ATE480244T1 - Neue, hyaluronsäure oder hyaluronsaure derivate und collagenase enthaltende pharmazeutische zusammensetzungen zur topischen behandlung von wunden, verbrennungen und geschwüren - Google Patents
Neue, hyaluronsäure oder hyaluronsaure derivate und collagenase enthaltende pharmazeutische zusammensetzungen zur topischen behandlung von wunden, verbrennungen und geschwürenInfo
- Publication number
- ATE480244T1 ATE480244T1 AT06754678T AT06754678T ATE480244T1 AT E480244 T1 ATE480244 T1 AT E480244T1 AT 06754678 T AT06754678 T AT 06754678T AT 06754678 T AT06754678 T AT 06754678T AT E480244 T1 ATE480244 T1 AT E480244T1
- Authority
- AT
- Austria
- Prior art keywords
- hyaluronic acid
- ulcers
- wounds
- burns
- compositions containing
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
- 102000029816 Collagenase Human genes 0.000 title abstract 2
- 108060005980 Collagenase Proteins 0.000 title abstract 2
- 208000025865 Ulcer Diseases 0.000 title abstract 2
- 206010052428 Wound Diseases 0.000 title abstract 2
- 208000027418 Wounds and injury Diseases 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 title abstract 2
- 231100000397 ulcer Toxicity 0.000 title abstract 2
- 229960002424 collagenase Drugs 0.000 title 1
- 206010011985 Decubitus ulcer Diseases 0.000 abstract 1
- 208000008960 Diabetic foot Diseases 0.000 abstract 1
- 206010023330 Keloid scar Diseases 0.000 abstract 1
- 208000004210 Pressure Ulcer Diseases 0.000 abstract 1
- 230000001969 hypertrophic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24003—Microbial collagenase (3.4.24.3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000207A ITPD20050207A1 (it) | 2005-07-07 | 2005-07-07 | Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere |
| PCT/EP2006/006616 WO2007006484A1 (en) | 2005-07-07 | 2006-07-05 | New pharmaceutical compositions containing hyaluronic acid and collagenase for the topical treatment of wounds, burns and ulcers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480244T1 true ATE480244T1 (de) | 2010-09-15 |
Family
ID=37023161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06754678T ATE480244T1 (de) | 2005-07-07 | 2006-07-05 | Neue, hyaluronsäure oder hyaluronsaure derivate und collagenase enthaltende pharmazeutische zusammensetzungen zur topischen behandlung von wunden, verbrennungen und geschwüren |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8900576B2 (de) |
| EP (1) | EP1901755B1 (de) |
| JP (1) | JP5322637B2 (de) |
| AT (1) | ATE480244T1 (de) |
| AU (1) | AU2006268950B2 (de) |
| BR (1) | BRPI0612736A2 (de) |
| CA (1) | CA2613976C (de) |
| DE (1) | DE602006016799D1 (de) |
| DK (1) | DK1901755T3 (de) |
| ES (1) | ES2352350T3 (de) |
| IT (1) | ITPD20050207A1 (de) |
| PL (1) | PL1901755T3 (de) |
| PT (1) | PT1901755E (de) |
| SI (1) | SI1901755T1 (de) |
| WO (1) | WO2007006484A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ600403A (en) | 2009-12-08 | 2014-01-31 | Smith & Nephew Orthopaedics Ag | Enzymatic wound debriding compositions with enhanced enzymatic activity |
| EP2570124B1 (de) * | 2010-05-14 | 2016-11-02 | Sanidad Y Residencias 21, S.A. | Oleuropein zusammensetzungen zur behandlung von wunden und geschwüren bei älteren menschen und/oder diabetikern |
| KR101831918B1 (ko) | 2010-06-11 | 2018-02-27 | 한국원자력의학원 | 히알루론산의 탈아세틸화 가수분해효소, 및 이에 의해 탈아세틸화된 히알루론산 및 이의 유도체 |
| ES2385239B1 (es) * | 2010-09-30 | 2013-06-19 | Proteos Biotech S.L.U. | Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno. |
| RU2625726C2 (ru) | 2011-07-20 | 2017-07-18 | Медиваунд Лтд. | Экстракт бромелаина с протеолитической активностью для лечения заболеваний соединительных тканей |
| EP4015627B1 (de) | 2012-01-12 | 2023-09-27 | Endo Global Ventures | Clostridium histolyticum enzym |
| CN102552479B (zh) * | 2012-01-19 | 2013-12-04 | 孙万奎 | 一种用于治疗糖尿病足的中药组合物 |
| ES2424294B1 (es) * | 2012-03-22 | 2014-07-21 | Lipotec, S.A. | Exopolisacárido para el tratamiento y/o cuidado de la piel, mucosas, cabello y/o uñas |
| ITPD20120118A1 (it) | 2012-04-18 | 2013-10-19 | Fidia Farmaceutici | "nuovo processo di produzione e purificazione dell'enzima collagenasi da vibrio alginolyticus" |
| ITPD20120173A1 (it) * | 2012-05-31 | 2013-12-01 | Fidia Farmaceutici | "nuovo sistema di rilascio di proteine idrofobiche" |
| ITPD20120360A1 (it) * | 2012-11-30 | 2014-05-31 | Fidia Farmaceutici | "nuovi geli viscoelastici in chirurgia oftalmica" |
| US20140328826A1 (en) * | 2013-05-01 | 2014-11-06 | COLE Research & Design, Inc. | Product and method for treating keloid scars, hypertrophic scars and burn scars with contracture |
| US10117892B2 (en) * | 2013-08-29 | 2018-11-06 | Allergan, Inc. | Devices and methods for reducing the appearance of cellulite |
| US20170020808A1 (en) * | 2015-07-23 | 2017-01-26 | Mary Kay Inc. | Topical skin formulations |
| EP4591945A2 (de) | 2017-03-01 | 2025-07-30 | Endo Operations Limited | Vorrichtung und verfahren zur beurteilung und behandlung von cellulite |
| US11473074B2 (en) | 2017-03-28 | 2022-10-18 | Endo Global Aesthetics Limited | Method of producing collagenase |
| KR102766474B1 (ko) * | 2017-09-01 | 2025-02-12 | 엑셀 메드, 엘엘씨 | 켈로이드를 치료하기 위한 약제학적 조성물 및 그의 용도 |
| CN113759122A (zh) * | 2020-06-05 | 2021-12-07 | 张曼 | 尿液蛋白质z及其多肽片段在烧伤中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4174389A (en) * | 1977-05-13 | 1979-11-13 | Cope Louise A | Ophthalmic use of collagenase |
| IT1212892B (it) * | 1983-10-11 | 1989-11-30 | Della Valle Francesco | Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica |
| CA1227132A (fr) * | 1983-01-05 | 1987-09-22 | Robert J. Weill | Preparation a activite collagenolytique ayant une activite elevee et compositions pharmaceutiques la contenant |
| DE3504905A1 (de) | 1985-02-13 | 1986-08-14 | J. Kühn GmbH & Co Präzisionswerkzeug KG, 4270 Dorsten | Werkzeughalter o.dgl. |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| JP3449738B2 (ja) * | 1991-07-10 | 2003-09-22 | 武田薬品工業株式会社 | 水溶性組成物 |
| US5393792A (en) | 1991-11-20 | 1995-02-28 | Advance Biofactures Of Curacao, N.V. | High dosage topical forms of collagenase |
| IL100112A (en) * | 1991-11-21 | 1996-01-31 | Yeda Res & Dev | Microdelivery device for enhanced drug administration to the eye |
| DE4200080A1 (de) * | 1992-01-03 | 1993-09-30 | Reinmueller Johannes | Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung |
| WO1994024273A1 (en) * | 1993-04-16 | 1994-10-27 | Baxter International Inc. | Stable collagenase compositions and methods for their preparation |
| EP0637450A3 (de) * | 1993-08-04 | 1995-04-05 | Collagen Corp | Verfahren und Zusammensetzung zur Wiederbelebung von Nerbgewebe. |
| US5589171A (en) * | 1994-08-22 | 1996-12-31 | Advance Biofactures Of Curacao | Treatment of Dupuytren's disease with collagenase |
| US5718897A (en) | 1995-06-07 | 1998-02-17 | Trustees Of Tufts College | Enhancing keratinocyte migration and proliferation |
| DE19641672A1 (de) * | 1996-10-10 | 1998-04-16 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen |
| US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6086872A (en) * | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
| IT1302534B1 (it) * | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per |
| IT1306679B1 (it) | 1999-06-29 | 2001-10-02 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico per la preparazione dicomposizoni farmaceutiche e biomateriali per la prevenzione della |
| JP2002020279A (ja) * | 2000-06-30 | 2002-01-23 | Taisho Pharmaceut Co Ltd | 点眼液 |
| DE10246340A1 (de) | 2002-10-04 | 2004-04-29 | Wohlrab, David, Dr. | Kombinationspräparat aus Hyaluronsäure und mindestens einem Lokalanästhetikum und dessen Verwendung |
| EP1433845A1 (de) * | 2002-12-23 | 2004-06-30 | Georg-August-Universität | Collagenase aus Clostridium tetani und ihre Verwendungen |
-
2005
- 2005-07-07 IT IT000207A patent/ITPD20050207A1/it unknown
-
2006
- 2006-07-05 AU AU2006268950A patent/AU2006268950B2/en active Active
- 2006-07-05 JP JP2008519863A patent/JP5322637B2/ja active Active
- 2006-07-05 CA CA2613976A patent/CA2613976C/en active Active
- 2006-07-05 WO PCT/EP2006/006616 patent/WO2007006484A1/en not_active Ceased
- 2006-07-05 BR BRPI0612736-3A patent/BRPI0612736A2/pt not_active Application Discontinuation
- 2006-07-05 DE DE602006016799T patent/DE602006016799D1/de active Active
- 2006-07-05 ES ES06754678T patent/ES2352350T3/es active Active
- 2006-07-05 DK DK06754678.8T patent/DK1901755T3/da active
- 2006-07-05 PT PT06754678T patent/PT1901755E/pt unknown
- 2006-07-05 AT AT06754678T patent/ATE480244T1/de active
- 2006-07-05 US US11/921,835 patent/US8900576B2/en active Active
- 2006-07-05 SI SI200630841T patent/SI1901755T1/sl unknown
- 2006-07-05 PL PL06754678T patent/PL1901755T3/pl unknown
- 2006-07-05 EP EP06754678A patent/EP1901755B1/de active Active
-
2014
- 2014-09-09 US US14/481,615 patent/US9603910B2/en active Active
-
2017
- 2017-02-02 US US15/423,208 patent/US11040089B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20080206228A1 (en) | 2008-08-28 |
| SI1901755T1 (sl) | 2011-01-31 |
| US11040089B2 (en) | 2021-06-22 |
| US20140377249A1 (en) | 2014-12-25 |
| DK1901755T3 (da) | 2011-01-10 |
| JP5322637B2 (ja) | 2013-10-23 |
| US20170209552A1 (en) | 2017-07-27 |
| WO2007006484A1 (en) | 2007-01-18 |
| EP1901755A1 (de) | 2008-03-26 |
| HK1116683A1 (en) | 2009-01-02 |
| EP1901755B1 (de) | 2010-09-08 |
| ITPD20050207A1 (it) | 2007-01-08 |
| PL1901755T3 (pl) | 2011-03-31 |
| AU2006268950A1 (en) | 2007-01-18 |
| US9603910B2 (en) | 2017-03-28 |
| CA2613976A1 (en) | 2007-01-18 |
| DE602006016799D1 (de) | 2010-10-21 |
| ES2352350T3 (es) | 2011-02-17 |
| JP2009500367A (ja) | 2009-01-08 |
| PT1901755E (pt) | 2010-12-16 |
| CA2613976C (en) | 2013-11-19 |
| AU2006268950B2 (en) | 2011-01-06 |
| US8900576B2 (en) | 2014-12-02 |
| BRPI0612736A2 (pt) | 2012-10-02 |
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