ATE443777T1 - Methoden und zusammensetzungen zur analyse von ribonukleinsäuren - Google Patents
Methoden und zusammensetzungen zur analyse von ribonukleinsäurenInfo
- Publication number
- ATE443777T1 ATE443777T1 AT05815286T AT05815286T ATE443777T1 AT E443777 T1 ATE443777 T1 AT E443777T1 AT 05815286 T AT05815286 T AT 05815286T AT 05815286 T AT05815286 T AT 05815286T AT E443777 T1 ATE443777 T1 AT E443777T1
- Authority
- AT
- Austria
- Prior art keywords
- probe
- compositions
- methods
- nucleic acid
- analyzing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/963,415 US20060078894A1 (en) | 2004-10-12 | 2004-10-12 | Methods and compositions for analyzing nucleic acids |
PCT/US2005/036799 WO2006042303A2 (en) | 2004-10-12 | 2005-10-12 | Methods and compositions for analyzing ribonucleic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE443777T1 true ATE443777T1 (de) | 2009-10-15 |
Family
ID=36145799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05815286T ATE443777T1 (de) | 2004-10-12 | 2005-10-12 | Methoden und zusammensetzungen zur analyse von ribonukleinsäuren |
Country Status (5)
Country | Link |
---|---|
US (1) | US20060078894A1 (de) |
EP (1) | EP1812599B1 (de) |
AT (1) | ATE443777T1 (de) |
DE (1) | DE602005016828D1 (de) |
WO (1) | WO2006042303A2 (de) |
Families Citing this family (74)
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US20100022414A1 (en) | 2008-07-18 | 2010-01-28 | Raindance Technologies, Inc. | Droplet Libraries |
EP2290069A3 (de) | 2004-05-28 | 2011-08-10 | Asuragen, Inc. | Verfahren und Zusammensetzungen mit MicroRNA |
WO2008073922A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
ES2503742T3 (es) | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ATE540750T1 (de) | 2006-05-11 | 2012-01-15 | Raindance Technologies Inc | Mikrofluidische vorrichtung und verfahren |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US20090023221A1 (en) * | 2006-05-19 | 2009-01-22 | Exigon A/S | Oligonucleotide probes useful for detection and analysis of microrna precursors |
CA2663962A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
EP2061901A2 (de) * | 2006-10-31 | 2009-05-27 | Noxxon Pharma AG | Verfahren zum nachweis eines einzel- oder doppelsträngigen nukleinsäuremoleküls |
US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
EP2104735A2 (de) * | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-21-regulierte gene und pfade als ziele für therapeutische interventionen |
AU2007333106A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-20 regulated genes and pathways as targets for therapeutic intervention |
CN101622349A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-21调节的基因和途径 |
US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US20080274458A1 (en) * | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
EP2167138A2 (de) * | 2007-06-08 | 2010-03-31 | Asuragen, INC. | Mir-34-regulierte gene und pfade als targets für therapeutische intervention |
US8008010B1 (en) | 2007-06-27 | 2011-08-30 | Applied Biosystems, Llc | Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor |
US8389215B2 (en) * | 2007-07-26 | 2013-03-05 | University Of Utah Research Foundation | Non-invasive recovery of RNA and analysis of gene expression in skin |
EP2198050A1 (de) | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon |
US7993831B2 (en) * | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
WO2009052386A1 (en) * | 2007-10-18 | 2009-04-23 | Asuragen, Inc. | Micrornas differentially expressed in lung diseases and uses thereof |
US8357277B2 (en) * | 2007-11-27 | 2013-01-22 | Laboratory Corp. of America Holdings | Enhanced method for detecting and/or quantifying an analyte in a sample |
US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
US20090192114A1 (en) * | 2007-12-21 | 2009-07-30 | Dmitriy Ovcharenko | miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
EP2260110B1 (de) * | 2008-02-08 | 2014-11-12 | Asuragen, INC. | In lymphknoten von krebspatienten differentiell exprimierte mirnas |
WO2009154835A2 (en) * | 2008-03-26 | 2009-12-23 | Asuragen, Inc. | Compositions and methods related to mir-16 and therapy of prostate cancer |
US20090258928A1 (en) * | 2008-04-08 | 2009-10-15 | Asuragen, Inc. | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
EP2990487A1 (de) * | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Zusammensetzungen und verfahren in zusammenhang mit der mirna-modulation von neovaskularisation oder angiogenese |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
WO2010120803A2 (en) | 2009-04-13 | 2010-10-21 | Somagenics Inc. | Methods and compositions for detection of small rnas |
AU2010242073C1 (en) | 2009-04-30 | 2015-12-24 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
US8597892B2 (en) | 2009-05-22 | 2013-12-03 | Asuragen, Inc. | MiRNA biomarkers of prostate disease |
JP5995721B2 (ja) | 2009-08-28 | 2016-09-21 | アスラジェン, インコーポレイテッド | 肺疾患のmiRNAバイオマーカー |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
EP4435111A1 (de) | 2010-02-12 | 2024-09-25 | Bio-Rad Laboratories, Inc. | Digitale analytanalyse |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
EP3709018A1 (de) | 2011-06-02 | 2020-09-16 | Bio-Rad Laboratories, Inc. | Mikrofluidische vorrichtung zum nachweis von komponenten einer chemischen reaktion |
CA2840196C (en) | 2011-06-27 | 2022-09-20 | Eisai R&D Management Co., Ltd. | Microrna biomarkers indicative of alzheimer's disease |
EP2744916A4 (de) | 2011-07-13 | 2015-06-17 | Primeradx Inc | Multimodale verfahren zur simultanen erkennung und quantifizierung mehrerer nukleinsäuren in einer probe |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
AU2012316129B2 (en) * | 2011-09-28 | 2017-10-05 | Htg Molecular Diagnostics, Inc. | Methods of co-detecting mRNA and small non-coding RNA |
WO2013058907A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
US9816130B2 (en) | 2011-12-22 | 2017-11-14 | Somagenics, Inc. | Methods of constructing small RNA libraries and their use for expression profiling of target RNAs |
US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
US9765385B2 (en) | 2012-06-29 | 2017-09-19 | Htg Molecular Diagnostics, Inc. | Nuclease protection methods for detection of nucleotide variants |
WO2014074611A1 (en) | 2012-11-07 | 2014-05-15 | Good Start Genetics, Inc. | Methods and systems for identifying contamination in samples |
US8778609B1 (en) | 2013-03-14 | 2014-07-15 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
WO2014197377A2 (en) | 2013-06-03 | 2014-12-11 | Good Start Genetics, Inc. | Methods and systems for storing sequence read data |
WO2015057565A1 (en) | 2013-10-18 | 2015-04-23 | Good Start Genetics, Inc. | Methods for assessing a genomic region of a subject |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
CN106164290A (zh) | 2014-01-05 | 2016-11-23 | 拜奥米尔纳控股有限公司 | 使用mirna比率确定肺癌 |
WO2015120382A1 (en) | 2014-02-07 | 2015-08-13 | The Johns Hopkins University | Predicting response to epigenetic drug therapy |
US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
WO2016048829A1 (en) | 2014-09-24 | 2016-03-31 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
WO2016094330A2 (en) | 2014-12-08 | 2016-06-16 | 20/20 Genesystems, Inc | Methods and machine learning systems for predicting the liklihood or risk of having cancer |
US10066259B2 (en) | 2015-01-06 | 2018-09-04 | Good Start Genetics, Inc. | Screening for structural variants |
EP3292214A1 (de) | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Verfahren zur quantifizierung von mirnas mittels normalisierung |
EP3394292B1 (de) | 2015-12-21 | 2021-04-28 | RealSeq Biosciences, Inc. | Verfahren zur bibliothekskonstruktion zur sequenzierung von polynukleotiden |
ES2942577T3 (es) * | 2017-01-16 | 2023-06-02 | Spectrum Solutions L L C | Solución de conservación de ácidos nucleicos y procedimientos de uso |
US20200263233A1 (en) * | 2017-06-23 | 2020-08-20 | Eiken Kagaku Kabushiki Kaisha | Method For Nucleic Acid Detection, Primer For Nucleic Acid Detection, And Kit For Nucleic Acid Detection |
EP3719144A1 (de) | 2019-04-05 | 2020-10-07 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung |
WO2021013592A1 (en) | 2019-07-19 | 2021-01-28 | Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz (Fibhulp) | Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc) |
EP4208566A2 (de) * | 2020-09-02 | 2023-07-12 | Meso Scale Technologies, LLC | Kits zum nachweis eines oder mehrerer zielanalyten in einer probe und verfahren zur herstellung und verwendung davon |
KR20230055951A (ko) | 2021-10-15 | 2023-04-26 | 아주대학교산학협력단 | miR-625-3p의 건선 중증도 진단용 바이오마커로서의 용도 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4876187A (en) * | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
US5011769A (en) * | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
US4999290A (en) * | 1988-03-31 | 1991-03-12 | The Board Of Regents, The University Of Texas System | Detection of genomic abnormalities with unique aberrant gene transcripts |
US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
AU8102694A (en) * | 1993-11-17 | 1995-06-06 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
US5801155A (en) * | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
PT912766E (pt) * | 1996-06-04 | 2009-07-16 | Univ Utah Res Found | Monitorização da hibridização durante a pcr |
US6232066B1 (en) * | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
US6458533B1 (en) * | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
US6238869B1 (en) * | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
US5942398A (en) * | 1998-02-26 | 1999-08-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glutx and uses thereof |
GB9904991D0 (en) * | 1999-03-05 | 1999-04-28 | Univ Nottingham | Genetic screening |
US7005261B1 (en) * | 1999-07-29 | 2006-02-28 | British Biocell International Limited | Method for detecting nucleic acid target sequences involving in vitro transcription from an RNA polymerase promoter |
US7205105B2 (en) * | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
AU2001234608A1 (en) * | 2000-01-28 | 2001-08-07 | Genetrace Systems, Inc. | Methods for analysis of gene expression |
US6573048B1 (en) * | 2000-04-18 | 2003-06-03 | Naxcor | Degradable nucleic acid probes and nucleic acid detection methods |
US20030170623A1 (en) * | 2001-04-13 | 2003-09-11 | Jingwen Chen | Multiplexed gene analysis on a mobile solid support |
AU2002341752B2 (en) * | 2001-09-19 | 2008-04-03 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
-
2004
- 2004-10-12 US US10/963,415 patent/US20060078894A1/en not_active Abandoned
-
2005
- 2005-10-12 WO PCT/US2005/036799 patent/WO2006042303A2/en active Application Filing
- 2005-10-12 DE DE602005016828T patent/DE602005016828D1/de active Active
- 2005-10-12 AT AT05815286T patent/ATE443777T1/de not_active IP Right Cessation
- 2005-10-12 EP EP05815286A patent/EP1812599B1/de not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
US20060078894A1 (en) | 2006-04-13 |
DE602005016828D1 (de) | 2009-11-05 |
WO2006042303A3 (en) | 2006-09-21 |
EP1812599A2 (de) | 2007-08-01 |
WO2006042303A2 (en) | 2006-04-20 |
EP1812599B1 (de) | 2009-09-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |