MX2009008531A - Nitrogen-containing heterocyclyl ketones and methods of use. - Google Patents

Nitrogen-containing heterocyclyl ketones and methods of use.

Info

Publication number
MX2009008531A
MX2009008531A MX2009008531A MX2009008531A MX2009008531A MX 2009008531 A MX2009008531 A MX 2009008531A MX 2009008531 A MX2009008531 A MX 2009008531A MX 2009008531 A MX2009008531 A MX 2009008531A MX 2009008531 A MX2009008531 A MX 2009008531A
Authority
MX
Mexico
Prior art keywords
methods
ketones
nitrogen
diseases
containing heterocyclyl
Prior art date
Application number
MX2009008531A
Other languages
Spanish (es)
Inventor
Shon Booker
Markian Stec
Mark H Norman
Jean-Christophe Harmange
Longbin Liu
Derin C D Amico
Kevin Yang
Tae-Seong Kim
Steven Bellon
Ning Xi
Brian K Albrecht
Noel D Angelo
Aaron C Siegmund
Alan C Cheng
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2009008531A publication Critical patent/MX2009008531A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
MX2009008531A 2007-02-16 2008-02-15 Nitrogen-containing heterocyclyl ketones and methods of use. MX2009008531A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90203007P 2007-02-16 2007-02-16
PCT/US2008/002007 WO2008103277A2 (en) 2007-02-16 2008-02-15 Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors

Publications (1)

Publication Number Publication Date
MX2009008531A true MX2009008531A (en) 2009-08-26

Family

ID=39563458

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008531A MX2009008531A (en) 2007-02-16 2008-02-15 Nitrogen-containing heterocyclyl ketones and methods of use.

Country Status (7)

Country Link
US (1) US8314087B2 (en)
EP (1) EP2114898A2 (en)
JP (1) JP2010519204A (en)
AU (1) AU2008219166B2 (en)
CA (1) CA2676173A1 (en)
MX (1) MX2009008531A (en)
WO (1) WO2008103277A2 (en)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101538811B1 (en) 2007-04-03 2015-07-22 이 아이 듀폰 디 네모아 앤드 캄파니 substituted benzene fungicides
DE102007025718A1 (en) * 2007-06-01 2008-12-04 Merck Patent Gmbh pyridazinone derivatives
CN101910159B (en) * 2007-12-26 2013-06-19 卫材R&D管理有限公司 Process for production of heterocycle-substituted pyridine derivative
DE102008019907A1 (en) * 2008-04-21 2009-10-22 Merck Patent Gmbh pyridazinone derivatives
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
EP2320909B8 (en) 2008-07-25 2016-03-30 VIIV Healthcare Company Chemical compounds
KR101712576B1 (en) 2008-11-10 2017-03-06 버텍스 파마슈티칼스 인코포레이티드 Compounds useful as Inhibitors of ATR kinase
ES2763540T3 (en) 2008-12-11 2020-05-29 Viiv Healthcare Co Intermediates for carbamoylpyridone HIV integrase inhibitors
BRPI0923217A2 (en) 2008-12-11 2017-05-23 Glaxosmithkline Llc processes for the preparation of a pyridone compound, and for the preparation of a crystalline form, compound, salt or a hydrate thereof, crystalline form of a sodium salt or a hydrate thereof, and a pharmaceutical composition.
PT2376485T (en) 2008-12-19 2018-03-12 Vertex Pharma Pyrazine derivatives useful as inhibitors of atr kinase
TWI518084B (en) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 Process for pyrone and pyridone derivatives
TW201124078A (en) 2009-12-22 2011-07-16 Du Pont Fungicidal 2-(bicyclic aryloxy) carboxamides
TWI582097B (en) 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 Process for preparing carbamoylpyridone derivatives and intermediates
WO2011143399A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2011143419A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Pyrazines useful as inhibitors of atr kinase
CN102947272A (en) 2010-05-12 2013-02-27 沃泰克斯药物股份有限公司 2 -aminopyridine derivatives useful as inhibitors of atr kinase
WO2011143425A2 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP5836367B2 (en) 2010-05-12 2015-12-24 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Compounds useful as ATR kinase inhibitors
JP2013529200A (en) 2010-05-12 2013-07-18 バーテックス ファーマシューティカルズ インコーポレイテッド Compounds useful as ATR kinase inhibitors
CA2841142C (en) 2010-06-23 2020-12-15 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
WO2011163527A1 (en) 2010-06-23 2011-12-29 Vertex Pharmaceuticals Incorporated Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
JP2013532627A (en) 2010-07-01 2013-08-19 武田薬品工業株式会社 Combination of cMET inhibitor with antibody against HGF and / or cMET
EP2593107A1 (en) * 2010-07-12 2013-05-22 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
EP2611450A1 (en) * 2010-08-31 2013-07-10 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
TWI526421B (en) 2010-09-08 2016-03-21 住友化學股份有限公司 Method for producing pyridazinone compounds and intermediate thereof
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
KR102061353B1 (en) 2010-09-10 2020-01-02 에피자임, 인코포레이티드 Inhibitors of human ezh2, and methods of use thereof
WO2012087372A1 (en) 2010-12-22 2012-06-28 E. I. Du Pont De Nemours And Company Fungicidal 2-(bicyclic aryloxy)carboxamides
CN102558147B (en) * 2010-12-23 2014-09-17 江苏先声药物研究有限公司 Compound, and preparation method and application thereof
AU2012223448B2 (en) 2011-02-28 2017-03-16 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
KR20140027974A (en) 2011-04-05 2014-03-07 버텍스 파마슈티칼스 인코포레이티드 Aminopyrazine compounds useful as inhibitors of tra kinase
JO3438B1 (en) 2011-04-13 2019-10-20 Epizyme Inc Aryl- or heteroaryl-substituted benzene compounds
TW201733984A (en) 2011-04-13 2017-10-01 雅酶股份有限公司 Substituted benzene compounds
JP2014522818A (en) 2011-06-22 2014-09-08 バーテックス ファーマシューティカルズ インコーポレイテッド Compounds useful as ATR kinase inhibitors
JP2014520161A (en) 2011-06-22 2014-08-21 バーテックス ファーマシューティカルズ インコーポレイテッド Compounds useful as ATR kinase inhibitors
US9309250B2 (en) 2011-06-22 2016-04-12 Vertex Pharmaceuticals Incorporated Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
IN2014KN00943A (en) 2011-09-30 2015-08-21 Vertex Pharma
AU2012315615A1 (en) 2011-09-30 2014-04-17 Vertex Pharmaceuticals Incorporated Processes for making compounds useful as inhibitors of ATR kinase
US8765751B2 (en) 2011-09-30 2014-07-01 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US8853217B2 (en) 2011-09-30 2014-10-07 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
CA3089792C (en) 2011-09-30 2023-03-14 Vertex Pharmaceuticals Incorporated Treating non-small cell lung cancer with atr inhibitors
EP2776419B1 (en) 2011-11-09 2016-05-11 Vertex Pharmaceuticals Incorporated Pyrazine compounds useful as inhibitors of atr kinase
WO2013071094A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP2776422A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013071088A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP2776420A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Pyrazine compounds useful as inhibitors of atr kinase
EP2780013A4 (en) 2011-11-18 2015-07-01 Constellation Pharmaceuticals Inc Modulators of methyl modifying enzymes, compositions and uses thereof
EP2780014A4 (en) * 2011-11-18 2015-07-01 Constellation Pharmaceuticals Inc Modulators of methyl modifying enzymes, compositions and uses thereof
WO2013120104A2 (en) 2012-02-10 2013-08-15 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
CN104582795B (en) 2012-04-05 2018-04-20 沃泰克斯药物股份有限公司 It can be used as the compound of ATR kinase inhibitors and combinations thereof therapy
ES2745016T3 (en) 2012-04-13 2020-02-27 Epizyme Inc N - ((4,6-Dimethyl-2-oxo-L, 2-dihydropyridin-3-yl) methyl) -5- (ethyl (tetrahydro-2H-pyran-4-yl) amino) -4-methyl hydrobromide -4 '- (morpholinomethyl) - [L, 1'-biphenyl] -3-carboxamide for use in the treatment of a cell proliferative disorder of the hematological system
UA112897C2 (en) 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт BICYCLIC SUBSTITUTED URATILES AND THEIR APPLICATIONS FOR THE TREATMENT AND / OR PREVENTION OF DISEASES
AR092742A1 (en) 2012-10-02 2015-04-29 Intermune Inc ANTIFIBROTIC PYRIDINONES
WO2014055756A1 (en) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
EP3628662A1 (en) 2012-10-15 2020-04-01 Epizyme, Inc. Substituted benzene compounds
EP2909202A1 (en) 2012-10-16 2015-08-26 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
DK3486245T3 (en) 2012-12-07 2021-07-19 Vertex Pharma 2-AMINO-N- (PIPERIDIN-1-YL-PYRIDIN-3-YL) PYRAZOLO [1,5ALPHA] PYRIMIDINE-3-CARBOXAMIDE INHIBITATING ATR CHINASE
UA115462C2 (en) 2012-12-28 2017-11-10 Адама Махтешім Лтд. -(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxylate derivatives
AU2013370470B2 (en) * 2012-12-28 2018-05-10 Adama Makhteshim Ltd. 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one derivatives
EP2945634A4 (en) 2012-12-28 2016-05-25 Dow Agrosciences Llc N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxamides derivatives
AU2013370494B2 (en) 2012-12-31 2017-08-17 Adama Makhteshim Ltd. 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides
JP6669499B2 (en) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド Therapeutic compounds
JP2016510000A (en) 2013-02-20 2016-04-04 カラ ファーマシューティカルズ インコーポレイテッド Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
US9663519B2 (en) 2013-03-15 2017-05-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
EP2970305B1 (en) 2013-03-15 2017-02-22 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
CN105592888A (en) 2013-08-06 2016-05-18 伊美格生物科学公司 Kdm1a inhibitors for the treatment of disease
EP3033334A1 (en) 2013-08-15 2016-06-22 Constellation Pharmaceuticals, Inc. Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
WO2015057626A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv QUINOLINYL MODULATORS OF RORyT
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
PE20161273A1 (en) 2013-10-16 2016-12-18 Epizyme Inc SALINE FORM OF HYDROCHLORIDE FOR EZH2 INHIBITION
JP6445574B2 (en) 2013-10-18 2018-12-26 セルジーン クオンティセル リサーチ，インク． Bromodomain inhibitor
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
KR20160099084A (en) 2013-11-01 2016-08-19 칼라 파마슈티컬스, 인크. Crystalline forms of therapeutic compounds and uses thereof
JP2016535769A (en) 2013-11-08 2016-11-17 バイエル ファーマ アクチエンゲゼルシャフト Substituted uracils as chymase inhibitors
EP3066098A1 (en) 2013-11-08 2016-09-14 Bayer Pharma Aktiengesellschaft Substituted uracils and use thereof
SI3077397T1 (en) 2013-12-06 2020-02-28 Vertex Pharmaceuticals Inc. 2-amino-6-fluoro-n-(5-fluoro-pyridin-3-yl)pyrazolo(1,5-a)pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
EP3096761A1 (en) * 2014-01-24 2016-11-30 Confluence Life Sciences, Inc. Substituted pyroolopyridines and pyrrolopyrazines for treating cancer or inflammatory diseases
WO2015112847A1 (en) * 2014-01-24 2015-07-30 Confluence Life Sciences, Inc. Arylpyridinone itk inhibitors for treating inflammation and cancer
MX2016012808A (en) 2014-04-02 2017-01-05 Intermune Inc Anti-fibrotic pyridinones.
SG10201902206QA (en) 2014-06-05 2019-04-29 Vertex Pharma Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
HUE044280T2 (en) 2014-06-17 2019-10-28 Vertex Pharma Method for treating cancer using a combination of chk1 and atr inhibitors
US10752640B2 (en) 2014-08-01 2020-08-25 Nuevolution A/S Compounds active towards bromodomains
KR101891933B1 (en) 2014-08-14 2018-08-24 에프. 호프만-라 로슈 아게 Novel pyridazones and triazinones for the treatment and prophylaxis of hepatitis b virus infection
JP6864953B2 (en) 2014-12-09 2021-04-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Human monoclonal antibody against AXL
EP3247353A4 (en) 2015-01-23 2018-07-04 Confluence Life Sciences, Inc. Heterocyclic itk inhibitors for treating inflammation and cancer
KR102626978B1 (en) 2015-02-12 2024-01-18 이마고 바이오사이언시즈 인코포레이티드 Kdm1a inhibitors for the treatment of disease
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
CA2990791A1 (en) * 2015-06-25 2016-12-29 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for fibrosis
AU2016297786A1 (en) 2015-07-24 2018-02-08 Noeleen Melody Quinstatin compounds
IL257340B2 (en) * 2015-08-12 2023-10-01 Neomed Inst Substituted benzimidazoles, their preparation and their use as pharmaceuticals
WO2017040190A1 (en) 2015-08-28 2017-03-09 Constellation Pharmaceuticals, Inc. Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide
KR20180054657A (en) 2015-09-30 2018-05-24 버텍스 파마슈티칼스 인코포레이티드 Methods of treating cancer with a combination of DNA damaging agents and ATR inhibitors
US20190112317A1 (en) 2015-10-05 2019-04-18 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
EP3362442B1 (en) 2015-10-14 2020-01-29 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
UY37026A (en) 2015-12-16 2017-06-30 Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware HETEROARILHYDROXIPIRIMIDINONAS AS APJ RECEIVER AGONISTS
CA3018346A1 (en) 2016-03-24 2017-09-28 Bristol-Myers Squibb Company 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists
US11390590B2 (en) 2016-08-16 2022-07-19 Imago Biosciences, Inc. Methods and processes for the preparation of KDM1A inhibitors
CA3036340A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US10253036B2 (en) 2016-09-08 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2017324251A1 (en) 2016-09-08 2019-03-21 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN109843870A (en) 2016-10-19 2019-06-04 星座制药公司 The synthesis of EZH2 inhibitor
CA3041676A1 (en) * 2016-10-26 2018-05-03 Daniel Parks Pyridazine derivatives, compositions and methods for modulating cftr
RS61126B1 (en) * 2016-10-27 2020-12-31 Fujian Cosunter Pharmaceutical Co Ltd Pyridone compound as c-met inhibitor
US10316038B2 (en) 2017-01-25 2019-06-11 Aclaris Therapeutics, Inc. Pyrrolopyrimidine ITK inhibitors for treating inflammation and cancer
US11632954B2 (en) 2017-07-17 2023-04-25 Adama Makhteshim Ltd. Polymorphs of 5-fluoro-4-imino-3-methyl-1 -tosyl-3,4-dihydropyrimidin-2-one
CN110117278B (en) * 2018-02-07 2022-07-19 石家庄以岭药业股份有限公司 Alkoxybenzo five-membered (six-membered) heterocyclic amine compound and pharmaceutical application thereof
JP7450559B2 (en) * 2018-05-11 2024-03-15 イマーゴ バイオサイエンシーズ インコーポレイテッド KDM1A inhibitors for the treatment of diseases
JP2021527636A (en) * 2018-06-04 2021-10-14 オハイオ・ステイト・イノベーション・ファウンデーション EAAT2 activator and its usage
CN113272280A (en) 2018-11-06 2021-08-17 艾知怀斯治疗学公司 Pyridazinone compound and use thereof
DK3877376T3 (en) 2018-11-06 2023-10-02 Edgewise Therapeutics Inc Pyridazinone compounds and uses thereof
CN111393375A (en) * 2020-04-07 2020-07-10 中国药科大学 Nitrogen-substituted hexabasic aromatic heterocyclic ketone compound and pharmaceutical composition, preparation method and application thereof
EP4149621A1 (en) * 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
WO2023230205A1 (en) 2022-05-25 2023-11-30 Ikena Oncology, Inc. Mek inhibitors and uses thereof
CN115872976A (en) * 2022-12-30 2023-03-31 中国药科大学 Quinoline derivative, pharmaceutical composition containing quinoline derivative and application of quinoline derivative

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3009A (en) * 1843-03-21 Lard-lamp
US3956287A (en) * 1973-11-07 1976-05-11 Richardson-Merrell Inc. 7-[(2-Oxo-1-pyridinyl)acylamino]cephalosporin derivatives
CH629240A5 (en) * 1976-09-02 1982-04-15 Henkel Kgaa AGENT FOR COLORING MATERIAL CONTAINING KERATINE.
EP0092520B1 (en) * 1982-04-15 1986-11-12 Sandoz Ag Basic compounds, their preparation and their use
US4673735A (en) * 1982-04-15 1987-06-16 Sandoz Ltd. Azo compounds having at least one 6-hydroxypyrid-2-one coupling component radical metal complexes thereof and intermediates therefor
JP2762522B2 (en) 1989-03-06 1998-06-04 藤沢薬品工業株式会社 Angiogenesis inhibitor
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
US5892112A (en) 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
FR2670208B1 (en) 1990-12-07 1993-08-13 Pf Medicament DERIVATIVES OF PHENYL-1 DIHYDRO 1-4 ARYLALCOYLAMINO-3 OXO-4 PYRIDAZINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
CZ403592A3 (en) * 1992-02-20 1993-12-15 Hoechst Ag Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
PT669929E (en) 1992-11-13 2007-04-30 Immunex Corp Elk ligand, a cytokine
PT672031E (en) 1992-12-02 2003-06-30 Pfizer DIETERES OF CATECOL AS SELECTIVE INHIBITORS OF PDE IV
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5516658A (en) 1993-08-20 1996-05-14 Immunex Corporation DNA encoding cytokines that bind the cell surface receptor hek
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
JPH09512167A (en) 1994-04-15 1997-12-09 アムジエン・インコーポレーテツド HEK5, HEK7, HEK8, HEK11, novel EPH-like receptor protein tyrosine kinase
US6303769B1 (en) 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna
US5919905A (en) 1994-10-05 1999-07-06 Immunex Corporation Cytokine designated LERK-6
US6057124A (en) 1995-01-27 2000-05-02 Amgen Inc. Nucleic acids encoding ligands for HEK4 receptors
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
CO4950519A1 (en) 1997-02-13 2000-09-01 Novartis Ag PHTHALAZINES, PHARMACEUTICAL PREPARATIONS THAT UNDERSTAND THEM AND THE PROCESS FOR THEIR PREPARATION
RS49779B (en) 1998-01-12 2008-06-05 Glaxo Group Limited, Byciclic heteroaromatic compounds as protein tyrosine kinase inhibitors
DE69940808D1 (en) 1998-03-04 2009-06-10 Bristol Myers Squibb Co HETEROCYCLES SUBSTITUTED IMIDAZOPYRAZINES AS PROTEIN TYROSINE KINASE INHIBITORS
EP1082305A4 (en) 1998-05-29 2001-09-26 Sugen Inc Pyrrole substituted 2-indolinone protein kinase inhibitors
UA60365C2 (en) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Isothiazole derivatives, a method for preparing thereof, a pharmaceutical composition and a method for treatment of hyperproliferative disease of mammal
CA2336848A1 (en) 1998-07-10 2000-01-20 Merck & Co., Inc. Novel angiogenesis inhibitors
EP1109555A4 (en) 1998-08-31 2001-11-21 Merck & Co Inc Novel angiogenesis inhibitors
WO2000041698A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
TW506993B (en) * 1999-03-15 2002-10-21 Ciba Sc Holding Ag Reactive dyes, processes for their preparation and process for dyeing or printing a fibre material
DE60010362T2 (en) * 1999-03-30 2005-05-04 Ciba Specialty Chemicals Holding Inc. Reactive dyes, process for their preparation and their use
AU766081B2 (en) 1999-03-30 2003-10-09 Novartis Ag Phthalazine derivatives for treating inflammatory diseases
US6521424B2 (en) 1999-06-07 2003-02-18 Immunex Corporation Recombinant expression of Tek antagonists
DK1187918T4 (en) 1999-06-07 2009-02-23 Immunex Corp Tek antagonists
SI1676845T1 (en) 1999-11-05 2008-10-31 Astrazeneca Ab New quinazoline derivatives
PT1233943E (en) 1999-11-24 2011-09-01 Sugen Inc Ionizable indolinone derivatives and their use as ptk ligands
US6515004B1 (en) 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6727225B2 (en) 1999-12-20 2004-04-27 Immunex Corporation TWEAK receptor
AU2001247219B2 (en) 2000-02-25 2007-01-04 Immunex Corporation Integrin antagonists
EP1270577B1 (en) * 2000-03-23 2006-12-06 Takeda Pharmaceutical Company Limited Furoisoquinoline derivatives, process for producing the same and use thereof
JP2001335579A (en) * 2000-03-23 2001-12-04 Takeda Chem Ind Ltd Furoisoquinoline derivative, method for producing the same and use
US6630500B2 (en) 2000-08-25 2003-10-07 Cephalon, Inc. Selected fused pyrrolocarbazoles
DE122010000038I1 (en) 2000-12-21 2011-01-27 Glaxosmithkline Llc PYRIMIDINAMINES AS ANGIOGENESIS MODULATORS
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US20020147198A1 (en) 2001-01-12 2002-10-10 Guoqing Chen Substituted arylamine derivatives and methods of use
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
ES2195785B1 (en) * 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
TWI329112B (en) 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US7560558B2 (en) * 2002-08-23 2009-07-14 Kirin Beer Kabushiki Kaisha Compound having TGFβ inhibitory activity and medicinal composition containing the same
WO2004037807A2 (en) * 2002-10-22 2004-05-06 Glaxo Group Limited Medicinal arylethanolamine compounds
WO2005000818A1 (en) * 2003-06-27 2005-01-06 Warner-Lambert Company Llc 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
RU2339381C2 (en) * 2004-02-09 2008-11-27 Ниссан Кемикал Индастриз, Лтд. Preventer of blood vessels intima hyperplasia
US20080161305A1 (en) 2005-04-06 2008-07-03 Exelixis, Inc. C-Met Modulators and Methods of Use
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Substituted Amid derivatives & methods of use
CA2630233A1 (en) * 2005-12-05 2007-06-14 Boehringer Ingelheim International Gmbh Substituted pyrazole compounds useful as soluble epoxide hydrolase inhibitors
CA2637392A1 (en) * 2006-01-23 2007-07-26 Crystalgenomics, Inc. Imidazopyridine derivatives inhibiting protein kinase activity, method for the preparation thereof and pharmaceutical composition containing same
RU2008150485A (en) * 2006-05-22 2010-06-27 Янссен Фармацевтика Н.В. (Be) SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINAL PRODUCT
DE102006037478A1 (en) 2006-08-10 2008-02-14 Merck Patent Gmbh 2- (Heterocyclylbenzyl) -pyridazinone derivatives
WO2008038841A1 (en) * 2006-09-30 2008-04-03 Japan Tobacco Inc. Thiadiazolone derivative and use thereof
MX2009006312A (en) * 2006-12-14 2009-08-07 Astellas Pharma Inc Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents.
US8163779B2 (en) * 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
TWI407960B (en) * 2007-03-23 2013-09-11 Jerini Ag Small molecule bradykinin b2 receptor modulators
US8258134B2 (en) * 2008-04-16 2012-09-04 Hoffmann-La Roche Inc. Pyridazinone glucokinase activators
TWI367598B (en) * 2008-06-23 2012-07-01 Ind Tech Res Inst Antenna radome

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