ATE449618T1 - Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln - Google Patents

Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln

Info

Publication number
ATE449618T1
ATE449618T1 AT05777319T AT05777319T ATE449618T1 AT E449618 T1 ATE449618 T1 AT E449618T1 AT 05777319 T AT05777319 T AT 05777319T AT 05777319 T AT05777319 T AT 05777319T AT E449618 T1 ATE449618 T1 AT E449618T1
Authority
AT
Austria
Prior art keywords
high molecular
ultra high
molecular polyethylene
uhmwpe
polyethylene articles
Prior art date
Application number
AT05777319T
Other languages
English (en)
Inventor
Niels Abt
Werner Schneider-Storrer
Original Assignee
Zimmer Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36499465&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE449618(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zimmer Gmbh filed Critical Zimmer Gmbh
Application granted granted Critical
Publication of ATE449618T1 publication Critical patent/ATE449618T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/28Treatment by wave energy or particle radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/16Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505Stabilizers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/24Crosslinking, e.g. vulcanising, of macromolecules
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12Chemical modification
    • C08J7/123Treatment by wave energy or particle radiation
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/04Oxygen-containing compounds
    • C08K5/15Heterocyclic compounds having oxygen in the ring
    • C08K5/151Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04Homopolymers or copolymers of ethene
    • C08L23/06Polyethene
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04Homopolymers or copolymers of ethene
    • C08J2323/06Polyethene
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/0008Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/005Stabilisers against oxidation, heat, light, ozone
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/02Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2207/00Properties characterising the ingredient of the composition
    • C08L2207/06Properties of polyethylene
    • C08L2207/068Ultra high molecular weight polyethylene
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04Homopolymers or copolymers of ethene
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00Crosslinking
    • C08L2312/06Crosslinking by radiation
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2314/00Polymer mixtures characterised by way of preparation
    • C08L2314/02Ziegler natta catalyst
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/26Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
    • Y10T428/269Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension including synthetic resin or polymer layer or component

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT05777319T 2005-08-18 2005-08-18 Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln ATE449618T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2005/008967 WO2007019874A1 (en) 2005-08-18 2005-08-18 Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles

Publications (1)

Publication Number Publication Date
ATE449618T1 true ATE449618T1 (de) 2009-12-15

Family

ID=36499465

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05777319T ATE449618T1 (de) 2005-08-18 2005-08-18 Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln

Country Status (9)

Country Link
US (6) US7846376B2 (de)
EP (6) EP2792373B1 (de)
JP (1) JP5314423B2 (de)
AT (1) ATE449618T1 (de)
AU (1) AU2005335669B2 (de)
CA (1) CA2619502C (de)
DE (1) DE602005017949D1 (de)
ES (4) ES2441608T3 (de)
WO (1) WO2007019874A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2513538C (en) * 2003-01-16 2010-08-24 Massachusetts General Hospital Methods for making oxidation resistant polymeric material
ES2441608T3 (es) 2005-08-18 2014-02-05 Zimmer Gmbh Artículos de polietileno de peso molecular ultra-alto y métodos para formar artículos de polietileno de peso molecular ulra-alto
US7923020B2 (en) * 2006-09-29 2011-04-12 Depuy Products, Inc. Composite for implantation in the body of an animal and method for making the same
EP2464195A1 (de) 2007-01-25 2012-06-13 The General Hospital Corporation Verfahren zur Herstellung von oxidationsbeständigem vernetztem Polymermaterial
JP2010529213A (ja) * 2007-03-02 2010-08-26 ザ・ジェネラル・ホスピタル・コーポレイション 酸化防止剤含有ポリマーの架橋
WO2008113388A1 (en) * 2007-03-20 2008-09-25 Plus Orthopedics Ag Oxidation resistant highly-crosslinked uhmwpe
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
AU2013200780B2 (en) * 2007-04-10 2015-01-22 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
AU2014274546B2 (en) * 2007-04-10 2016-06-02 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US20080319137A1 (en) * 2007-04-10 2008-12-25 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US8641959B2 (en) * 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
CA2698258C (en) 2007-09-04 2016-05-17 Smith & Nephew Orthopaedics Ag Ultra high molecular weight polyethylene for bearing surfaces
CA2712559C (en) * 2008-01-30 2015-03-31 Zimmer, Inc. Orthopedic component of low stiffness
EP2291417B1 (de) 2008-05-13 2013-09-25 Smith & Nephew Orthopaedics AG Oxidationsbeständiges hochvernetztes uhmwpe
WO2009158318A1 (en) 2008-06-27 2009-12-30 Zimmer, Inc. Acl accommodating tibial design
GB0812890D0 (en) * 2008-07-11 2008-08-20 Smith & Nephew Orthopaedics Ag Compositions and methods of making compositions
US8133436B2 (en) * 2008-08-05 2012-03-13 Howmedica Osteonics Corp. Polyethylene cross-linked with an anthocyanin
CN102307945B (zh) 2008-11-20 2015-07-01 捷迈有限责任公司 聚乙烯材料
CN102405066B (zh) 2009-02-19 2017-02-15 史密夫和内修整形外科股份公司 产生具有良性身体应答的磨损颗粒的医疗植入物
WO2010096771A2 (en) 2009-02-20 2010-08-26 The General Hospital Corporation Dba High temperature melting
US8771369B2 (en) * 2009-03-31 2014-07-08 Zimmer, Inc. Surface modification of ultrahigh molecular weight polyethylene
EP2427225B8 (de) * 2009-05-04 2017-03-22 Smith & Nephew, Inc Synergistische effekte der vermischung mehrerer zusatzstoffe bei uhmwpe
WO2010135526A2 (en) * 2009-05-20 2010-11-25 The General Hospital Corporation Methods of preventing oxidation
US8968411B2 (en) * 2009-12-17 2015-03-03 Zimmer, Inc. Modular elbow prosthesis
GB0922339D0 (en) 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
WO2012061499A1 (en) 2010-11-03 2012-05-10 Zimmer, Inc. Polymer articles having chemically bonded agents and methods of making the same
US20120109301A1 (en) 2010-11-03 2012-05-03 Zimmer, Inc. Modified Polymeric Materials And Methods Of Modifying Polymeric Materials
WO2012076728A1 (en) 2010-12-10 2012-06-14 Dsm Ip Assets B.V. Hppe member and method of making a hppe member
US8747479B2 (en) 2011-04-26 2014-06-10 Michael A. McShane Tibial component
ITVR20110196A1 (it) * 2011-10-21 2013-04-22 Luigi Costa Metodo per la realizzazione di un dispositivo medicale, quale una protesi, in polietilene
CN102604188B (zh) * 2012-03-02 2014-02-05 中国科学院宁波材料技术与工程研究所 一种抗氧化交联聚合物及其制备方法
US8936647B2 (en) 2012-06-22 2015-01-20 Zimmer, Inc. Elbow prosthesis
US10201374B2 (en) 2012-06-22 2019-02-12 Zimmer, Inc. Assembly tool for a prosthesis
JP6004225B2 (ja) * 2012-09-04 2016-10-05 帝人ナカシマメディカル株式会社 成形品の製造方法
WO2014058003A1 (ja) * 2012-10-11 2014-04-17 国立大学法人京都工芸繊維大学 成形品の製造方法
US10654948B2 (en) 2013-03-13 2020-05-19 Chevron Phillips Chemical Company Lp Radically coupled resins and methods of making and using same
US10577440B2 (en) 2013-03-13 2020-03-03 Chevron Phillips Chemical Company Lp Radically coupled resins and methods of making and using same
WO2015050851A1 (en) 2013-10-01 2015-04-09 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
US10220547B2 (en) 2013-10-17 2019-03-05 The General Hospital Corporation Peroxide cross-linking and high temperature melting
AU2015229947A1 (en) 2014-03-12 2016-10-27 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
EP3166541B1 (de) 2014-07-08 2018-04-25 Zimmer, Inc. Interkondyläre komponente zur verwendung in der knieathroplastie
CA2969751C (en) 2014-12-03 2020-09-22 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
WO2016145025A1 (en) 2015-03-12 2016-09-15 Zimmer, Inc. Tibial implant for use in knee arthroplasty
CZ2015267A3 (cs) * 2015-04-21 2016-11-09 Ústav makromolekulární chemie AV ČR, v. v. i. Směs pro stabilizaci polyethylenu, polyethylen a způsob jeho přípravy, polyethylenové implantáty
BR112018008055A2 (pt) 2015-10-20 2018-10-23 Locus Solutions Llc aparelho, sistema e métodos para crescimento de microorganismos
AU2016352992A1 (en) 2015-11-12 2018-05-24 The General Hospital Corporation Methods of making therapeutic polymeric material
US12115289B2 (en) 2016-02-05 2024-10-15 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
DE102016116597A1 (de) 2016-09-06 2018-03-08 Aesculap Ag Verfahren zur Herstellung eines vernetzten Formkörpers aus UHMWPE
WO2019046243A2 (en) 2017-08-29 2019-03-07 The General Hospital Corporation UV-INITIATED REACTIONS IN POLYMERIC MATERIALS
CN110194889B (zh) * 2018-02-27 2022-11-15 嘉丰工业科技(惠州)有限公司 一种制备抗微生物附着的改性热塑性塑料及产品的方法及用于制备改性热塑性塑料的组合物
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010A (en) * 1858-04-20 Bit-holder
JPS5284258A (en) 1976-01-01 1977-07-13 Toyo Contact Lens Co Ltd Silicone having hydrophilized surface and contact lens consisted of said silicone
CS221405B1 (cs) 1981-12-23 1983-04-29 Ludmila Adamirova Způsob zdravotně nezávadné stabilizace polyolefinů proti degradaci ionizujícím zářením
CS221403B1 (cs) 1981-12-23 1983-04-29 Bretislav Dolezel Způsob zdravotně nezávadné stabilizace polyolefinů proti termooxidační a fotooxidační degradaci
WO1989000755A1 (en) 1986-01-14 1989-01-26 Raychem Corporation Conductive polymer composition
US5308549A (en) 1991-11-12 1994-05-03 Hoffmann-La Roche Inc. Stabilizers for thermo plastic materials
US5282861A (en) 1992-03-11 1994-02-01 Ultramet Open cell tantalum structures for cancellous bone implants and cell and tissue receptors
US5414049A (en) 1993-06-01 1995-05-09 Howmedica Inc. Non-oxidizing polymeric medical implant
US5559167A (en) 1993-07-22 1996-09-24 General Electric Company Gamma irradiated thermoplastics and articles
WO1995006148A1 (en) 1993-08-20 1995-03-02 Smith & Nephew Richards, Inc. Self-reinforced ultra-high molecular weight polyethylene composites
TW317568B (de) 1994-04-13 1997-10-11 Ciba Sc Holding Ag
US20050125074A1 (en) 1995-01-20 2005-06-09 Ronald Salovey Crosslinking of polyethylene for low wear using radiation and thermal treatments
CA2166450C (en) 1995-01-20 2008-03-25 Ronald Salovey Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
US5879398A (en) 1995-02-14 1999-03-09 Zimmer, Inc. Acetabular cup
US5577368A (en) 1995-04-03 1996-11-26 Johnson & Johnson Professional, Inc. Method for improving wear resistance of polymeric bioimplantable components
US6087559A (en) * 1995-06-07 2000-07-11 Pioneer Hi-Bred International, Inc. Plant cells and plants transformed with Streptococcus mutans genes encoding wild-type or mutant glucosyltransferase B enzymes
WO1997014725A1 (fr) 1995-10-18 1997-04-24 Chisso Corporation Composition de (co)polymere d'olefine, procede de production, catalyseur de (co)polymerisation de l'olefine et procede de production de ce catalyseur
EP0864589A4 (de) 1995-12-01 2003-04-02 Chisso Corp Geformte harzgegenstände
US5827104A (en) * 1996-01-11 1998-10-27 Patent Category Corporation Constructional toy pieces
US20020156536A1 (en) 1996-02-13 2002-10-24 Harris William H. Polyethylene hip joint prosthesis with extended range of motion
US8865788B2 (en) 1996-02-13 2014-10-21 The General Hospital Corporation Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices
US8563623B2 (en) 1996-02-13 2013-10-22 The General Hospital Corporation Radiation melt treated ultra high molecular weight polyethylene prosthetic devices
EP1563857A3 (de) 1996-02-13 2008-06-04 Massachusetts Institute Of Technology Bestrahlte und Schmeltz behandelte ultrahoch molekulare Polyethylen Prothesen
US5879400A (en) 1996-02-13 1999-03-09 Massachusetts Institute Of Technology Melt-irradiated ultra high molecular weight polyethylene prosthetic devices
US5753182A (en) 1996-02-14 1998-05-19 Biomet, Inc. Method for reducing the number of free radicals present in ultrahigh molecular weight polyethylene orthopedic components
US5721334A (en) 1996-02-16 1998-02-24 Newyork Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Process for producing ultra-high molecular weight low modulus polyethylene shaped articles via controlled pressure and temperature and compositions and articles produced therefrom
US6087553A (en) 1996-02-26 2000-07-11 Implex Corporation Implantable metallic open-celled lattice/polyethylene composite material and devices
EP2319546A1 (de) 1996-07-09 2011-05-11 Orthopaedic Hospital Vernetzung von Polyethylen für geringen Verschleiss mit Hilfe von Strahlen- und Wärmebehandlung
US6228900B1 (en) 1996-07-09 2001-05-08 The Orthopaedic Hospital And University Of Southern California Crosslinking of polyethylene for low wear using radiation and thermal treatments
GB9617671D0 (en) * 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
US5827904A (en) 1996-09-27 1998-10-27 Hahn; David Medical implant composition
US6017975A (en) * 1996-10-02 2000-01-25 Saum; Kenneth Ashley Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance
AU4986497A (en) 1996-10-15 1998-05-11 Orthopaedic Hospital, The Wear resistant surface-gradient cross-linked polyethylene
US6231804B1 (en) 1997-04-02 2001-05-15 Chisso Corporation Modified olefin (co)polymer composition, process for preparing the same, and modified olefin (co)polymer composition molding
JP4315261B2 (ja) 1998-02-25 2009-08-19 ナカシマメディカル株式会社 人工関節用摺動部材および製造方法
US6692679B1 (en) 1998-06-10 2004-02-17 Depuy Orthopaedics, Inc. Cross-linked molded plastic bearings
WO2000001686A1 (en) 1998-07-06 2000-01-13 Eastman Chemical Company Method of producing vitamin e
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
EP0995449A1 (de) 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate
SE9900519D0 (sv) 1999-02-17 1999-02-17 Lars Lidgren A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
ES2240101T3 (es) 1999-05-27 2005-10-16 Monsanto Company Biomateriales modificados con mimeticos de superoxido dismutasa.
US6245276B1 (en) 1999-06-08 2001-06-12 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6627141B2 (en) 1999-06-08 2003-09-30 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6432349B1 (en) 1999-06-29 2002-08-13 Zimmer, Inc. Process of making an articulating bearing surface
US6184265B1 (en) 1999-07-29 2001-02-06 Depuy Orthopaedics, Inc. Low temperature pressure stabilization of implant component
US6620198B2 (en) 1999-10-07 2003-09-16 Exactech, Inc. Composite bearing inserts for total knee joints
US6664317B2 (en) 2000-02-18 2003-12-16 Ciba Specialty Chemicals Corporation Stabilized gamma irradiated polyolefins
US6391390B1 (en) 2000-03-22 2002-05-21 Basf Corporation Curable coating composition with improved durability
ATE418933T1 (de) 2000-04-27 2009-01-15 Orthopaedic Hospital Oxidationsbeständige und abriebfeste polyethylene fur menschlichen gelenkersatz und verfahren zu deren herstellung
US6503439B1 (en) 2000-06-15 2003-01-07 Albert H. Burstein Process for forming shaped articles of ultra high molecular weight polyethylene suitable for use as a prosthetic device or a component thereof
US6558794B1 (en) 2000-06-26 2003-05-06 Technology Assessment & Transfer, Inc. Ceramic particulate reinforced orthopedic implants
US6818172B2 (en) 2000-09-29 2004-11-16 Depuy Products, Inc. Oriented, cross-linked UHMWPE molding for orthopaedic applications
US7205339B2 (en) 2000-12-12 2007-04-17 Massachusetts General Hospital Selective controlled manipulation of polymers
US6547828B2 (en) 2001-02-23 2003-04-15 Smith & Nephew, Inc. Cross-linked ultra-high molecular weight polyethylene for medical implant use
US20020156436A1 (en) * 2001-04-18 2002-10-24 Jeffrey Kerchner Treatment assembly and method of treatment
US8524884B2 (en) 2001-10-30 2013-09-03 Colorado State University Research Foundation Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest
WO2003049930A1 (en) 2001-12-12 2003-06-19 Depuy Products, Inc. Orthopaedic device and method for making same
JP2005514496A (ja) 2002-01-04 2005-05-19 マサチューセッツ、ゼネラル、ホスピタル 溶融体を下回る温度で調製した残留フリーラジカルが減少した高弾性率架橋ポリエチレン
US7595074B2 (en) 2002-04-05 2009-09-29 University Of Massachusetts Lowell Polymeric antioxidants
AU2003262390A1 (en) 2002-04-19 2003-11-03 Gammatron (Pty) Ltd Method of increasing the hydrostatic stress strength of a polymer
AU2003245420A1 (en) 2002-06-21 2004-01-06 Massachusetts General Hospital Metal back or mesh crosslinking
EP1525258A2 (de) 2002-07-18 2005-04-27 Exxonmobil Chemical Patents Inc. Gegen ultraviolettstrahlung stabilisierte polyolefine
US8337968B2 (en) 2002-09-11 2012-12-25 Boston Scientific Scimed, Inc. Radiation sterilized medical devices comprising radiation sensitive polymers
US6976999B2 (en) 2002-11-19 2005-12-20 Zimmer Technology, Inc. Prosthetic device and method of making the same
CA2513538C (en) 2003-01-16 2010-08-24 Massachusetts General Hospital Methods for making oxidation resistant polymeric material
US6933026B2 (en) * 2003-02-06 2005-08-23 Aradgim Corporation Method to reduce damage caused by irradiation of halogenated polymers
US8021680B2 (en) * 2003-05-02 2011-09-20 Surmodics, Inc. Controlled release bioactive agent delivery device
US6853772B2 (en) 2003-05-13 2005-02-08 3M Innovative Properties Company Fiber grating writing interferometer with continuous wavelength tuning and chirp capability
AT412969B (de) 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
US7214764B2 (en) 2003-06-30 2007-05-08 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
US20040265165A1 (en) * 2003-06-30 2004-12-30 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
JP2005054145A (ja) 2003-08-07 2005-03-03 Mitsubishi Gas Chem Co Inc ガスバリア性(メタ)アクリレート樹脂硬化物および塗料、接着剤、フィルム
US7205051B2 (en) 2003-09-30 2007-04-17 Depuy Products, Inc. Medical implant or medical implant part
AU2005209868B8 (en) 2004-02-03 2010-06-03 The General Hospital Corporation Dba Massachusetts General Hospital Highly crystalline cross-linked oxidation-resistant polyethylene
EP1750614B1 (de) 2004-05-11 2017-09-27 The General Hospital Corporation Verfahren zur herstellung von oxidationsbeständigem polymermaterial
US7384430B2 (en) 2004-06-30 2008-06-10 Depuy Products, Inc. Low crystalline polymeric material for orthopaedic implants and an associated method
US7344672B2 (en) 2004-10-07 2008-03-18 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
GB0422666D0 (en) 2004-10-12 2004-11-10 Benoist Girard Sas Prosthetic acetabular cups
US7335697B2 (en) 2004-12-23 2008-02-26 Depuy Products, Inc. Polymer composition comprising cross-linked polyethylene and methods for making the same
US7435372B2 (en) 2005-03-31 2008-10-14 Zimmer, Inc. Liquid bath annealing of polymers for orthopaedic implants
EP1888136A2 (de) 2005-05-18 2008-02-20 The General Hospital Corporation doing business as Massachusetts General Hospital Hydrogele und hydrogelteilchen
US8034029B2 (en) 2005-05-25 2011-10-11 Palyon Medical (Bvi) Limited Multi-reservoir implantable pump with patient controlled actuation
AU2012203503B2 (en) 2005-08-18 2014-01-30 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
ES2441608T3 (es) 2005-08-18 2014-02-05 Zimmer Gmbh Artículos de polietileno de peso molecular ultra-alto y métodos para formar artículos de polietileno de peso molecular ulra-alto
EP2441782A1 (de) 2005-08-22 2012-04-18 The General Hospital Corporation d/b/a Massachusetts General Hospital Hochkristallines Polyethylen
EP1919983B1 (de) 2005-08-22 2011-10-19 The General Hospital Corporation Dba Massachusetts General Hospital Oxidationsbeständiges homogenisiertes polymermaterial
US20070043137A1 (en) 2005-08-22 2007-02-22 The General Hospital Corporation Dba Massachusetts General Hospital Highly cross-linked and wear-resistant polyethylene prepared below the melt
US20070077268A1 (en) 2005-09-30 2007-04-05 Depuy Products, Inc. Hydrophobic carrier modified implants for beneficial agent delivery
WO2007050985A2 (en) 2005-10-27 2007-05-03 Polnox Corporation Macromolecular antioxidants based on stξrically hindered phenolic phosphites
EP1966293A1 (de) 2005-10-27 2008-09-10 Polnox Corporation Stabilisierte polyolefinzusammensetzungen
US7615075B2 (en) 2005-11-04 2009-11-10 Rush University Medical Center Plastic implant impregnated with a degradation protector
WO2007056561A2 (en) 2005-11-09 2007-05-18 Liquidia Technologies, Inc. Medical device, materials, and methods
US7635725B2 (en) * 2006-02-21 2009-12-22 The Brigham And Women's Hospital, Inc. Crosslinked polymers
US20070232762A1 (en) 2006-03-31 2007-10-04 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
US20070239283A1 (en) 2006-04-11 2007-10-11 Berger Richard A Acetabular cup conversion ring
EP2021094A4 (de) 2006-05-25 2010-02-10 Gen Hospital Corp Antivernetzungsmittel und verfahren zur hemmung der vernetzung injizierbarer hydrogelformulierungen
ITMI20061375A1 (it) 2006-07-14 2008-01-15 Fabio Conteduca Maeriale protesico sintetico a ridotta ossidabilita' e relativo processo di preparazione
JP4902455B2 (ja) 2006-08-01 2012-03-21 東レ東燃機能膜合同会社 ポリオレフィン多層微多孔膜、その製造方法、電池用セパレータ及び電池
DK1891987T3 (da) * 2006-08-25 2010-12-13 Depuy Products Inc Bæremateriale for medicinsk implantat
EP2083981B1 (de) 2006-10-30 2021-10-06 Smith & Nephew Orthopaedics AG Vernetzen von polyethylen oder verwendung von vernetztem polyethylen umfassende verfahren
US7966043B2 (en) 2006-12-09 2011-06-21 Cisco Technology, Inc. Method for creating multiple-input-multiple-output channel with beamforming using signals transmitted from single transmit antenna
EP2464195A1 (de) 2007-01-25 2012-06-13 The General Hospital Corporation Verfahren zur Herstellung von oxidationsbeständigem vernetztem Polymermaterial
US20100190920A1 (en) 2007-02-14 2010-07-29 Anuj Bellare Crosslinked polymers and methods of making the same
JP2010529213A (ja) 2007-03-02 2010-08-26 ザ・ジェネラル・ホスピタル・コーポレイション 酸化防止剤含有ポリマーの架橋
WO2008113388A1 (en) 2007-03-20 2008-09-25 Plus Orthopedics Ag Oxidation resistant highly-crosslinked uhmwpe
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US20080319137A1 (en) 2007-04-10 2008-12-25 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US8641959B2 (en) 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
CA2698258C (en) 2007-09-04 2016-05-17 Smith & Nephew Orthopaedics Ag Ultra high molecular weight polyethylene for bearing surfaces
WO2009045658A1 (en) 2007-10-05 2009-04-09 The Brigham And Women's Hospital, Inc. Crosslinked polymers and methods of making the same
WO2009060043A2 (en) 2007-11-06 2009-05-14 Dsm Ip Assets Bv Process for producing high molecular weight polyethylene
CA2712559C (en) 2008-01-30 2015-03-31 Zimmer, Inc. Orthopedic component of low stiffness
US7806064B2 (en) * 2008-03-12 2010-10-05 Wellman John G Friction reducing pollution control system for marine vehicles
EP2291417B1 (de) 2008-05-13 2013-09-25 Smith & Nephew Orthopaedics AG Oxidationsbeständiges hochvernetztes uhmwpe
GB0812890D0 (en) 2008-07-11 2008-08-20 Smith & Nephew Orthopaedics Ag Compositions and methods of making compositions
CN102307945B (zh) 2008-11-20 2015-07-01 捷迈有限责任公司 聚乙烯材料
EP2427225B8 (de) 2009-05-04 2017-03-22 Smith & Nephew, Inc Synergistische effekte der vermischung mehrerer zusatzstoffe bei uhmwpe
WO2010135526A2 (en) 2009-05-20 2010-11-25 The General Hospital Corporation Methods of preventing oxidation
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
WO2012061499A1 (en) 2010-11-03 2012-05-10 Zimmer, Inc. Polymer articles having chemically bonded agents and methods of making the same
US9370602B2 (en) 2010-12-06 2016-06-21 Zimmer, Inc. Crosslinked polymers including one or more antioxidants, methods for making same and methods for selecting antioxidants
JP5735443B2 (ja) 2012-03-06 2015-06-17 ジンマー ゲーエムベーハー 超高分子量ポリエチレン物品および超高分子量ポリエチレン物品を形成する方法
US10000305B2 (en) 2012-05-11 2018-06-19 The General Hospital Corporation Antioxidant-stabilized joint implants
US9765271B2 (en) 2012-06-27 2017-09-19 James J. Myrick Nanoparticles, compositions, manufacture and applications
WO2015050851A1 (en) 2013-10-01 2015-04-09 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
AU2015229947A1 (en) 2014-03-12 2016-10-27 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
CA2969751C (en) 2014-12-03 2020-09-22 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
JP5969637B2 (ja) 2015-01-30 2016-08-17 ジンマー ゲーエムベーハー 超高分子量ポリエチレン物品および超高分子量ポリエチレン物品を形成する方法
CN107667137A (zh) 2015-03-25 2018-02-06 捷迈有限公司 熔融稳定的超高分子量聚乙烯

Also Published As

Publication number Publication date
EP2277561A1 (de) 2011-01-26
EP2277560B1 (de) 2013-10-09
EP3170515A1 (de) 2017-05-24
ES2334045T3 (es) 2010-03-04
US20070059334A1 (en) 2007-03-15
AU2005335669A1 (en) 2007-02-22
US20140135415A1 (en) 2014-05-15
US20090118390A1 (en) 2009-05-07
CA2619502A1 (en) 2007-02-22
US20170335074A1 (en) 2017-11-23
US8673202B2 (en) 2014-03-18
EP2277561B1 (de) 2012-09-19
US7846376B2 (en) 2010-12-07
EP2792373A1 (de) 2014-10-22
JP5314423B2 (ja) 2013-10-16
ES2509884T3 (es) 2014-10-20
JP2009504283A (ja) 2009-02-05
US11015030B2 (en) 2021-05-25
US8470903B2 (en) 2013-06-25
EP2792373B1 (de) 2017-03-01
WO2007019874A1 (en) 2007-02-22
US20110136933A1 (en) 2011-06-09
US11001680B2 (en) 2021-05-11
ES2441608T3 (es) 2014-02-05
DE602005017949D1 (de) 2010-01-07
EP2172229B1 (de) 2014-07-16
US20110135917A1 (en) 2011-06-09
EP1924299B1 (de) 2009-11-25
ES2396794T3 (es) 2013-02-27
US7863348B2 (en) 2011-01-04
EP2277560A1 (de) 2011-01-26
EP1924299A1 (de) 2008-05-28
CA2619502C (en) 2012-11-20
EP2172229A1 (de) 2010-04-07
AU2005335669B2 (en) 2012-03-15

Similar Documents

Publication Publication Date Title
ATE449618T1 (de) Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln
US9971267B2 (en) Synergistic effects on blending multiple additives in UHMWPE
Oral et al. Radiation cross-linking in ultra-high molecular weight polyethylene for orthopaedic applications
US9889224B2 (en) Spatial control of additives by high temperature
US8586667B2 (en) Oxidation resistant highly-crosslinked UHMWPE
US10000305B2 (en) Antioxidant-stabilized joint implants
JP2009504897A5 (de)
WO2004064618A3 (en) Methods for making oxidation resistant polymeric material
WO2005110276A8 (en) Methods for making oxidation resistant polymeric material
US20100144930A1 (en) Oxidation resistant highly-crosslinked uhmwpe
ES2271074T3 (es) Tratamiento con un fluido supercritico de una preforma irradiada de un soporte protesico de polietileno.
ATE539710T1 (de) Anteriores hybrid-implantat
JP2010516517A5 (de)
DE60011243D1 (de) Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat
AU6108301A (en) Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them
MX2007005743A (es) Composiciones de polimero de poliester y copolimero que contienen particulas de titanio metalico.
EP2272542A3 (de) Vernetztes ultrahochmolekulares Polyethylen zur Verwendung als medizinisches Implantat
WO2016153925A8 (en) Melt-stabilized ultra high molecular weight polyethylene
ATE491478T1 (de) Gelenkeoberflächematerialen zur herstellung von medizinische implantate
US20140024736A1 (en) Polymer articles having chemically bonded agents and methods of making the same
Oral et al. High vitamin E content, impact resistant UHMWPE blend without loss of wear resistance
WO2007140557A3 (en) Prosthesis for anastomosis
EP1779876A2 (de) Orthopaedischer Gelenkoberfläche
WO2006041940A3 (en) Compositions having improved osteogenesis and methods for making and using same
ATE398664T1 (de) Verfahren zur herstellung eines multifunktionalen additivs und dessen verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties