ATE504584T1 - Salze aus benzimidazolylpyridylethern und formulierungen daraus - Google Patents

Salze aus benzimidazolylpyridylethern und formulierungen daraus

Info

Publication number
ATE504584T1
ATE504584T1 AT07837588T AT07837588T ATE504584T1 AT E504584 T1 ATE504584 T1 AT E504584T1 AT 07837588 T AT07837588 T AT 07837588T AT 07837588 T AT07837588 T AT 07837588T AT E504584 T1 ATE504584 T1 AT E504584T1
Authority
AT
Austria
Prior art keywords
salts
formulations
ethers
benzimidazolylpyridyl
trifluoromethyl
Prior art date
Application number
AT07837588T
Other languages
English (en)
Inventor
Rampurna Gullapalli
Ahmad Hashash
Piotr Karpinski
Kangwen Lin
Eric Loeser
Augustus Okhamafe
Paul Sutton
Eduardo Sy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE504584T1 publication Critical patent/ATE504584T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT07837588T 2006-08-30 2007-08-30 Salze aus benzimidazolylpyridylethern und formulierungen daraus ATE504584T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84117706P 2006-08-30 2006-08-30
US95446607P 2007-08-07 2007-08-07
PCT/US2007/019152 WO2008027523A2 (en) 2006-08-30 2007-08-30 Salts of benzimidazolyl pyridyl ethers and formulations thereof

Publications (1)

Publication Number Publication Date
ATE504584T1 true ATE504584T1 (de) 2011-04-15

Family

ID=39027583

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07837588T ATE504584T1 (de) 2006-08-30 2007-08-30 Salze aus benzimidazolylpyridylethern und formulierungen daraus

Country Status (34)

Country Link
US (2) US8202998B2 (de)
EP (1) EP2059518B1 (de)
JP (1) JP5279712B2 (de)
KR (1) KR20090043542A (de)
CN (1) CN101516870B (de)
AT (1) ATE504584T1 (de)
AU (1) AU2007290388B2 (de)
BR (1) BRPI0716243A2 (de)
CA (1) CA2660376C (de)
CL (1) CL2007002533A1 (de)
CO (1) CO6150180A2 (de)
CY (1) CY1112187T1 (de)
DE (1) DE602007013774D1 (de)
DK (1) DK2059518T3 (de)
ES (1) ES2360968T3 (de)
GT (1) GT200900045A (de)
HK (1) HK1131613A1 (de)
HR (1) HRP20110311T1 (de)
IL (1) IL196811A (de)
JO (1) JO2702B1 (de)
MA (1) MA30711B1 (de)
MX (1) MX2009002279A (de)
MY (1) MY161829A (de)
NO (1) NO20091236L (de)
NZ (1) NZ574620A (de)
PE (2) PE20080766A1 (de)
PL (1) PL2059518T3 (de)
PT (1) PT2059518E (de)
RU (1) RU2457206C2 (de)
SI (1) SI2059518T1 (de)
TN (1) TN2009000068A1 (de)
TW (1) TW200819438A (de)
WO (1) WO2008027523A2 (de)
ZA (1) ZA200900664B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20080766A1 (es) * 2006-08-30 2008-06-15 Novartis Ag Sales de benzimidazolil piridil eteres y formulaciones que las contienen
MY148438A (en) * 2007-03-02 2013-04-30 Novartis Ag Solid forms of a raf kinase inhibitor
EP2288354A1 (de) * 2008-06-13 2011-03-02 Novartis AG Substituierte benzimidazole für neurofibromatose
WO2010088335A1 (en) * 2009-01-29 2010-08-05 Novartis Ag Substituted benzimidazoles for the treatment of astrocytomas
WO2011044072A1 (en) 2009-10-05 2011-04-14 Novartis Ag Combination of raf-265 and an activator of ampk for use in the treatment of a proliferative disease
CN103237544A (zh) * 2010-12-03 2013-08-07 诺华有限公司 药物组合物
EP4069199B1 (de) * 2019-12-02 2024-01-17 Astrazeneca AB Feste zusammensetzungen von 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
WO2022083741A1 (zh) * 2020-10-23 2022-04-28 上海辉启生物医药科技有限公司 吡唑并吡啶类化合物或其盐及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299108B2 (en) * 2002-03-29 2012-10-30 Novartis Ag Substituted benzazoles and methods of their use as inhibitors of raf kinase
MXPA04009541A (es) * 2002-03-29 2005-01-25 Chiron Corp Benzazoles sustituidos y uso de los mismos como inhibidores de cinasa raf.
US20060189619A1 (en) 2005-02-24 2006-08-24 Wyeth 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
TWI387592B (zh) * 2005-08-30 2013-03-01 Novartis Ag 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
US7731795B2 (en) 2005-12-02 2010-06-08 Clemson University Rhombohedral fluoroberyllium borate crystals and hydrothermal growth thereof for use in laser and non-linear optical applications and devices
PT2046292E (pt) * 2006-07-21 2010-04-26 Novartis Ag Formulações de éteres benzimidazolil-piridílicos
PE20080766A1 (es) 2006-08-30 2008-06-15 Novartis Ag Sales de benzimidazolil piridil eteres y formulaciones que las contienen

Also Published As

Publication number Publication date
AU2007290388A1 (en) 2008-03-06
CA2660376A1 (en) 2008-03-06
US20100168060A1 (en) 2010-07-01
HRP20110311T1 (hr) 2011-08-31
WO2008027523A3 (en) 2008-04-10
EP2059518B1 (de) 2011-04-06
PE20080766A1 (es) 2008-06-15
PL2059518T3 (pl) 2011-09-30
US20120308651A1 (en) 2012-12-06
TN2009000068A1 (en) 2010-08-19
RU2009111384A (ru) 2010-10-10
JO2702B1 (en) 2013-03-03
EP2059518A2 (de) 2009-05-20
ZA200900664B (en) 2009-12-30
CY1112187T1 (el) 2015-12-09
TW200819438A (en) 2008-05-01
JP2010502622A (ja) 2010-01-28
PE20130814A1 (es) 2013-08-08
IL196811A (en) 2013-03-24
AU2007290388B2 (en) 2011-07-14
NO20091236L (no) 2009-03-27
US8202998B2 (en) 2012-06-19
BRPI0716243A2 (pt) 2013-09-03
PT2059518E (pt) 2011-07-11
NZ574620A (en) 2011-05-27
DK2059518T3 (da) 2011-05-16
MY161829A (en) 2017-05-15
GT200900045A (es) 2010-06-14
IL196811A0 (en) 2009-11-18
CL2007002533A1 (es) 2008-02-08
HK1131613A1 (en) 2010-01-29
MX2009002279A (es) 2009-03-20
CA2660376C (en) 2014-04-15
JP5279712B2 (ja) 2013-09-04
KR20090043542A (ko) 2009-05-06
DE602007013774D1 (de) 2011-05-19
US8501785B2 (en) 2013-08-06
CN101516870A (zh) 2009-08-26
CO6150180A2 (es) 2010-04-20
WO2008027523A2 (en) 2008-03-06
MA30711B1 (fr) 2009-09-01
ES2360968T3 (es) 2011-06-10
CN101516870B (zh) 2013-09-11
SI2059518T1 (sl) 2011-06-30
RU2457206C2 (ru) 2012-07-27

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