ATE427489T1 - Diagnostische marker fur ischamie und mortalitatsrisiken - Google Patents

Diagnostische marker fur ischamie und mortalitatsrisiken

Info

Publication number
ATE427489T1
ATE427489T1 AT02768861T AT02768861T ATE427489T1 AT E427489 T1 ATE427489 T1 AT E427489T1 AT 02768861 T AT02768861 T AT 02768861T AT 02768861 T AT02768861 T AT 02768861T AT E427489 T1 ATE427489 T1 AT E427489T1
Authority
AT
Austria
Prior art keywords
ischemia
diagnostic markers
mortality risk
concentration
ischemic
Prior art date
Application number
AT02768861T
Other languages
English (en)
Inventor
Alan Kleinfeld
Original Assignee
Torrey Pines Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrey Pines Inst filed Critical Torrey Pines Inst
Application granted granted Critical
Publication of ATE427489T1 publication Critical patent/ATE427489T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/324Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/815Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02768861T 2001-09-14 2002-09-16 Diagnostische marker fur ischamie und mortalitatsrisiken ATE427489T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32252301P 2001-09-14 2001-09-14
US10/243,566 US7262017B2 (en) 2001-09-14 2002-09-13 Diagnostic markers for ischemia

Publications (1)

Publication Number Publication Date
ATE427489T1 true ATE427489T1 (de) 2009-04-15

Family

ID=26935946

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02768861T ATE427489T1 (de) 2001-09-14 2002-09-16 Diagnostische marker fur ischamie und mortalitatsrisiken

Country Status (10)

Country Link
US (2) US7262017B2 (de)
EP (1) EP1425582B1 (de)
JP (2) JP4579537B2 (de)
KR (1) KR20040039177A (de)
CN (1) CN100554963C (de)
AT (1) ATE427489T1 (de)
AU (1) AU2002331867B2 (de)
CA (1) CA2425784A1 (de)
DE (1) DE60231814D1 (de)
WO (1) WO2003025571A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050154407A1 (en) * 2000-12-20 2005-07-14 Fox Hollow Technologies, Inc. Method of evaluating drug efficacy for treating atherosclerosis
US7699790B2 (en) * 2000-12-20 2010-04-20 Ev3, Inc. Debulking catheters and methods
US20100121360A9 (en) * 2000-12-20 2010-05-13 Fox Hollow Technologies, Inc Testing a patient population having a cardiovascular condition for drug efficacy
US7202089B2 (en) * 2001-09-14 2007-04-10 Alan Kleinfeld Early diagnosis of stroke
US7063782B2 (en) 2001-11-26 2006-06-20 Ischemia Technologies, Inc. Electrochemical detection of ischemia
US7074194B2 (en) 2003-05-19 2006-07-11 Ischemia Technologies, Inc. Apparatus and method for risk stratification of patients with chest pain of suspected cardiac origin
US7634360B2 (en) * 2003-09-23 2009-12-15 Prediction Sciences, LL Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US7274772B2 (en) * 2004-05-27 2007-09-25 Cabot Microelectronics Corporation X-ray source with nonparallel geometry
WO2006036476A2 (en) * 2004-09-07 2006-04-06 The General Hospital Corporation Methods of detecting myocardial ischemia and myocardial infarction
US7794413B2 (en) * 2005-04-19 2010-09-14 Ev3, Inc. Libraries and data structures of materials removed by debulking catheters
US20080117416A1 (en) * 2006-10-27 2008-05-22 Hunter Ian W Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
WO2008060841A2 (en) * 2006-10-27 2008-05-22 Ffa Sciences, Llc Use of probes for unbound metabolites
US20100179066A1 (en) * 2007-06-07 2010-07-15 Inserm (Institut National De La Santé Et De La Rec Method for Assessing the Risk of a Cardiovascular Disease and for Diagnosing Dyslipidemia
WO2009036376A1 (en) * 2007-09-13 2009-03-19 University Of Hawaii Fatty acid markers for the diagnosis, prognosis and management of cardiovascular disease
JP5481023B2 (ja) * 2007-10-25 2014-04-23 株式会社小松製作所 作業車両および作業車両の制御方法
WO2010077741A1 (en) * 2008-12-09 2010-07-08 The Trustees Of Columbia University In The City Of New York Diagnosis and therapy of organ dysfunction using sphinganine-1-phosphate
US20100228101A1 (en) * 2009-03-04 2010-09-09 Michael Maschke Workflow for stroke diagnosis combining in-vitro diagnosis (ivd) with an imaging modality
CN103154742B (zh) 2010-06-20 2017-11-21 佐拉生物科学公司 用于鉴定高风险冠状动脉疾病患者的脂质组学标志
ES2595028T3 (es) 2011-10-17 2016-12-27 F. Hoffmann-La Roche Ag Diagnóstico basado en Troponina y BNP de pacientes en riesgo y causa de ictus
GB201304460D0 (en) 2013-03-13 2013-04-24 Univ Leeds Biomarker
EP3077827B1 (de) 2013-12-03 2023-11-01 Kleinfeld, Alan M. Bestimmung der ungebundenen freien fettsäureprofile in biologischen und industriellen proben
GB201509974D0 (en) * 2015-06-09 2015-07-22 Sarissa Biomedical Ltd Methods and device to detect the presence of ischaemia in a subject

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5217085A (en) 1975-07-30 1977-02-08 Ono Pharmaceut Co Ltd Method of quantitative determination of free fatty acids in serum usin g fatty acid activating enzymes
FR2508487B1 (fr) 1981-06-25 1986-06-27 Toyo Jozo Kk Procede de dosage pour composant apparente aux lipides, composition pour dosage et procede de production d'enzyme utilisee a cet effet
US4369250A (en) 1981-07-31 1983-01-18 Sherwood Medical Industries Inc. Fatty acid determination
SU1270706A1 (ru) 1981-09-30 1986-11-15 Украинский научно-исследовательский институт кардиологии им.акад.Н.Д.Стражеско Способ определени фосфолипидов в инфарктной зоне сердечной мышцы
AT390840B (de) 1983-06-08 1990-07-10 Avl Verbrennungskraft Messtech Verfahren zur fluorimetrischen bestimmung der konzentration von in einer substanz enthaltenen stoffen und anordnung zur durchfuehrung dieses verfahrens
JP2657225B2 (ja) * 1987-03-31 1997-09-24 株式会社 日本抗体研究所 脂質代謝異常の検出方法
US4833332A (en) 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
US5512429A (en) 1989-09-19 1996-04-30 British Technology Group Limited Assay for enzyme activity
DE69023488T2 (de) 1989-12-12 1996-05-09 Lidak Pharmaceuticals BESTIMMUNG FREIER FETTSäUREN.
US5470714A (en) 1989-12-12 1995-11-28 Lidak Pharmaceuticals One-step free fatty acid determination method
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
GB9105707D0 (en) 1991-03-18 1991-05-01 Wilton David C Assay
US5227307A (en) * 1991-07-26 1993-07-13 Diagnostic Markers, Inc. Test for the rapid evaluation of ischemic state
US5225329A (en) 1991-10-18 1993-07-06 Yale University Method for early detection of intestinal ischemia
WO1994006014A1 (en) 1992-09-02 1994-03-17 Kleinfeld Alan M Diagnostic aid for early detection of cancer and diabetes
US5362649A (en) 1993-02-16 1994-11-08 The United States Of America As Represented By The Secretary Of The Air Force Method for concentration based analysis of lipid fatty acids and its use in determining the likelihood that a patient is at risk for coronary artery disease
US5914112A (en) 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
WO1998057179A1 (en) * 1997-06-10 1998-12-17 Medlyte Diagnostics, Inc. Methods for early detection of heart disease
AU3395697A (en) 1997-06-13 1998-12-30 Medical Biology Institute Method of detection of cardiac ischemia using fatty acid binding protein
US6444432B1 (en) 1997-06-13 2002-09-03 Alan M. Kleinfeld Method of detection of cardiac ischemia using fatty acid binding protein
US6727258B2 (en) 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
TW562926B (en) 1997-11-26 2003-11-21 Tanabe Seiyaku Co Method for testing renal diseases
US5977174A (en) 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
DE19836617C2 (de) * 1998-08-12 2001-02-08 Ulrich Frei In vitro Verfahren zur Erkennung und Diagnostik akuter koronarer Syndrome
US6461875B1 (en) * 1998-10-02 2002-10-08 Ischemia Technologies, Inc. Test for rapid evaluation of ischemic states and kit
US6475743B1 (en) * 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US6492179B1 (en) * 1998-10-02 2002-12-10 Ischemia Techologies, Inc. Test for rapid evaluation of ischemic states and kit
WO2000020840A1 (en) 1998-10-02 2000-04-13 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US6264960B1 (en) 1998-11-10 2001-07-24 Sander J. Robins Treatment of vascular events using lipid-modifying compositions
JP2002536459A (ja) 1999-02-12 2002-10-29 プレジデント アンド フェローズ オブ ハーヴァード カレッジ アテローム性動脈硬化症性病変の形成の阻害
US6663862B1 (en) 1999-06-04 2003-12-16 Duke University Reagents for detection and purification of antibody fragments
GB9923146D0 (en) 1999-09-30 1999-12-01 Imperial College Detector array
US6563585B1 (en) 1999-11-24 2003-05-13 University Of Maryland Biotechnology Institute Ratiometric fluorometer
US20040077017A1 (en) 2001-01-12 2004-04-22 Amelie Karlstrom Detection methods
WO2002072872A2 (en) 2001-03-14 2002-09-19 Clf Medical Technology Acceleration Program, Inc. System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby
WO2002089656A2 (en) 2001-05-04 2002-11-14 Ischemia Technologies, Inc. Diagnosis of acute myocardial infarction
US7202089B2 (en) 2001-09-14 2007-04-10 Alan Kleinfeld Early diagnosis of stroke
US20050239155A1 (en) 2002-01-04 2005-10-27 Javier Alarcon Entrapped binding protein as biosensors
AU2003228817A1 (en) 2002-05-01 2003-11-17 Adipogenix, Inc. Human adipocyte cell populations and methods for identifying modulators of same
US7335481B2 (en) 2002-07-24 2008-02-26 Christer Owman Methods of identifying compounds that affect a fatty acid cell-surface receptor
AU2005227312B2 (en) 2004-03-22 2011-04-07 Ffa Sciences, Llp Development and use of fluorescent probes of unbound analytes
US20060257938A1 (en) 2005-05-10 2006-11-16 Kleinfeld Alan M Method of screening for drugs that block ligand binding to a lipid binding protein

Also Published As

Publication number Publication date
CN1630818A (zh) 2005-06-22
WO2003025571A1 (en) 2003-03-27
JP2010223972A (ja) 2010-10-07
CA2425784A1 (en) 2003-03-27
US7262017B2 (en) 2007-08-28
JP5244156B2 (ja) 2013-07-24
EP1425582A4 (de) 2005-02-16
US20030064522A1 (en) 2003-04-03
US7879558B2 (en) 2011-02-01
US20080004210A1 (en) 2008-01-03
EP1425582B1 (de) 2009-04-01
EP1425582A1 (de) 2004-06-09
JP4579537B2 (ja) 2010-11-10
KR20040039177A (ko) 2004-05-10
DE60231814D1 (de) 2009-05-14
JP2005504277A (ja) 2005-02-10
AU2002331867B2 (en) 2007-08-02
CN100554963C (zh) 2009-10-28

Similar Documents

Publication Publication Date Title
ATE427489T1 (de) Diagnostische marker fur ischamie und mortalitatsrisiken
DK1945622T3 (da) Isotopisk-mærkede benzofuranforbindelser som billeddannelsesmidler til amyloidogene proteiner
McPherson Henry's Clinical Diagnosis and Management by Laboratory Methods, 22/e
CY1120434T1 (el) Πρωτεϊνες προσδεσης il-1
BRPI0512209A (pt) composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens de um corpo humano ou de animal por formação de imagem óptica, e de monitoração do efeito de tratamento de um corpo humano ou de animal com uma droga para combater uma condição associada com angiogênese
CR8230A (es) Sondas para enfermedades en las cuales se acumula amiloide, agentes para tincion del amiloide, farmacos para tratamiento y profilaxis de enfermedades con amiloide acumulado y sondas para diagnostico de ovillos neuro fibrilares yagentes...
CY1110967T1 (el) Απεικονιση, διαγνωση και θεραπεια ασθενειας
ATE480553T1 (de) Replikin-peptide und anwendungen
RU2005131961A (ru) Система для оптической биопсии с одноразовым игольчатым зондом
ATE523788T1 (de) ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN
PE20071038A1 (es) Procedimiento para la preparacion de ferrisuccinilcaseina
UY29327A1 (es) Derivados de n-(heteroaril)- 1 h- indol-2-carboxamidas, su preparacion y su aplicacion en terapeutica
ATE556092T1 (de) Mittel zur diagnose und therapie von ctcl
ATE376428T1 (de) Metallkomplexverbindungen
ATE433115T1 (de) Timp-2 als ziel/marker des versagens von beta- zellen
ATE349181T1 (de) Verbesserungen der diagnose des akuten myokardinfarkts und anderer klinischer zustände
BR0014150A (pt) Diagnósticos e terapêuticos para osteoporose
DE60122673D1 (de) Methoden zur diagnose und behandlung von herzkrankheiten
ATE352311T1 (de) Verwendung von brustkrebs membranproteine für behandlung, prophylaxe und diagnose von brustkrebs
NO20076119L (no) Diagnostisk markor for diabetiske vaskulaere komplikasjoner
DE602008004556D1 (de) Zusammensetzungen und verfahren zum nachweis von störungen in verbindung mit histamin
BR0317404A (pt) Variantes do fator xiia
RU2014152876A (ru) Изоформы тропомиозина, связанные с болезнью альцгеймера и умеренными когнитивными нарушениями
RU2005115419A (ru) Способ оценки эффективности лечения рака шейки матки
DK1251875T3 (da) Anvendelse af kontrastmidler til fremstilling af et diagnostisk middel til visualisering af intestinallumen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties