enExample)
DE (1) DE102006033168A1 (enExample)
ES (1) ES2367004T3 (enExample)
WO (1) WO2008006544A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006033167A1 (de) * 2006-07-10 2008-01-24 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers
CN101854960B (zh) 2006-12-15 2014-06-25 生命连结有限公司 明胶-转谷氨酰胺酶止血敷料和密封材料
AU2009261559B2 (en) * 2008-06-18 2014-01-16 Lifebond Ltd Improved cross-linked compositions
JP5237714B2 (ja) * 2008-07-29 2013-07-17 BioROIS株式会社 細胞輸送用担体及びそれを使用した細胞の輸送方法
EP2464241B1 (en) * 2009-08-13 2014-07-09 Bioenol S.r.l. Process for producing instantaneous cold soluble gelatin and product thereof
EP2963111A1 (en) 2009-12-22 2016-01-06 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
DK2600910T3 (en) 2010-08-05 2016-04-04 Lifebond Ltd Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS
KR101272484B1 (ko) * 2011-01-19 2013-06-10 세원셀론텍(주) 방사선 가교화된 콜라겐 겔 및 그 제조방법과 사용방법
DE102015220583A1 (de) * 2015-10-21 2017-04-27 Tetec Tissue Engineering Technologies Ag Medizinische Zusammensetzung und medizinisches Hydrogel zur Anwendung bei der Vorbeugung und/oder Behandlung einer Erkrankung der Facettengelenke und/oder zur Anwendung beim Ersatz und/oder der Regeneration von Facettengelenkknorpel
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
CN113024846B (zh) * 2021-03-17 2021-12-14 北京大学 一种可调控粘附界面的水凝胶材料、制备方法及其应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3438374A (en) * 1966-02-28 1969-04-15 Us Health Education & Welfare Method of bonding tissue surfaces and controlling hemorrhaging thereof using a tissue adhesive and hemostatic composition
JPS61152247A (ja) 1984-12-26 1986-07-10 Ajinomoto Co Inc 蛋白質膜の製造法
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5385606A (en) 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5939385A (en) 1993-08-13 1999-08-17 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5428014A (en) 1993-08-13 1995-06-27 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
JPH09507212A (ja) * 1993-10-04 1997-07-22 マウリツィオ、トネッティ 組織治癒及び再生を高めるための医薬組成物とそれを含む適用キット
FR2715309B1 (fr) 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
WO1996010374A1 (en) * 1994-10-03 1996-04-11 Otogen Corporation Differentially biodegradable biomedical implants
FR2726571B1 (fr) * 1994-11-03 1997-08-08 Izoret Georges Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique
US6565842B1 (en) * 1995-06-07 2003-05-20 American Bioscience, Inc. Crosslinkable polypeptide compositions
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
WO1997029715A1 (en) * 1996-02-20 1997-08-21 Fusion Medical Technologies, Inc. Compositions and methods for sealing tissue and preventing post-surgical adhesions
DE69739540D1 (de) * 1996-04-19 2009-10-01 Osiris Therapeutics Inc Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen
US5834232A (en) * 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
US6039901A (en) 1997-01-31 2000-03-21 Givaudan Roure Flavors Corporation Enzymatically protein encapsulating oil particles by complex coacervation
US20020098222A1 (en) * 1997-03-13 2002-07-25 John F. Wironen Bone paste
DE19732917C1 (de) 1997-07-30 1998-10-15 Fuchsbauer Hans Lothar Verfahren zum Transglutaminase-katalysierten Koppeln von Protein oder Peptid an einen Träger
US20020076429A1 (en) * 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
US20020015724A1 (en) 1998-08-10 2002-02-07 Chunlin Yang Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
AU759991B2 (en) * 1998-08-26 2003-05-01 Neo Mend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers or covering structures
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6730299B1 (en) 1999-07-21 2004-05-04 Imedex Biomateriaux Adhesive protein foam for surgical and/or therapeutic uses
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
EP1335687B1 (en) * 2000-11-15 2007-01-10 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
DE10152407A1 (de) 2001-10-24 2003-05-08 Aesculap Ag & Co Kg Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten
JP4489437B2 (ja) * 2002-02-21 2010-06-23 エンセル,インコーポレイテッド 表面コーティングとしての固定化生物活性ヒドロゲルマトリックス
ATE340566T1 (de) * 2002-12-05 2006-10-15 Symrise Gmbh & Co Kg Nahtlose gefüllte kapseln
JP2004283371A (ja) * 2003-03-20 2004-10-14 Nagoya Industrial Science Research Inst 医用材料
EP1664168B1 (en) * 2003-08-29 2008-12-03 Mayo Foundation for Medical Education and Research Hydrogel porogens for fabricating biodegradable scaffolds
US7157428B2 (en) * 2003-11-26 2007-01-02 Histogenics, Corp. Method for treatment and repair of meniscal injuries
US7560432B2 (en) * 2003-11-26 2009-07-14 Histogenics Corporation In situ method for treatment and repair of meniscal injuries
DE102004024635A1 (de) 2004-05-12 2005-12-08 Deutsche Gelatine-Fabriken Stoess Ag Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine
JP2005325075A (ja) * 2004-05-14 2005-11-24 Yasuhiko Tabata 架橋ゼラチンゲルを担体とする半月板損傷治療剤
EP1748803A2 (en) 2004-05-27 2007-02-07 Humanitas Mirasole S.p.A. Use of fibrin for separating body organs
US7972621B2 (en) * 2004-06-03 2011-07-05 R.P. Scherer Technologies, Llc Process for formulating fast dispersing dosage forms comprising at least one fish gelatin selected on the basis of molecular weight
EP2980206A1 (en) * 2004-07-01 2016-02-03 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
GB0421298D0 (en) * 2004-09-24 2004-10-27 Univ Bristol Cellular bandage
WO2006059984A1 (en) * 2004-11-30 2006-06-08 The Regents Of The University Of Michigan Modified porous materials and method of forming the same
US7837986B2 (en) 2004-12-01 2010-11-23 E. I. Du Pont De Nemours And Company Protein-based polymer tissue adhesives for medical use
WO2006101548A2 (en) * 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
DE102005054938A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Formkörper auf Basis eines vernetzten, Gelatine enthaltenden Materials, Verfahren zu deren Herstellung sowie deren Verwendung
DE102006033167A1 (de) * 2006-07-10 2008-01-24 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers

Also Published As

Publication number Publication date
DE102006033168A1 (de) 2008-01-17
JP5319524B2 (ja) 2013-10-16
JP2009542383A (ja) 2009-12-03
ES2367004T3 (es) 2011-10-27
US20140170119A1 (en) 2014-06-19
US8637081B2 (en) 2014-01-28
US9744218B2 (en) 2017-08-29
EP2037974A2 (de) 2009-03-25
WO2008006544A3 (de) 2008-11-27
WO2008006544A2 (de) 2008-01-17
US20090191269A1 (en) 2009-07-30
EP2037974B1 (de) 2011-05-25

Similar Documents

Publication Publication Date Title
ATE525098T1 (de) Verwendung von gelatine und transglutaminase zur herstellung eines vernetzenden medizinischen klebers
ATE455534T1 (de) Verwendung einer hydrophilen matrix mit einem polyacrylsäurederivat, einem celluloseether und einem sprengmittel zur herstellung eines medikaments zur behandlung von erkrankungen der weiblichen genitalorgane
DE602005018981D1 (de) Verfahren zur Herstellung von L-Cystein, und L-Cystein-produzierender Mikroorganismus
DE602005023243D1 (de) Verfahren zur Herstellung von Saugkernen
DE602005009866D1 (de) Verfahren zur herstellung von n-phenylpyrazol-1-carboxamiden
DE602005018601D1 (de) Verfahren zur herstellung von 2-aminothiazol-5-aro
BRPI0409357B8 (pt) película de gel termorreversível homogênea, processo para fabricar as películas de gel, cápsulas moles, processo para fabricar as cápsulas moles, e, forma sólida
DE60314865D1 (de) Verfahren zur herstellung von modifiziertem polymer, danach erhaltenes modifiziertes polymer und kautschukzusammensetzung
DE102009035301A8 (de) Verfahren zur Herstellung von Dibenz[c,e][1,2]-oxaphosphorin-Derivaten, Amino-dibenz[c,e][1,2]-oxaphosphorin sowie deren Verwendung
DE502007002289D1 (de) Methacrylatharze zur herstellung von fahrbahnmarkierungen
DE602004031134D1 (de) Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
DE602004017731D1 (de) Verfahren zur herstellung von 1-ä(benzimidazol-1-yl)chinolin-8-ylüpiperidin-4-ylaminderivaten
ATE512970T1 (de) Dimere von artemisininderivaten, deren herstellung und deren therapeutische verwendung
DE602005017027D1 (de) Verfahren zur enzymatischen herstellung von (s)-3-cyano-5-methylhexansäure
DE602004024902D1 (de) Verbesserte formulierung zur bereitstellung eines magensaftresitenten beschichtungsmaterials
DE502006004101D1 (de) Verfahren zur Herstellung von Dispersionen von vernetzten Organopolysiloxanen
ATE482966T1 (de) Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide
DE102005001078A8 (de) Glaspulver, insbesondere biologisch aktives Glaspulver und Verfahren zur Herstellung von Glaspulver, insbesondere biologisch aktivem Glaspulver
DE602005017503D1 (de) Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen
EA201591621A1 (ru) Пригодная для инъекции способная к полимеризации in situ коллагеновая композиция
DE602005007734D1 (de) Verfahren zur herstellung von telmisartan
SE0401969D0 (sv) Piperidine derivatives
DE502005005085D1 (de) Verfahren zur Herstellung von Iminooxadiazindiongruppen aufweisenden Polyisocyanaten
DE60228400D1 (de) Verfahren zur Herstellung von modifiziertem Polymerkautschuk
DE602006018721D1 (de) Cyanidfreie lösungsmittelzusammensetzung und verwendungsverfahren dafür zur messung von hämoglobin und weissen blutkörperchen