ATE49233T1 - Vektoren zur transformation von hefe. - Google Patents
Vektoren zur transformation von hefe.Info
- Publication number
- ATE49233T1 ATE49233T1 AT84104456T AT84104456T ATE49233T1 AT E49233 T1 ATE49233 T1 AT E49233T1 AT 84104456 T AT84104456 T AT 84104456T AT 84104456 T AT84104456 T AT 84104456T AT E49233 T1 ATE49233 T1 AT E49233T1
- Authority
- AT
- Austria
- Prior art keywords
- yeast
- polypeptides
- exogenous
- endorphin
- secretion
- Prior art date
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 3
- 230000009466 transformation Effects 0.000 title abstract 3
- 239000013598 vector Substances 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 8
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 239000002243 precursor Substances 0.000 abstract 3
- 230000028327 secretion Effects 0.000 abstract 2
- 210000005253 yeast cell Anatomy 0.000 abstract 2
- 102400000748 Beta-endorphin Human genes 0.000 abstract 1
- 101800005049 Beta-endorphin Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 101500024092 Homo sapiens Beta-endorphin Proteins 0.000 abstract 1
- 101710089743 Mating factor alpha Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/675—Beta-endorphins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48775383A | 1983-04-22 | 1983-04-22 | |
| EP84104456A EP0123294B1 (de) | 1983-04-22 | 1984-04-19 | Vektoren zur Transformation von Hefe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE49233T1 true ATE49233T1 (de) | 1990-01-15 |
Family
ID=23936984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84104456T ATE49233T1 (de) | 1983-04-22 | 1984-04-19 | Vektoren zur transformation von hefe. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0123294B1 (de) |
| JP (1) | JPS60501140A (de) |
| AT (1) | ATE49233T1 (de) |
| DE (1) | DE3480939D1 (de) |
| IL (1) | IL71615A0 (de) |
| WO (1) | WO1984004330A1 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7198919B1 (en) | 1983-04-25 | 2007-04-03 | Genentech, Inc. | Use of alpha factor sequences in yeast expression systems |
| DE3486216T2 (de) * | 1983-04-25 | 1994-02-17 | Chiron Corp | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren. |
| NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| AU573883B2 (en) * | 1984-07-20 | 1988-06-23 | Celltech Limited | Vectors |
| GB2177095B (en) * | 1984-07-20 | 1988-05-25 | Celltech Ltd | Eucaryotic expression vectors |
| US5187263A (en) * | 1984-10-12 | 1993-02-16 | Zymogenetics, Inc. | Expression of biologically active PDGE analogs in eucaryotic cells |
| EP0487116B1 (de) * | 1984-10-12 | 1999-12-29 | ZymoGenetics, Inc. | Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen |
| US5498600A (en) * | 1984-10-12 | 1996-03-12 | Zymogenetics, Inc. | Biologically active mosaic proteins |
| US5045633A (en) * | 1985-02-25 | 1991-09-03 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| FR2593518B1 (fr) * | 1985-05-02 | 1989-09-08 | Transgene Sa | Vecteurs d'expression et de secretion de l'hirudine par les levures transformees |
| US5821079A (en) * | 1985-05-02 | 1998-10-13 | Transgene S.A. | Vectors for the expression and secretion of hirudin by transformed yeasts |
| US4935350A (en) * | 1985-11-18 | 1990-06-19 | Amgen | Materials and methods for controlling plasmid copy number and stability |
| MY101203A (en) * | 1985-12-12 | 1991-08-17 | Ucp Gen Pharma Ag | Production of thrombin iinhibitors. |
| GB8530631D0 (en) | 1985-12-12 | 1986-01-22 | Ciba Geigy Ag | Thrombin inhibitors |
| US5024941A (en) * | 1985-12-18 | 1991-06-18 | Biotechnica International, Inc. | Expression and secretion vector for yeast containing a glucoamylase signal sequence |
| EP0234862A3 (de) * | 1986-02-28 | 1988-10-05 | Merck & Co. Inc. | Expression rekombinanter Proteine in Hefe |
| EP0234871A3 (de) * | 1986-02-28 | 1988-10-12 | Merck & Co. Inc. | Regulierbare Expression rekombinanter Proteine in Hefe |
| FR2599755B1 (fr) * | 1986-06-10 | 1990-04-20 | Transgene Sa | Bloc d'expression d'une amyloglucosidase dans une levure, levure transformee et procede de preparation d'enzyme |
| DK293787A (da) * | 1986-06-10 | 1987-12-11 | Transgene Sa | Ekspression af en amyloglucosidase |
| IT1196484B (it) * | 1986-07-11 | 1988-11-16 | Sclavo Spa | Vettore ad espressione e secrezione in lieviti,utile per la preparazione di proteine eterologhe |
| CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| US5037743A (en) * | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| WO1996029397A1 (en) | 1995-03-17 | 1996-09-26 | Novo Nordisk A/S | Novel endoglucanases |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| CZ297338B6 (cs) | 1996-03-01 | 2006-11-15 | Novo Nordisk A/S | Peptid potlacující chut k jídlu, farmaceutický prostredek jej obsahující a jeho pouzití |
| JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CZ20032454A3 (en) | 2001-03-22 | 2004-03-17 | Novo Nordisk Health Care Ag | Coagulation factor vii derivative |
| US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ES2376694T3 (es) | 2001-09-27 | 2012-03-16 | Novo Nordisk Health Care Ag | Polipã‰ptidos del factor vii de coagulaciã“n humano. |
| ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
| EP1604008B1 (de) | 2002-09-13 | 2010-12-22 | Cornell Research Foundation, Inc. | Verwendung von mutationen zur verbesserung von aspergillus-phytasen |
| EP1594530A4 (de) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albuminfusionsproteine |
| ATE547519T1 (de) | 2003-09-09 | 2012-03-15 | Novo Nordisk Healthcare Ag | Gerinnungsfaktor-vii-polypeptide |
| DK2275556T3 (da) | 2004-01-17 | 2013-07-08 | Korea Res Inst Of Bioscience | Hurtig fremgangsmåde til screening af translationsfusionspartnere til fremstilling af rekombinante proteiner og translationsfusionpartnere screenet derfra |
| BRPI0609079A2 (pt) | 2005-04-18 | 2010-11-16 | Novo Nordisk As | peptìdeo, composição farmacêutica, método para o tratamento de cáncer, uso de um peptìdeo construto de ácido nucleico, vetor, hospedeiro, e, anticorpo |
| US7575920B2 (en) * | 2005-07-25 | 2009-08-18 | The Gi Company, Inc. | Yeast expression vectors for production of ITF |
| JP5690047B2 (ja) | 2005-09-14 | 2015-03-25 | ノボ ノルディスク ヘルス ケア アーゲー | ヒト凝固第ｖｉｉ因子ポリペプチド |
| US20120107267A1 (en) | 2009-03-11 | 2012-05-03 | Novo Nordisk A/S | Interleukin-21 variants having antagonistic binding to the il-21 receptor |
| US20120282285A1 (en) | 2009-07-17 | 2012-11-08 | Rigshospitalet | Masp isoforms as inhibitors of complement activation |
| JP5931738B2 (ja) | 2009-12-01 | 2016-06-08 | ノヴォ ノルディスク アー／エス | 新規のペプチジルアルファ−ヒドロキシグリシンアルファ−アミド化リアーゼ |
| AU2011222883B2 (en) | 2010-03-05 | 2016-05-26 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| ES2676029T3 (es) | 2012-02-09 | 2018-07-16 | Var2 Pharmaceuticals Aps | Direccionamiento de glicanos de sulfato de condroitina |
| EP2906693A1 (de) | 2012-10-15 | 2015-08-19 | Novo Nordisk Health Care AG | Gerinnungsfaktor-vii-polypeptide |
| CN120060321A (zh) * | 2014-02-28 | 2025-05-30 | 诺和诺德股份有限公司 | 交配因子α原肽变体 |
| EA037848B1 (ru) | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| EP3821244A1 (de) | 2018-07-13 | 2021-05-19 | Varct Diagnostics ApS | Isolierung von zirkulierenden zellen fetalen ursprungs unter verwendung von rekombinantem malaria-protein var2csa |
| WO2022049409A1 (en) | 2020-09-02 | 2022-03-10 | Sia Terragen | Express diagnosticum for sars-cov-2 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411994A (en) * | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
| US4430428A (en) * | 1980-02-05 | 1984-02-07 | The Upjohn Company | Composition of matter and process |
| US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
| US4350764A (en) * | 1980-03-10 | 1982-09-21 | The Regents Of The University Of California | Microbiological synthesis of beta endorphin |
| NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| DK368882A (da) * | 1981-08-25 | 1983-02-26 | Alan John Kingsman | Expessions vektorer |
| EP0116201B1 (de) * | 1983-01-12 | 1992-04-22 | Chiron Corporation | Sekretorische Expression in Eukaryoten |
-
1984
- 1984-04-18 WO PCT/US1984/000601 patent/WO1984004330A1/en not_active Ceased
- 1984-04-18 JP JP59501817A patent/JPS60501140A/ja active Pending
- 1984-04-19 AT AT84104456T patent/ATE49233T1/de not_active IP Right Cessation
- 1984-04-19 DE DE8484104456T patent/DE3480939D1/de not_active Expired - Fee Related
- 1984-04-19 EP EP84104456A patent/EP0123294B1/de not_active Expired - Lifetime
- 1984-04-22 IL IL71615A patent/IL71615A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL71615A0 (en) | 1984-07-31 |
| JPS60501140A (ja) | 1985-07-25 |
| WO1984004330A1 (en) | 1984-11-08 |
| DE3480939D1 (de) | 1990-02-08 |
| EP0123294A1 (de) | 1984-10-31 |
| EP0123294B1 (de) | 1990-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |