ATE486945T1 - Vektoren mit erhöhter expression, sowie verfahren zu deren herstellung und deren verwendungen - Google Patents
Vektoren mit erhöhter expression, sowie verfahren zu deren herstellung und deren verwendungenInfo
- Publication number
- ATE486945T1 ATE486945T1 AT04075152T AT04075152T ATE486945T1 AT E486945 T1 ATE486945 T1 AT E486945T1 AT 04075152 T AT04075152 T AT 04075152T AT 04075152 T AT04075152 T AT 04075152T AT E486945 T1 ATE486945 T1 AT E486945T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- nucleic acid
- transcription factor
- reading frame
- open reading
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Image Generation (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/816,155 US5990091A (en) | 1997-03-12 | 1997-03-12 | Vectors having enhanced expression, and methods of making and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE486945T1 true ATE486945T1 (de) | 2010-11-15 |
Family
ID=25219820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04075152T ATE486945T1 (de) | 1997-03-12 | 1998-02-13 | Vektoren mit erhöhter expression, sowie verfahren zu deren herstellung und deren verwendungen |
Country Status (9)
Country | Link |
---|---|
US (2) | US5990091A (de) |
EP (2) | EP0970226A4 (de) |
JP (2) | JP2001514518A (de) |
AT (1) | ATE486945T1 (de) |
AU (1) | AU746402B2 (de) |
CA (1) | CA2283537C (de) |
DE (1) | DE69841986D1 (de) |
DK (1) | DK1475443T3 (de) |
WO (1) | WO1998040501A1 (de) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7767449B1 (en) | 1981-12-24 | 2010-08-03 | Health Research Incorporated | Methods using modified vaccinia virus |
US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
WO2002010379A2 (en) * | 2000-07-31 | 2002-02-07 | Aventis Pasteur Limited | Modified cea and uses thereof |
FR2772047B1 (fr) | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
CA2318493A1 (en) * | 1998-01-16 | 1999-07-22 | The Johns Hopkins University | Oral delivery of nucleic acid vaccines by particulate complexes |
US6762038B1 (en) | 1998-09-09 | 2004-07-13 | The Cleveland Clinic Foundation | Mutant cell lines and methods for producing enhanced levels of recombinant proteins |
US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
AU2487300A (en) * | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
US6497883B1 (en) | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
CA2388337C (en) | 1999-10-22 | 2013-01-08 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
BR0016567A (pt) * | 1999-12-21 | 2002-10-01 | Merial Sas | Composições e vacinas contendo antìgeno(s) de cryptosporidium parvum e de outro patógeno entérico |
DE60125927T2 (de) * | 2000-04-27 | 2007-10-18 | Sanofi Pasteur Ltd., Toronto | Impfstoffe gegen hiv |
CA2408328C (en) | 2000-05-10 | 2012-04-17 | Aventis Pasteur Limited | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
AU2001284695A1 (en) | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
US20110091428A1 (en) * | 2000-07-31 | 2011-04-21 | New York Medical College | Compositions of adult organ stem cells and uses thereof |
US7862810B2 (en) * | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
EP1317281A1 (de) * | 2000-09-08 | 2003-06-11 | Aventis Pasteur | Verwendung fon lipopeptiden zur behandlung von hiv-patienten |
FR2813793B1 (fr) * | 2000-09-08 | 2003-01-24 | Aventis Pasteur | Utilisation de lipopeptides pour l'immunotherapie des sujets vih+ |
US6727060B2 (en) | 2000-09-26 | 2004-04-27 | Health Research, Inc. | Analysis of HIV-1 coreceptor use in the clinical care of HIV-1-infected patients |
US7129343B2 (en) * | 2001-02-13 | 2006-10-31 | University Of Florida | Bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes |
WO2002070695A2 (en) * | 2001-03-05 | 2002-09-12 | Mount Sinai Hospital | Tumor associated proteins |
FI116851B (fi) * | 2001-05-03 | 2006-03-15 | Fit Biotech Oyj Plc | Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita |
US20030148973A1 (en) * | 2001-05-23 | 2003-08-07 | Peter Emtage | MAGE-A1 peptides for treating or preventing cancer |
US20030113919A1 (en) * | 2001-08-17 | 2003-06-19 | Aventis Pasteur, Ltd. | Immunogenic targets for melanoma |
DE10144664B4 (de) * | 2001-09-11 | 2005-06-09 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Vacciniavirus MVA-E3L-Knock-Out-Mutanten und Verwendung hiervon |
CA2469738A1 (en) | 2001-11-07 | 2003-08-07 | Mannkind Corporation | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
AU2002365275A1 (en) * | 2001-11-16 | 2003-07-09 | Aventis Pasteur | Novel chimeric rev, tat, and nef antigens |
AU2002364161A1 (en) * | 2001-12-12 | 2003-06-23 | Aventis Pasteur Limited | Enhancement of the immune response using cd36-binding domain |
US20040241723A1 (en) * | 2002-03-18 | 2004-12-02 | Marquess Foley Leigh Shaw | Systems and methods for improving protein and milk production of dairy herds |
AU2003223527B2 (en) | 2002-04-09 | 2009-01-15 | Sanofi Pasteur Limited | Modified CEA nucleic acid and expression vectors |
US6952160B1 (en) * | 2002-08-07 | 2005-10-04 | Ford Global Technologies, Llc | Method and apparatus, for identifying the location of pressure sensors in a tire pressure monitoring system |
EP1529113B1 (de) * | 2002-08-07 | 2011-04-06 | Bavarian Nordic A/S | Vaccinia virus wirtspektrum gene zur erhöhung des titers von avipoxviren |
EP1903056A3 (de) | 2002-12-10 | 2008-05-07 | Idm Pharma, Inc. | HLA-A1, -A2, -A3, -A24, -B7 and -B44 bindende Peptide die Tumorassoziiert-Antigen Epitopen enthalten, und Zusammensetzungen davon |
EP1572985A4 (de) * | 2002-12-13 | 2008-03-19 | Aventis Pasteur Inc | Produktion von alvac auf embryonalenstammzellen von vögeln |
WO2005048957A2 (en) * | 2003-02-20 | 2005-06-02 | Therion Biologics Corporation | Novel insertion sites in pox vectors |
EP1606419A1 (de) | 2003-03-18 | 2005-12-21 | Quantum Genetics Ireland Limited | Systeme und methoden zur erhohung der milchproduktion in tieren |
WO2004094454A2 (en) | 2003-04-18 | 2004-11-04 | Idm Pharma, Inc. | Hla-a2 tumor associated antigen peptides and compositions |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
EP1670926B1 (de) * | 2003-10-08 | 2011-04-20 | Sanofi Pasteur Limited | Modifizierter cea/b7-vektor |
US20050214316A1 (en) | 2003-11-13 | 2005-09-29 | Brown Thomas P | Methods of characterizing infectious bursal disease virus |
JP2007525217A (ja) | 2004-02-19 | 2007-09-06 | ザ ガバナーズ オブ ザ ユニバーシティー オブ アルバータ | レプチンプロモーター多型及びその使用 |
CN100549021C (zh) | 2004-05-27 | 2009-10-14 | 森托科尔公司 | 猕猴前列腺特异性抗原 |
EP1773406A4 (de) * | 2004-06-15 | 2008-09-03 | Centocor Inc | Verfahren zum screening von mitteln gegen erkrankung der menschlichen prostata |
JP5449673B2 (ja) | 2004-10-08 | 2014-03-19 | クリヌベール、ファーマスーティカルズ、リミテッド | 対象者におけるメラニン形成を誘導するための組成物および方法 |
CN101208104B (zh) | 2005-04-25 | 2012-10-31 | 梅瑞尔有限公司 | Nipah病毒疫苗 |
US20070178115A1 (en) | 2005-08-15 | 2007-08-02 | Tang De-Chu C | Immunization of avians by administration of non-replicating vectored vaccines |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
EP3536704B1 (de) | 2005-11-14 | 2021-08-25 | Boehringer Ingelheim Animal Health USA Inc. | Gentherapie für nierenversagen |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
EP2023954B1 (de) * | 2006-05-19 | 2013-07-17 | Sanofi Pasteur, Inc. | Immunologische zusammensetzung |
US7862821B2 (en) * | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
ZA200901365B (en) * | 2006-08-28 | 2010-05-26 | Clinuvel Pharmaceuticals Ltd | Method for reducing incidence or rate of development of skin cancers and related conditions |
EP2056855B1 (de) | 2006-08-31 | 2014-09-17 | Clinuvel Pharmaceuticals Limited | Alpha-msh derivate zur behandlung von photodermatosen |
EP2152890A1 (de) * | 2007-05-23 | 2010-02-17 | MannKind Corporation | Multicistronische vektoren und verfahren zu deren konstruktion |
EP2219656A2 (de) | 2007-11-09 | 2010-08-25 | New York Medical College | Verfahren zur reparatur und/oder regeneration von geschädigtem myokard mit varianten des hepatozyten-wachstumsfaktors |
CN102257134B (zh) | 2008-02-12 | 2014-03-05 | 赛诺菲巴斯德有限公司 | 使用离子交换和凝胶过滤色谱进行痘病毒纯化的方法 |
DK2957292T3 (en) | 2008-03-27 | 2018-01-22 | Clinuvel Pharmaceuticals Ltd | VITILIGOTERAPHY |
EP2376526A4 (de) | 2008-12-24 | 2013-02-27 | Kingdom Of The Netherlands Represented By The Min Ister Of Health Welfare & Sport On Behalf Of The M | Modifizierte streptococcus pneumoniae pneumolysin (ply)-polypeptide |
CN103585643A (zh) | 2009-04-03 | 2014-02-19 | 梅里亚有限公司 | 运载新城疫病毒的禽疫苗 |
EP2424999A1 (de) | 2009-04-30 | 2012-03-07 | Centre Hospitalier Universitaire Vaudois Lausanne (CHUV) | Modifizierte immunisierungsvektoren |
ES2609847T3 (es) | 2010-08-31 | 2017-04-24 | Merial, Inc. | Vacunas de herpesvirus basadas en vectores del virus de la enfermedad de Newcastle |
WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
EP2668201A2 (de) | 2011-01-28 | 2013-12-04 | Sanofi Pasteur SA | Immunologische zusammensetzungen mit hiv-gp41-polypeptidderivaten |
EP2487185A1 (de) | 2011-02-11 | 2012-08-15 | Clinuvel Pharmaceuticals Limited | Hexapeptid mit verbesserter Aktivität bei der Reparatur von zellulärer DNA von Dermiszellen |
MX348172B (es) | 2011-03-21 | 2017-06-02 | Altimmune Inc | Sustancia inmunologica terapeutica rapida y prolongada. |
US20140296248A1 (en) | 2011-04-04 | 2014-10-02 | Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
WO2012138789A2 (en) | 2011-04-04 | 2012-10-11 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
WO2012145577A1 (en) | 2011-04-20 | 2012-10-26 | Merial Limited | Adjuvanted rabies vaccine with improved viscosity profile |
US10081658B2 (en) | 2011-04-25 | 2018-09-25 | Advanced Bioscience Laboratories, Inc. | Truncated HIV envelope proteins (ENV), methods and compositions related thereto |
ES2674439T3 (es) | 2011-06-01 | 2018-06-29 | Merial, Inc. | Administración sin aguja de vacunas contra el VSRRP |
CA2844283C (en) | 2011-08-08 | 2024-06-04 | Curelab Oncology, Inc. | Methods and compositions relating to p62 for the treatment and prophylaxis of cancer |
HUE035774T2 (en) | 2011-08-12 | 2018-05-28 | Merial Inc | Biological substances, in particular vaccines, preserved by vacuum |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
WO2014012090A1 (en) | 2012-07-13 | 2014-01-16 | The Broad Institute, Inc. | Molecular sleds comprising a positively-charged amino acid sequence and a molecular cargo and uses thereof |
PL3494997T3 (pl) | 2012-07-25 | 2020-04-30 | The Broad Institute, Inc. | Indukowalne białka wiążące dna i narzędzia perturbacji genomu oraz ich zastosowania |
KR101484605B1 (ko) | 2012-07-25 | 2015-01-20 | 대한민국 | Bei로 불활화된 일본뇌염 바이러스 kv1899주 항원 및 돼지의 gm-csf 재조합 단백질을 포함하는 일본뇌염 불활화 백신 조성물 |
US9556419B2 (en) | 2013-03-12 | 2017-01-31 | Merial Inc. | Reverse genetics Schmallenberg virus vaccine compositions, and methods of use thereof |
WO2014140938A2 (en) | 2013-03-14 | 2014-09-18 | Centre Hospitalier Universitaire Vaudois | Immunological methods |
US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
CN105579060B (zh) | 2013-09-25 | 2021-03-16 | 硕腾服务有限责任公司 | Pcv2b趋异株疫苗组合物以及使用方法 |
WO2015057671A1 (en) | 2013-10-14 | 2015-04-23 | The Broad Institute, Inc. | Artificial transcription factors comprising a sliding domain and uses thereof |
WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
AU2014368898B2 (en) | 2013-12-20 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Combination therapy with neoantigen vaccine |
EP3089753B8 (de) | 2013-12-29 | 2020-10-28 | Curelab Oncology, Inc. | Verfahren und zusammensetzungen im zusammenhang mit p62/sqstm1 zur behandlung und prävention von entzündungsbedingten erkrankungen |
CA2966191A1 (en) | 2014-11-03 | 2016-05-12 | Merial, Inc. | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
EP3234193B1 (de) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molekulare biomarker für krebsimmuntherapie |
WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
CR20200476A (es) | 2015-05-20 | 2020-12-02 | Dana Farber Cancer Inst Inc | ANTÍGENOS COMPARTIDOS (Divisional 2017-0584) |
TWI750122B (zh) | 2015-06-09 | 2021-12-21 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
NZ738957A (en) | 2015-06-23 | 2019-09-27 | Boehringer Ingelheim Animal Health Usa Inc | Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof |
US20190346442A1 (en) | 2016-04-18 | 2019-11-14 | The Broad Institute, Inc. | Improved hla epitope prediction |
EP3574116A1 (de) | 2017-01-24 | 2019-12-04 | The Broad Institute, Inc. | Zusammensetzungen und verfahren zum nachweis einer mutanten variante eines polynukleotids |
US20210382068A1 (en) | 2018-10-02 | 2021-12-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
WO2020076079A2 (ko) * | 2018-10-10 | 2020-04-16 | 주식회사 바이오리더스 | 락토바실러스 카제이 유래의 두 종류 프로모터를 이용한 두 가지 목적단백질의 동시 표면발현벡터 및 이를 이용한 단백질의 미생물표면 발현 방법 |
WO2020131586A2 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Methods for identifying neoantigens |
JPWO2023277069A1 (de) * | 2021-06-30 | 2023-01-05 | ||
WO2024015892A1 (en) | 2022-07-13 | 2024-01-18 | The Broad Institute, Inc. | Hla-ii immunopeptidome methods and systems for antigen discovery |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
US5505941A (en) | 1981-12-24 | 1996-04-09 | Health Research, Inc. | Recombinant avipox virus and method to induce an immune response |
US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
US4738922A (en) * | 1984-05-25 | 1988-04-19 | Dana Farber Cancer Institute | Trans-acting transcriptional factors |
US5302517A (en) * | 1987-06-16 | 1994-04-12 | The Board Of Regents Of The University Of Nebraska | Method of controlling the expression of a gene in a cell culture, cell culture vector used in the method and method of making the vector |
US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5192669A (en) * | 1987-11-09 | 1993-03-09 | Eli Lilly And Company | Method to produce recombinant proteins using an expression vector comprising transcriptional and translational activating sequences |
CA1307482C (en) * | 1987-11-09 | 1992-09-15 | Ronald G. Schoner | Vectors and expression sequences for production of polypeptides |
WO1990001550A1 (en) * | 1988-07-29 | 1990-02-22 | Zymogenetics, Inc. | High efficiency translation of polycistronic messages in eucaryotic cells |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
EP1156102A1 (de) * | 1991-06-14 | 2001-11-21 | Virogenetics Corporation | Rekombinanter hiv-spezifischer Impfstoff aus Poxvirus |
JPH0638773A (ja) * | 1992-01-31 | 1994-02-15 | Toyobo Co Ltd | 薬剤耐性構造タンパク質遺伝子を選択遺伝子として用いた発現ベクター |
JPH06277074A (ja) * | 1993-03-31 | 1994-10-04 | Terumo Corp | 発現ベクター |
GB2299336A (en) * | 1993-12-23 | 1996-10-02 | Merck & Co Inc | Homologous recombination antibody expression sysstem for murine cells |
IL112820A0 (en) * | 1994-03-07 | 1995-05-26 | Merck & Co Inc | Coordinate in vivo gene expression |
EP0805854A4 (de) * | 1995-01-13 | 2000-06-07 | Virogenetics Corp | Immunogene zusammensetzungen welche rekombinant abgeschwächte pockenviren enthalten, die ein htlv antigen expremieren |
-
1997
- 1997-03-12 US US08/816,155 patent/US5990091A/en not_active Expired - Lifetime
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1998
- 1998-02-13 WO PCT/US1998/002669 patent/WO1998040501A1/en not_active Application Discontinuation
- 1998-02-13 DK DK04075152.1T patent/DK1475443T3/da active
- 1998-02-13 EP EP98906338A patent/EP0970226A4/de not_active Withdrawn
- 1998-02-13 EP EP04075152A patent/EP1475443B1/de not_active Expired - Lifetime
- 1998-02-13 JP JP53956498A patent/JP2001514518A/ja active Pending
- 1998-02-13 CA CA002283537A patent/CA2283537C/en not_active Expired - Lifetime
- 1998-02-13 AU AU61584/98A patent/AU746402B2/en not_active Ceased
- 1998-02-13 DE DE69841986T patent/DE69841986D1/de not_active Expired - Lifetime
- 1998-02-13 AT AT04075152T patent/ATE486945T1/de not_active IP Right Cessation
- 1998-05-15 US US09/079,587 patent/US6130066A/en not_active Expired - Lifetime
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2008
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CA2283537A1 (en) | 1998-09-17 |
DK1475443T3 (da) | 2011-02-21 |
EP0970226A1 (de) | 2000-01-12 |
EP1475443A2 (de) | 2004-11-10 |
WO1998040501A1 (en) | 1998-09-17 |
EP1475443A3 (de) | 2004-12-01 |
AU746402B2 (en) | 2002-05-02 |
JP2008307056A (ja) | 2008-12-25 |
JP2001514518A (ja) | 2001-09-11 |
CA2283537C (en) | 2009-04-28 |
JP5405780B2 (ja) | 2014-02-05 |
AU6158498A (en) | 1998-09-29 |
US6130066A (en) | 2000-10-10 |
EP0970226A4 (de) | 2002-06-12 |
US5990091A (en) | 1999-11-23 |
EP1475443B1 (de) | 2010-11-03 |
DE69841986D1 (de) | 2010-12-16 |
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