ATE48646T1 - Herstellung von peptiden mit c-terminalem prolinamid. - Google Patents
Herstellung von peptiden mit c-terminalem prolinamid.Info
- Publication number
- ATE48646T1 ATE48646T1 AT86302598T AT86302598T ATE48646T1 AT E48646 T1 ATE48646 T1 AT E48646T1 AT 86302598 T AT86302598 T AT 86302598T AT 86302598 T AT86302598 T AT 86302598T AT E48646 T1 ATE48646 T1 AT E48646T1
- Authority
- AT
- Austria
- Prior art keywords
- prolyl
- terminal
- peptides
- production
- peptide
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- VLJNHYLEOZPXFW-BYPYZUCNSA-N L-prolinamide Chemical group NC(=O)[C@@H]1CCCN1 VLJNHYLEOZPXFW-BYPYZUCNSA-N 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- YCYXUKRYYSXSLJ-CVEARBPZSA-N (2r)-4-methyl-2-[[(2s)-1-phenylmethoxycarbonylpyrrolidine-2-carbonyl]amino]pentanoic acid Chemical group CC(C)C[C@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)OCC1=CC=CC=C1 YCYXUKRYYSXSLJ-CVEARBPZSA-N 0.000 abstract 1
- 102000005572 Cathepsin A Human genes 0.000 abstract 1
- 108010059081 Cathepsin A Proteins 0.000 abstract 1
- 101000741445 Homo sapiens Calcitonin Proteins 0.000 abstract 1
- OCYROESYHWUPBP-CIUDSAMLSA-N Pro-Ile Chemical group CC[C@H](C)[C@@H](C([O-])=O)NC(=O)[C@@H]1CCC[NH2+]1 OCYROESYHWUPBP-CIUDSAMLSA-N 0.000 abstract 1
- AWJGUZSYVIVZGP-YUMQZZPRSA-N Pro-Val Chemical group CC(C)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 AWJGUZSYVIVZGP-YUMQZZPRSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229940045644 human calcitonin Drugs 0.000 abstract 1
- 108010015796 prolylisoleucine Chemical group 0.000 abstract 1
- 108010090894 prolylleucine Proteins 0.000 abstract 1
- 108010053725 prolylvaline Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7270585 | 1985-04-08 | ||
| EP86302598A EP0197794B1 (en) | 1985-04-08 | 1986-04-08 | Preparation of peptides with c-terminal proline amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE48646T1 true ATE48646T1 (de) | 1989-12-15 |
Family
ID=13497032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86302598T ATE48646T1 (de) | 1985-04-08 | 1986-04-08 | Herstellung von peptiden mit c-terminalem prolinamid. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4709014A (forum.php) |
| EP (1) | EP0197794B1 (forum.php) |
| JP (1) | JPS6229997A (forum.php) |
| AT (1) | ATE48646T1 (forum.php) |
| CA (1) | CA1251153A (forum.php) |
| DE (1) | DE3667490D1 (forum.php) |
| ES (1) | ES8800265A1 (forum.php) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5332664A (en) * | 1981-07-15 | 1994-07-26 | Celltech Limited | Human calcitonin precursor polyprotein structural gene |
| US6319685B1 (en) * | 1984-09-27 | 2001-11-20 | Unigene Laboratories, Inc. | Alpha-amidating enzyme compositions and processes for their production and use |
| US5789234A (en) * | 1987-08-14 | 1998-08-04 | Unigene Laboratories, Inc. | Expression systems for amidating enzyme |
| AU629552B2 (en) * | 1988-06-16 | 1992-10-08 | Teijin Limited | S-sulfonated calcitonin derivatives |
| JP2535398B2 (ja) * | 1989-01-17 | 1996-09-18 | サントリー株式会社 | アミド化ペプチドの製造方法 |
| US5580751A (en) * | 1990-09-14 | 1996-12-03 | Carlsberg A/S | Process for the preparation of C-terminally amidated peptides |
| DK220890D0 (da) * | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| DK67691D0 (da) * | 1991-03-01 | 1991-04-15 | Carlbiotech Ltd As | Enzymatisk fremgangsmaade til c-terminal modificering af peptider og mellemprodukter til brug ved fremgangsmaaden |
| ATE173022T1 (de) * | 1991-08-08 | 1998-11-15 | Amylin Pharmaceuticals Inc | Produktion von peptid-amiden |
| JP3187201B2 (ja) * | 1992-05-14 | 2001-07-11 | 三共株式会社 | Ｃ末端にプロリンアミドを有するペプチドの製法 |
| US5656456A (en) * | 1992-07-13 | 1997-08-12 | Bionebraska, Inc. | Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof |
| AU673190B2 (en) * | 1992-07-13 | 1996-10-31 | Bionebraska, Inc. | Method for modification of recombinant polypeptides |
| WO1996017941A2 (en) * | 1994-12-07 | 1996-06-13 | Bionebraska, Inc. | Production of c-terminal amidated peptides from recombinant protein constructs |
| WO1997045117A1 (en) * | 1996-05-29 | 1997-12-04 | Prototek, Inc. | Prodrugs of thalidomide and methods for using same as modulators of t-cell function |
| WO2000010506A2 (en) * | 1998-08-20 | 2000-03-02 | University Of Vermont And State Agriculture College | Angiogenesis inhibitors and uses thereof |
| US6461834B1 (en) | 1998-11-06 | 2002-10-08 | Bionebraska, Inc. | Clostripain catalyzed amidation of peptides |
| US20130125449A1 (en) * | 2011-11-22 | 2013-05-23 | Anthony E. Winston | Control of Dust Mites |
| EP3256144B1 (en) | 2015-02-13 | 2021-03-24 | The Board of Trustees of the University of Illionis | Peptide inhibition of ccr3-mediated diseases or conditions |
| MX2022001020A (es) | 2019-07-29 | 2022-04-06 | Univ Illinois | Composicion y metodo para promover la cicatrizacion de heridas. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
-
1986
- 1986-03-31 JP JP61074063A patent/JPS6229997A/ja active Granted
- 1986-04-01 US US06/846,877 patent/US4709014A/en not_active Expired - Lifetime
- 1986-04-08 ES ES553792A patent/ES8800265A1/es not_active Expired
- 1986-04-08 EP EP86302598A patent/EP0197794B1/en not_active Expired
- 1986-04-08 DE DE8686302598T patent/DE3667490D1/de not_active Expired - Fee Related
- 1986-04-08 CA CA000506086A patent/CA1251153A/en not_active Expired
- 1986-04-08 AT AT86302598T patent/ATE48646T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES553792A0 (es) | 1987-11-01 |
| JPS6229997A (ja) | 1987-02-07 |
| EP0197794A2 (en) | 1986-10-15 |
| ES8800265A1 (es) | 1987-11-01 |
| JPH0570433B2 (forum.php) | 1993-10-05 |
| DE3667490D1 (de) | 1990-01-18 |
| US4709014A (en) | 1987-11-24 |
| EP0197794A3 (en) | 1988-08-10 |
| EP0197794B1 (en) | 1989-12-13 |
| CA1251153A (en) | 1989-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |