ATE471986T1 - Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemen - Google Patents
Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemenInfo
- Publication number
- ATE471986T1 ATE471986T1 AT01999652T AT01999652T ATE471986T1 AT E471986 T1 ATE471986 T1 AT E471986T1 AT 01999652 T AT01999652 T AT 01999652T AT 01999652 T AT01999652 T AT 01999652T AT E471986 T1 ATE471986 T1 AT E471986T1
- Authority
- AT
- Austria
- Prior art keywords
- interest
- secretion
- homogeneity
- relates
- improvement
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 230000028327 secretion Effects 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 2
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL14011000A IL140110A0 (en) | 2000-12-05 | 2000-12-05 | Improvement of homogeneity and secretion of recombinant proteins in mammalian systems |
| PCT/IL2001/001125 WO2002046430A2 (en) | 2000-12-05 | 2001-12-05 | Improvement of homogeneity and secretion of recombinant proteins in mammalian systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE471986T1 true ATE471986T1 (de) | 2010-07-15 |
Family
ID=11074884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01999652T ATE471986T1 (de) | 2000-12-05 | 2001-12-05 | Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemen |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040115775A1 (de) |
| EP (1) | EP1339855B1 (de) |
| JP (1) | JP2004516830A (de) |
| AT (1) | ATE471986T1 (de) |
| AU (2) | AU2002222454B2 (de) |
| CA (1) | CA2429094A1 (de) |
| CY (1) | CY1110670T1 (de) |
| DE (1) | DE60142446D1 (de) |
| DK (1) | DK1339855T3 (de) |
| ES (1) | ES2346956T3 (de) |
| IL (1) | IL140110A0 (de) |
| PT (1) | PT1339855E (de) |
| SI (1) | SI1339855T1 (de) |
| WO (1) | WO2002046430A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2864810A1 (en) * | 2003-04-18 | 2004-11-04 | Biogen Idec Ma, Inc. | Polymer-conjugated glycosylated neublastin |
| GB0314856D0 (en) | 2003-06-25 | 2003-07-30 | Unitargeting Res As | Protein expression system |
| WO2005030963A1 (en) | 2003-09-26 | 2005-04-07 | Applied Research Systems Ars Holding N.V. | Leader sequences for use in production of proteins |
| US7598059B2 (en) | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
| NZ553420A (en) | 2004-08-19 | 2010-02-26 | Biogen Idec Inc | Refolding transforming growth factor beta family proteins |
| EP2267024B1 (de) * | 2005-06-03 | 2012-05-09 | Ares Trading S.A. | Herstellung von rekombinantem Il-18 bindendem Protein |
| JP2009501522A (ja) * | 2005-07-12 | 2009-01-22 | コドン デバイシズ インコーポレイテッド | 生体触媒工学のための組成物及び方法 |
| TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
| WO2008108344A1 (ja) * | 2007-03-02 | 2008-09-12 | Cellgentech, Inc. | Ｌｃａｔ欠損症の遺伝子治療用細胞並びにこれを産生するのに用いられる複製欠損性レトロウイルスベクター及びプラスミド |
| JP5583005B2 (ja) | 2007-05-01 | 2014-09-03 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 血管新生を増大させるための組成物および方法 |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| US9157097B2 (en) | 2008-09-25 | 2015-10-13 | Proteovec Holding, L.L.C. | Vectors for production of growth hormone |
| WO2010036976A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of antibodies |
| EP2417263B1 (de) | 2009-04-09 | 2015-09-23 | ProteoVec Holding L.L.C. | Herstellung von proteinen unter verwendung von vektoren auf transposonbasis |
| CA2904146C (en) * | 2013-03-08 | 2023-03-21 | Neuclone Biologics Pty Ltd | A cell expression system |
| DK2970456T3 (da) * | 2013-03-14 | 2021-07-05 | Translate Bio Inc | Fremgangsmåder og sammensætninger til levering af mrna-kodede antistoffer |
| JP6836999B2 (ja) | 2015-03-24 | 2021-03-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | アデノ随伴ウイルス変異体及びその使用方法 |
| SG11202009761YA (en) | 2018-04-02 | 2020-10-29 | Pact Pharma Inc | Peptide-mhc compacts |
| CN111304243A (zh) * | 2018-12-12 | 2020-06-19 | 普莱柯生物工程股份有限公司 | 一种高效表达外源蛋白的cho细胞株的构建方法、构建的cho细胞株及其应用 |
| EP3999647A1 (de) * | 2019-07-18 | 2022-05-25 | Lysogene | Zusammensetzungen und verfahren zur behandlung von sanfilippo-syndrom und anderen erkrankungen |
| WO2022042673A1 (zh) * | 2020-08-28 | 2022-03-03 | 江苏恒瑞医药股份有限公司 | 用于降低异源多肽末端异质性的信号肽 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4923805A (en) * | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| FR2619719B1 (fr) * | 1987-09-01 | 1991-05-10 | Sanofi Sa | Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices |
| US5417970A (en) * | 1988-10-21 | 1995-05-23 | Sanofi | Drugs containing a glycosylated interleukin-2 |
| JP4001925B2 (ja) * | 1996-09-13 | 2007-10-31 | トランスカーヨティック セラピーズ インク． | α―ガラクトシダーゼＡ欠損症の治療 |
| IL126562A0 (en) * | 1998-10-14 | 1999-08-17 | Interpharm Lab Ltd | Expression and secretion of icil-1 receptor antagonist type ii |
-
2000
- 2000-12-05 IL IL14011000A patent/IL140110A0/xx unknown
-
2001
- 2001-12-05 US US10/432,196 patent/US20040115775A1/en not_active Abandoned
- 2001-12-05 JP JP2002548147A patent/JP2004516830A/ja active Pending
- 2001-12-05 PT PT01999652T patent/PT1339855E/pt unknown
- 2001-12-05 AU AU2002222454A patent/AU2002222454B2/en not_active Ceased
- 2001-12-05 DE DE60142446T patent/DE60142446D1/de not_active Expired - Lifetime
- 2001-12-05 DK DK01999652.9T patent/DK1339855T3/da active
- 2001-12-05 AT AT01999652T patent/ATE471986T1/de active
- 2001-12-05 AU AU2245402A patent/AU2245402A/xx active Pending
- 2001-12-05 EP EP01999652A patent/EP1339855B1/de not_active Expired - Lifetime
- 2001-12-05 CA CA002429094A patent/CA2429094A1/en not_active Abandoned
- 2001-12-05 SI SI200130972T patent/SI1339855T1/sl unknown
- 2001-12-05 ES ES01999652T patent/ES2346956T3/es not_active Expired - Lifetime
- 2001-12-05 WO PCT/IL2001/001125 patent/WO2002046430A2/en not_active Ceased
-
2004
- 2004-06-02 US US10/858,928 patent/US7282352B2/en not_active Expired - Fee Related
-
2010
- 2010-07-20 CY CY20101100677T patent/CY1110670T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1339855A2 (de) | 2003-09-03 |
| SI1339855T1 (sl) | 2010-08-31 |
| CY1110670T1 (el) | 2015-06-10 |
| AU2245402A (en) | 2002-06-18 |
| PT1339855E (pt) | 2010-07-07 |
| WO2002046430A2 (en) | 2002-06-13 |
| DK1339855T3 (da) | 2010-08-30 |
| AU2002222454B2 (en) | 2007-04-05 |
| CA2429094A1 (en) | 2002-06-13 |
| DE60142446D1 (de) | 2010-08-05 |
| IL140110A0 (en) | 2002-02-10 |
| ES2346956T3 (es) | 2010-10-22 |
| US20040115775A1 (en) | 2004-06-17 |
| EP1339855B1 (de) | 2010-06-23 |
| WO2002046430A3 (en) | 2003-01-03 |
| JP2004516830A (ja) | 2004-06-10 |
| US20060234352A1 (en) | 2006-10-19 |
| US7282352B2 (en) | 2007-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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