ATE474855T1 - Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnp - Google Patents
Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnpInfo
- Publication number
- ATE474855T1 ATE474855T1 AT03811319T AT03811319T ATE474855T1 AT E474855 T1 ATE474855 T1 AT E474855T1 AT 03811319 T AT03811319 T AT 03811319T AT 03811319 T AT03811319 T AT 03811319T AT E474855 T1 ATE474855 T1 AT E474855T1
- Authority
- AT
- Austria
- Prior art keywords
- probnp
- human
- elisa assay
- purified
- specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7019—Ischaemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/300,733 US20040096919A1 (en) | 2002-11-18 | 2002-11-18 | Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP |
US10/359,051 US20040096920A1 (en) | 2002-11-18 | 2003-02-04 | Polyclonal-monoclonal elisa assay for detecting n-terminus proBNP |
PCT/CA2003/001771 WO2004046194A2 (en) | 2002-11-18 | 2003-11-17 | Polyclonal-monoclonal elisa assay for detecting n-terminus probnp |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE474855T1 true ATE474855T1 (de) | 2010-08-15 |
Family
ID=32297956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03811319T ATE474855T1 (de) | 2002-11-18 | 2003-11-17 | Polyklonaler-monoklonaler-elisa-assay zum nachweis von n-terminalem probnp |
Country Status (6)
Country | Link |
---|---|
US (3) | US20040096919A1 (de) |
EP (3) | EP3450457A1 (de) |
AT (1) | ATE474855T1 (de) |
DE (1) | DE60333471D1 (de) |
ES (2) | ES2568894T3 (de) |
HK (1) | HK1223947A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2511680A1 (en) | 2002-11-18 | 2004-06-03 | Syn X Pharma, Inc. | Polyclonal-monoclonal elisa assay for detecting n-terminus probnp |
US7109023B2 (en) * | 2002-11-18 | 2006-09-19 | Princeton Biomeditech Corporation | Immunossay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients |
US7135329B2 (en) * | 2002-11-18 | 2006-11-14 | Princeton Biomeditech Corporation | Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients |
HUE025169T2 (en) * | 2003-05-12 | 2016-02-29 | Hoffmann La Roche | A method for detecting proBNP with a monoclonal antibody |
DE10355731A1 (de) * | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
AT500800B1 (de) * | 2004-09-08 | 2008-07-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
CA2660691C (en) | 2006-08-04 | 2020-01-14 | Medizinische Hochschule Hannover | Means and methods for assessing the risk of cardiac interventions based on gdf-15 |
EP1884777A1 (de) * | 2006-08-04 | 2008-02-06 | Medizinische Hochschule Hannover | Mittel und Verfahren zur Risikobewertung von Herzeingriffen auf GDF-15-Basis |
AT504942B1 (de) | 2007-03-07 | 2009-08-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
CA2807240A1 (en) | 2010-08-04 | 2012-02-09 | Idexx Laboratories, Inc. | Detection of degradation products of canine nt-probnp |
US8481333B2 (en) | 2011-05-31 | 2013-07-09 | Idexx Laboratories, Inc. | Detection of degradation products of feline NT-proBNP |
CN102323418A (zh) * | 2011-08-31 | 2012-01-18 | 内蒙古科慧生物科技有限责任公司 | B型利钠肽原前体(proBNP)定量测定试剂盒及其检测方法 |
CN102879589A (zh) * | 2012-09-26 | 2013-01-16 | 中国人民解放军总医院 | 一种能稳定保存的人NT-proBNP制剂及其制备方法 |
US11117974B2 (en) | 2015-08-25 | 2021-09-14 | Mochida Pharmaceutical Co., Ltd. | Specifically purified anti-presepsin antibody |
CN108613977B (zh) * | 2018-05-15 | 2021-02-26 | 绍兴圣康生物科技有限公司 | 一种n末端脑钠肽前体检测试剂盒 |
US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
CN114207444A (zh) | 2019-08-13 | 2022-03-18 | 挪威金田有限公司 | 用于NT-proBNP定量的高灵敏度颗粒增强测定 |
CN111848775B (zh) * | 2020-08-05 | 2022-03-11 | 武汉生之源生物科技股份有限公司 | 一种NT-proBNP重组蛋白的保存液及其制备方法 |
WO2023052642A1 (en) | 2021-10-01 | 2023-04-06 | Gentian As | Novel method for determining a concentration of n-terminal pro-hormone bnp (nt-probnp) in a sample |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9211686D0 (en) * | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
US6117644A (en) * | 1998-06-04 | 2000-09-12 | Ottawa Heart Institute Research Corporation | Predicting and detecting cardiac allograft rejection |
GB9827348D0 (en) * | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
IL144062A0 (en) | 1999-01-29 | 2002-04-21 | Roche Diagnostics Gmbh | METHOD OF IDENTIFYING N-TERMINAL proBNP |
US6960472B2 (en) * | 2002-11-18 | 2005-11-01 | Ottawa Heart Institute Research Corporation | Monoclonal antibodies against N-Terminus proBNP |
CA2511680A1 (en) * | 2002-11-18 | 2004-06-03 | Syn X Pharma, Inc. | Polyclonal-monoclonal elisa assay for detecting n-terminus probnp |
-
2002
- 2002-11-18 US US10/300,733 patent/US20040096919A1/en not_active Abandoned
-
2003
- 2003-02-04 US US10/359,051 patent/US20040096920A1/en not_active Abandoned
- 2003-11-17 ES ES10169301.8T patent/ES2568894T3/es not_active Expired - Lifetime
- 2003-11-17 EP EP18186495.0A patent/EP3450457A1/de active Pending
- 2003-11-17 AT AT03811319T patent/ATE474855T1/de not_active IP Right Cessation
- 2003-11-17 EP EP15203244.7A patent/EP3061769B1/de not_active Expired - Lifetime
- 2003-11-17 EP EP10169301.8A patent/EP2251356B1/de not_active Expired - Lifetime
- 2003-11-17 ES ES15203244.7T patent/ES2688545T3/es not_active Expired - Lifetime
- 2003-11-17 DE DE60333471T patent/DE60333471D1/de not_active Expired - Lifetime
-
2016
- 2016-10-20 HK HK16112137.1A patent/HK1223947A1/zh not_active IP Right Cessation
-
2021
- 2021-05-19 US US17/324,685 patent/US20220099687A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2251356B1 (de) | 2016-03-02 |
EP3061769A1 (de) | 2016-08-31 |
DE60333471D1 (de) | 2010-09-02 |
US20220099687A1 (en) | 2022-03-31 |
ES2568894T3 (es) | 2016-05-05 |
US20040096920A1 (en) | 2004-05-20 |
EP3450457A1 (de) | 2019-03-06 |
EP3061769B1 (de) | 2018-08-01 |
US20040096919A1 (en) | 2004-05-20 |
HK1223947A1 (zh) | 2017-08-11 |
EP2251356A2 (de) | 2010-11-17 |
EP2251356A3 (de) | 2011-08-31 |
ES2688545T3 (es) | 2018-11-05 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |