ATE450274T1 - Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungen - Google Patents
Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungenInfo
- Publication number
- ATE450274T1 ATE450274T1 AT03738319T AT03738319T ATE450274T1 AT E450274 T1 ATE450274 T1 AT E450274T1 AT 03738319 T AT03738319 T AT 03738319T AT 03738319 T AT03738319 T AT 03738319T AT E450274 T1 ATE450274 T1 AT E450274T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxypropymethacrylamide
- conjugates
- nuclide activation
- methacrylate copolymers
- anticancer compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
- A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02255107 | 2002-07-22 | ||
PCT/GB2003/002919 WO2004009136A2 (en) | 2002-07-22 | 2003-07-04 | Conjugates of n-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE450274T1 true ATE450274T1 (de) | 2009-12-15 |
Family
ID=30470320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03738319T ATE450274T1 (de) | 2002-07-22 | 2003-07-04 | Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US7662360B2 (de) |
EP (1) | EP1534347B1 (de) |
JP (1) | JP2006502993A (de) |
CN (2) | CN101524549A (de) |
AT (1) | ATE450274T1 (de) |
AU (2) | AU2003250391A1 (de) |
CA (1) | CA2493252A1 (de) |
DE (1) | DE60330355D1 (de) |
HK (1) | HK1077513A1 (de) |
WO (2) | WO2004009135A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1765403A4 (de) * | 2004-05-10 | 2011-03-30 | Univ Utah Res Found | Kombiniertes aktives und passives targeting von biologisch aktiven wirkstoffen |
EP1797427A4 (de) * | 2004-09-22 | 2009-04-08 | Odyssey Thera Inc | Verfahren zur identifizierung neuer arzneimittel-leads und neuer therapeutischer verwendungen für bekannte arzneimittel |
CN101265331B (zh) * | 2007-03-12 | 2010-10-13 | 中国科学院化学研究所 | Peg改性phpma材料及其制备方法 |
CA2739757C (en) * | 2008-10-07 | 2016-07-05 | Rexahn Pharmaceuticals, Inc. | Hpma - docetaxel or gemcitabine conjugates and uses therefore |
WO2011008863A2 (en) * | 2009-07-14 | 2011-01-20 | Lucia Irene Gonzalez | Stereoisomer peptides and their polymer conjugates for hiv disease |
WO2011059779A2 (en) * | 2009-10-29 | 2011-05-19 | Lucia Irene Gonzalez | Ligand-targeted multi- stereoisomer peptide polymer conjugates and uses thereof |
ES2627026T3 (es) * | 2011-09-05 | 2017-07-26 | Hiroshi Maeda | Sonda molecular fluorescente de tipo polímero |
JP6253008B2 (ja) * | 2013-08-27 | 2017-12-27 | 国立大学法人 筑波大学 | 高分子化ホウ素化合物及びその使用 |
WO2015156385A1 (ja) * | 2014-04-11 | 2015-10-15 | 国立研究開発法人産業技術総合研究所 | ホウ素化合物を内包および外壁に担持するカーボンナノホーン及びその製造方法 |
CZ308742B6 (cs) * | 2015-01-14 | 2021-04-21 | Ústav Organické Chemie A Biochemie Av Čr, V.V.I. | Makromolekulární konjugáty pro izolaci, imobilizaci a vizualizaci proteinů |
CZ308807B6 (cs) * | 2015-01-14 | 2021-06-02 | Ústav Organické Chemie A Biochemie Av Čr, V.V.I. | Makromolekulární konjugáty pro vizualizaci a separaci proteinů a buněk |
CN105503918A (zh) * | 2015-12-08 | 2016-04-20 | 南京林业大学 | 一种含二氧杂戊硼基卟啉锌配合物及其制备方法 |
CN105777790B (zh) * | 2016-05-17 | 2017-11-14 | 南京远淑医药科技有限公司 | 一种邻碳硼烷苯酚衍生物及其制备方法和应用 |
WO2018071767A1 (en) * | 2016-10-14 | 2018-04-19 | University Of Utah Research Foundation | Antibody-polymer-drug conjugates |
CN107163097B (zh) * | 2017-04-20 | 2020-04-14 | 童永彭 | 环磷酸腺苷硼酸络合物及其制备方法,以及抗肿瘤药物和中子俘获治疗的硼剂 |
EP3757137B1 (de) * | 2018-02-20 | 2022-09-07 | Tokyo Institute of Technology | P-borophenylalaninderivat und zusammensetzung damit und kit zur herstellung des derivats und der zusammensetzung |
CN112334158B (zh) * | 2018-06-20 | 2023-10-13 | 国立大学法人弘前大学 | 用于硼中子俘获疗法的能够在短时间内选择性地或局部地靶向肿瘤组织的聚集性硼10药剂 |
EP3852768A4 (de) * | 2018-09-20 | 2022-09-14 | Glyscend, Inc. | Boronsäurepolymere und verwendungsverfahren |
AU2020348451A1 (en) | 2019-09-20 | 2022-04-21 | Glyscend, Inc. | Substituted phenyl boronic acid containing polymers and methods of use |
JP2021063033A (ja) * | 2019-10-11 | 2021-04-22 | 国立大学法人 東京大学 | 環状ペプチド |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856551A (en) * | 1993-03-12 | 1999-01-05 | The Regents Of The University Of California | Macromolecular structure for boron neutron-capture therapy |
US6180766B1 (en) * | 1993-12-02 | 2001-01-30 | Raymond F. Schinazi | Nucleosides and oligonucleotides containing boron clusters |
JPH07206690A (ja) * | 1994-01-14 | 1995-08-08 | Seitai Kagaku Kenkyusho:Kk | 癌治療薬およびその中間体 |
US6017902A (en) * | 1999-02-25 | 2000-01-25 | Brookhaven Science Associates | Boron containing amino acid compounds and methods for their use |
-
2003
- 2003-07-04 DE DE60330355T patent/DE60330355D1/de not_active Expired - Lifetime
- 2003-07-04 WO PCT/GB2003/002898 patent/WO2004009135A2/en not_active Application Discontinuation
- 2003-07-04 CN CNA2009101184891A patent/CN101524549A/zh active Pending
- 2003-07-04 WO PCT/GB2003/002919 patent/WO2004009136A2/en active Application Filing
- 2003-07-04 AT AT03738319T patent/ATE450274T1/de not_active IP Right Cessation
- 2003-07-04 AU AU2003250391A patent/AU2003250391A1/en not_active Abandoned
- 2003-07-04 CN CNA038207419A patent/CN1678353A/zh active Pending
- 2003-07-04 JP JP2004522288A patent/JP2006502993A/ja active Pending
- 2003-07-04 US US10/521,814 patent/US7662360B2/en not_active Expired - Fee Related
- 2003-07-04 EP EP03738319A patent/EP1534347B1/de not_active Expired - Lifetime
- 2003-07-04 AU AU2003244843A patent/AU2003244843B2/en not_active Ceased
- 2003-07-04 CA CA002493252A patent/CA2493252A1/en not_active Abandoned
-
2005
- 2005-11-22 HK HK05110532.9A patent/HK1077513A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003244843B2 (en) | 2008-06-19 |
DE60330355D1 (de) | 2010-01-14 |
CN1678353A (zh) | 2005-10-05 |
AU2003244843A1 (en) | 2004-02-09 |
AU2003250391A1 (en) | 2004-02-09 |
EP1534347A2 (de) | 2005-06-01 |
WO2004009136A3 (en) | 2004-04-08 |
WO2004009135A3 (en) | 2004-05-06 |
WO2004009136A2 (en) | 2004-01-29 |
US20070258891A1 (en) | 2007-11-08 |
JP2006502993A (ja) | 2006-01-26 |
EP1534347B1 (de) | 2009-12-02 |
HK1077513A1 (en) | 2006-02-17 |
US7662360B2 (en) | 2010-02-16 |
WO2004009135A2 (en) | 2004-01-29 |
CN101524549A (zh) | 2009-09-09 |
CA2493252A1 (en) | 2004-01-29 |
AU2003250391A8 (en) | 2004-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1077513A1 (en) | Conjugates of n-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds | |
ATE507845T1 (de) | Polyacetal-arzneimittelkonjugate als freisetzungssystem | |
ATE296105T1 (de) | Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel | |
DE60224296D1 (de) | Haarpflegezusammensetzungen | |
WO2008076333A8 (en) | Polymer-drug conjugates with tether groups for controlled drug delivery | |
DE60004172D1 (de) | Gcsf konjugate | |
TR200003161T2 (tr) | Poliol-IFN-Beta konjugatları | |
DE50102595D1 (de) | Kosmetisches mittel | |
DE602005004811D1 (de) | Körperpflegezusammensetzungen mit silikonen und dihydroxypropyl-trialkyl-ammoniumsalzen | |
ATE515290T1 (de) | Körperpflegezusammensetzungen mit glycerin und hydroxypropyl-quarternär-ammoniumsalzen | |
WO2006060533A3 (en) | Conjugates of 1, 8-bis-naphthalimides with an antibody | |
DE60323756D1 (de) | Pharmazeutisch aktive oligosaccharid-conjugate | |
TW200716151A (en) | Polymeric derivative of cytidine metabolic antagonist | |
MXPA04004026A (es) | Conjugados polimericos de inhibidores de la proteina quinasa c. | |
ATE538124T1 (de) | Imidazokondensierte tricyclische verbindungen auf thiazoloä4,5-büpyridin-basis und pharmazeutische zusammensetzungen damit | |
GB2436996B8 (en) | Rigid amines | |
MX2009006410A (es) | Conjugados de polimero-oligonucleotido, proteina y/o peptido. | |
ATE491475T1 (de) | Konjugate enthaltend gm-csf und ein polymer | |
TW200740781A (en) | Novel compounds | |
BR0312850A (pt) | Copolìmeros e seu uso em composições de tratamento pessoal | |
CY1106713T1 (el) | Συνδυασμενη θεραπεια εναντιον καρκινωματων η οποια περιλαμβανει παραγωγα υποκαταστημενης ακρυλοϋλ δισταμυσινης και αλκυλιωτικους παραγοντες | |
WO2005027828A3 (en) | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | |
UA42695C2 (uk) | Полімерзв'язаний антрациклін, фармацевтична композиція та проміжна сполука | |
WO2004014350A3 (en) | Polymer conjugates of a local anaesthetic drug | |
ATE307579T1 (de) | Pektin und ascorbinsäure enthaltende zusammensetzungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |