ATE506358T1 - 2-benzylpyridazinonderivate als met-kinasehemmer - Google Patents
2-benzylpyridazinonderivate als met-kinasehemmerInfo
- Publication number
- ATE506358T1 ATE506358T1 AT08865961T AT08865961T ATE506358T1 AT E506358 T1 ATE506358 T1 AT E506358T1 AT 08865961 T AT08865961 T AT 08865961T AT 08865961 T AT08865961 T AT 08865961T AT E506358 T1 ATE506358 T1 AT E506358T1
- Authority
- AT
- Austria
- Prior art keywords
- benzylpyridazinone
- derivatives
- kinase inhibitors
- met kinase
- met
- Prior art date
Links
- FPYJSJDOHRDAMT-KQWNVCNZSA-N 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- Chemical compound C=1C=C2NC(=O)\C(=C/C3=C(C(C(=O)N4CCN(C)CC4)=C(C)N3)C)C2=CC=1S(=O)(=O)N(C)C1=CC=CC(Cl)=C1 FPYJSJDOHRDAMT-KQWNVCNZSA-N 0.000 title 1
- FSXKVYGFNNIDBZ-UHFFFAOYSA-N 2-benzylpyridazin-3-one Chemical class O=C1C=CC=NN1CC1=CC=CC=C1 FSXKVYGFNNIDBZ-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007061963A DE102007061963A1 (de) | 2007-12-21 | 2007-12-21 | Pyridazinonderivate |
| PCT/EP2008/009970 WO2009083076A1 (de) | 2007-12-21 | 2008-11-25 | 2-benzylpyridazinonderivate als met-kinasehemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE506358T1 true ATE506358T1 (de) | 2011-05-15 |
Family
ID=40262707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08865961T ATE506358T1 (de) | 2007-12-21 | 2008-11-25 | 2-benzylpyridazinonderivate als met-kinasehemmer |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8557813B2 (https=) |
| EP (1) | EP2220070B1 (https=) |
| JP (1) | JP5443381B2 (https=) |
| KR (1) | KR101606945B1 (https=) |
| CN (1) | CN101903374B (https=) |
| AR (1) | AR069843A1 (https=) |
| AT (1) | ATE506358T1 (https=) |
| AU (1) | AU2008342339B2 (https=) |
| BR (1) | BRPI0821743B8 (https=) |
| CA (1) | CA2710092C (https=) |
| CL (1) | CL2008003854A1 (https=) |
| CO (1) | CO6220964A2 (https=) |
| CY (1) | CY1111556T1 (https=) |
| DE (2) | DE102007061963A1 (https=) |
| DK (1) | DK2220070T3 (https=) |
| EA (1) | EA021362B1 (https=) |
| EC (1) | ECSP10010361A (https=) |
| ES (1) | ES2362472T3 (https=) |
| HR (1) | HRP20110441T1 (https=) |
| IL (1) | IL206394A (https=) |
| MY (1) | MY155719A (https=) |
| NZ (1) | NZ586894A (https=) |
| PE (1) | PE20091527A1 (https=) |
| PL (1) | PL2220070T3 (https=) |
| PT (1) | PT2220070E (https=) |
| SI (1) | SI2220070T1 (https=) |
| TW (1) | TWI433845B (https=) |
| UA (1) | UA100540C2 (https=) |
| WO (1) | WO2009083076A1 (https=) |
| ZA (1) | ZA201005166B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| SI2361250T1 (sl) | 2008-12-22 | 2013-12-31 | Merck Patent Gmbh | Nove polimorfne oblike 6-(1-metil-1h-pirazol-4-il)-2-(3-(5-(2-morfolin-4-il-etoksi)-pirimidin- 2-il)-benzil)-2h-piridazin-3-on dihidrogenfosfata in postopki za proizvodnjo le-tega |
| DE102008062826A1 (de) * | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102009003954A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102009004061A1 (de) | 2009-01-08 | 2010-07-15 | Merck Patent Gmbh | Pyridazinonderivate |
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| CN102731409A (zh) * | 2011-04-08 | 2012-10-17 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物，其药物组合物、制备方法及用途 |
| US9090694B2 (en) | 2012-04-30 | 2015-07-28 | Janssen Biotech, Inc. | ST2L antibody antagonists |
| JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ａｘｌに対するヒトモノクローナル抗体 |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| GB201514015D0 (en) | 2015-08-07 | 2015-09-23 | Arnér Elias S J And Dept Of Health And Human Services | Novel pyridazinones and their use in the treatment of cancer |
| US11180480B2 (en) | 2017-10-17 | 2021-11-23 | Sensorion | Synthesis of 4-aminopyrimidine compounds |
| IL286481B2 (en) | 2019-03-20 | 2025-12-01 | Goldfinch Bio Inc | Pyridazinones and methods of use thereof |
| US12576033B2 (en) | 2019-04-11 | 2026-03-17 | Gfb (Abc), Llc | Spray-dried formulation of a pyridazinone TRPC5 inhibitor |
| AR128430A1 (es) * | 2022-02-03 | 2024-05-08 | De Shaw Res Llc | Compuestos de piridazinona como inhibidores de trpa1 |
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| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
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| AU691673B2 (en) | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
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| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
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| DE102005055354A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| KR20080080584A (ko) | 2005-11-30 | 2008-09-04 | 버텍스 파마슈티칼스 인코포레이티드 | ｃ-Ｍｅｔ의 억제제 및 이의 용도 |
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-
2007
- 2007-12-21 DE DE102007061963A patent/DE102007061963A1/de not_active Withdrawn
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2008
- 2008-11-25 DK DK08865961.0T patent/DK2220070T3/da active
- 2008-11-25 ES ES08865961T patent/ES2362472T3/es active Active
- 2008-11-25 PL PL08865961T patent/PL2220070T3/pl unknown
- 2008-11-25 CN CN2008801212236A patent/CN101903374B/zh not_active Expired - Fee Related
- 2008-11-25 EA EA201001005A patent/EA021362B1/ru not_active IP Right Cessation
- 2008-11-25 EP EP08865961A patent/EP2220070B1/de active Active
- 2008-11-25 CA CA2710092A patent/CA2710092C/en active Active
- 2008-11-25 AT AT08865961T patent/ATE506358T1/de active
- 2008-11-25 BR BRPI0821743A patent/BRPI0821743B8/pt not_active IP Right Cessation
- 2008-11-25 US US12/808,928 patent/US8557813B2/en not_active Expired - Fee Related
- 2008-11-25 HR HR20110441T patent/HRP20110441T1/hr unknown
- 2008-11-25 MY MYPI2010002840A patent/MY155719A/en unknown
- 2008-11-25 NZ NZ586894A patent/NZ586894A/en not_active IP Right Cessation
- 2008-11-25 KR KR1020107016204A patent/KR101606945B1/ko not_active Expired - Fee Related
- 2008-11-25 SI SI200830314T patent/SI2220070T1/sl unknown
- 2008-11-25 JP JP2010538390A patent/JP5443381B2/ja not_active Expired - Fee Related
- 2008-11-25 AU AU2008342339A patent/AU2008342339B2/en not_active Ceased
- 2008-11-25 WO PCT/EP2008/009970 patent/WO2009083076A1/de not_active Ceased
- 2008-11-25 DE DE502008003317T patent/DE502008003317D1/de active Active
- 2008-11-25 UA UAA201008995A patent/UA100540C2/ru unknown
- 2008-11-25 PT PT08865961T patent/PT2220070E/pt unknown
- 2008-12-19 AR ARP080105562A patent/AR069843A1/es not_active Application Discontinuation
- 2008-12-19 PE PE2008002158A patent/PE20091527A1/es not_active Application Discontinuation
- 2008-12-19 CL CL2008003854A patent/CL2008003854A1/es unknown
- 2008-12-19 TW TW097149958A patent/TWI433845B/zh not_active IP Right Cessation
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2010
- 2010-06-15 IL IL206394A patent/IL206394A/en active IP Right Grant
- 2010-06-18 CO CO10073802A patent/CO6220964A2/es active IP Right Grant
- 2010-07-20 EC EC2010010361A patent/ECSP10010361A/es unknown
- 2010-07-20 ZA ZA2010/05166A patent/ZA201005166B/en unknown
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2011
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2013
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