ATE448788T1 - Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen - Google Patents
Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungenInfo
- Publication number
- ATE448788T1 ATE448788T1 AT04778892T AT04778892T ATE448788T1 AT E448788 T1 ATE448788 T1 AT E448788T1 AT 04778892 T AT04778892 T AT 04778892T AT 04778892 T AT04778892 T AT 04778892T AT E448788 T1 ATE448788 T1 AT E448788T1
- Authority
- AT
- Austria
- Prior art keywords
- methylene
- vitamin
- inflammatory bowel
- bowel disease
- compounds
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 3
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001934 delay Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/680,881 US7704980B2 (en) | 2003-10-08 | 2003-10-08 | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| PCT/US2004/023586 WO2005039592A1 (en) | 2003-10-08 | 2004-07-23 | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin d compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE448788T1 true ATE448788T1 (de) | 2009-12-15 |
Family
ID=34422197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04778892T ATE448788T1 (de) | 2003-10-08 | 2004-07-23 | Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7704980B2 (enExample) |
| EP (1) | EP1673095B1 (enExample) |
| JP (1) | JP2007508298A (enExample) |
| AT (1) | ATE448788T1 (enExample) |
| AU (1) | AU2004283073B2 (enExample) |
| CA (1) | CA2541991A1 (enExample) |
| DE (1) | DE602004024221D1 (enExample) |
| ES (1) | ES2338428T3 (enExample) |
| NZ (1) | NZ546440A (enExample) |
| WO (1) | WO2005039592A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2461815B1 (en) * | 2009-08-03 | 2014-10-22 | Wisconsin Alumni Research Foundation | Method of preventing renal disease and treating symptoms thereof |
| JP5770261B2 (ja) * | 2010-03-23 | 2015-08-26 | ウイスコンシン アラムニ リサーチ ファンデーション | （２０Ｓ）−２−メチレン−１９−ノル−２２−ジメチル−１α，２５−ジヒドロキシビタミンＤ３および（２０Ｒ）−２−メチレン−１９−ノル−２２−ジメチル−１α，２５−ヒドロキシビタミンＤ３ |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| EP2556054B1 (en) * | 2010-03-23 | 2017-09-27 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3 |
| FR2961401B1 (fr) * | 2010-06-17 | 2013-04-05 | Laetitia Mathez | Composition anti-inflammatoire |
| CN102631354B (zh) * | 2011-02-11 | 2015-01-21 | 广东泰禾医药科技有限公司 | 含维生素d3和二甲双胍的药物组合物 |
| EP2714656B1 (en) | 2011-06-03 | 2017-05-03 | Wisconsin Alumni Research Foundation | (22e)-2-methylene-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin d3 derivatives |
| US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
| JP2015522015A (ja) | 2012-06-29 | 2015-08-03 | ウイスコンシン アラムニ リサーチ ファンデーション | 続発性副甲状腺機能亢進症を治療するための２−メチレン−１９−ノル−（２０Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用 |
| US9370527B2 (en) | 2012-12-28 | 2016-06-21 | The Regents Of The University Of Michigan | Amelioration of intestinal fibrosis and treatment of Crohn's disease |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| US20170296558A1 (en) * | 2016-04-18 | 2017-10-19 | Wisconsin Alumni Research Foundation | Use of 2amd and 2md to treat fibrosis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4221961A1 (de) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6989377B2 (en) * | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) * | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| AU6527201A (en) * | 2000-05-31 | 2001-12-11 | Wisconsin Alumni Res Found | 2-ethyl and 2-ethylidene-19-nor-vitamin d compounds |
| JP4022144B2 (ja) * | 2000-09-08 | 2007-12-12 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | １アルファ−ヒドロキシ−２−メチレン−１９−ノル−ホモプレグナカルシフェロール及びその療法的適用 |
| EP1453798B1 (en) * | 2001-12-13 | 2008-10-15 | Wisconsin Alumni Research Foundation | (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
-
2003
- 2003-10-08 US US10/680,881 patent/US7704980B2/en not_active Expired - Fee Related
-
2004
- 2004-07-23 CA CA002541991A patent/CA2541991A1/en not_active Abandoned
- 2004-07-23 NZ NZ546440A patent/NZ546440A/xx not_active IP Right Cessation
- 2004-07-23 WO PCT/US2004/023586 patent/WO2005039592A1/en not_active Ceased
- 2004-07-23 ES ES04778892T patent/ES2338428T3/es not_active Expired - Lifetime
- 2004-07-23 AT AT04778892T patent/ATE448788T1/de not_active IP Right Cessation
- 2004-07-23 DE DE602004024221T patent/DE602004024221D1/de not_active Expired - Lifetime
- 2004-07-23 JP JP2006533831A patent/JP2007508298A/ja not_active Ceased
- 2004-07-23 AU AU2004283073A patent/AU2004283073B2/en not_active Expired
- 2004-07-23 EP EP04778892A patent/EP1673095B1/en not_active Expired - Lifetime
-
2010
- 2010-02-17 US US12/707,358 patent/US20100160267A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004283073B2 (en) | 2010-05-27 |
| EP1673095B1 (en) | 2009-11-18 |
| AU2004283073A1 (en) | 2005-05-06 |
| NZ546440A (en) | 2009-08-28 |
| DE602004024221D1 (de) | 2009-12-31 |
| CA2541991A1 (en) | 2005-05-06 |
| ES2338428T3 (es) | 2010-05-07 |
| EP1673095A1 (en) | 2006-06-28 |
| US7704980B2 (en) | 2010-04-27 |
| WO2005039592A1 (en) | 2005-05-06 |
| JP2007508298A (ja) | 2007-04-05 |
| US20050080059A1 (en) | 2005-04-14 |
| US20100160267A1 (en) | 2010-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |