DE602004024221D1 - Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen - Google Patents

Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen

Info

Publication number
DE602004024221D1
DE602004024221D1 DE602004024221T DE602004024221T DE602004024221D1 DE 602004024221 D1 DE602004024221 D1 DE 602004024221D1 DE 602004024221 T DE602004024221 T DE 602004024221T DE 602004024221 T DE602004024221 T DE 602004024221T DE 602004024221 D1 DE602004024221 D1 DE 602004024221D1
Authority
DE
Germany
Prior art keywords
methylene
vitamin
compounds
endurance
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004024221T
Other languages
German (de)
English (en)
Inventor
Hector F Deluca
Margherita Cantorna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penn State Research Foundation
Wisconsin Alumni Research Foundation
Original Assignee
Penn State Research Foundation
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Research Foundation, Wisconsin Alumni Research Foundation filed Critical Penn State Research Foundation
Publication of DE602004024221D1 publication Critical patent/DE602004024221D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602004024221T 2003-10-08 2004-07-23 Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen Expired - Lifetime DE602004024221D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/680,881 US7704980B2 (en) 2003-10-08 2003-10-08 Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds
PCT/US2004/023586 WO2005039592A1 (en) 2003-10-08 2004-07-23 Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin d compounds

Publications (1)

Publication Number Publication Date
DE602004024221D1 true DE602004024221D1 (de) 2009-12-31

Family

ID=34422197

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004024221T Expired - Lifetime DE602004024221D1 (de) 2003-10-08 2004-07-23 Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen

Country Status (10)

Country Link
US (2) US7704980B2 (enExample)
EP (1) EP1673095B1 (enExample)
JP (1) JP2007508298A (enExample)
AT (1) ATE448788T1 (enExample)
AU (1) AU2004283073B2 (enExample)
CA (1) CA2541991A1 (enExample)
DE (1) DE602004024221D1 (enExample)
ES (1) ES2338428T3 (enExample)
NZ (1) NZ546440A (enExample)
WO (1) WO2005039592A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2764577C (en) * 2009-08-03 2017-12-19 Wisconsin Alumni Research Foundation Method of preventing renal disease and treating symptoms thereof
JP5931845B2 (ja) * 2010-03-23 2016-06-08 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー
EP2556053B1 (en) * 2010-03-23 2015-07-29 Wisconsin Alumni Research Foundation (20s)-2-methylene-19-nor-22-dimethyl-1alpha,25- dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1alpha,25-hydroxyvitamin d3
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
FR2961401B1 (fr) * 2010-06-17 2013-04-05 Laetitia Mathez Composition anti-inflammatoire
CN102631354B (zh) * 2011-02-11 2015-01-21 广东泰禾医药科技有限公司 含维生素d3和二甲双胍的药物组合物
CA2837882C (en) 2011-06-03 2019-03-26 Wisconsin Alumni Research Foundation (22e)-2-methylene-26,27-cyclo-22-dehydro-1.alpha.-hydroxy-19-norvitamin d3 derivatives
US20130295083A1 (en) * 2012-05-02 2013-11-07 Wisconsin Alumni Research Foundation 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes
EP2866811A1 (en) 2012-06-29 2015-05-06 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-(20S)-1 alpha,25-DIHYDROXYVITAMIN D³ TO TREAT SECONDARY HYPERPARATHYROIDISM
US9370527B2 (en) 2012-12-28 2016-06-21 The Regents Of The University Of Michigan Amelioration of intestinal fibrosis and treatment of Crohn's disease
US9539264B2 (en) 2014-12-30 2017-01-10 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics
US10369161B2 (en) 2014-12-30 2019-08-06 Wisconsin Alumni Research Foundation Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism
US20170296558A1 (en) * 2016-04-18 2017-10-19 Wisconsin Alumni Research Foundation Use of 2amd and 2md to treat fibrosis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US5981597A (en) * 1995-02-13 1999-11-09 Trustees Of The University Of Pennsylvania Differentiating agents for the treatment of inflammatory intestinal diseases
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6989377B2 (en) * 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
CA2410880C (en) * 2000-05-31 2009-03-03 Wisconsin Alumni Research Foundation 2-ethyl and 2-ethylidene-19-nor-vitamin d compounds
AU7544501A (en) * 2000-09-08 2002-03-22 Wisconsin Alumni Res Found 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications
EP1453798B1 (en) * 2001-12-13 2008-10-15 Wisconsin Alumni Research Foundation (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
US7259143B2 (en) * 2002-09-05 2007-08-21 Wisconsin Alumni Research Foundation Method of extending the dose range of vitamin D compounds

Also Published As

Publication number Publication date
NZ546440A (en) 2009-08-28
CA2541991A1 (en) 2005-05-06
EP1673095B1 (en) 2009-11-18
US20050080059A1 (en) 2005-04-14
JP2007508298A (ja) 2007-04-05
WO2005039592A1 (en) 2005-05-06
AU2004283073A1 (en) 2005-05-06
EP1673095A1 (en) 2006-06-28
US20100160267A1 (en) 2010-06-24
ES2338428T3 (es) 2010-05-07
US7704980B2 (en) 2010-04-27
ATE448788T1 (de) 2009-12-15
AU2004283073B2 (en) 2010-05-27

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