JP2007508298A - ２−メチレン−１９−ノル−ビタミンｄ化合物を用いた炎症性腸疾患の治療 - Google Patents

２−メチレン−１９−ノル−ビタミンｄ化合物を用いた炎症性腸疾患の治療 Download PDF

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Publication number
JP2007508298A
JP2007508298A JP2006533831A JP2006533831A JP2007508298A JP 2007508298 A JP2007508298 A JP 2007508298A JP 2006533831 A JP2006533831 A JP 2006533831A JP 2006533831 A JP2006533831 A JP 2006533831A JP 2007508298 A JP2007508298 A JP 2007508298A
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Japan
Prior art keywords
hydroxy
compound
group
vitamin
methylene
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Ceased
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JP2006533831A
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English (en)
Japanese (ja)
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JP2007508298A5 (enExample
Inventor
デルーカ，ヘクター・エフ
カントルナ，マルゲリータ
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006533831A 2003-10-08 2004-07-23 ２−メチレン−１９−ノル−ビタミンｄ化合物を用いた炎症性腸疾患の治療 Ceased JP2007508298A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/680,881 US7704980B2 (en) 2003-10-08 2003-10-08 Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds
PCT/US2004/023586 WO2005039592A1 (en) 2003-10-08 2004-07-23 Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin d compounds

Publications (2)

Publication Number Publication Date
JP2007508298A true JP2007508298A (ja) 2007-04-05
JP2007508298A5 JP2007508298A5 (enExample) 2007-05-31

Family

ID=34422197

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006533831A Ceased JP2007508298A (ja) 2003-10-08 2004-07-23 ２−メチレン−１９−ノル−ビタミンｄ化合物を用いた炎症性腸疾患の治療

Country Status (10)

Country Link
US (2) US7704980B2 (enExample)
EP (1) EP1673095B1 (enExample)
JP (1) JP2007508298A (enExample)
AT (1) ATE448788T1 (enExample)
AU (1) AU2004283073B2 (enExample)
CA (1) CA2541991A1 (enExample)
DE (1) DE602004024221D1 (enExample)
ES (1) ES2338428T3 (enExample)
NZ (1) NZ546440A (enExample)
WO (1) WO2005039592A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501049A (ja) * 2009-08-03 2013-01-10 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 腎疾患の予防方法およびその症状を処置する方法
JP2014505079A (ja) * 2011-02-11 2014-02-27 グアンドン タイヘー メディスン サイエンス アンド テクノロジー カンパニー リミテッド ビタミンｄおよびメトホルミン含有医薬組成物
US9205096B2 (en) 2012-06-29 2015-12-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism
US9814736B2 (en) 2014-12-30 2017-11-14 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism
US10369161B2 (en) 2014-12-30 2019-08-06 Wisconsin Alumni Research Foundation Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110237557A1 (en) * 2010-03-23 2011-09-29 Deluca Hector F Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3
US8604009B2 (en) * 2010-03-23 2013-12-10 Wisconsin Alumni Research Foundation (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
FR2961401B1 (fr) * 2010-06-17 2013-04-05 Laetitia Mathez Composition anti-inflammatoire
WO2012166938A2 (en) 2011-06-03 2012-12-06 Wisconsin Alumni Research Foundation (22e)-2-methylene-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin d3 derivatives
US20130295083A1 (en) * 2012-05-02 2013-11-07 Wisconsin Alumni Research Foundation 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes
US9370527B2 (en) 2012-12-28 2016-06-21 The Regents Of The University Of Michigan Amelioration of intestinal fibrosis and treatment of Crohn's disease
WO2017184262A1 (en) * 2016-04-18 2017-10-26 Wisconsin Alumni Research Foundation Use of 2amd and 2md to treat fibrosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020021A1 (en) * 2000-09-08 2002-03-14 Wisconsin Alumni Research Foundation 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
WO2003051828A2 (en) * 2001-12-13 2003-06-26 Wisconsin Alumni Research Foundation (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4221961A1 (de) 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US5981597A (en) * 1995-02-13 1999-11-09 Trustees Of The University Of Pennsylvania Differentiating agents for the treatment of inflammatory intestinal diseases
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) * 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6806262B2 (en) * 2000-05-31 2004-10-19 Wisconsin Alumni Research Foundation 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds
US7259143B2 (en) * 2002-09-05 2007-08-21 Wisconsin Alumni Research Foundation Method of extending the dose range of vitamin D compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020021A1 (en) * 2000-09-08 2002-03-14 Wisconsin Alumni Research Foundation 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications
WO2003051828A2 (en) * 2001-12-13 2003-06-26 Wisconsin Alumni Research Foundation (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501049A (ja) * 2009-08-03 2013-01-10 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 腎疾患の予防方法およびその症状を処置する方法
JP2014505079A (ja) * 2011-02-11 2014-02-27 グアンドン タイヘー メディスン サイエンス アンド テクノロジー カンパニー リミテッド ビタミンｄおよびメトホルミン含有医薬組成物
US9205096B2 (en) 2012-06-29 2015-12-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism
US9717744B2 (en) 2012-06-29 2017-08-01 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to prevent secondary hyperparathyroidism or the symptoms thereof
US10046000B2 (en) 2012-06-29 2018-08-14 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-Dihydroxyvitamin D3 to treat and prevent secondary hyperparathyroidism in a subject having renal failure
US9814736B2 (en) 2014-12-30 2017-11-14 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism
US10369161B2 (en) 2014-12-30 2019-08-06 Wisconsin Alumni Research Foundation Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism

Also Published As

Publication number Publication date
DE602004024221D1 (de) 2009-12-31
AU2004283073A1 (en) 2005-05-06
ES2338428T3 (es) 2010-05-07
US20100160267A1 (en) 2010-06-24
ATE448788T1 (de) 2009-12-15
NZ546440A (en) 2009-08-28
EP1673095B1 (en) 2009-11-18
EP1673095A1 (en) 2006-06-28
WO2005039592A1 (en) 2005-05-06
US7704980B2 (en) 2010-04-27
US20050080059A1 (en) 2005-04-14
CA2541991A1 (en) 2005-05-06
AU2004283073B2 (en) 2010-05-27

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