ATE457971T1 - Derivate von 4-hydroxybutansäure und deren höheren homologen als liganden von g- hydroxybutyrat- (gbh-)rezeptoren, pharmazeutische zusammensetzungen, die diese enthalten, und pharmazeutische anwendungen - Google Patents

Derivate von 4-hydroxybutansäure und deren höheren homologen als liganden von g- hydroxybutyrat- (gbh-)rezeptoren, pharmazeutische zusammensetzungen, die diese enthalten, und pharmazeutische anwendungen

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Publication number
ATE457971T1
ATE457971T1 AT01997471T AT01997471T ATE457971T1 AT E457971 T1 ATE457971 T1 AT E457971T1 AT 01997471 T AT01997471 T AT 01997471T AT 01997471 T AT01997471 T AT 01997471T AT E457971 T1 ATE457971 T1 AT E457971T1
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pharmaceutical
hydroxybutyrate
compositions containing
derivatives
receptors
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AT01997471T
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English (en)
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Jean-Jacques Bourguignon
Michel Maitre
Evelyne Klotz
Martine Schmitt
Serge Gobaille
Jean-Paul Macher
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Univ Louis Pasteur Etablisseme
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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AT01997471T 2000-11-27 2001-11-16 Derivate von 4-hydroxybutansäure und deren höheren homologen als liganden von g- hydroxybutyrat- (gbh-)rezeptoren, pharmazeutische zusammensetzungen, die diese enthalten, und pharmazeutische anwendungen ATE457971T1 (de)

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FR0015291A FR2817256B1 (fr) 2000-11-27 2000-11-27 Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques
PCT/FR2001/003615 WO2002042250A1 (fr) 2000-11-27 2001-11-16 DERIVES DE L'ACIDE 4-HYDROXYBUTANOÏQUE ET DE SON HOMOLOGUE SUPERIEUR COMME LIGANDS DES RECEPTEURS DU η-HYDROXYBUTYRATE (GHB) COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET UTILISATIONS PHARMACEUTIQUES

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US (1) US20050113366A1 (de)
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AT (1) ATE457971T1 (de)
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DE (1) DE60141351D1 (de)
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003055366A (ja) * 2001-08-20 2003-02-26 Shiseido Co Ltd ラクトン誘導体、並びに、これを有効成分とする植物成長調整剤および発根誘導剤
WO2005117854A2 (en) * 2004-05-14 2005-12-15 Emisphere Technologies, Inc. Aryl ketone compounds and compositions for delivering active agents
WO2006012310A2 (en) * 2004-06-25 2006-02-02 Genzyme Corporation Carbazole derivatives for treating polycystic kidney disease
JP2008531709A (ja) 2005-03-01 2008-08-14 ワイス シンノリン化合物および肝臓ｘ受容体調節物質としてのそれらの使用
US8119692B2 (en) 2007-04-02 2012-02-21 Panthera Biopharma Llc Hydroxamic acid derivatives of 4-phenyl 4-hydroxy, 4-phenyl 4-alkoxy and 4-phenyl 4-arylalkoxy butyric acid useful as therapeutic agents for treating anthrax poisoning
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
CN106554334B (zh) * 2015-09-30 2017-09-22 山东省联合农药工业有限公司 一种含内酯环的杀线虫剂及其制备方法和用途
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
KR20210094513A (ko) 2018-11-19 2021-07-29 재즈 파마슈티칼즈 아일랜드 리미티드 알코올-내성 약물 제형
BR112021013766A2 (pt) 2019-03-01 2021-09-21 Flamel Ireland Limited Composições de gama-hidroxibutirato com farmacocinética melhorada no estado alimentado
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2112716A1 (de) * 1971-03-17 1972-10-05 Thomae Gmbh Dr K Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester
DE2112715A1 (de) * 1971-03-17 1972-10-05 Thomae Gmbh Dr K Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone
DE2123858A1 (de) * 1971-05-13 1972-12-07
DE2141926A1 (de) * 1971-08-20 1973-03-01 Thomae Gmbh Dr K Neue 4-(4-biphenylyl)-4-hydroxybuttersaeureamide
DE2205732A1 (de) * 1972-02-08 1973-08-16 Thomae Gmbh Dr K Neue 4-(4-biphenylyl)-butensaeurederivate
US4498809A (en) 1983-06-20 1985-02-12 Farmer Edward J Flow compensated computing controller
DE3535167A1 (de) * 1985-10-02 1987-04-09 Boehringer Mannheim Gmbh Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
PT85110A (en) * 1986-06-23 1987-07-01 Merck Frosst Canada Inc Process for preparing benzenealkanoic acid derivatives useful as leukotriene antagonists
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
DE4009117A1 (de) * 1990-03-19 1991-09-26 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IL111613A0 (en) * 1993-11-12 1995-01-24 Rhone Poulenc Rorer Ltd Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
US5451578A (en) * 1994-08-12 1995-09-19 Merck & Co., Inc. Fibrinogen receptor antagonists

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FR2817256B1 (fr) 2005-07-15
US20050113366A1 (en) 2005-05-26
WO2002042250A1 (fr) 2002-05-30
FR2817256A1 (fr) 2002-05-31
AU2002220792A1 (en) 2002-06-03
WO2002042250B1 (fr) 2002-07-18
DE60141351D1 (de) 2010-04-01
EP1347950A1 (de) 2003-10-01
EP1347950B1 (de) 2010-02-17

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