ATE482393T1 - Diagnose und überwachung von entzündlichen krankheiten mittels messung der zusätzlichen komponenten von leukozyten - Google Patents

Diagnose und überwachung von entzündlichen krankheiten mittels messung der zusätzlichen komponenten von leukozyten

Info

Publication number
ATE482393T1
ATE482393T1 AT05747945T AT05747945T ATE482393T1 AT E482393 T1 ATE482393 T1 AT E482393T1 AT 05747945 T AT05747945 T AT 05747945T AT 05747945 T AT05747945 T AT 05747945T AT E482393 T1 ATE482393 T1 AT E482393T1
Authority
AT
Austria
Prior art keywords
monitoring
inflammatory diseases
leukocytes
diagnosis
measurement
Prior art date
Application number
AT05747945T
Other languages
English (en)
Inventor
Joseph M Ahearn
Susan M Manzi
Chau-Ching Liu
Original Assignee
Univ Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Application granted granted Critical
Publication of ATE482393T1 publication Critical patent/ATE482393T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/821—Chemistry: analytical and immunological testing involving complement factors or complement systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT05747945T 2004-05-11 2005-05-11 Diagnose und überwachung von entzündlichen krankheiten mittels messung der zusätzlichen komponenten von leukozyten ATE482393T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57040604P 2004-05-11 2004-05-11
PCT/US2005/016436 WO2005111612A1 (en) 2004-05-11 2005-05-11 Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells

Publications (1)

Publication Number Publication Date
ATE482393T1 true ATE482393T1 (de) 2010-10-15

Family

ID=35394276

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05747945T ATE482393T1 (de) 2004-05-11 2005-05-11 Diagnose und überwachung von entzündlichen krankheiten mittels messung der zusätzlichen komponenten von leukozyten

Country Status (10)

Country Link
US (3) US7585640B2 (de)
EP (2) EP1745287B1 (de)
JP (1) JP2007537449A (de)
AT (1) ATE482393T1 (de)
AU (1) AU2005242719B2 (de)
CA (1) CA2564492C (de)
DE (1) DE602005023725D1 (de)
DK (1) DK1745287T3 (de)
ES (1) ES2353311T3 (de)
WO (1) WO2005111612A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004232007B2 (en) * 2003-04-16 2009-10-22 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Identification and monitoring of systematic lupus erythematosus
ES2353311T3 (es) * 2004-05-11 2011-03-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Diagnóstico de enfermedades o afecciones inflamatorias para la medición de componentes del complemento sobre la superficie de glóbulos blancos.
JP5117336B2 (ja) * 2008-09-18 2013-01-16 国立大学法人 千葉大学 多発性硬化症またはｎｍｏの検査マーカーの測定方法
US20100233752A1 (en) * 2008-10-16 2010-09-16 Cypress Bioscience, Inc. Method for diagnosis and monitoring of disease activity and response to treatment in systemic lupus erythematosus (sle) and other autoimmune diseases
EP2392352B1 (de) * 2009-01-28 2017-10-25 Korea Research Institute of Bioscience and Biotechnology Cd93 bzw. verwendung eines löslichen fragments davon
US10132813B2 (en) 2011-02-11 2018-11-20 Exagen Diagnostics, Inc. Methods for diagnosing systemic lupus erythematosus
US10413620B2 (en) 2012-08-17 2019-09-17 The Regents Of The University Of Colorado, A Body Corporate Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging
WO2014028865A1 (en) * 2012-08-17 2014-02-20 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for detecting complement activation
RU2680270C2 (ru) 2013-02-08 2019-02-19 Аллегени-Сингер Рисерч Инститьют Клеточно-связанные продукты активации комплемента в качестве диагностических биомаркеров волчанки в доклинической стадии
US9863946B2 (en) 2013-02-08 2018-01-09 Allegheny-Singer Research Institute Cell-bound complement activation products as diagnostic biomarkers for pre-lupus
WO2014151238A1 (en) 2013-03-15 2014-09-25 Exagen Diagnostics, Inc. Methods for treating and diagnosing systemic lupus erythematosus
WO2016023006A1 (en) * 2014-08-08 2016-02-11 Allegheny-Singer Research Institute Anti-lymphocyte autoantibodies as diagnostic biomarkers
EP3191509B1 (de) * 2014-09-09 2019-02-20 Euro-diagnostica AB Komplementkomponente c4d-spezifische antikörper und verwendungen davon
JP2017530356A (ja) 2014-09-26 2017-10-12 ソマロジック, インコーポレイテッドSomaLogic, Inc. 心血管系のリスクイベントの予測及びその使用
AU2016303499B2 (en) * 2015-07-31 2020-07-02 Allegheny-Singer Research Institute Cell-bound complement activation product assays as companion diagnostics for antibody-based drugs
EP3519828A4 (de) 2016-09-29 2020-06-03 Animantis, LLC Verfahren und vorrichtung zur beurteilung der immunsystemaktivität und der therapeutischen wirksamkeit
JP7126668B2 (ja) * 2017-08-09 2022-08-29 国立大学法人金沢大学 膠原病判定方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8426467D0 (en) 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0814159B1 (de) 1990-08-29 2005-07-27 GenPharm International, Inc. Transgene Mäuse fähig zur Produktion heterologer Antikörper
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
AU686577B2 (en) 1992-10-30 1998-02-12 Innogenetics, Inc. Measurement of total molecule in a sample and methods based thereon
JP3104197B2 (ja) * 1993-06-11 2000-10-30 ポーラ化成工業株式会社 補体レセプター発現量の測定法
JP4570872B2 (ja) 2001-09-10 2010-10-27 ユニヴァーシティ オブ ピッツバーグ 全身性紅斑性狼瘡および強皮症の診断およびモニタリング方法
US8080382B2 (en) * 2003-06-13 2011-12-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Monitoring immunologic, hematologic and inflammatory diseases
AU2005241415A1 (en) * 2004-04-09 2005-11-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Real time method of detecting acute inflammatory conditions
ES2353311T3 (es) * 2004-05-11 2011-03-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Diagnóstico de enfermedades o afecciones inflamatorias para la medición de componentes del complemento sobre la superficie de glóbulos blancos.

Also Published As

Publication number Publication date
WO2005111612A1 (en) 2005-11-24
AU2005242719B2 (en) 2011-02-24
EP1745287B1 (de) 2010-09-22
US20110275060A1 (en) 2011-11-10
DE602005023725D1 (de) 2010-11-04
EP1745287A1 (de) 2007-01-24
US20090298198A1 (en) 2009-12-03
CA2564492A1 (en) 2005-11-24
ES2353311T3 (es) 2011-03-01
US7585640B2 (en) 2009-09-08
EP2214014A1 (de) 2010-08-04
CA2564492C (en) 2012-05-22
EP1745287A4 (de) 2008-04-16
AU2005242719A1 (en) 2005-11-24
DK1745287T3 (da) 2011-01-24
JP2007537449A (ja) 2007-12-20
US20070026387A1 (en) 2007-02-01

Similar Documents

Publication Publication Date Title
ATE482393T1 (de) Diagnose und überwachung von entzündlichen krankheiten mittels messung der zusätzlichen komponenten von leukozyten
DE602004026724D1 (de) Überwachung von immunologischen, hämatologischen und entzündlichen erkrankungen
ATE456055T1 (de) Diagnoseverfahren für erkrankungen im zusammenhang mit hirnschäden
ATE485764T1 (de) Vorrichtung zur schätzung des hämatokrits
DE602005023009D1 (de) Verfahren in echtzeit zur erkennung von akuten entzündungszuständen
FI3712279T3 (fi) Menetelmät ei-alkoholiperäisen steatohepatiitin diagnosointia ja arviointia varten
DE602004030586D1 (de) Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis
ATE312550T1 (de) Vorrichtung zur segmentären bioimpedanzmessung von einem dialysepatienten
JP2009501333A5 (de)
DK2848938T3 (da) Evaluering af effektiviteten af en behandling hos et individ baseret på st2- niveauer
ATE550642T1 (de) Verfahren zur messung von 1,5-anhydroglucitol in vollblut
ATE502304T1 (de) Verfahren und mittel zur bestimmung der blutplättchenfunktion und zur diagnose von mit blutplättchen verbundenen störungen und herz- kreislauf-erkrankungen
ATE500850T1 (de) Okulare diagnose der alzheimer-krankheit
ATE427489T1 (de) Diagnostische marker fur ischamie und mortalitatsrisiken
ATE511651T1 (de) Transglutaminase 6 als diagnostischer indikator für autoimmunerkrankungen
ATE451477T1 (de) Diagnose und überwachung von hepatozellulärem karzinom
ATE370414T1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
WO2008005771A3 (en) Methods for identifying patients with increased risk of an adverse cardiovascular event
DE602008004556D1 (de) Zusammensetzungen und verfahren zum nachweis von störungen in verbindung mit histamin
ATE470152T1 (de) Diagnostikverfahren mittels messungen der antiglykan-antikörper-spiegeln
BR0317404A (pt) Variantes do fator xiia
DE602004001994D1 (de) Verwendung des proteins masp als marker für kolorektale karzinome
WO2006093932A3 (en) Use of eotaxin as a diagnostic indicator for atherosclerosis and vascular inflammation
DE60310655D1 (de) Kombination von CRP und D-Dimer zur Diagnose von tiefer Venenthrombose
BR0209681A (pt) Método e kit para o diagnóstico in vivo ou para o monitoramento de uma doença que envolve uma reação inflamatória dentro de um paciente

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties