AU2002220792A1 - Derivatives of 4-hydroxybutanoic acid and of its higher homologue as ligands of gamma-hydroxybutyrate (ghb) receptors, pharmaceutical compositions containing same and pharmaceutical uses - Google Patents

Derivatives of 4-hydroxybutanoic acid and of its higher homologue as ligands of gamma-hydroxybutyrate (ghb) receptors, pharmaceutical compositions containing same and pharmaceutical uses

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Publication number
AU2002220792A1
AU2002220792A1 AU2002220792A AU2079202A AU2002220792A1 AU 2002220792 A1 AU2002220792 A1 AU 2002220792A1 AU 2002220792 A AU2002220792 A AU 2002220792A AU 2079202 A AU2079202 A AU 2079202A AU 2002220792 A1 AU2002220792 A1 AU 2002220792A1
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Australia
Prior art keywords
pharmaceutical
ghb
hydroxybutyrate
gamma
compositions containing
Prior art date
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Abandoned
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AU2002220792A
Inventor
Jean-Jacques Bourguignon
Serge Gobaille
Evelyne Klotz
Jean-Paul Macher
Michel Maitre
Martine Schmitt
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Universite Louis Pasteur Strasbourg I
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Universite Louis Pasteur Strasbourg I
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Application filed by Universite Louis Pasteur Strasbourg I filed Critical Universite Louis Pasteur Strasbourg I
Publication of AU2002220792A1 publication Critical patent/AU2002220792A1/en
Abandoned legal-status Critical Current

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  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention concerns the field of synthesis organic chemistry applied to the pharmaceutical field and concerns novel derivatives of 4-hydroxybutanoic acid and its higher homologue, 5-hydroxypentanoic acid, their crotonic homologues, pharmaceutical compositions containing them and their pharmaceutical uses. Said novel derivatives are capable of binding with gamma-hydroxybutyrate (GHB)-specific receptors and hence capable of exhibiting agonist or antagonist properties, in particular for treating sleep disorders, anxiety and general diseases of the central nervous system. The invention also concerns compounds of general formula (I) wherein the substituents are as defined in the description.
AU2002220792A 2000-11-27 2001-11-16 Derivatives of 4-hydroxybutanoic acid and of its higher homologue as ligands of gamma-hydroxybutyrate (ghb) receptors, pharmaceutical compositions containing same and pharmaceutical uses Abandoned AU2002220792A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0015291A FR2817256B1 (en) 2000-11-27 2000-11-27 DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND ITS SUPERIOR APPROACHES AS GAMMA-HYDROXYBUTYRATE (GHB) RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES
FR0015291 2000-11-27
PCT/FR2001/003615 WO2002042250A1 (en) 2000-11-27 2001-11-16 DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND OF ITS HIGHER HOMOLOGUE AS LIGANDS OF η-HYDROXYBUTYRATE (GHB) RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

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AU2002220792A1 true AU2002220792A1 (en) 2002-06-03

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US (1) US20050113366A1 (en)
EP (1) EP1347950B1 (en)
AT (1) ATE457971T1 (en)
AU (1) AU2002220792A1 (en)
DE (1) DE60141351D1 (en)
FR (1) FR2817256B1 (en)
WO (1) WO2002042250A1 (en)

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UY37341A (en) 2016-07-22 2017-11-30 Flamel Ireland Ltd FORMULATIONS OF GAMMA-MODIFIED RELEASE HYDROXIBUTIRATE WITH IMPROVED PHARMACOCINETICS
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
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US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
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FR2817256B1 (en) 2005-07-15
FR2817256A1 (en) 2002-05-31
EP1347950A1 (en) 2003-10-01
US20050113366A1 (en) 2005-05-26
DE60141351D1 (en) 2010-04-01
WO2002042250B1 (en) 2002-07-18
EP1347950B1 (en) 2010-02-17
WO2002042250A1 (en) 2002-05-30
ATE457971T1 (en) 2010-03-15

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