ATE446299T1 - Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin - Google Patents
Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecinInfo
- Publication number
- ATE446299T1 ATE446299T1 AT06708893T AT06708893T ATE446299T1 AT E446299 T1 ATE446299 T1 AT E446299T1 AT 06708893 T AT06708893 T AT 06708893T AT 06708893 T AT06708893 T AT 06708893T AT E446299 T1 ATE446299 T1 AT E446299T1
- Authority
- AT
- Austria
- Prior art keywords
- ethyl
- hydroxycamptothecine
- producing
- temperature
- hydroxycamptothecin
- Prior art date
Links
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- HHCZNCHGYNRIBP-UHFFFAOYSA-N 1-(2-amino-5-hydroxyphenyl)propan-1-one Chemical compound CCC(=O)C1=CC(O)=CC=C1N HHCZNCHGYNRIBP-UHFFFAOYSA-N 0.000 abstract 1
- IGKWOGMVAOYVSJ-UHFFFAOYSA-N 4-ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10-trione Chemical compound C1=C2C(=O)CCN2C(=O)C2=C1C(CC)(O)C(=O)OC2 IGKWOGMVAOYVSJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65017505P | 2005-02-07 | 2005-02-07 | |
| PCT/FI2006/000034 WO2006082279A1 (en) | 2005-02-07 | 2006-02-06 | Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446299T1 true ATE446299T1 (de) | 2009-11-15 |
Family
ID=36588759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06708893T ATE446299T1 (de) | 2005-02-07 | 2006-02-06 | Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7910737B2 (de) |
| EP (1) | EP1846412B1 (de) |
| JP (1) | JP5133705B2 (de) |
| AT (1) | ATE446299T1 (de) |
| CA (1) | CA2591081C (de) |
| DE (1) | DE602006009901D1 (de) |
| ES (1) | ES2333462T3 (de) |
| PL (1) | PL1846412T3 (de) |
| WO (1) | WO2006082279A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5133705B2 (ja) | 2005-02-07 | 2013-01-30 | フェルミオン オサケ ユキチュア | ７−エチル−１０−ヒドロキシカンプトテシンの製造方法 |
| CA2591071C (en) * | 2005-02-08 | 2014-04-29 | Fermion Oy | Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof |
| CA2591074C (en) * | 2005-02-08 | 2015-01-20 | Fermion Oy | Preparation method |
| TWI375678B (en) * | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
| NZ566807A (en) * | 2005-09-20 | 2011-05-27 | Scinopharm Singapore Pte Ltd | Novel crystal forms of irinotecan hydrochloride |
| AU2008269148B2 (en) * | 2007-06-25 | 2013-02-21 | Scinopharm Taiwan, Ltd. | Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin |
| WO2012032531A1 (en) * | 2010-09-06 | 2012-03-15 | Avra Laboratories Pvt. Ltd. | Process for the manufacture of irinotecan hydrochloride by total synthesis |
| KR101327720B1 (ko) * | 2013-02-15 | 2013-11-11 | 제일약품주식회사 | 이리노테칸의 제조방법 |
| CN107428770B (zh) * | 2014-10-22 | 2019-10-01 | 维瓦西塔斯肿瘤学公司 | 用于喜树碱类似物合成的方法和体系 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US182990A (en) * | 1876-10-10 | Improvement in corner-finish for rooms | ||
| US103309A (en) * | 1870-05-24 | Improvement in machines for burring wool | ||
| US4473692A (en) | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4894456A (en) | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5053512A (en) | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| TW438775B (en) | 1995-04-07 | 2001-06-07 | Pharmacia & Upjohn Co Llc | Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds |
| GEP20043254B (en) | 1998-08-05 | 2004-06-25 | Aventis Pharma Sa | Use of Camptothecin Derivatives with Reduced Gastrointestinal Toxicity |
| TWI245768B (en) | 2001-02-21 | 2005-12-21 | Yakult Honsha Kk | Process for synthesizing camptothecin related compound(s) |
| RU2300535C2 (ru) | 2002-03-01 | 2007-06-10 | Фармация Италия С.П.А. | Полиморфная форма кристаллического гидрохлорида иринотекана, способ ее получения и фармацевтическая композиция на ее основе |
| CA2482712A1 (en) | 2002-04-17 | 2003-10-30 | Pharmacia Corporation | Compounds useful in preparing camptothecin derivatives |
| US20050267141A1 (en) | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
| EP1791846A1 (de) | 2004-08-09 | 2007-06-06 | Shilpa Medicare Limited | Verbessertes verfahren zur zubereitung von irinotecanhydrochloridtrihydrat |
| JP5133705B2 (ja) | 2005-02-07 | 2013-01-30 | フェルミオン オサケ ユキチュア | ７−エチル−１０−ヒドロキシカンプトテシンの製造方法 |
-
2006
- 2006-02-06 JP JP2007553634A patent/JP5133705B2/ja not_active Expired - Fee Related
- 2006-02-06 DE DE602006009901T patent/DE602006009901D1/de not_active Expired - Lifetime
- 2006-02-06 EP EP06708893A patent/EP1846412B1/de not_active Expired - Lifetime
- 2006-02-06 CA CA2591081A patent/CA2591081C/en not_active Expired - Fee Related
- 2006-02-06 US US11/883,576 patent/US7910737B2/en active Active
- 2006-02-06 WO PCT/FI2006/000034 patent/WO2006082279A1/en not_active Ceased
- 2006-02-06 AT AT06708893T patent/ATE446299T1/de not_active IP Right Cessation
- 2006-02-06 ES ES06708893T patent/ES2333462T3/es not_active Expired - Lifetime
- 2006-02-06 PL PL06708893T patent/PL1846412T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7910737B2 (en) | 2011-03-22 |
| US20080103309A1 (en) | 2008-05-01 |
| CA2591081A1 (en) | 2006-08-10 |
| DE602006009901D1 (de) | 2009-12-03 |
| JP5133705B2 (ja) | 2013-01-30 |
| CA2591081C (en) | 2014-10-28 |
| PL1846412T3 (pl) | 2010-03-31 |
| ES2333462T3 (es) | 2010-02-22 |
| EP1846412B1 (de) | 2009-10-21 |
| JP2008529993A (ja) | 2008-08-07 |
| EP1846412A1 (de) | 2007-10-24 |
| WO2006082279A1 (en) | 2006-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |