ATE48617T1 - Leukoregulin, ein antitumor-lymphokin und dessen verwendung als heilmittel. - Google Patents
Leukoregulin, ein antitumor-lymphokin und dessen verwendung als heilmittel.Info
- Publication number
- ATE48617T1 ATE48617T1 AT85902248T AT85902248T ATE48617T1 AT E48617 T1 ATE48617 T1 AT E48617T1 AT 85902248 T AT85902248 T AT 85902248T AT 85902248 T AT85902248 T AT 85902248T AT E48617 T1 ATE48617 T1 AT E48617T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- new
- tumour
- subunit
- patient
- Prior art date
Links
- 108010002060 leukoregulin Proteins 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 abstract 7
- 210000004027 cell Anatomy 0.000 abstract 6
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 210000004408 hybridoma Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 102000005348 Neuraminidase Human genes 0.000 abstract 1
- 108010006232 Neuraminidase Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 238000005571 anion exchange chromatography Methods 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 210000002798 bone marrow cell Anatomy 0.000 abstract 1
- 230000000711 cancerogenic effect Effects 0.000 abstract 1
- 231100000315 carcinogenic Toxicity 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 238000001155 isoelectric focusing Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60030384A | 1984-04-13 | 1984-04-13 | |
| PCT/US1985/000626 WO1985004662A1 (en) | 1984-04-13 | 1985-04-11 | Leukoregulin, an antitumor lymphokine, and its therapeutic uses |
| EP85902248A EP0179127B1 (de) | 1984-04-13 | 1985-04-11 | Leukoregulin, ein antitumor-lymphokin und dessen verwendung als heilmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE48617T1 true ATE48617T1 (de) | 1989-12-15 |
Family
ID=24403068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85902248T ATE48617T1 (de) | 1984-04-13 | 1985-04-11 | Leukoregulin, ein antitumor-lymphokin und dessen verwendung als heilmittel. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0179127B1 (de) |
| JP (2) | JP2562014B2 (de) |
| AT (1) | ATE48617T1 (de) |
| AU (2) | AU592529B2 (de) |
| DE (1) | DE3574710D1 (de) |
| DK (2) | DK170781B1 (de) |
| FI (1) | FI85867C (de) |
| NO (1) | NO170423C (de) |
| WO (1) | WO1985004662A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE48617T1 (de) * | 1984-04-13 | 1989-12-15 | Litton Bionetics Inc | Leukoregulin, ein antitumor-lymphokin und dessen verwendung als heilmittel. |
| US5683688A (en) * | 1984-05-31 | 1997-11-04 | Genentech, Inc. | Unglycosylated recombinant human lymphotoxin polypeptides and compositions |
| US6087166A (en) | 1997-07-03 | 2000-07-11 | Basf Aktiengesellschaft | Transcriptional activators with graded transactivation potential |
| EP2026776A2 (de) | 2006-05-15 | 2009-02-25 | Paratek Pharmaceuticals, Inc. | Verfahren zur regelung der genexpression oder genprodukte mithilfe von substituierten tetracyclinverbindungen |
| WO2012156535A1 (en) | 2011-05-19 | 2012-11-22 | Fundación Progreso Y Salud | Highly inducible dual-promoter lentiviral tet-on system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394448A (en) * | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
| US4403035A (en) * | 1981-06-19 | 1983-09-06 | Regents Of The University Of Minnesota | In vitro DNA-Protein viral assembly and gene cloning system |
| DE3138230A1 (de) * | 1981-09-25 | 1983-04-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur gewinnung von makrophagen- aktivierungsfaktor (maf) |
| JPS6011889B2 (ja) * | 1981-10-28 | 1985-03-28 | 電気化学工業株式会社 | 継代可能なリンホカイン産生ヒトｔ細胞融合株及びその取得方法 |
| US4464465A (en) * | 1982-04-05 | 1984-08-07 | Genetic Systems Corporation | Cell-driven viral transfer in eukaryotes |
| US4443427A (en) * | 1982-06-21 | 1984-04-17 | Sidney Farber Cancer Institute, Inc. | Monoclonal antibody |
| ZA834976B (en) * | 1982-07-30 | 1984-08-29 | Genentech Inc | Human lymphotoxin |
| EP0135797A3 (de) * | 1983-08-30 | 1987-11-11 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA |
| ATE48617T1 (de) * | 1984-04-13 | 1989-12-15 | Litton Bionetics Inc | Leukoregulin, ein antitumor-lymphokin und dessen verwendung als heilmittel. |
-
1985
- 1985-04-11 AT AT85902248T patent/ATE48617T1/de not_active IP Right Cessation
- 1985-04-11 JP JP60501862A patent/JP2562014B2/ja not_active Expired - Lifetime
- 1985-04-11 DE DE8585902248T patent/DE3574710D1/de not_active Expired - Lifetime
- 1985-04-11 EP EP85902248A patent/EP0179127B1/de not_active Expired
- 1985-04-11 AU AU42341/85A patent/AU592529B2/en not_active Ceased
- 1985-04-11 WO PCT/US1985/000626 patent/WO1985004662A1/en not_active Ceased
- 1985-12-04 FI FI854803A patent/FI85867C/fi not_active IP Right Cessation
- 1985-12-04 DK DK562285A patent/DK170781B1/da active
- 1985-12-12 NO NO85854994A patent/NO170423C/no unknown
-
1990
- 1990-04-18 AU AU53653/90A patent/AU641386B2/en not_active Ceased
-
1992
- 1992-08-04 DK DK098692A patent/DK170423B1/da not_active IP Right Cessation
-
1993
- 1993-11-30 JP JP5300409A patent/JP2564245B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2562014B2 (ja) | 1996-12-11 |
| FI854803A0 (fi) | 1985-12-04 |
| AU5365390A (en) | 1990-09-20 |
| FI85867B (fi) | 1992-02-28 |
| JPS61501853A (ja) | 1986-08-28 |
| JP2564245B2 (ja) | 1996-12-18 |
| JPH06253832A (ja) | 1994-09-13 |
| WO1985004662A1 (en) | 1985-10-24 |
| FI85867C (fi) | 1992-06-10 |
| DK562285A (da) | 1985-12-04 |
| NO170423B (no) | 1992-07-06 |
| DK170423B1 (da) | 1995-08-28 |
| AU641386B2 (en) | 1993-09-23 |
| NO170423C (no) | 1992-10-14 |
| DK98692A (da) | 1992-08-04 |
| DK98692D0 (da) | 1992-08-04 |
| DE3574710D1 (de) | 1990-01-18 |
| NO854994L (no) | 1985-12-12 |
| DK170781B1 (da) | 1996-01-15 |
| FI854803L (fi) | 1985-12-04 |
| DK562285D0 (da) | 1985-12-04 |
| EP0179127B1 (de) | 1989-12-13 |
| AU4234185A (en) | 1985-11-01 |
| EP0179127A1 (de) | 1986-04-30 |
| AU592529B2 (en) | 1990-01-18 |
| EP0179127A4 (de) | 1986-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |