ATE502105T1 - Modifizierte faktor-viia-polypeptide - Google Patents
Modifizierte faktor-viia-polypeptideInfo
- Publication number
- ATE502105T1 ATE502105T1 AT09156971T AT09156971T ATE502105T1 AT E502105 T1 ATE502105 T1 AT E502105T1 AT 09156971 T AT09156971 T AT 09156971T AT 09156971 T AT09156971 T AT 09156971T AT E502105 T1 ATE502105 T1 AT E502105T1
- Authority
- AT
- Austria
- Prior art keywords
- factor viia
- modified factor
- polypeptides
- viia polypeptides
- mammals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/302,239 US6693075B1 (en) | 1997-10-23 | 1999-04-29 | Modified vitamin K-dependent polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE502105T1 true ATE502105T1 (de) | 2011-04-15 |
Family
ID=23166903
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT09156971T ATE502105T1 (de) | 1999-04-29 | 2000-04-28 | Modifizierte faktor-viia-polypeptide |
AT00928505T ATE434046T1 (de) | 1999-04-29 | 2000-04-28 | Modifizierte faktor viia proteine |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00928505T ATE434046T1 (de) | 1999-04-29 | 2000-04-28 | Modifizierte faktor viia proteine |
Country Status (9)
Country | Link |
---|---|
US (3) | US6693075B1 (de) |
EP (3) | EP1177304B1 (de) |
JP (3) | JP4709395B2 (de) |
AT (2) | ATE502105T1 (de) |
AU (1) | AU4673800A (de) |
DE (2) | DE60045752D1 (de) |
DK (2) | DK1177304T3 (de) |
ES (2) | ES2363307T3 (de) |
WO (1) | WO2000066753A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6693075B1 (en) * | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6998122B1 (en) | 1999-04-30 | 2006-02-14 | Eli Lilly And Company | Protein C derivatives |
JP2003514545A (ja) * | 1999-11-19 | 2003-04-22 | イーライ・リリー・アンド・カンパニー | プロテインc誘導体 |
US6630138B2 (en) | 2000-02-11 | 2003-10-07 | Eli Lilly And Company | Protein C derivatives |
EP1982732A3 (de) * | 2000-02-11 | 2011-06-08 | Bayer HealthCare LLC | Faktor VII- oder VIIA-ähnliche Konjugate |
US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
US7160540B2 (en) | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
US6933367B2 (en) | 2000-10-18 | 2005-08-23 | Maxygen Aps | Protein C or activated protein C-like molecules |
EP1370649A1 (de) * | 2001-03-02 | 2003-12-17 | T.A.C. Thrombosis and Coagulation AB | Varianten von protein c |
US7015193B2 (en) * | 2001-04-20 | 2006-03-21 | University Of Vermont | Compositions and methods to control bleeding |
PL373728A1 (en) * | 2002-04-30 | 2005-09-05 | Maxygen Holdings Ltd. | Factor vii or viia polypeptide variants |
ATE505487T1 (de) * | 2002-09-30 | 2011-04-15 | Bayer Healthcare Llc | Fvii- oder fviia-varianten mit erhöhter koagulationswirkung |
ES2543588T3 (es) | 2002-12-03 | 2015-08-20 | Pharmacyclics Llc | Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa |
ES2327044T3 (es) * | 2003-03-20 | 2009-10-23 | Bayer Healthcare Llc | Variantes de fvii o fviia. |
DE602004025576D1 (de) * | 2003-06-19 | 2010-04-01 | Bayer Healthcare Llc | Varianten der faktor-vii- oder -viia-gla-domäne |
CN101870729A (zh) | 2003-09-09 | 2010-10-27 | 诺和诺德医疗保健公司 | 凝固因子ⅶ多肽 |
BRPI0416950B8 (pt) | 2003-12-01 | 2021-05-25 | Novo Nordisk Healthcare Ag | métodos para remover vírus de uma composição do fator vii líquida, para inativar vírus em uma composição do fator vii líquida, e para eliminar em alto nível a presença de vírus ativos em uma composição do fator vii líquida. |
PL2298287T3 (pl) | 2003-12-19 | 2019-02-28 | Novo Nordisk Health Care Ag | Stabilizowane kompozycje polipeptydów czynnika VII |
EP1713906A2 (de) * | 2004-02-03 | 2006-10-25 | Novo Nordisk Health Care AG | Keine funktionelle lipid-membran-bindungsdomäne aufweisende koagulationsfaktor vii/viia-varianten |
DK1781782T3 (da) | 2004-08-17 | 2010-08-23 | Csl Behring Gmbh | Modificerede vitamin K-afhængige polypeptider |
EP1831242B1 (de) | 2004-12-23 | 2012-09-26 | Novo Nordisk Health Care AG | Reduktion des gehaltes an kontaminierenden proteinen in zusammensetzungen, die vitamin k-abhängige proteine von interesse umfassen |
JP5335422B2 (ja) | 2005-06-17 | 2013-11-06 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 少なくとも1つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化 |
JP5147692B2 (ja) | 2005-07-13 | 2013-02-20 | ノボ ノルディスク ヘルス ケア アーゲー | 治療用タンパク質生成のための宿主細胞タンパク質ノックアウト細胞 |
EP1926817A2 (de) | 2005-09-14 | 2008-06-04 | Novo Nordisk Health Care AG | Menschliche gerinnungsfaktor-vii-polypeptide |
US8383388B2 (en) * | 2006-06-19 | 2013-02-26 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
EP2059527B1 (de) | 2006-09-01 | 2014-12-03 | Novo Nordisk Health Care AG | Modifizierte glykoproteine |
EP2114379A2 (de) * | 2006-12-20 | 2009-11-11 | Bayer HealthCare LLC | Faktor-vi- und -viia-zusammensetzungen |
DK2147096T3 (da) | 2007-04-13 | 2015-06-15 | Catalyst Biosciences Inc | Modificerede faktor-VII-polypeptider og anvendelser deraf |
TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
US20150337284A1 (en) * | 2012-10-29 | 2015-11-26 | Regents Of The University Of Minnesota | Factor ix variants |
EP3617316A4 (de) * | 2017-04-27 | 2020-12-23 | Chugai Seiyaku Kabushiki Kaisha | Koagulationsfaktor ix mit verbesserter pharmakokinetik |
EP3833381B1 (de) | 2019-08-15 | 2022-08-03 | Catalyst Biosciences, Inc. | Modifizierte faktor-vii-polypeptide zur subkutanen verabreichung |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258288A (en) | 1986-07-25 | 1993-11-02 | Genzyme Corporation | Vector containing DNA encoding mature human protein S |
DK323587D0 (da) * | 1987-06-25 | 1987-06-25 | Novo Industri As | Protein |
JP2799316B2 (ja) | 1987-06-12 | 1998-09-17 | ヘキスト・マリオン・ルセル株式会社 | 雑種ヒトプロテインcおよびその遺伝子工学的製法 |
US5009889A (en) | 1987-12-31 | 1991-04-23 | Oklahoma Medical Research Foundation | Treatment of dysfunctional vascular endothelium using activated protein C |
JPH0246296A (ja) | 1988-08-09 | 1990-02-15 | Hoechst Japan Ltd | 雑種プロテインc及びその製造方法 |
US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
US5580560A (en) | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
JP3330932B2 (ja) | 1990-01-29 | 2002-10-07 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 抗凝固剤タンパク質 |
US5817788A (en) | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
US5861374A (en) | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
US5504064A (en) | 1991-04-10 | 1996-04-02 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with an activator of FVII |
US5374617A (en) | 1992-05-13 | 1994-12-20 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with FVIIa |
JPH0720127A (ja) * | 1993-05-07 | 1995-01-24 | Eisai Co Ltd | 各種pivkaの測定方法および測定試薬 |
US5837843A (en) * | 1996-11-08 | 1998-11-17 | Oklahoma Medical Research Foundation | Modified protein C |
JP2001523949A (ja) | 1996-11-08 | 2001-11-27 | オクラホマ メディカル リサーチ ファウンデーション | 改変したプロテインcおよびその使用方法 |
ID23908A (id) | 1997-06-05 | 2000-05-25 | Lilly Co Eli | Metode pengobatan dari penyakit trombosis |
US6017882A (en) * | 1997-10-23 | 2000-01-25 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6693075B1 (en) * | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
EP1370649A1 (de) | 2001-03-02 | 2003-12-17 | T.A.C. Thrombosis and Coagulation AB | Varianten von protein c |
-
1999
- 1999-04-29 US US09/302,239 patent/US6693075B1/en not_active Expired - Lifetime
-
2000
- 2000-04-28 AT AT09156971T patent/ATE502105T1/de not_active IP Right Cessation
- 2000-04-28 EP EP00928505A patent/EP1177304B1/de not_active Expired - Lifetime
- 2000-04-28 JP JP2000615775A patent/JP4709395B2/ja not_active Expired - Fee Related
- 2000-04-28 DE DE60045752T patent/DE60045752D1/de not_active Expired - Lifetime
- 2000-04-28 DE DE60042403T patent/DE60042403D1/de not_active Expired - Lifetime
- 2000-04-28 ES ES09156971T patent/ES2363307T3/es not_active Expired - Lifetime
- 2000-04-28 WO PCT/US2000/011416 patent/WO2000066753A2/en active Application Filing
- 2000-04-28 ES ES00928505T patent/ES2327811T3/es not_active Expired - Lifetime
- 2000-04-28 EP EP10182187A patent/EP2305802A1/de not_active Withdrawn
- 2000-04-28 AT AT00928505T patent/ATE434046T1/de not_active IP Right Cessation
- 2000-04-28 DK DK00928505T patent/DK1177304T3/da active
- 2000-04-28 AU AU46738/00A patent/AU4673800A/en not_active Abandoned
- 2000-04-28 DK DK09156971.5T patent/DK2085471T3/da active
- 2000-04-28 EP EP09156971A patent/EP2085471B1/de not_active Expired - Lifetime
-
2001
- 2001-03-12 US US09/803,810 patent/US6762286B2/en not_active Expired - Lifetime
-
2004
- 2004-05-27 US US10/855,068 patent/US7294699B2/en not_active Expired - Lifetime
-
2011
- 2011-02-02 JP JP2011020351A patent/JP5642581B2/ja not_active Expired - Fee Related
-
2013
- 2013-12-20 JP JP2013264144A patent/JP2014094009A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2327811T3 (es) | 2009-11-04 |
JP2011135881A (ja) | 2011-07-14 |
EP2085471A3 (de) | 2009-09-09 |
JP2014094009A (ja) | 2014-05-22 |
DK2085471T3 (da) | 2011-05-16 |
DE60042403D1 (de) | 2009-07-30 |
JP2002542831A (ja) | 2002-12-17 |
WO2000066753A2 (en) | 2000-11-09 |
ES2363307T3 (es) | 2011-07-29 |
EP2085471A2 (de) | 2009-08-05 |
JP5642581B2 (ja) | 2014-12-17 |
WO2000066753A3 (en) | 2001-04-26 |
EP1177304A2 (de) | 2002-02-06 |
EP2305802A1 (de) | 2011-04-06 |
US20040220106A1 (en) | 2004-11-04 |
DK1177304T3 (da) | 2009-08-10 |
DE60045752D1 (de) | 2011-04-28 |
AU4673800A (en) | 2000-11-17 |
US6762286B2 (en) | 2004-07-13 |
EP2085471B1 (de) | 2011-03-16 |
US6693075B1 (en) | 2004-02-17 |
ATE434046T1 (de) | 2009-07-15 |
US7294699B2 (en) | 2007-11-13 |
JP4709395B2 (ja) | 2011-06-22 |
EP1177304B1 (de) | 2009-06-17 |
US20010018414A1 (en) | 2001-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE502105T1 (de) | Modifizierte faktor-viia-polypeptide | |
AP2000001811A0 (en) | Modified vitamin K- dependent polypeptides. | |
ATE522609T1 (de) | Neurotrophe faktoren | |
DE50012863D1 (de) | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften | |
ATE339507T1 (de) | Erythropoietin-analog-menschliches serum-albumin fusionsprotein | |
CY1111750T1 (el) | Νευροτροφικοι παραγοντες | |
DK1860187T3 (da) | Apo-2-receptor | |
PT939767E (pt) | Factor viii porcino e seus hibridos | |
DK1427750T3 (da) | Modificerede transferrin-fusionsproteiner | |
IL161016A (en) | Polypeptides capable of ang-2 binding | |
DE69733567D1 (de) | Teilnehmergesteuerte deregistrierung von der anrufliste | |
BR9913190A (pt) | Modulação de proteìnas quinase de linhagemmúltipla | |
ATE283286T1 (de) | Adnf mischungen zur verbesserung der lernfähigkeit und der gedächtnisfunktion | |
DK0984983T3 (da) | Modulatorer af intracellulære inflammations-, celledöds- og celleoverlevelsesforlöb indeholdende et CARD- og et kinasedomæne | |
DE29902414U1 (de) | Gerät zur Erzeugung von Kohlendioxid mit konstanter Generationsleistung | |
DE60221501D1 (de) | Bfit (brown fat inducible thioesterase) polypeptide und polynukleotide und ihre verwendung | |
BR0108187A (pt) | Moléculas trade e usos relacionados com as mesmas | |
DE69535039D1 (de) | Cytoplasmische tyrosin kinase | |
DE60128487D1 (de) | Biomarkierungen des übergangszellkarzinoms der blase | |
UA50891A (uk) | Рейкове стикове ізолювальне з'єднання | |
AR003807A1 (es) | Citostaticos modificados con hidratos de carbono. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |