ATE426166T1 - Nachweis von autoantikírpern gegen antigene molekule von pankreas-inselzellen - Google Patents

Nachweis von autoantikírpern gegen antigene molekule von pankreas-inselzellen

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Publication number
ATE426166T1
ATE426166T1 AT02779738T AT02779738T ATE426166T1 AT E426166 T1 ATE426166 T1 AT E426166T1 AT 02779738 T AT02779738 T AT 02779738T AT 02779738 T AT02779738 T AT 02779738T AT E426166 T1 ATE426166 T1 AT E426166T1
Authority
AT
Austria
Prior art keywords
isle
pancreas
cells
detection
source
Prior art date
Application number
AT02779738T
Other languages
English (en)
Inventor
Bernard Rees Smith
Jadwiga Furmaniak
Michael Powell
Original Assignee
Rsr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9926667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE426166(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rsr Ltd filed Critical Rsr Ltd
Application granted granted Critical
Publication of ATE426166T1 publication Critical patent/ATE426166T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01048—Fusarinine-C ornithinesterase (3.1.1.48)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01015—Glutamate decarboxylase (4.1.1.15)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02779738T 2001-11-28 2002-11-26 Nachweis von autoantikírpern gegen antigene molekule von pankreas-inselzellen ATE426166T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0128583.2A GB0128583D0 (en) 2001-11-28 2001-11-28 Detection of autoantibodies indicative of diabetes

Publications (1)

Publication Number Publication Date
ATE426166T1 true ATE426166T1 (de) 2009-04-15

Family

ID=9926667

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02779738T ATE426166T1 (de) 2001-11-28 2002-11-26 Nachweis von autoantikírpern gegen antigene molekule von pankreas-inselzellen

Country Status (11)

Country Link
US (4) US8129132B2 (de)
EP (1) EP1448993B1 (de)
JP (2) JP2005512056A (de)
CN (1) CN100439920C (de)
AT (1) ATE426166T1 (de)
AU (1) AU2002343076A1 (de)
DE (1) DE60231639D1 (de)
DK (1) DK1448993T3 (de)
ES (1) ES2320427T3 (de)
GB (1) GB0128583D0 (de)
WO (1) WO2003048772A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128583D0 (en) * 2001-11-28 2002-01-23 Rsr Ltd Detection of autoantibodies indicative of diabetes
US7131202B2 (en) * 2004-03-11 2006-11-07 The Gillette Company Cutting members for shaving razors with multiple blades
GB2426581A (en) * 2005-05-27 2006-11-29 Univ Nottingham Immunoassay methods
JP2011106644A (ja) 2009-10-22 2011-06-02 Honda Motor Co Ltd 変速機の油圧制御装置
WO2012054584A2 (en) 2010-10-19 2012-04-26 The Regents Of The University Of Colorado, A Body Corporate Peptides for modulating t-cell activity and uses thereof
EP2631653A1 (de) * 2012-02-24 2013-08-28 Charité - Universitätsmedizin Berlin Identifizierung von Modulatoren der Bindungseigenschaften von mit einem Mitglied der Insulinrezeptorfamilie reaktiven Antikörpern
CN102967704B (zh) * 2012-11-26 2014-05-14 深圳市伯劳特生物制品有限公司 一种用于糖尿病自身抗体6项联检试剂盒
CN104969070B (zh) * 2013-02-05 2017-11-07 希森美康株式会社 作为1型糖尿病的早期诊断指标的gad抗体的高灵敏度测定方法
CN104098677A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
CN104098670A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
CN104560911B (zh) * 2014-12-18 2018-06-05 深圳市新产业生物医学工程股份有限公司 一种融合抗原蛋白质
CN104569425B (zh) * 2014-12-18 2017-02-08 深圳市新产业生物医学工程股份有限公司 一种与酪氨酸磷酸酶抗体特异结合的抗原蛋白质
CN107044977A (zh) * 2016-06-30 2017-08-15 深圳市亚辉龙生物科技股份有限公司 一种酪氨酸磷酸酶抗体化学发光免疫检测试剂盒及其制备方法
US11793854B2 (en) 2019-03-21 2023-10-24 Op-T Llc Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction
EP3953708A1 (de) * 2019-04-12 2022-02-16 Op-T Llc Diagnose und behandlung von autoimmunerkrankungen
CN112710839A (zh) * 2020-12-14 2021-04-27 三诺生物传感股份有限公司 一种gad65自身抗体检测试剂盒及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009933A1 (en) 1987-06-09 1988-12-15 Walker Laboratories Ltd. Immunoassay method
CN1036080A (zh) * 1988-03-23 1989-10-04 广东省肇庆地区第一人民医院 表面抗原的快速检测法
JPH07507441A (ja) * 1991-11-01 1995-08-24 ジヨスリン・ダイアビーテイス・センター １型真性糖尿病に関連する抗原
ATE205854T1 (de) 1991-11-19 2001-10-15 Amylin Pharmaceuticals Inc Peptide als amylin-agonisten und ihre verwendung
US5200318A (en) 1992-05-13 1993-04-06 Miles Inc. Diagnosis of IDDM with a panel of immunoreagents
DK0701569T3 (da) * 1992-12-03 2009-02-23 Univ California Forbedrede reagenser og fremgangsmåder til diagnosticering og behandling af diabetes og stiff man-syndrom
CN1053276C (zh) * 1997-03-11 2000-06-07 中日友好医院 一种检测胰岛细胞抗体的方法
DE19723463A1 (de) * 1997-06-04 1998-12-10 Dade Behring Marburg Gmbh Immunchemische Bestimmung von multivalenten Analyten
GB9719357D0 (en) * 1997-09-11 1997-11-12 Ortho Clinical Diagnostics Immunoassay Utilizing Two Incubations With Labelled Antigen
US6187563B1 (en) * 1998-08-07 2001-02-13 Yale University βIV-spectrin-polypeptides and nucleic acids encoding same
CN1283794A (zh) * 2000-07-12 2001-02-14 华西医科大学 同步快速测定多项免疫指标技术
GB0128583D0 (en) * 2001-11-28 2002-01-23 Rsr Ltd Detection of autoantibodies indicative of diabetes

Also Published As

Publication number Publication date
WO2003048772A3 (en) 2003-10-16
WO2003048772A2 (en) 2003-06-12
DK1448993T3 (da) 2009-06-22
EP1448993B1 (de) 2009-03-18
JP2005512056A (ja) 2005-04-28
US9435797B2 (en) 2016-09-06
US20160356771A1 (en) 2016-12-08
JP2009265109A (ja) 2009-11-12
US20120225955A1 (en) 2012-09-06
GB0128583D0 (en) 2002-01-23
AU2002343076A1 (en) 2003-06-17
US20050019837A1 (en) 2005-01-27
JP5711449B2 (ja) 2015-04-30
US10481156B2 (en) 2019-11-19
CN1585900A (zh) 2005-02-23
US10488410B2 (en) 2019-11-26
US8129132B2 (en) 2012-03-06
CN100439920C (zh) 2008-12-03
ES2320427T3 (es) 2009-05-22
DE60231639D1 (de) 2009-04-30
EP1448993A2 (de) 2004-08-25
US20160356772A1 (en) 2016-12-08

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