WO2004014350A3 - Polymer conjugates of a local anaesthetic drug - Google Patents
Polymer conjugates of a local anaesthetic drug Download PDFInfo
- Publication number
- WO2004014350A3 WO2004014350A3 PCT/GB2003/003525 GB0303525W WO2004014350A3 WO 2004014350 A3 WO2004014350 A3 WO 2004014350A3 GB 0303525 W GB0303525 W GB 0303525W WO 2004014350 A3 WO2004014350 A3 WO 2004014350A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- aryl
- halogen
- hydrogen
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
- C08G73/1092—Polysuccinimides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003267542A AU2003267542A1 (en) | 2002-08-13 | 2003-08-13 | Polymer conjugates of a local anaesthetic drug |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0218830.8A GB0218830D0 (en) | 2002-08-13 | 2002-08-13 | Anaesthetic conjugate |
GB0218830.8 | 2002-08-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004014350A2 WO2004014350A2 (en) | 2004-02-19 |
WO2004014350A3 true WO2004014350A3 (en) | 2004-10-07 |
Family
ID=9942247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/003525 WO2004014350A2 (en) | 2002-08-13 | 2003-08-13 | Polymer conjugates of a local anaesthetic drug |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003267542A1 (en) |
GB (1) | GB0218830D0 (en) |
WO (1) | WO2004014350A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003267540A1 (en) * | 2002-08-13 | 2004-02-25 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
WO2009054916A2 (en) * | 2007-10-19 | 2009-04-30 | Nektar Therapeutics Al, Corporation | Oligomer conjugates of lidocaine and its derivatives |
CN106310289B (en) * | 2015-06-24 | 2020-10-13 | 天津键凯科技有限公司 | Conjugate of polyethylene glycol and anesthetic and preparation method thereof |
CN107789628B (en) * | 2016-12-29 | 2021-07-23 | 天津键凯科技有限公司 | Application of conjugate of polyethylene glycol and local anesthetic in non-anesthesia analgesia |
WO2019109065A1 (en) * | 2017-12-01 | 2019-06-06 | The Children's Medical Center Corporation | Covalent anesthetic-polymer conjugates for prolonged local anesthesia |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2084871A (en) * | 1980-09-10 | 1982-04-21 | Johansson Johan Alfred Olof | An element containing a therapeutic or palliative agent |
US4636387A (en) * | 1982-06-21 | 1987-01-13 | Research Corporation | Anesthetic polyorganophosphazenes |
US4650771A (en) * | 1983-11-04 | 1987-03-17 | Miles Laboratories, Inc. | Immunogens, antibodies, labeled conjugates, and related derivatives for lidocaine and analogs thereof |
WO2002005800A2 (en) * | 2000-07-17 | 2002-01-24 | Guilford Pharmaceuticals, Inc. | Compositions for sustained release of analgesic agents, and methods of making and using the same |
WO2002080979A2 (en) * | 2001-03-16 | 2002-10-17 | Fresenius Kabi Deutschland Gmbh | Conjugate of hydroxyalkyl starch and an active agent |
WO2004014973A2 (en) * | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
WO2004014841A1 (en) * | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Compounds, pro-drugs and conjugates derived from mexiletine |
-
2002
- 2002-08-13 GB GBGB0218830.8A patent/GB0218830D0/en not_active Ceased
-
2003
- 2003-08-13 AU AU2003267542A patent/AU2003267542A1/en not_active Abandoned
- 2003-08-13 WO PCT/GB2003/003525 patent/WO2004014350A2/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2084871A (en) * | 1980-09-10 | 1982-04-21 | Johansson Johan Alfred Olof | An element containing a therapeutic or palliative agent |
US4636387A (en) * | 1982-06-21 | 1987-01-13 | Research Corporation | Anesthetic polyorganophosphazenes |
US4650771A (en) * | 1983-11-04 | 1987-03-17 | Miles Laboratories, Inc. | Immunogens, antibodies, labeled conjugates, and related derivatives for lidocaine and analogs thereof |
WO2002005800A2 (en) * | 2000-07-17 | 2002-01-24 | Guilford Pharmaceuticals, Inc. | Compositions for sustained release of analgesic agents, and methods of making and using the same |
WO2002080979A2 (en) * | 2001-03-16 | 2002-10-17 | Fresenius Kabi Deutschland Gmbh | Conjugate of hydroxyalkyl starch and an active agent |
WO2004014973A2 (en) * | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
WO2004014841A1 (en) * | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Compounds, pro-drugs and conjugates derived from mexiletine |
Non-Patent Citations (11)
Title |
---|
ARRANZ F ET AL: "ADDUCTS OF SUCCINYLATED DEXTRAN-BENZOCAINE. SYNTHESIS AND CONTROLLED RELEASE BEHAVIOUR", MAKROMOLEKULARE CHEMIE, RAPID COMMUNICATIONS, HUTHIG UND WEPF VERLAG. BASEL, CH, vol. 13, no. 9, 1 September 1992 (1992-09-01), pages 403 - 407, XP000301002 * |
BUCKLIN S E ET AL: "THERAPEUTIC EFFICACY OF A POLYMYXIN B-DEXTRAN 70 CONJUGATE IN EXPERIMENTAL MODEL OF ENDOTOXEMIA", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 39, no. 7, 1 July 1995 (1995-07-01), pages 1462 - 1466, XP000605390, ISSN: 0066-4804 * |
COESSENS V ET AL: "Synthesis of polyglutamine and dextran conjugates of streptomycin with an acid-sensitive drug-carrier linkage", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 38, no. 2, 1 February 1996 (1996-02-01), pages 141 - 150, XP004037399, ISSN: 0168-3659 * |
GIAMMONA G ET AL: "SYNTHESIS OF MACROMOLECULAR PRODRUGS OF PROCAINE HISTAMINE AND ISONIAZID", CHEMICAL & PHARMACEUTICAL BULLETIN (TOKYO), vol. 37, no. 8, 1989, pages 2245 - 2247, XP002244282, ISSN: 0009-2363 * |
GORNER T ET AL: "Lidocaine-loaded biodegradable nanospheres. I. Optimization of the drug incorporation into the polymer matrix", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 57, no. 3, 22 February 1999 (1999-02-22), pages 259 - 268, XP004159028, ISSN: 0168-3659 * |
MCLEOD A D ET AL: "GLUCOCORTICIOD-DEXTRAN CONJUGATES AS POTENTIAL PRODRUGS FOR COLON-SPECIFIC DELIVERY: HYDROLYSIS IN RAT GASTROINTESTINAL TRACT CONTENTS.", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 83, no. 9, 1 September 1994 (1994-09-01), pages 1284 - 1288, XP000465805, ISSN: 0022-3549 * |
NOMURA T ET AL: "Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 52, no. 3, 31 March 1998 (1998-03-31), pages 239 - 252, XP004115435, ISSN: 0168-3659 * |
NURKEEVA ZAURESH S ET AL: "Polymeric complexes of lidocaine hydrochloride with poly(acrylic acid) and poly(2-hydroxyethyl vinyl ether).", JOURNAL OF BIOMATERIALS SCIENCE POLYMER EDITION, vol. 13, no. 7, July 2002 (2002-07-01), pages 759 - 768, XP002244286, ISSN: 0920-5063 * |
ROBERT E D ET AL: "ABSENCE OF SUPER SENSITIVITY TO ACETYL CHOLINE IN INNERVATED MUSCLE SUBJECTED TO A PROLONGED PHARMACOLOGIC NERVE BLOCK", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 174, no. 1, 1970, pages 133 - 140, XP008017395, ISSN: 0022-3565 * |
SCHERLUND M ET AL: "Nonionic cellulose ethers as potential drug delivery systems for periodontal anesthesia", JOURNAL OF COLLOID AND INTERFACE SCIENCE 15 SEP 2000 UNITED STATES, vol. 229, no. 2, 15 September 2000 (2000-09-15), pages 365 - 374, XP001151860, ISSN: 0021-9797 * |
WON C-Y ET AL: "Dextran-estrone conjugate: synthesis and in vitro release study", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 36, no. 4, 1 August 1998 (1998-08-01), pages 327 - 334, XP004145636, ISSN: 0144-8617 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003267542A8 (en) | 2004-02-25 |
WO2004014350A2 (en) | 2004-02-19 |
AU2003267542A1 (en) | 2004-02-25 |
GB0218830D0 (en) | 2002-09-18 |
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