ATE504648T1 - Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen - Google Patents
Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellenInfo
- Publication number
- ATE504648T1 ATE504648T1 AT04715568T AT04715568T ATE504648T1 AT E504648 T1 ATE504648 T1 AT E504648T1 AT 04715568 T AT04715568 T AT 04715568T AT 04715568 T AT04715568 T AT 04715568T AT E504648 T1 ATE504648 T1 AT E504648T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer cell
- cell growth
- rna interference
- inhibiting cancer
- cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 101000708574 Homo sapiens Histone-lysine N-methyltransferase SMYD3 Proteins 0.000 title abstract 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 title 1
- 230000010261 cell growth Effects 0.000 title 1
- 230000009368 gene silencing by RNA Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 abstract 1
- 102100032804 Histone-lysine N-methyltransferase SMYD3 Human genes 0.000 abstract 1
- 108020004459 Small interfering RNA Proteins 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01043—Histone-lysine N-methyltransferase (2.1.1.43)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45064403P | 2003-02-28 | 2003-02-28 | |
| PCT/JP2004/002446 WO2004076623A2 (en) | 2003-02-28 | 2004-02-27 | Rna-interference for znfn3a1-gene as a method for inhibiting cancer cell growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE504648T1 true ATE504648T1 (de) | 2011-04-15 |
Family
ID=32927675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04715568T ATE504648T1 (de) | 2003-02-28 | 2004-02-27 | Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP1599586B9 (de) |
| JP (1) | JP4467559B2 (de) |
| CN (2) | CN102172408A (de) |
| AT (1) | ATE504648T1 (de) |
| DE (1) | DE602004032114D1 (de) |
| ES (1) | ES2363500T3 (de) |
| WO (1) | WO2004076623A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2283592T3 (es) | 2001-09-25 | 2007-11-01 | Oncotherapy Science, Inc. | Gen y proteina relacionados con el carcinoma hepatocelular. |
| TWI350373B (en) | 2004-01-23 | 2011-10-11 | Oncotherapy Science Inc | Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators |
| CA2576925C (en) | 2004-08-16 | 2013-12-10 | The Cbr Institute For Biomedical Research, Inc. | Method of delivering rna interference and uses thereof |
| EP2295601A1 (de) | 2005-02-10 | 2011-03-16 | Oncotherapy Science, Inc. | Verfahren zur Diagnose von Blasenkrebs |
| CN101189346A (zh) * | 2005-02-28 | 2008-05-28 | 肿瘤疗法科学股份有限公司 | 乳腺癌相关基因znfn3a1 |
| WO2006121208A1 (en) * | 2005-05-12 | 2006-11-16 | Oncotherapy Science, Inc. | Polymorphisms of the e2f-1 binding element and methods of determining cancer susceptibility |
| TW200741009A (en) | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| EP2295570A1 (de) * | 2005-07-27 | 2011-03-16 | Oncotherapy Science, Inc. | Verfahren zur Diagnose von kleinzelligem Lungenkrebs |
| EP2171082B1 (de) | 2007-06-14 | 2012-11-28 | Oncotherapy Science, Inc. | Verfahren zur identifizierung von die methylierung von vegfr1 durch smyd3 modulierenden stoffen |
| WO2011115810A2 (en) * | 2010-03-16 | 2011-09-22 | Massachusetts Institute Of Technology | Isoform-specific rnai based on codon redundancy/degeneracy |
| US20120310140A1 (en) | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| JP2023524679A (ja) | 2020-04-30 | 2023-06-13 | フィジーン、エルエルシー | 癌線維芽細胞を標的化するための免疫療法の方法および組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| JP2003521231A (ja) * | 1999-01-29 | 2003-07-15 | インサイト・ファーマスーティカルズ・インコーポレイテッド | 核酸結合タンパク質 |
| ES2546829T3 (es) * | 2001-07-23 | 2015-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Métodos y composiciones para la inhibición mediada por iARN de la expresión génica en mamíferos |
| ES2283592T3 (es) * | 2001-09-25 | 2007-11-01 | Oncotherapy Science, Inc. | Gen y proteina relacionados con el carcinoma hepatocelular. |
-
2004
- 2004-02-27 CN CN2011101031982A patent/CN102172408A/zh active Pending
- 2004-02-27 EP EP04715568A patent/EP1599586B9/de not_active Expired - Lifetime
- 2004-02-27 CN CN200480011109XA patent/CN1780912B/zh not_active Expired - Fee Related
- 2004-02-27 WO PCT/JP2004/002446 patent/WO2004076623A2/en not_active Ceased
- 2004-02-27 ES ES04715568T patent/ES2363500T3/es not_active Expired - Lifetime
- 2004-02-27 AT AT04715568T patent/ATE504648T1/de not_active IP Right Cessation
- 2004-02-27 DE DE602004032114T patent/DE602004032114D1/de not_active Expired - Lifetime
- 2004-02-27 EP EP10180084A patent/EP2311948A1/de not_active Withdrawn
- 2004-02-27 JP JP2006502685A patent/JP4467559B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4467559B2 (ja) | 2010-05-26 |
| CN1780912B (zh) | 2011-06-15 |
| WO2004076623A2 (en) | 2004-09-10 |
| ES2363500T3 (es) | 2011-08-05 |
| EP2311948A1 (de) | 2011-04-20 |
| CN1780912A (zh) | 2006-05-31 |
| DE602004032114D1 (de) | 2011-05-19 |
| EP1599586B9 (de) | 2012-03-14 |
| CN102172408A (zh) | 2011-09-07 |
| JP2006519009A (ja) | 2006-08-24 |
| EP1599586A2 (de) | 2005-11-30 |
| WO2004076623A3 (en) | 2004-12-23 |
| EP1599586B1 (de) | 2011-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |