ATE445405T1 - Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen - Google Patents

Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen

Info

Publication number
ATE445405T1
ATE445405T1 AT02805203T AT02805203T ATE445405T1 AT E445405 T1 ATE445405 T1 AT E445405T1 AT 02805203 T AT02805203 T AT 02805203T AT 02805203 T AT02805203 T AT 02805203T AT E445405 T1 ATE445405 T1 AT E445405T1
Authority
AT
Austria
Prior art keywords
oxidative stress
intracellular levels
glutathione
phase
compounds
Prior art date
Application number
AT02805203T
Other languages
English (en)
Inventor
Xiangqun Gao
Albena Dinkova-Kostova
Paul Talalay
Original Assignee
Brassica Foundation For Chemop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brassica Foundation For Chemop filed Critical Brassica Foundation For Chemop
Application granted granted Critical
Publication of ATE445405T1 publication Critical patent/ATE445405T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT02805203T 2001-12-18 2002-12-18 Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen ATE445405T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34027301P 2001-12-18 2001-12-18
PCT/US2002/040457 WO2003051313A2 (en) 2001-12-18 2002-12-18 Prevention and treatment of oxidative stress disorders by glutathione and phase ii detoxification enzymes

Publications (1)

Publication Number Publication Date
ATE445405T1 true ATE445405T1 (de) 2009-10-15

Family

ID=23332637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02805203T ATE445405T1 (de) 2001-12-18 2002-12-18 Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen

Country Status (9)

Country Link
US (3) US7407986B2 (de)
EP (3) EP2138170A3 (de)
JP (1) JP2005536449A (de)
CN (1) CN1620304B (de)
AT (1) ATE445405T1 (de)
AU (1) AU2002357311A1 (de)
CA (1) CA2470583C (de)
DE (1) DE60234052D1 (de)
WO (1) WO2003051313A2 (de)

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US11407713B2 (en) 2011-01-03 2022-08-09 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US10273205B2 (en) 2011-01-03 2019-04-30 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms
US10308599B2 (en) 2011-01-03 2019-06-04 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US8865765B2 (en) 2011-01-12 2014-10-21 The William M. Yarbrough Foundation Method for treating eczema
US9532969B2 (en) 2011-02-08 2017-01-03 The William M. Yarbrough Foundation Method for treating psoriasis
JP6009467B2 (ja) 2011-02-22 2016-10-19 コーディル・シード・カンパニー・インコーポレイテッドＣａｕｄｉｌｌ Ｓｅｅｄ Ｃｏｍｐａｎｙ， Ｉｎｃ． 噴霧乾燥ミロシナーゼ、及びイソチオシアネートを製造するための使用
EP2601946A1 (de) 2011-12-06 2013-06-12 Pécsi Tudomànyegyetem Behandlung und Prävention von Erkrankungen in Beziehung mit oxidativer Belastung
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WO2014018874A1 (en) 2012-07-26 2014-01-30 The William M. Yarbrough Foundation Method for treating skin cancer
US9949943B2 (en) 2012-07-26 2018-04-24 The William M. Yarbrough Foundation Method for treating neurodegenerative diseases
US10441561B2 (en) 2012-07-26 2019-10-15 The William M. Yanbrough Foundation Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
US10335387B2 (en) 2012-07-26 2019-07-02 The William M. Yarbrough Foundation Method for treating infectious diseases with isothiocyanate functional compounds
US10434082B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
US9839621B2 (en) 2012-07-26 2017-12-12 The William M. Yarbrough Foundation Method for treating bladder cancer
US10080734B2 (en) 2012-07-26 2018-09-25 The William M. Yarbrough Foundation Method for treating autism and other neurodevelopmental disorders
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Also Published As

Publication number Publication date
EP2698153A1 (de) 2014-02-19
CA2470583A1 (en) 2003-06-26
CN1620304A (zh) 2005-05-25
AU2002357311A1 (en) 2003-06-30
JP2005536449A (ja) 2005-12-02
CA2470583C (en) 2011-03-15
EP1474158A4 (de) 2006-09-13
CN1620304B (zh) 2010-06-23
US8303949B2 (en) 2012-11-06
US20130157965A1 (en) 2013-06-20
EP1474158B1 (de) 2009-10-14
WO2003051313A2 (en) 2003-06-26
US20090017002A1 (en) 2009-01-15
EP2138170A3 (de) 2010-06-23
US8709406B2 (en) 2014-04-29
US20050063965A1 (en) 2005-03-24
DE60234052D1 (de) 2009-11-26
WO2003051313A3 (en) 2003-10-16
EP1474158A2 (de) 2004-11-10
US7407986B2 (en) 2008-08-05
EP2138170A2 (de) 2009-12-30

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