ATE502017T1 - Pyrazolderivate als p2x7-modulatoren - Google Patents

Pyrazolderivate als p2x7-modulatoren

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Publication number
ATE502017T1
ATE502017T1 AT08750215T AT08750215T ATE502017T1 AT E502017 T1 ATE502017 T1 AT E502017T1 AT 08750215 T AT08750215 T AT 08750215T AT 08750215 T AT08750215 T AT 08750215T AT E502017 T1 ATE502017 T1 AT E502017T1
Authority
AT
Austria
Prior art keywords
receptor
pyrazole derivatives
modulators
salts
formula
Prior art date
Application number
AT08750215T
Other languages
English (en)
Inventor
Paul John Beswick
Laura Jane Chambers
Iain Patrick Chessell
David John Davies
Emmanuel Hubert Demont
Robert James Gleave
David George Hubert Livermore
Pamela Joan Theobald
Mythily Vimal
Daryl Simon Walter
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0709038.4A external-priority patent/GB0709038D0/en
Priority claimed from GB0808123A external-priority patent/GB0808123D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE502017T1 publication Critical patent/ATE502017T1/de

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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AT08750215T 2007-05-10 2008-05-08 Pyrazolderivate als p2x7-modulatoren ATE502017T1 (de)

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PCT/EP2008/055724 WO2008138876A1 (en) 2007-05-10 2008-05-08 Pyrazole derivatives as p2x7 modulators

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AU2013210682B2 (en) 2012-01-20 2017-05-25 Idorsia Pharmaceuticals Ltd Heterocyclic amide derivatives as P2X7 receptor antagonists
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CN104812749B (zh) 2012-12-12 2016-12-14 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物
KR102232744B1 (ko) 2012-12-18 2021-03-26 이도르시아 파마슈티컬스 리미티드 Ｐ２ｘ７ 수용체 길항제로서의 인돌 카르복사미드 유도체
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JP6896715B2 (ja) 2015-09-30 2021-06-30 マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ヴィッセンシャフテン エーファウ −ジェネラルフェルヴァルトゥング セピアプテリン還元酵素としてのヘテロアリール誘導体
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EP2155685B1 (de) 2011-03-16
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US20110046137A1 (en) 2011-02-24
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