ATE459602T1 - Polymorphe von atorvastatin-tert.-butylester und deren verwendung als zwischenprodukte für die herstellung von atorvastatin - Google Patents
Polymorphe von atorvastatin-tert.-butylester und deren verwendung als zwischenprodukte für die herstellung von atorvastatinInfo
- Publication number
- ATE459602T1 ATE459602T1 AT05729986T AT05729986T ATE459602T1 AT E459602 T1 ATE459602 T1 AT E459602T1 AT 05729986 T AT05729986 T AT 05729986T AT 05729986 T AT05729986 T AT 05729986T AT E459602 T1 ATE459602 T1 AT E459602T1
- Authority
- AT
- Austria
- Prior art keywords
- atorvastatin
- polymorphs
- production
- tert
- intermediate products
- Prior art date
Links
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005370 atorvastatin Drugs 0.000 title abstract 3
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
- -1 ATORVASTATIN TERT-BUTYL Chemical class 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- FQCKMBLVYCEXJB-MNSAWQCASA-L atorvastatin calcium Chemical compound [Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 FQCKMBLVYCEXJB-MNSAWQCASA-L 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200400112A SI21745A (sl) | 2004-04-09 | 2004-04-09 | Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina |
| PCT/EP2005/003733 WO2005097742A1 (en) | 2004-04-09 | 2005-04-08 | Polymorphs of atorvastatin tert.-butylester and use as intermediates for the preparation of atorvastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE459602T1 true ATE459602T1 (de) | 2010-03-15 |
Family
ID=34963800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05729986T ATE459602T1 (de) | 2004-04-09 | 2005-04-08 | Polymorphe von atorvastatin-tert.-butylester und deren verwendung als zwischenprodukte für die herstellung von atorvastatin |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1732886B1 (e) |
| CN (2) | CN101538238B (e) |
| AT (1) | ATE459602T1 (e) |
| DE (1) | DE602005019703D1 (e) |
| DK (1) | DK1732886T3 (e) |
| EA (1) | EA010166B1 (e) |
| ES (1) | ES2339570T3 (e) |
| HR (1) | HRP20100217T1 (e) |
| NO (1) | NO20065146L (e) |
| PL (1) | PL1732886T3 (e) |
| PT (1) | PT1732886E (e) |
| RS (1) | RS51259B (e) |
| SI (2) | SI21745A (e) |
| UA (1) | UA86059C2 (e) |
| WO (1) | WO2005097742A1 (e) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006313430B2 (en) * | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| US20100260851A1 (en) * | 2007-07-11 | 2010-10-14 | Actavis Group Ptc Ehf | Novel Polymorph of Atorvastatin Calcium and Use Thereof for the Preparation of Amorphous Atorvastatin Calcium |
| WO2009023260A2 (en) * | 2007-08-15 | 2009-02-19 | Teva Pharmaceutical Industries Ltd. | An improved process for synthesis of pyrrole derivative, an intermediate for atorvastatin |
| CN101560177B (zh) * | 2008-04-16 | 2012-10-03 | 北京万全阳光医学技术有限公司 | 一种阿托伐他汀钙的制备方法 |
| SI2413911T1 (sl) | 2009-03-31 | 2014-04-30 | Krka, D.D., Novo Mesto | Progresivna emulzijska kristalizacija |
| CN105693587A (zh) * | 2016-01-15 | 2016-06-22 | 安徽悦康凯悦制药有限公司 | 一种阿托伐他汀钙的生产工艺 |
| CN109280024A (zh) * | 2018-10-09 | 2019-01-29 | 河南师范大学 | 一种高纯度阿托伐他汀叔丁酯的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| EP1341785B1 (en) * | 2000-11-16 | 2008-10-08 | Teva Pharmaceutical Industries Ltd. | Hydrolysis of r(r*,r*)-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide |
| US6476235B2 (en) * | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| CN100430405C (zh) * | 2001-08-16 | 2008-11-05 | 特瓦制药工业有限公司 | 制备他汀类的钙盐形式的方法 |
-
2004
- 2004-04-09 SI SI200400112A patent/SI21745A/sl not_active IP Right Cessation
-
2005
- 2005-04-08 AT AT05729986T patent/ATE459602T1/de active
- 2005-04-08 CN CN2009101368132A patent/CN101538238B/zh not_active Expired - Fee Related
- 2005-04-08 CN CN200580012246XA patent/CN1946687B/zh not_active Expired - Fee Related
- 2005-04-08 WO PCT/EP2005/003733 patent/WO2005097742A1/en active Application Filing
- 2005-04-08 EA EA200601651A patent/EA010166B1/ru not_active IP Right Cessation
- 2005-04-08 DE DE602005019703T patent/DE602005019703D1/de not_active Expired - Lifetime
- 2005-04-08 PT PT05729986T patent/PT1732886E/pt unknown
- 2005-04-08 PL PL05729986T patent/PL1732886T3/pl unknown
- 2005-04-08 DK DK05729986.9T patent/DK1732886T3/da active
- 2005-04-08 RS RSP-2010/0173A patent/RS51259B/sr unknown
- 2005-04-08 EP EP05729986A patent/EP1732886B1/en not_active Expired - Lifetime
- 2005-04-08 HR HR20100217T patent/HRP20100217T1/hr unknown
- 2005-04-08 ES ES05729986T patent/ES2339570T3/es not_active Expired - Lifetime
- 2005-04-08 SI SI200531002T patent/SI1732886T1/sl unknown
- 2005-08-04 UA UAA200610957A patent/UA86059C2/ru unknown
-
2006
- 2006-11-08 NO NO20065146A patent/NO20065146L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005019703D1 (de) | 2010-04-15 |
| CN101538238B (zh) | 2012-08-29 |
| UA86059C2 (ru) | 2009-03-25 |
| EA200601651A1 (ru) | 2007-02-27 |
| RS51259B (sr) | 2010-12-31 |
| ES2339570T3 (es) | 2010-05-21 |
| DK1732886T3 (da) | 2010-06-14 |
| HRP20100217T1 (hr) | 2010-05-31 |
| WO2005097742A1 (en) | 2005-10-20 |
| CN1946687A (zh) | 2007-04-11 |
| EA010166B1 (ru) | 2008-06-30 |
| SI1732886T1 (sl) | 2010-06-30 |
| EP1732886A1 (en) | 2006-12-20 |
| PT1732886E (pt) | 2010-03-12 |
| CN1946687B (zh) | 2011-09-28 |
| EP1732886B1 (en) | 2010-03-03 |
| CN101538238A (zh) | 2009-09-23 |
| SI21745A (sl) | 2005-10-31 |
| NO20065146L (no) | 2006-11-08 |
| PL1732886T3 (pl) | 2010-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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