ATE503747T1 - Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on - Google Patents

Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on

Info

Publication number
ATE503747T1
ATE503747T1 AT04748126T AT04748126T ATE503747T1 AT E503747 T1 ATE503747 T1 AT E503747T1 AT 04748126 T AT04748126 T AT 04748126T AT 04748126 T AT04748126 T AT 04748126T AT E503747 T1 ATE503747 T1 AT E503747T1
Authority
AT
Austria
Prior art keywords
methoxyethoxy
bis
quinazolin
producing
benzoate
Prior art date
Application number
AT04748126T
Other languages
English (en)
Inventor
Shigeyoshi Nishino
Kenji Hirotsu
Hidetaka Shima
Hiroyuki Oda
Shinobu Suzuki
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Application granted granted Critical
Publication of ATE503747T1 publication Critical patent/ATE503747T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
AT04748126T 2003-07-30 2004-07-30 Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on ATE503747T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003282696 2003-07-30
PCT/JP2004/010965 WO2005012264A1 (ja) 2003-07-30 2004-07-30 ６，７−ビス（２−メトキシエトキシ）キナゾリン−４−オンの製造法

Publications (1)

Publication Number Publication Date
ATE503747T1 true ATE503747T1 (de) 2011-04-15

Family

ID=34113782

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04748126T ATE503747T1 (de) 2003-07-30 2004-07-30 Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on

Country Status (8)

Country Link
US (2) US20060276647A1 (de)
EP (1) EP1650196B1 (de)
JP (1) JP4569876B2 (de)
CN (1) CN100540539C (de)
AT (1) ATE503747T1 (de)
DE (1) DE602004032028D1 (de)
ES (1) ES2362734T3 (de)
WO (1) WO2005012264A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367824B2 (en) * 2002-01-28 2013-02-05 Ube Industries Ltd. Process for producing quinazolin-4-one derivative
CN101137412B (zh) 2005-01-13 2012-11-07 布里斯托尔-迈尔斯·斯奎布公司 用作凝血因子XIa抑制剂的取代的二芳基化合物
CN101798289B (zh) * 2010-02-08 2012-04-18 天津市炜杰科技有限公司 一种埃罗替尼中间体的制备方法
CN102321033B (zh) * 2011-08-22 2013-10-09 江苏辉丰农化股份有限公司 一种它塞瓦的制备方法
WO2013156835A1 (en) * 2012-04-16 2013-10-24 Laurus Labs Private Limited An improved process for the preparation of erlotinib hydrochloride form a
CN102850279A (zh) * 2012-10-10 2013-01-02 山东金城医药化工股份有限公司 6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮的制备方法
CN104725327B (zh) * 2015-03-03 2017-08-25 山东大学 一种盐酸厄洛替尼的环保制备方法
CN106892821B (zh) * 2015-12-21 2021-06-11 浙江九洲药业股份有限公司 一种3,4-二(2-甲氧基乙氧基)苯甲酸乙酯的制备方法
CN105566233B (zh) * 2015-12-31 2018-08-17 重庆威鹏药业有限公司 厄洛替尼中间体的制备方法
CN106928069B (zh) * 2017-03-21 2019-03-19 上海玉函化工有限公司 一种4,5-二(2-甲氧基乙氧基)-2-硝基苯甲酸乙酯的制备方法
CN108358798A (zh) * 2018-02-12 2018-08-03 黑龙江鑫创生物科技开发有限公司 一种微通道反应器合成厄洛替尼中间体的方法
CN113603650B (zh) * 2021-08-03 2023-03-10 杭州职业技术学院 一种埃罗替尼关键中间体的催化环合制备方法及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3119824A (en) * 1964-01-28 L-substituted-l
US4096144A (en) * 1970-12-08 1978-06-20 Sumitomo Chemical Company, Limited Process for preparing quinazolinone derivatives and their 2-(N-mono-substituted amino)-phenyl ketone intermediate derivatives
JPS63126867A (ja) * 1986-11-14 1988-05-30 Mitsui Petrochem Ind Ltd イミダゾ−ル誘導体の製法
JPH0629234B2 (ja) * 1986-12-26 1994-04-20 三井石油化学工業株式会社 α−アシロキシケトン誘導体
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
AU2001293207A1 (en) * 2000-08-18 2002-03-04 Cor Therapeutics, Inc. Nitrogenous heterocyclic compounds
JP2002293773A (ja) 2001-03-30 2002-10-09 Sumika Fine Chemicals Co Ltd キナゾリン誘導体の製造方法
EP1408980A4 (de) 2001-06-21 2004-10-20 Ariad Pharma Inc Neue chinazoline und ihre verwendungszwecke
AU2002357621A1 (en) * 2001-12-19 2003-06-30 Ube Industries, Ltd. Process for producing quinazolin-4-one and derivative thereof
US8367824B2 (en) * 2002-01-28 2013-02-05 Ube Industries Ltd. Process for producing quinazolin-4-one derivative
DE10204150A1 (de) 2002-02-01 2003-08-14 Schott Glas Erdalkalialuminosilicatglas und Verwendung

Also Published As

Publication number Publication date
DE602004032028D1 (de) 2011-05-12
US8133999B2 (en) 2012-03-13
US20060276647A1 (en) 2006-12-07
US20090253909A1 (en) 2009-10-08
JP4569876B2 (ja) 2010-10-27
EP1650196A1 (de) 2006-04-26
EP1650196A4 (de) 2007-02-28
CN1860105A (zh) 2006-11-08
CN100540539C (zh) 2009-09-16
WO2005012264A1 (ja) 2005-02-10
ES2362734T3 (es) 2011-07-12
JPWO2005012264A1 (ja) 2007-09-27
EP1650196B1 (de) 2011-03-30

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