ATE453389T1 - Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen - Google Patents
Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclenInfo
- Publication number
- ATE453389T1 ATE453389T1 AT03719457T AT03719457T ATE453389T1 AT E453389 T1 ATE453389 T1 AT E453389T1 AT 03719457 T AT03719457 T AT 03719457T AT 03719457 T AT03719457 T AT 03719457T AT E453389 T1 ATE453389 T1 AT E453389T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted aminoalkyl
- certain pharmaceutically
- pharmaceutically valuable
- heterocycles
- valuable substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36841502P | 2002-03-27 | 2002-03-27 | |
| PCT/US2003/009039 WO2003082192A2 (en) | 2002-03-27 | 2003-03-26 | Certain pharmaceutically useful substituted aminoalkyl heterocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453389T1 true ATE453389T1 (de) | 2010-01-15 |
Family
ID=28675483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03719457T ATE453389T1 (de) | 2002-03-27 | 2003-03-26 | Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7323494B2 (enExample) |
| EP (1) | EP1490047B1 (enExample) |
| JP (1) | JP2005521705A (enExample) |
| AT (1) | ATE453389T1 (enExample) |
| AU (1) | AU2003223340A1 (enExample) |
| DE (1) | DE60330758D1 (enExample) |
| ES (1) | ES2337037T3 (enExample) |
| WO (1) | WO2003082192A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509161A (ja) * | 2000-09-18 | 2004-03-25 | グラクソ グループ リミテッド | Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体 |
| AU2003220521A1 (en) * | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Methods of treatment with lxr modulators |
| AU2003220558A1 (en) | 2002-03-27 | 2004-06-03 | Smithkline Beecham Corporation | Amide compounds and methods of using the same |
| JP2005521721A (ja) | 2002-03-27 | 2005-07-21 | スミスクライン・ビーチャム・コーポレイション | 酸およびエステル化合物ならびにその使用方法 |
| JP2006512280A (ja) | 2002-03-27 | 2006-04-13 | スミスクライン・ビーチャム・コーポレイション | 化合物および方法 |
| CA2504878A1 (en) * | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| FR2869904B1 (fr) | 2004-05-07 | 2006-07-28 | Fournier S A Sa Lab | Modulateurs des recepteurs lxr |
| IL166149A0 (en) * | 2005-01-05 | 2006-01-15 | Hadasit Med Res Service | Use of ezetimibe and amiodarone in protection against beta-amyloid neurotoxicity |
| ATE544756T1 (de) | 2006-11-30 | 2012-02-15 | Kowa Co | Substituierte carbinolverbindungen |
| EP2248811B1 (en) | 2008-02-29 | 2012-11-14 | Kowa Company, Ltd. | 2-oxochromene derivative |
| US7951822B2 (en) | 2008-03-31 | 2011-05-31 | Kowa Company, Ltd. | 1,3-dihydroisobenzofuran derivatives |
| WO2009133692A1 (ja) | 2008-04-30 | 2009-11-05 | 興和株式会社 | キノリン化合物 |
| EA018584B1 (ru) | 2008-05-29 | 2013-09-30 | Кова Компани, Лтд. | Замещённое карбинольное соединение, содержащее циклический линкер |
| MX2011011281A (es) | 2009-04-29 | 2012-02-22 | Kowa Co | Compuesto de carbinol que tiene un enlazante heterociclico. |
| RU2013115395A (ru) | 2010-09-07 | 2014-10-20 | СНУ Ар энд ДиБи ФАУНДЕЙШН | Сестертерпеновое соединение и его применение |
| KR20240032149A (ko) | 2017-03-03 | 2024-03-08 | 인스피르나, 인크. | 향상된 안정성을 갖는 제제 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0394440B1 (en) | 1987-10-20 | 1994-05-11 | Otsuka Pharmaceutical Co., Ltd. | Phenylcarboxylic acid derivatives |
| US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
| US6316503B1 (en) | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| WO2001060818A1 (en) | 2000-02-14 | 2001-08-23 | Tularik Inc. | Lxr modulators |
| JP2004509161A (ja) * | 2000-09-18 | 2004-03-25 | グラクソ グループ リミテッド | Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体 |
| US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| US20030229062A1 (en) * | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| CA2468989A1 (en) * | 2001-12-07 | 2003-06-19 | Daniel M. Schwartz | Treatment for age-related macular degeneration |
| AU2003220558A1 (en) | 2002-03-27 | 2004-06-03 | Smithkline Beecham Corporation | Amide compounds and methods of using the same |
| AU2003220521A1 (en) * | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Methods of treatment with lxr modulators |
| JP2005521721A (ja) | 2002-03-27 | 2005-07-21 | スミスクライン・ビーチャム・コーポレイション | 酸およびエステル化合物ならびにその使用方法 |
| JP2006512280A (ja) * | 2002-03-27 | 2006-04-13 | スミスクライン・ビーチャム・コーポレイション | 化合物および方法 |
| US20050036992A1 (en) * | 2002-12-23 | 2005-02-17 | Irm Llc | Novel use of liver X receptor agonists |
| GB0230177D0 (en) | 2002-12-24 | 2003-02-05 | Karobio Ab | LXR beta crystal |
| EP1635773A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. (a New Jersey corp.) | Combination therapy for the treatment of hypertension |
| EP1635832A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes |
| JP2006528200A (ja) | 2003-07-22 | 2006-12-14 | グラクソ グループ リミテッド | Ｌｘｒアゴニストを用いる治療方法 |
| JP2007500158A (ja) | 2003-07-28 | 2007-01-11 | グラクソ グループ リミテッド | Ｌｘｒアゴニストを用いる炎症性腸疾患の治療方法 |
| WO2005055998A1 (en) | 2003-12-04 | 2005-06-23 | Smithkline Beecham Corporation | Methods of treatment with lxr agonists |
| AU2004298486A1 (en) * | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
| MXPA06014576A (es) | 2004-06-24 | 2007-03-23 | Galapagos Nv | Agonistas de lxr para promover homeostasis osea. |
| CA2572872C (en) | 2004-07-02 | 2013-10-22 | Sankyo Company Limited | Tissue factor production inhibitor |
-
2003
- 2003-03-26 AU AU2003223340A patent/AU2003223340A1/en not_active Abandoned
- 2003-03-26 EP EP03719457A patent/EP1490047B1/en not_active Expired - Lifetime
- 2003-03-26 DE DE60330758T patent/DE60330758D1/de not_active Expired - Lifetime
- 2003-03-26 JP JP2003579735A patent/JP2005521705A/ja active Pending
- 2003-03-26 WO PCT/US2003/009039 patent/WO2003082192A2/en not_active Ceased
- 2003-03-26 ES ES03719457T patent/ES2337037T3/es not_active Expired - Lifetime
- 2003-03-26 US US10/508,822 patent/US7323494B2/en not_active Expired - Lifetime
- 2003-03-26 AT AT03719457T patent/ATE453389T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2337037T3 (es) | 2010-04-20 |
| US20050165045A1 (en) | 2005-07-28 |
| WO2003082192A3 (en) | 2003-12-18 |
| EP1490047B1 (en) | 2009-12-30 |
| EP1490047A4 (en) | 2006-01-04 |
| JP2005521705A (ja) | 2005-07-21 |
| AU2003223340A1 (en) | 2003-10-13 |
| AU2003223340A8 (en) | 2003-10-13 |
| EP1490047A2 (en) | 2004-12-29 |
| WO2003082192A2 (en) | 2003-10-09 |
| US7323494B2 (en) | 2008-01-29 |
| DE60330758D1 (de) | 2010-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |