ATE445405T1 - Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen - Google Patents

Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen

Info

Publication number
ATE445405T1
ATE445405T1 AT02805203T AT02805203T ATE445405T1 AT E445405 T1 ATE445405 T1 AT E445405T1 AT 02805203 T AT02805203 T AT 02805203T AT 02805203 T AT02805203 T AT 02805203T AT E445405 T1 ATE445405 T1 AT E445405T1
Authority
AT
Austria
Prior art keywords
oxidative stress
intracellular levels
glutathione
phase
compounds
Prior art date
Application number
AT02805203T
Other languages
English (en)
Inventor
Xiangqun Gao
Albena Dinkova-Kostova
Paul Talalay
Original Assignee
Brassica Foundation For Chemop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brassica Foundation For Chemop filed Critical Brassica Foundation For Chemop
Application granted granted Critical
Publication of ATE445405T1 publication Critical patent/ATE445405T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02805203T 2001-12-18 2002-12-18 Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen ATE445405T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34027301P 2001-12-18 2001-12-18
PCT/US2002/040457 WO2003051313A2 (en) 2001-12-18 2002-12-18 Prevention and treatment of oxidative stress disorders by glutathione and phase ii detoxification enzymes

Publications (1)

Publication Number Publication Date
ATE445405T1 true ATE445405T1 (de) 2009-10-15

Family

ID=23332637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02805203T ATE445405T1 (de) 2001-12-18 2002-12-18 Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen

Country Status (9)

Country Link
US (3) US7407986B2 (de)
EP (3) EP1474158B1 (de)
JP (1) JP2005536449A (de)
CN (1) CN1620304B (de)
AT (1) ATE445405T1 (de)
AU (1) AU2002357311A1 (de)
CA (1) CA2470583C (de)
DE (1) DE60234052D1 (de)
WO (1) WO2003051313A2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015913A (en) 1996-09-06 2000-01-18 Mars, Incorporated Method for producing fat and/or solids from cocoa beans
CN1620304B (zh) * 2001-12-18 2010-06-23 布拉西卡化学保护研究基金会股份有限公司 通过谷胱甘肽和ii型解毒酶预防和治疗氧化应激症
SI1696958T1 (sl) * 2003-12-22 2007-08-31 Alcon Inc Sredstva za zdravljenje glavkomatozne retinopatije in optične nevropatije
CA2548146A1 (en) * 2003-12-22 2005-07-14 Alcon, Inc. Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration
CN100571696C (zh) * 2005-01-05 2009-12-23 国防教育研究基金会 尿苷二磷酸-葡萄糖醛酸基转化酵素2b(ugt2b)的抑制剂及促进剂
US7744937B2 (en) * 2005-08-09 2010-06-29 Kraft Foods Global Brands Llc Chemoprotectants from crucifer seeds and sprouts
WO2008016095A1 (en) * 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. PREVENTIVE OR REMEDY FOR KERATOCONJUNCTIVAL DISORDERS CONTAINING Nrf2 ACTIVATOR AS THE ACTIVE INGREDIENT
WO2008111497A1 (ja) * 2007-03-08 2008-09-18 Santen Pharmaceutical Co., Ltd. トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
US20080311192A1 (en) * 2007-06-12 2008-12-18 Kraft Foods Holdings, Inc. Enteric-Coated Glucosinolates And Beta-Thioglucosidases
US20080311276A1 (en) * 2007-06-12 2008-12-18 Kraft Foods Holdings, Inc. Production of Glucosinolates from Agricultural By-Products & Waste
ES2764480T3 (es) * 2008-04-29 2020-06-03 Impact Coatings Ab Composiciones de combinación para tratar la enfermedad de Alzheimer y trastornos relacionados con zonisamida y acamprosato
US20090324522A1 (en) * 2008-06-18 2009-12-31 Western Holdings, Llc Skin protectant compositions
US20120108654A1 (en) * 2008-06-30 2012-05-03 The Johns Hopkins University Compositions and methods for the treatment of ocular oxidative stress and retinitis pigmentosa
GB0811992D0 (en) * 2008-07-01 2008-08-06 Mithen Richard Treatment
WO2010084661A1 (ja) * 2009-01-23 2010-07-29 金印株式会社 イソチオシアネート類含有組成物、食品、食品素材、医薬品、化粧品および日用品雑貨類
US8927007B2 (en) 2010-09-17 2015-01-06 Paul Talalay Formulations for treatment with glucosinolates
US10273205B2 (en) 2011-01-03 2019-04-30 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms
US9962361B2 (en) 2011-01-03 2018-05-08 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US10640464B2 (en) 2011-01-03 2020-05-05 The William M. Yarbrough Foundation Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
US11279674B2 (en) 2011-01-03 2022-03-22 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US11407713B2 (en) 2011-01-03 2022-08-09 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US10308599B2 (en) 2011-01-03 2019-06-04 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US10647668B2 (en) 2011-01-03 2020-05-12 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US8933119B2 (en) 2011-01-03 2015-01-13 The William M. Yarbrough Foundation Method for treating phytophotodermatitis
US8865765B2 (en) 2011-01-12 2014-10-21 The William M. Yarbrough Foundation Method for treating eczema
US9532969B2 (en) 2011-02-08 2017-01-03 The William M. Yarbrough Foundation Method for treating psoriasis
JP6009467B2 (ja) 2011-02-22 2016-10-19 コーディル・シード・カンパニー・インコーポレイテッドＣａｕｄｉｌｌ Ｓｅｅｄ Ｃｏｍｐａｎｙ， Ｉｎｃ． 噴霧乾燥ミロシナーゼ、及びイソチオシアネートを製造するための使用
EP2601946A1 (de) 2011-12-06 2013-06-12 Pécsi Tudomànyegyetem Behandlung und Prävention von Erkrankungen in Beziehung mit oxidativer Belastung
CN104622856A (zh) * 2011-10-31 2015-05-20 约翰霍普金斯大学 用于治疗自闭症的方法和组合物
US9949943B2 (en) 2012-07-26 2018-04-24 The William M. Yarbrough Foundation Method for treating neurodegenerative diseases
US9839621B2 (en) 2012-07-26 2017-12-12 The William M. Yarbrough Foundation Method for treating bladder cancer
US10335387B2 (en) 2012-07-26 2019-07-02 The William M. Yarbrough Foundation Method for treating infectious diseases with isothiocyanate functional compounds
US10080734B2 (en) 2012-07-26 2018-09-25 The William M. Yarbrough Foundation Method for treating autism and other neurodevelopmental disorders
US10441561B2 (en) 2012-07-26 2019-10-15 The William M. Yanbrough Foundation Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
US10434081B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Inhibitors of macrophage migration inhibitory factor
US8865772B2 (en) 2012-07-26 2014-10-21 The William M. Yarbrough Foundation Method for treating skin cancer
US10434082B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
ITMI20121774A1 (it) * 2012-10-19 2014-04-20 Placido Bramanti Uso di un fitochimico bioattivato come agente neuroprotettivo per la prevenzione ed il trattamento di patologie correlate al sistema nervoso
CA3153463A1 (en) 2012-10-29 2014-05-08 The University Of North Carolina At Chapel Hill Methods and compositions for treating mucosal tissue disorders
WO2014100361A1 (en) * 2012-12-19 2014-06-26 The Johns Hopkins University Protection from oxidative damage by gene transfer by glutamate cysteine ligase and glutathione synthase
WO2015002279A1 (ja) * 2013-07-03 2015-01-08 味の素株式会社 グルタチオン生成促進用組成物
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
CN110198728A (zh) 2016-11-17 2019-09-03 莱诺翁股份有限公司 用谷胱甘肽组合物治疗呼吸道疾病和感染
DK3710036T3 (da) 2017-11-17 2025-01-13 Renovion Inc Stable ascorbic acid compositions and methods of using the same
US10441578B2 (en) 2018-01-19 2019-10-15 Louis Habash Altering expression level of glutathione S-transferase genes by treating a human subject with a nitroxide
JP2025502856A (ja) 2022-01-04 2025-01-28 レノビオン インコーポレイテッド グルタチオン塩を含む水溶液
EP4580994A1 (de) * 2022-08-30 2025-07-09 Shawn J. Green Zusammensetzungen und verfahren zur verbesserung des stickoxidspiegels im intraoralen, nasalen und/oder nasopharyngealen bereich

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US36784A (en) 1862-10-28 Improvement in separators and smut-mach ines
US5747459A (en) 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
IT1256178B (it) * 1992-11-30 1995-11-29 Lorenzo Ferrari Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
US5411986A (en) 1993-03-12 1995-05-02 The Johns Hopkins University Chemoprotective isothiocyanates
AU7596994A (en) * 1993-11-01 1995-05-18 Free Radical Sciences, Inc. Methods and compositions for retarding the aging process
FR2723588B1 (fr) * 1994-08-12 1996-09-20 Rhone Poulenc Rorer Sa Adenovirus comprenant un gene codant pour la glutathion peroxydase
AU5620598A (en) * 1996-12-31 1998-07-31 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
US6270780B1 (en) * 1997-07-25 2001-08-07 Chesebrough-Pond's Usa Co., Division Of Conopco Cosmetic compositions containing resveratrol
JPH11124311A (ja) * 1997-10-20 1999-05-11 Shiseido Co Ltd 光毒性抑制剤
CN1154484C (zh) * 1998-03-16 2004-06-23 萨默塞特药品有限公司 司来吉兰或去甲基司吉兰在生产治疗创伤、烧伤、光照损害的药物中的用途
CA2239205A1 (en) * 1998-05-29 1999-11-29 Gabrielle Boulianne Extension of lifespan by overexpression of a gene that increases reactive oxygen metabolism
JP3899210B2 (ja) * 1999-08-27 2007-03-28 金印株式会社 グルタチオン−ｓ−トランスフエラーゼの活性誘導物質およびこれを含む食品
AU1784301A (en) * 1999-11-24 2001-06-04 Alticor Inc. Topical skin composition
EP1239826A2 (de) * 1999-12-20 2002-09-18 Cognis France S.A. Kosmetische und/oder pharmazeutische zubereitungen
JP2001316262A (ja) * 2000-02-29 2001-11-13 Santen Pharmaceut Co Ltd 抗酸化剤
MXPA02010866A (es) * 2000-05-05 2003-07-14 Wisconsin Alumni Res Found Composiciones y metodos para proteger celulas durante la quimioterapia y radioterapia contra el cancer.
US6495170B1 (en) 2000-08-16 2002-12-17 N. V. Nutricia Method of increasing the presence of glutathione in cells
CN100522154C (zh) 2000-08-21 2009-08-05 杰德W·费伊 异硫氰酸酯类化合物在制备治疗螺杆菌感染的药物中的用途
CN1620304B (zh) * 2001-12-18 2010-06-23 布拉西卡化学保护研究基金会股份有限公司 通过谷胱甘肽和ii型解毒酶预防和治疗氧化应激症
CN101208079B (zh) * 2005-04-29 2012-07-04 约翰斯霍普金斯大学 抑制紫外光诱导的皮肤癌发生的药物

Also Published As

Publication number Publication date
CN1620304B (zh) 2010-06-23
US20130157965A1 (en) 2013-06-20
US8709406B2 (en) 2014-04-29
AU2002357311A1 (en) 2003-06-30
US7407986B2 (en) 2008-08-05
EP2698153A1 (de) 2014-02-19
EP1474158B1 (de) 2009-10-14
JP2005536449A (ja) 2005-12-02
EP1474158A2 (de) 2004-11-10
EP2138170A3 (de) 2010-06-23
DE60234052D1 (de) 2009-11-26
WO2003051313A2 (en) 2003-06-26
US20090017002A1 (en) 2009-01-15
EP2138170A2 (de) 2009-12-30
CA2470583C (en) 2011-03-15
CN1620304A (zh) 2005-05-25
CA2470583A1 (en) 2003-06-26
EP1474158A4 (de) 2006-09-13
WO2003051313A3 (en) 2003-10-16
US20050063965A1 (en) 2005-03-24
US8303949B2 (en) 2012-11-06

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