ATE501154T1 - Ein cefdinir-zwischenprodukt - Google Patents
Ein cefdinir-zwischenproduktInfo
- Publication number
- ATE501154T1 ATE501154T1 AT03787771T AT03787771T ATE501154T1 AT E501154 T1 ATE501154 T1 AT E501154T1 AT 03787771 T AT03787771 T AT 03787771T AT 03787771 T AT03787771 T AT 03787771T AT E501154 T1 ATE501154 T1 AT E501154T1
- Authority
- AT
- Austria
- Prior art keywords
- cefdinir
- cefdinir intermediate
- methylcarbonyloxyimino
- aminothiazol
- cephem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT12232002 | 2002-08-13 | ||
AT15882002 | 2002-10-18 | ||
PCT/EP2003/008944 WO2004016623A1 (en) | 2002-08-13 | 2003-08-12 | A cefdinir intermediate |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE501154T1 true ATE501154T1 (de) | 2011-03-15 |
Family
ID=31888705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03787771T ATE501154T1 (de) | 2002-08-13 | 2003-08-12 | Ein cefdinir-zwischenprodukt |
Country Status (8)
Country | Link |
---|---|
US (2) | US7250508B2 (de) |
EP (2) | EP1842852A1 (de) |
JP (1) | JP2006500356A (de) |
KR (2) | KR20050087776A (de) |
AT (1) | ATE501154T1 (de) |
AU (1) | AU2003255424A1 (de) |
DE (1) | DE60336331D1 (de) |
WO (1) | WO2004016623A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
ITMI20020913A0 (it) * | 2002-04-29 | 2002-04-29 | Acs Dobfar Spa | Nuova forma cristallina del cefdinir |
DE60336331D1 (de) | 2002-08-13 | 2011-04-21 | Sandoz Ag | Ein cefdinir-zwischenprodukt |
ITMI20022724A1 (it) * | 2002-12-20 | 2004-06-21 | Antibioticos Spa | Sali cristallini del cefdinir. |
CN100357294C (zh) * | 2003-03-24 | 2007-12-26 | 桑多斯股份公司 | 7-[2-(2-氨基噻唑-4-基)-2-羟基亚氨基乙酰胺-3-乙烯基-3-头孢烯-4-羧酸(顺式异构体)的新型晶体和其制备方法 |
US7105659B2 (en) * | 2003-06-02 | 2006-09-12 | Aurobind - Pharma Ltd. | Process for preparing cefdinir |
US20040242556A1 (en) * | 2003-06-02 | 2004-12-02 | Ramesh Dandala | Novel crystalline form of cefdinir |
US20050137182A1 (en) * | 2003-06-02 | 2005-06-23 | Ramesh Dandala | Novel crystalline form of cefdinir |
US20050209211A1 (en) * | 2004-03-16 | 2005-09-22 | Devalina Law | Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir |
US20060069079A1 (en) * | 2004-09-27 | 2006-03-30 | Sever Nancy E | Stable amorphous cefdinir |
US20050245738A1 (en) * | 2004-05-03 | 2005-11-03 | Lupin Ltd | Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof |
GB0416380D0 (en) * | 2004-07-22 | 2004-08-25 | Sandoz Ag | Organic compounds |
GB0416379D0 (en) * | 2004-07-22 | 2004-08-25 | Sandoz Ag | Organic compounds |
WO2006018807A1 (en) * | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir |
ES2532377T3 (es) * | 2004-09-29 | 2015-03-26 | Bayer Healthcare Llc | Procedimiento de preparación de 4-{4-[({[4-[cloro-3-(trifluorometil)fenil]amino}carbonil) amino]fenoxi}N-metilpiridina-2-carboxamida |
US7839409B2 (en) * | 2004-10-18 | 2010-11-23 | Ali Noorbakhsh | Acquisition of extended display identification data (EDID) using inter-IC (I2C) protocol |
MX2007006018A (es) | 2004-11-30 | 2007-06-07 | Astellas Pharma Inc | Suspension farmaceutica oral novedosa de cristal de cefdinir. |
WO2007053722A2 (en) * | 2005-10-31 | 2007-05-10 | Teva Pharmaceutical Industries Ltd. | Crystalline form of cefdinir cesium salt |
US20070128268A1 (en) * | 2005-12-07 | 2007-06-07 | Herwig Jennewein | Pharmaceutical compositions comprising an antibiotic |
GB0616865D0 (en) * | 2006-08-25 | 2007-03-28 | Phoenix Chemicals Ltd | Process |
KR101058135B1 (ko) | 2008-04-04 | 2011-08-24 | 대웅바이오 주식회사 | 세프디니르 합성에 유용한 중간체 및 이를 이용하여세프디니르를 제조하는 방법 |
CN102153566B (zh) * | 2010-02-11 | 2012-08-22 | 深圳市立国药物研究有限公司 | 头孢地尼的制备方法 |
CN101974020B (zh) * | 2010-11-19 | 2012-09-12 | 苏州中联化学制药有限公司 | 一种头孢地尼的合成方法 |
CN102010427B (zh) * | 2010-11-19 | 2012-09-12 | 苏州中联化学制药有限公司 | 一种头孢地尼的制备方法 |
JP5619657B2 (ja) * | 2011-03-22 | 2014-11-05 | 株式会社Lixil | 機能性アルミ材及びその電解処理方法 |
CN102643293A (zh) * | 2012-03-30 | 2012-08-22 | 石药集团中诺药业(石家庄)有限公司 | 头孢地尼三元复合物及其用于制备头孢地尼的方法 |
CN106279207A (zh) * | 2016-08-15 | 2017-01-04 | 苏州中联化学制药有限公司 | 一种头孢地尼的合成方法 |
CN107892676B (zh) * | 2017-12-21 | 2019-11-29 | 山东金城柯瑞化学有限公司 | 头孢地尼活性硫酯的制备方法 |
CN112645898A (zh) * | 2020-12-26 | 2021-04-13 | 山东金城柯瑞化学有限公司 | 氨基噻唑乙酰肟酸粒径可控的制备方法 |
CN113214186A (zh) * | 2021-05-18 | 2021-08-06 | 山东昌邑四方医药化工有限公司 | 头孢地尼活性酯的精制方法 |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5564M (de) | 1964-03-14 | 1968-01-02 | ||
US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
GB8323034D0 (en) * | 1983-08-26 | 1983-09-28 | Fujisawo Pharmaceutical Co Ltd | 7-substituted-3-vinyl-3-cephem compounds |
JPS59184186A (ja) * | 1983-04-01 | 1984-10-19 | Meiji Seika Kaisha Ltd | 新規セフエム化合物 |
JPS62206199A (ja) | 1986-03-07 | 1987-09-10 | 大竹 章 | 避難カプセル |
ZA885709B (en) * | 1987-08-19 | 1989-04-26 | Fujisawa Pharmaceutical Co | Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer) |
GB8800295D0 (en) | 1988-01-07 | 1988-02-10 | Fujisawa Pharmaceutical Co | Process for preparation of 7-(2-amino-thiazol-4-y)-2-hydroxyimino-acetanidol-3-cephem compounds |
PT630380E (pt) * | 1992-02-05 | 2002-02-28 | Biochemie Gmbh | Processo para a purificacao de um derivado do acido 3-cefem-4-carboxilico |
AT403049B (de) | 1995-08-14 | 1997-10-27 | Biochemie Gmbh | Abreicherung von 7-adca in 3-vinyl-aca |
JP3948628B2 (ja) * | 1995-12-27 | 2007-07-25 | ハンミ ファーマシューティカル シーオー.,エルティーディー. | セフディニルの製造方法 |
HU227821B1 (en) * | 1996-02-29 | 2012-03-28 | Astellas Pharma Inc | Tablets containing beta-lactam antibiotic and process for producing the same |
AT404251B (de) | 1996-08-14 | 1998-10-27 | Biochemie Gmbh | Neues kristallines salz von cefixim |
AT405283B (de) * | 1997-04-04 | 1999-06-25 | Biochemie Gmbh | Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung |
PE20000879A1 (es) | 1998-04-29 | 2000-09-23 | Dsm Nv | METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO |
JP4544692B2 (ja) | 2000-04-13 | 2010-09-15 | 大塚化学株式会社 | 3−ビニル−セフェム化合物の製造方法 |
JP4192599B2 (ja) * | 2000-12-04 | 2008-12-10 | アステラス製薬株式会社 | アミノチアゾール誘導体の無水物の製造方法 |
US6388070B1 (en) * | 2001-01-05 | 2002-05-14 | Orchid Chemicals & Pharmaceuticals Ltd. | Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds |
KR100451672B1 (ko) | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
WO2003050124A1 (en) | 2001-12-13 | 2003-06-19 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
EA200401428A1 (ru) | 2002-04-26 | 2006-04-28 | Рэнбакси Лабораториз Лимитед | Способ получения цефдинира |
ITMI20020913A0 (it) * | 2002-04-29 | 2002-04-29 | Acs Dobfar Spa | Nuova forma cristallina del cefdinir |
DE60336331D1 (de) * | 2002-08-13 | 2011-04-21 | Sandoz Ag | Ein cefdinir-zwischenprodukt |
ITMI20022076A1 (it) * | 2002-10-01 | 2004-04-02 | Antibioticos Spa | Sali di intermedi del cefdinir. |
US7244842B2 (en) * | 2002-11-15 | 2007-07-17 | Orchid Chemicals & Pharmaceuticals Ltd. | Amorphous hydrate of a cephalosporin antibiotic |
ITMI20022724A1 (it) * | 2002-12-20 | 2004-06-21 | Antibioticos Spa | Sali cristallini del cefdinir. |
US7452990B2 (en) * | 2002-12-26 | 2008-11-18 | Lupin Limited | Intermediates for synthesis of cephalosporins and process for preparation of such intermediates |
CN100357294C (zh) | 2003-03-24 | 2007-12-26 | 桑多斯股份公司 | 7-[2-(2-氨基噻唑-4-基)-2-羟基亚氨基乙酰胺-3-乙烯基-3-头孢烯-4-羧酸(顺式异构体)的新型晶体和其制备方法 |
WO2004104010A1 (en) | 2003-05-20 | 2004-12-02 | Ranbaxy Laboratories Limited | Crystalline form of cefdinir |
US20050137182A1 (en) * | 2003-06-02 | 2005-06-23 | Ramesh Dandala | Novel crystalline form of cefdinir |
US20040242556A1 (en) * | 2003-06-02 | 2004-12-02 | Ramesh Dandala | Novel crystalline form of cefdinir |
US7105659B2 (en) * | 2003-06-02 | 2006-09-12 | Aurobind - Pharma Ltd. | Process for preparing cefdinir |
US20050113355A1 (en) * | 2003-09-12 | 2005-05-26 | Duerst Richard W. | Cefdinir pyridine salt |
US20050059819A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Cefdinir pyridine salt |
US20050059818A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Polymorph of a pharmaceutical |
US20050131079A1 (en) * | 2003-12-10 | 2005-06-16 | Pujara Chetan P. | Cefdinir oral suspension |
US20060142261A1 (en) | 2004-03-16 | 2006-06-29 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
US20050209211A1 (en) | 2004-03-16 | 2005-09-22 | Devalina Law | Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir |
US20060025399A1 (en) * | 2004-03-16 | 2006-02-02 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
US20060211676A1 (en) * | 2004-03-16 | 2006-09-21 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
US20060287289A1 (en) * | 2004-03-16 | 2006-12-21 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
US20060142563A1 (en) * | 2004-03-16 | 2006-06-29 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
US20050215781A1 (en) * | 2004-03-17 | 2005-09-29 | Orchid Chemicals & Pharmaceuticals Ltd. | Novel polymorph of cefdinir |
WO2005090360A1 (en) | 2004-03-19 | 2005-09-29 | Orchid Chemicals & Pharmaceuticals Limited | Novel polymorph of cefdinir |
US20060029674A1 (en) * | 2004-04-09 | 2006-02-09 | Sever Nancy E | Stable amorphous Cefdinir |
US20060069079A1 (en) * | 2004-09-27 | 2006-03-30 | Sever Nancy E | Stable amorphous cefdinir |
US20050245738A1 (en) * | 2004-05-03 | 2005-11-03 | Lupin Ltd | Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof |
WO2005121154A1 (en) * | 2004-06-08 | 2005-12-22 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of cefdinir |
WO2006010978A1 (en) | 2004-06-30 | 2006-02-02 | Wockhardt Limited | Cefdinir polymorphic forms, and imidazole salt |
KR20070045195A (ko) | 2004-07-05 | 2007-05-02 | 오키드 케미칼즈 앤드 파마수티컬즈 리미티드 | 세팔로스포린 항생제의 제조에 있어서의 새로운 염 |
GB0416379D0 (en) * | 2004-07-22 | 2004-08-25 | Sandoz Ag | Organic compounds |
WO2006018807A1 (en) | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir |
WO2006035291A1 (en) | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir potassium |
ITMI20042231A1 (it) | 2004-11-19 | 2005-02-19 | Antibioticos Spa | Cefdinir sale d'ammonio in forma cristallina |
MX2007006018A (es) * | 2004-11-30 | 2007-06-07 | Astellas Pharma Inc | Suspension farmaceutica oral novedosa de cristal de cefdinir. |
GB2421024A (en) * | 2004-12-07 | 2006-06-14 | Sandoz Ag | Cefdinir crystalline form C |
WO2006117794A1 (en) | 2005-05-02 | 2006-11-09 | Hetero Drugs Limited | A novel crystalline form of cefdinir |
WO2006134607A1 (en) | 2005-06-15 | 2006-12-21 | Hetero Drugs Limited | Cefdinir process |
EP1848724A2 (de) * | 2005-10-31 | 2007-10-31 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von cefdinir |
-
2003
- 2003-08-12 DE DE60336331T patent/DE60336331D1/de not_active Expired - Lifetime
- 2003-08-12 JP JP2004528469A patent/JP2006500356A/ja active Pending
- 2003-08-12 EP EP07111390A patent/EP1842852A1/de not_active Withdrawn
- 2003-08-12 KR KR1020057002237A patent/KR20050087776A/ko active IP Right Grant
- 2003-08-12 EP EP03787771A patent/EP1554289B1/de not_active Expired - Lifetime
- 2003-08-12 US US10/524,397 patent/US7250508B2/en not_active Expired - Fee Related
- 2003-08-12 KR KR1020107026993A patent/KR20110005727A/ko not_active Application Discontinuation
- 2003-08-12 AU AU2003255424A patent/AU2003255424A1/en not_active Abandoned
- 2003-08-12 AT AT03787771T patent/ATE501154T1/de not_active IP Right Cessation
- 2003-08-12 WO PCT/EP2003/008944 patent/WO2004016623A1/en active Application Filing
-
2007
- 2007-06-21 US US11/766,132 patent/US7825241B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20050087776A (ko) | 2005-08-31 |
WO2004016623A1 (en) | 2004-02-26 |
EP1842852A1 (de) | 2007-10-10 |
US7825241B2 (en) | 2010-11-02 |
DE60336331D1 (de) | 2011-04-21 |
US20080081906A1 (en) | 2008-04-03 |
US20060025586A1 (en) | 2006-02-02 |
KR20110005727A (ko) | 2011-01-18 |
JP2006500356A (ja) | 2006-01-05 |
EP1554289B1 (de) | 2011-03-09 |
AU2003255424A1 (en) | 2004-03-03 |
EP1554289A1 (de) | 2005-07-20 |
US7250508B2 (en) | 2007-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |