WO2009036996A3 - Small molecule bradykinin b1 receptor antagonists - Google Patents
Small molecule bradykinin b1 receptor antagonists Download PDFInfo
- Publication number
- WO2009036996A3 WO2009036996A3 PCT/EP2008/007919 EP2008007919W WO2009036996A3 WO 2009036996 A3 WO2009036996 A3 WO 2009036996A3 EP 2008007919 W EP2008007919 W EP 2008007919W WO 2009036996 A3 WO2009036996 A3 WO 2009036996A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bradykinin
- small molecule
- receptor antagonists
- compounds
- pain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08802425A EP2195288A2 (en) | 2007-09-19 | 2008-09-19 | Small molecule bradykinin b1 receptor antagonists |
JP2010525265A JP2010539204A (en) | 2007-09-19 | 2008-09-19 | Small molecule bradykinin B1 receptor antagonist |
CA2700051A CA2700051A1 (en) | 2007-09-19 | 2008-09-19 | Small molecule bradykinin b1 receptor antagonists |
AU2008300822A AU2008300822A1 (en) | 2007-09-19 | 2008-09-19 | Small molecule bradykinin B1 receptor antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07018396 | 2007-09-19 | ||
EP07018396.7 | 2007-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009036996A2 WO2009036996A2 (en) | 2009-03-26 |
WO2009036996A3 true WO2009036996A3 (en) | 2009-06-18 |
Family
ID=40268352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/007919 WO2009036996A2 (en) | 2007-09-19 | 2008-09-19 | Small molecule bradykinin b1 receptor antagonists |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2195288A2 (en) |
JP (1) | JP2010539204A (en) |
AR (1) | AR068509A1 (en) |
AU (1) | AU2008300822A1 (en) |
CA (1) | CA2700051A1 (en) |
TW (1) | TW200930710A (en) |
WO (1) | WO2009036996A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2722704A1 (en) * | 2008-04-28 | 2009-11-05 | Zalicus Pharmaceuticals Ltd. | Cyclylamine derivatives as calcium channel blockers |
EP2344176A1 (en) * | 2008-09-18 | 2011-07-20 | Jerini AG | Use of bradykinin b1 receptor antagonists in intestinal fibrosis treatment |
SG185524A1 (en) | 2010-05-12 | 2012-12-28 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
MX2012015023A (en) * | 2010-06-30 | 2013-04-03 | Fujifilm Corp | Novel nicotinamide derivatives or salts thereof. |
US8937073B2 (en) | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
HUP1000598A2 (en) | 2010-11-05 | 2012-09-28 | Richter Gedeon Nyrt | Indole derivatives |
RU2576623C2 (en) | 2011-12-28 | 2016-03-10 | Фуджифилм Корпорэйшн | Novel nicotinamide derivative or its salt |
BR102014028162A2 (en) * | 2013-11-12 | 2015-09-08 | Dow Agrosciences Llc | process for fluorination of compounds |
US20210317092A1 (en) | 2016-12-23 | 2021-10-14 | Bayer Pharma Aktiengesellschaft | Tetrazole containing compounds |
JOP20190156B1 (en) | 2016-12-23 | 2023-09-17 | Bayer Pharma AG | Carboxylic acid aromatic amides as antagonists of bradykinin b1 receptor |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
AR118982A1 (en) * | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | CYCLIC BRADYKININ RECEPTOR ANTAGONISTS |
TW202229258A (en) * | 2020-09-29 | 2022-08-01 | 日商日本歐愛特農業科技股份有限公司 | Novel piperazine compound or the salt thereof |
WO2024059495A1 (en) * | 2022-09-12 | 2024-03-21 | The Regents Of The University Of California | Methods of preparing ergoline analogs |
Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3795678A (en) * | 1961-06-09 | 1974-03-05 | Hoffmann La Roche | Alpha-2-methylhydrazine-pyridinotoluidides and derivatives |
US4950668A (en) * | 1987-04-24 | 1990-08-21 | Mitsubishi Kasei Corporation | Pyrazole derivative, insecticidal or miticidal composition containing the same as the effective ingredient |
US5098900A (en) * | 1984-12-10 | 1992-03-24 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
US5216165A (en) * | 1990-10-03 | 1993-06-01 | American Home Products Corporation | N-substituted aminoquinolines as analgesic agents |
WO2000051973A1 (en) * | 1999-03-04 | 2000-09-08 | Sanofi-Synthelabo | Cyclobutene-3,4-dione derivatives, preparation method and therapeutic use |
WO2000063170A1 (en) * | 1999-04-20 | 2000-10-26 | Sanofi-Synthelabo | Cyclobutene-3,4-dione derivatives as inhibitors of phosphodiesterase 5 |
EP1300398A1 (en) * | 2000-07-05 | 2003-04-09 | Yamanouchi Pharmaceutical Co. Ltd. | Propane-1,3-dione derivatives |
WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
WO2004041788A1 (en) * | 2002-11-02 | 2004-05-21 | Aventis Pharma Deutschland Gmbh | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases |
US20040235753A1 (en) * | 2001-06-25 | 2004-11-25 | Pitt Gray Robert William | Oxytocin agonists |
US20050245503A1 (en) * | 2001-12-19 | 2005-11-03 | Yun-Xing Cheng | Therapeutic heterocycles |
US20050261327A1 (en) * | 2004-05-20 | 2005-11-24 | Bock Mark G | 2-(Bicyclo)alkylamino-derivatives as mediatores of chronic pain and inflammation |
US20070032529A1 (en) * | 2005-05-23 | 2007-02-08 | Japan Tobacco Inc. | Pyrazole compounds and their use as antidiabetes agents |
US20070155739A1 (en) * | 2005-12-30 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Substituted bis-amide metalloprotease inhibitors |
WO2007129195A2 (en) * | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
WO2008123582A1 (en) * | 2007-04-04 | 2008-10-16 | Kowa Company, Ltd. | Tetrahydroisoquinoline compound |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
CN100558718C (en) * | 2002-10-23 | 2009-11-11 | 詹森药业有限公司 | Piperazinyl and diazacyclo heptyl benzene methane amide and thiobenzamide |
WO2005014576A1 (en) * | 2003-08-12 | 2005-02-17 | Takeda Pharmaceutical Company Limited | Isoquinolinone derivative, process for producing the same and use thereof |
WO2005035534A1 (en) * | 2003-10-08 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | Heterocyclic bicyclo ring and heterocyclic tricyclo ring compounds and drugs comprising the same |
JP2007191461A (en) * | 2005-05-23 | 2007-08-02 | Japan Tobacco Inc | Pyrazole compound and antidiabetic containing the same |
-
2008
- 2008-09-15 AR ARP080104000A patent/AR068509A1/en not_active Application Discontinuation
- 2008-09-19 CA CA2700051A patent/CA2700051A1/en not_active Abandoned
- 2008-09-19 WO PCT/EP2008/007919 patent/WO2009036996A2/en active Application Filing
- 2008-09-19 AU AU2008300822A patent/AU2008300822A1/en not_active Abandoned
- 2008-09-19 TW TW097136164A patent/TW200930710A/en unknown
- 2008-09-19 EP EP08802425A patent/EP2195288A2/en not_active Withdrawn
- 2008-09-19 JP JP2010525265A patent/JP2010539204A/en active Pending
Patent Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3795678A (en) * | 1961-06-09 | 1974-03-05 | Hoffmann La Roche | Alpha-2-methylhydrazine-pyridinotoluidides and derivatives |
US5098900A (en) * | 1984-12-10 | 1992-03-24 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
US4950668A (en) * | 1987-04-24 | 1990-08-21 | Mitsubishi Kasei Corporation | Pyrazole derivative, insecticidal or miticidal composition containing the same as the effective ingredient |
US5216165A (en) * | 1990-10-03 | 1993-06-01 | American Home Products Corporation | N-substituted aminoquinolines as analgesic agents |
WO2000051973A1 (en) * | 1999-03-04 | 2000-09-08 | Sanofi-Synthelabo | Cyclobutene-3,4-dione derivatives, preparation method and therapeutic use |
WO2000063170A1 (en) * | 1999-04-20 | 2000-10-26 | Sanofi-Synthelabo | Cyclobutene-3,4-dione derivatives as inhibitors of phosphodiesterase 5 |
EP1300398A1 (en) * | 2000-07-05 | 2003-04-09 | Yamanouchi Pharmaceutical Co. Ltd. | Propane-1,3-dione derivatives |
US20040235753A1 (en) * | 2001-06-25 | 2004-11-25 | Pitt Gray Robert William | Oxytocin agonists |
US20050245503A1 (en) * | 2001-12-19 | 2005-11-03 | Yun-Xing Cheng | Therapeutic heterocycles |
WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
WO2004041788A1 (en) * | 2002-11-02 | 2004-05-21 | Aventis Pharma Deutschland Gmbh | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases |
US20050261327A1 (en) * | 2004-05-20 | 2005-11-24 | Bock Mark G | 2-(Bicyclo)alkylamino-derivatives as mediatores of chronic pain and inflammation |
US20070032529A1 (en) * | 2005-05-23 | 2007-02-08 | Japan Tobacco Inc. | Pyrazole compounds and their use as antidiabetes agents |
US20070155739A1 (en) * | 2005-12-30 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Substituted bis-amide metalloprotease inhibitors |
WO2007129195A2 (en) * | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
WO2008123582A1 (en) * | 2007-04-04 | 2008-10-16 | Kowa Company, Ltd. | Tetrahydroisoquinoline compound |
Non-Patent Citations (10)
Title |
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DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 16 August 2006 (2006-08-16), XP002512766, retrieved from STN Database accession no. 901750-58-1 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 17 July 2006 (2006-07-17), XP002523384, retrieved from STN Database accession no. 893748-03-3 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 21 August 2006 (2006-08-21), XP002512765, retrieved from STN Database accession no. 902939-75-7 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 August 2006 (2006-08-22), XP002523301, retrieved from STN Database accession no. 903169-03-9 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 7 June 2004 (2004-06-07), XP002523302, retrieved from STN Database accession no. 690245-28-4 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 7 June 2004 (2004-06-07), XP002523303, retrieved from STN Database accession no. 690245-29-5 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 8 June 2004 (2004-06-08), XP002523304, retrieved from STN Database accession no. 690644-01-0 * |
OKANO ATSUJI ET AL: "Medicinal chemical studies on antiplasmin drugs. 4. Chemical modification of trans-4-aminomethylcyclohexanecarboxylic acid and its effect on antiplasmin activity", JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 15, no. 3, 1 January 1972 (1972-01-01), pages 247 - 255, XP002317573, ISSN: 0022-2623 * |
RUAN Z ET AL: "Phenylsilane as an active amidation reagent for the preparation of carboxamides and peptides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 47, no. 43, 23 October 2006 (2006-10-23), pages 7649 - 7651, XP025005166, ISSN: 0040-4039, [retrieved on 20061023] * |
STOLL VINCENT ET AL.: "Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series", BIOCHEMISTRY, vol. 42, no. 3, 2003, pages 718 - 727, XP002512764 * |
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