ATE473985T1 - Tricyclische tetrahydrochinoline mit antibakterieller wirkung - Google Patents
Tricyclische tetrahydrochinoline mit antibakterieller wirkungInfo
- Publication number
- ATE473985T1 ATE473985T1 AT03799056T AT03799056T ATE473985T1 AT E473985 T1 ATE473985 T1 AT E473985T1 AT 03799056 T AT03799056 T AT 03799056T AT 03799056 T AT03799056 T AT 03799056T AT E473985 T1 ATE473985 T1 AT E473985T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydrocinolines
- tricyclic
- antibacterial effect
- antibacterial
- effect
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41668502P | 2002-10-07 | 2002-10-07 | |
| US42718902P | 2002-11-18 | 2002-11-18 | |
| US45762203P | 2003-03-26 | 2003-03-26 | |
| PCT/IB2003/004389 WO2004031195A1 (en) | 2002-10-07 | 2003-10-03 | Tricyclic tetrahydroquinoline antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473985T1 true ATE473985T1 (de) | 2010-07-15 |
Family
ID=32074379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03799056T ATE473985T1 (de) | 2002-10-07 | 2003-10-03 | Tricyclische tetrahydrochinoline mit antibakterieller wirkung |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US7208490B2 (enExample) |
| EP (1) | EP1551849B1 (enExample) |
| JP (1) | JP4009652B2 (enExample) |
| AR (1) | AR041546A1 (enExample) |
| AT (1) | ATE473985T1 (enExample) |
| AU (1) | AU2003264768A1 (enExample) |
| BR (1) | BR0315139A (enExample) |
| CA (1) | CA2500824C (enExample) |
| CY (1) | CY1110821T1 (enExample) |
| DE (1) | DE60333379D1 (enExample) |
| DK (1) | DK1551849T3 (enExample) |
| MX (1) | MXPA05002701A (enExample) |
| PT (1) | PT1551849E (enExample) |
| SI (1) | SI1551849T1 (enExample) |
| TW (1) | TWI295671B (enExample) |
| WO (1) | WO2004031195A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7208490B2 (en) | 2002-10-07 | 2007-04-24 | Pharmacia & Upjohn Company Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| JP2008543739A (ja) * | 2005-05-09 | 2008-12-04 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌剤 |
| DOP2006000268A (es) * | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
| CN101784553A (zh) * | 2007-07-02 | 2010-07-21 | 阿斯利康(瑞典)有限公司 | 3-螺嘧啶三酮-喹啉衍生物及其作为抗菌药物的应用 |
| RU2010105007A (ru) | 2007-07-16 | 2011-08-27 | Астразенека Аб (Se) | Химические соединения |
| AU2009305203B2 (en) * | 2008-10-14 | 2013-03-07 | Entasis Therapeutics Limited | Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections |
| US9040528B2 (en) | 2008-10-14 | 2015-05-26 | Astrazeneca Ab | Chemical compounds 542 |
| WO2010075380A1 (en) * | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| BR112013001138A2 (pt) | 2010-07-16 | 2016-07-05 | Abbvie Inc | ligantes de fosfina para reações catalíticas |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| WO2012009699A2 (en) | 2010-07-16 | 2012-01-19 | Abbott Laboratories | Process for preparing antiviral compounds |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| RU2644250C2 (ru) * | 2012-09-14 | 2018-02-08 | Элизабет ЛЕВИНА | Лекарственное средство с активностью против грамположительных бактерий, микобактерий и грибов |
| US8952149B2 (en) | 2012-09-26 | 2015-02-10 | Zoetis Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| US8889671B2 (en) | 2013-01-23 | 2014-11-18 | Astrazeneca Ab | Compounds and methods for treating bacterial infections |
| JP6156845B2 (ja) * | 2014-03-04 | 2017-07-05 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| EA033459B1 (ru) | 2014-05-29 | 2019-10-31 | Entasis Therapeutics Ltd | Конденсированные спироциклические гетероароматические соединения для лечения бактериальных инфекций |
| WO2017156519A1 (en) | 2016-03-11 | 2017-09-14 | The Board Of Trustees Of The University Of Illinois | Small-molecules active against gram-negative bacteria |
| US11274106B2 (en) | 2017-06-23 | 2022-03-15 | The Board Of Trustees Of The University Of Illinois | Topoisomerase inhibitors with antibacterial and anticancer activity |
| CN108101860B (zh) * | 2018-02-08 | 2021-11-23 | 苏州敬业医药化工有限公司 | 顺式-2，6-二甲基吗啉的制备方法 |
| CN115466212B (zh) * | 2022-10-26 | 2023-09-22 | 河南农业大学 | 一种2-三氟甲基喹啉类化合物及其合成方法和应用 |
| CN118878546B (zh) * | 2024-09-30 | 2025-01-03 | 苏州大学 | 一种螺环巴比妥酸衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011860A (en) | 1986-04-11 | 1991-04-30 | Schering Corporation | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases |
| DE19502178A1 (de) | 1994-01-27 | 1995-08-03 | Hoechst Ag | Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Vorprodukte zur Herstellung von Flüssigkristallen |
| CA2425283A1 (en) | 2000-10-26 | 2002-05-02 | Pfizer Products Inc. | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
| WO2003091252A1 (en) | 2002-04-25 | 2003-11-06 | Bristol-Myers Squibb Company | Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases |
| US7208490B2 (en) | 2002-10-07 | 2007-04-24 | Pharmacia & Upjohn Company Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| MXPA05003774A (es) | 2002-10-10 | 2005-06-08 | Pharmacia & Upjohn Co Llc | Compuestos de 1-aril-dihidropiridona con actividad antimicrobiana. |
-
2003
- 2003-10-02 US US10/677,551 patent/US7208490B2/en not_active Expired - Fee Related
- 2003-10-03 MX MXPA05002701A patent/MXPA05002701A/es active IP Right Grant
- 2003-10-03 CA CA2500824A patent/CA2500824C/en not_active Expired - Fee Related
- 2003-10-03 DE DE60333379T patent/DE60333379D1/de not_active Expired - Lifetime
- 2003-10-03 PT PT03799056T patent/PT1551849E/pt unknown
- 2003-10-03 DK DK03799056.1T patent/DK1551849T3/da active
- 2003-10-03 BR BR0315139-5A patent/BR0315139A/pt not_active IP Right Cessation
- 2003-10-03 WO PCT/IB2003/004389 patent/WO2004031195A1/en not_active Ceased
- 2003-10-03 JP JP2005500077A patent/JP4009652B2/ja not_active Expired - Fee Related
- 2003-10-03 AT AT03799056T patent/ATE473985T1/de active
- 2003-10-03 AU AU2003264768A patent/AU2003264768A1/en not_active Abandoned
- 2003-10-03 EP EP03799056A patent/EP1551849B1/en not_active Expired - Lifetime
- 2003-10-03 SI SI200331869T patent/SI1551849T1/sl unknown
- 2003-10-06 TW TW092127679A patent/TWI295671B/zh not_active IP Right Cessation
- 2003-10-07 AR ARP030103650A patent/AR041546A1/es not_active Application Discontinuation
-
2007
- 2007-03-07 US US11/715,213 patent/US7605157B2/en not_active Expired - Fee Related
-
2009
- 2009-08-28 US US12/549,407 patent/US20100022524A1/en not_active Abandoned
-
2010
- 2010-10-06 CY CY20101100894T patent/CY1110821T1/el unknown
- 2010-12-20 US US12/972,921 patent/US8420646B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7605157B2 (en) | 2009-10-20 |
| AR041546A1 (es) | 2005-05-18 |
| JP4009652B2 (ja) | 2007-11-21 |
| US7208490B2 (en) | 2007-04-24 |
| SI1551849T1 (sl) | 2010-11-30 |
| DK1551849T3 (da) | 2010-10-25 |
| CA2500824C (en) | 2011-03-22 |
| US20070161630A1 (en) | 2007-07-12 |
| EP1551849A1 (en) | 2005-07-13 |
| EP1551849B1 (en) | 2010-07-14 |
| US20110092494A1 (en) | 2011-04-21 |
| CA2500824A1 (en) | 2004-04-15 |
| TWI295671B (en) | 2008-04-11 |
| BR0315139A (pt) | 2005-08-09 |
| WO2004031195A1 (en) | 2004-04-15 |
| PT1551849E (pt) | 2010-09-27 |
| US20040162279A1 (en) | 2004-08-19 |
| AU2003264768A1 (en) | 2004-04-23 |
| JP2006511595A (ja) | 2006-04-06 |
| US20100022524A1 (en) | 2010-01-28 |
| DE60333379D1 (de) | 2010-08-26 |
| CY1110821T1 (el) | 2015-06-10 |
| TW200413394A (en) | 2004-08-01 |
| US8420646B2 (en) | 2013-04-16 |
| MXPA05002701A (es) | 2005-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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