ATE444289T1 - Antagonist des melanin-concentrating-hormone- rezeptors, enthaltend ein benzimidazolderivat als wirkstoff - Google Patents

Antagonist des melanin-concentrating-hormone- rezeptors, enthaltend ein benzimidazolderivat als wirkstoff

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Publication number
ATE444289T1
ATE444289T1 AT03771407T AT03771407T ATE444289T1 AT E444289 T1 ATE444289 T1 AT E444289T1 AT 03771407 T AT03771407 T AT 03771407T AT 03771407 T AT03771407 T AT 03771407T AT E444289 T1 ATE444289 T1 AT E444289T1
Authority
AT
Austria
Prior art keywords
antagonist
benzimidazole derivative
active ingredient
melanin concentrating
diseases
Prior art date
Application number
AT03771407T
Other languages
English (en)
Inventor
Minoru Moriya
Akio Kanatani
Hisashi Iwaasa
Akane Ishihara
Takehiro Fukami
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of ATE444289T1 publication Critical patent/ATE444289T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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AT03771407T 2002-07-30 2003-07-29 Antagonist des melanin-concentrating-hormone- rezeptors, enthaltend ein benzimidazolderivat als wirkstoff ATE444289T1 (de)

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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298567B9 (en) * 2002-08-29 2009-07-23 Temple University - Of The Commonwealth System Of Higher Education Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
ES2337254T3 (es) * 2003-02-14 2010-04-22 Glaxo Group Limited Derivados de carboxamida.
AR045979A1 (es) * 2003-04-28 2005-11-23 Astrazeneca Ab Amidas heterociclicas
BRPI0409949A (pt) * 2003-05-01 2006-04-25 Bristol Myers Squibb Co compostos de pirazol amida aril-substituìda úteis como inibidores de cinase
JP4630871B2 (ja) * 2003-09-22 2011-02-09 ユーロ−セルティーク エス．エイ． 疼痛を治療するのに有用な治療薬
CA2537010A1 (en) * 2003-09-22 2005-04-07 Euro-Celtique S.A. Phenyl - carboxamide compounds useful for treating pain
US7030113B2 (en) 2003-10-02 2006-04-18 Schering Corporation Aminobenzimidazoles as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
WO2005090340A1 (ja) * 2004-03-22 2005-09-29 Banyu Pharmaceutical Co., Ltd. ピペリジン－１－カルボキサミド誘導体
AU2005240942B2 (en) 2004-05-10 2010-08-05 Banyu Pharmaceutical Co., Ltd. Imidazopyridine compound
US7838552B2 (en) 2004-06-04 2010-11-23 Forest Laboratories Holdings Limited Compositions comprising nebivolol
US7803838B2 (en) 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
WO2005123714A1 (en) * 2004-06-16 2005-12-29 7Tm Pharma A/S Quinazoline compounds and their use in mch-related disease
DE602005009021D1 (de) * 2004-12-17 2008-09-25 Lilly Co Eli Neue mch-rezeptorantagonisten
SE0403117D0 (sv) * 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 1
SE0403118D0 (sv) * 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 2
SE0403171D0 (sv) * 2004-12-23 2004-12-23 Astrazeneca Ab New compounds
CN101163478B (zh) 2005-01-25 2013-11-27 幸讬制药公司 用于炎症及免疫相关用途之化合物
DE102005012872A1 (de) * 2005-03-19 2006-09-28 Sanofi-Aventis Deutschland Gmbh Substituierte, bizyklische 8-Pyrrolidino-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102005012873B4 (de) * 2005-03-19 2007-05-03 Sanofi-Aventis Deutschland Gmbh Aminocarbonyl substituierte 8-N-Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP1867341A4 (de) * 2005-03-29 2009-07-29 Banyu Pharma Co Ltd Therapeutisches mittel bei nicht alkoholbedingter fettleber und screening-verfahren für eine in frage kommende arzneiverbindung zur behandlung oder prävention von nicht alkoholbedingter fettleber
DOP2006000210A (es) * 2005-10-04 2007-06-15 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
WO2007047341A2 (en) * 2005-10-12 2007-04-26 Board Of Regents Of The University Of Texas System Peroxisome proliferator-activator receptor delta (ppar delta) and the development of preimplantation embryos
US7749829B2 (en) 2007-05-01 2010-07-06 Freescale Semiconductor, Inc. Step height reduction between SOI and EPI for DSO and BOS integration
SA110310332B1 (ar) * 2009-05-01 2013-12-10 Astrazeneca Ab مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
KR20130041177A (ko) 2010-07-06 2013-04-24 아스트라제네카 아베 치료제 976
UY34194A (es) 2011-07-15 2013-02-28 Astrazeneca Ab ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
CN103864753B (zh) * 2014-02-27 2016-01-20 华东师范大学 含有五元芳杂环结构的抗丙肝化合物及制备方法和用途
CN107108581B (zh) * 2014-08-21 2020-06-23 百时美施贵宝公司 作为强效rock抑制剂的回接苯甲酰胺衍生物
WO2017207340A1 (de) * 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Neue substituierte benzimidazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
CN111417394B (zh) 2017-10-19 2023-11-07 帝人制药株式会社 苯并咪唑衍生物及其用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06759B2 (ja) 1989-09-22 1994-01-05 ファイザー製薬株式会社 新規なベンゾイミダゾール化合物
CA2113817A1 (en) * 1991-08-27 1993-02-04 Jerry R. Colca A method for treatment of metabolic disorders
US5756496A (en) 1994-05-28 1998-05-26 Smithkline Beecham P.L.C. Amide derivatives having 5HT1D-antagonist activity
US20020107195A1 (en) 1998-07-21 2002-08-08 Smithkline Beecham Corporation Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha
US7115750B1 (en) 1999-09-20 2006-10-03 Takeda Pharmaceutical Company Limited Melanin concentrating hormone antagonist
AUPQ309399A0 (en) 1999-09-28 1999-10-21 Fujisawa Pharmaceutical Co., Ltd. Benzothiazoline derivatives
WO2001082925A1 (fr) 2000-04-28 2001-11-08 Takeda Chemical Industries, Ltd. Antagonistes de l'hormone concentrant la melanine
JP2004502423A (ja) 2000-07-05 2004-01-29 シナプティック・ファーマスーティカル・コーポレーション ヒトメラニン濃縮ホルモン受容体（ｍｃｈ１）をコードするｄｎａ及びその使用
MXPA03003002A (es) * 2000-10-05 2004-12-06 Fujisawa Pharmaceutical Co Compuestos de benzamina como inhibidores de la secrecion de la apo b.
WO2002060374A2 (en) * 2001-01-29 2002-08-08 Insight Strategy And Marketing Ltd Benz-1,3-azole derivatives and their uses as heparanase inhibitors
EP1256578B1 (de) 2001-05-11 2006-01-11 Pfizer Products Inc. Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
DE10139416A1 (de) * 2001-08-17 2003-03-06 Aventis Pharma Gmbh Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP2003064056A (ja) * 2001-08-27 2003-03-05 Sankyo Co Ltd アミド誘導体
JP2005519876A (ja) 2001-11-27 2005-07-07 メルク　エンド　カムパニー　インコーポレーテッド ２−アミノキノリン化合物

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AU2003252715A1 (en) 2004-02-16
DE60329513D1 (de) 2009-11-12
AU2003252715B2 (en) 2009-06-04
JP4595542B2 (ja) 2010-12-08
CA2494102A1 (en) 2004-02-05
EP1553089B1 (de) 2009-09-30
JPWO2004011440A1 (ja) 2005-11-24
EP1553089A4 (de) 2007-08-01

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